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Article Open Access

MicroRNA‑379 suppresses cell proliferation, migration and invasion in nasopharyngeal carcinoma by targeting tumor protein D52

Retraction in: /10.3892/etm.2024.12577
  • Authors:
    • Xiaojun Zhao
    • Jiusheng Chu
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology and Head Surgery, Taizhou People's Hospital, Taizhou, Jiangsu 225300, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1232-1240
    |
    Published online on: June 13, 2018
       https://doi.org/10.3892/etm.2018.6302
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Abstract

MicroRNAs (miRs) have been demonstrated to be important regulators of malignant behavior in nasopharyngeal carcinoma (NPC) tumorigenesis. The present study aimed to investigate the biological roles and underlying mechanisms of miR‑379 in NPC. The study initially observed that miR‑379 was significantly downregulated in NPC clinical tissues and cell lines using reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR). Next, gain‑of‑function assays were performed on human the NPC cell lines, C666‑1 and 5‑8F, including MTT, colony formation and transwell migration assays. The results indicated that ectopic expression of miR‑379 suppressed the NPC cell proliferation, colony formation, migration and invasion in vitro. In addition, tumor protein D52 (TPD52) was identified as a direct target of miR‑379 by a dual‑luciferase reporter assay, while overexpression of miR‑379 markedly reduced TPD52 expression at the mRNA and protein levels, as determined by RT‑qPCR and western blot analysis, respectively. Furthermore, silencing of TPD52 significantly inhibited the C666‑1 cell proliferation, migration and invasion. These findings suggest that miR‑379 negatively regulates the growth and migration of NPC cells by downregulating TPD52 expression, while modulation of miR‑379 expression may be a therapeutic strategy for NPC.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao X and Chu J: MicroRNA‑379 suppresses cell proliferation, migration and invasion in nasopharyngeal carcinoma by targeting tumor protein D52 Retraction in /10.3892/etm.2024.12577. Exp Ther Med 16: 1232-1240, 2018.
APA
Zhao, X., & Chu, J. (2018). MicroRNA‑379 suppresses cell proliferation, migration and invasion in nasopharyngeal carcinoma by targeting tumor protein D52 Retraction in /10.3892/etm.2024.12577. Experimental and Therapeutic Medicine, 16, 1232-1240. https://doi.org/10.3892/etm.2018.6302
MLA
Zhao, X., Chu, J."MicroRNA‑379 suppresses cell proliferation, migration and invasion in nasopharyngeal carcinoma by targeting tumor protein D52 Retraction in /10.3892/etm.2024.12577". Experimental and Therapeutic Medicine 16.2 (2018): 1232-1240.
Chicago
Zhao, X., Chu, J."MicroRNA‑379 suppresses cell proliferation, migration and invasion in nasopharyngeal carcinoma by targeting tumor protein D52 Retraction in /10.3892/etm.2024.12577". Experimental and Therapeutic Medicine 16, no. 2 (2018): 1232-1240. https://doi.org/10.3892/etm.2018.6302
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao X and Chu J: MicroRNA‑379 suppresses cell proliferation, migration and invasion in nasopharyngeal carcinoma by targeting tumor protein D52 Retraction in /10.3892/etm.2024.12577. Exp Ther Med 16: 1232-1240, 2018.
APA
Zhao, X., & Chu, J. (2018). MicroRNA‑379 suppresses cell proliferation, migration and invasion in nasopharyngeal carcinoma by targeting tumor protein D52 Retraction in /10.3892/etm.2024.12577. Experimental and Therapeutic Medicine, 16, 1232-1240. https://doi.org/10.3892/etm.2018.6302
MLA
Zhao, X., Chu, J."MicroRNA‑379 suppresses cell proliferation, migration and invasion in nasopharyngeal carcinoma by targeting tumor protein D52 Retraction in /10.3892/etm.2024.12577". Experimental and Therapeutic Medicine 16.2 (2018): 1232-1240.
Chicago
Zhao, X., Chu, J."MicroRNA‑379 suppresses cell proliferation, migration and invasion in nasopharyngeal carcinoma by targeting tumor protein D52 Retraction in /10.3892/etm.2024.12577". Experimental and Therapeutic Medicine 16, no. 2 (2018): 1232-1240. https://doi.org/10.3892/etm.2018.6302
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