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Article

Impact of proteasome inhibitor MG‑132 on expression of NF‑κB, IL‑1β and histological remodeling after myocardial infarction

  • Authors:
    • Xinhua Wu
    • Zhangrong Chen
    • Ying Yang
    • Yu Dong
    • Hong Liu
    • Shiquan Kuang
    • Kailiang Luo
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The First Affiliated Hospital of Dali University, Dali, Yunnan 671000, P.R. China, Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 404100, P.R. China
  • Pages: 1365-1372
    |
    Published online on: June 13, 2018
       https://doi.org/10.3892/etm.2018.6308
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Abstract

The aim of the present study was to investigate the impact of carbobenzoxy‑Leu‑Leu‑leucinal (MG‑132) on myocardial remodeling in rats with myocardial infarction (MI) and investigate the possible underlying mechanisms. The rat model of MI was established, followed by administration of MG‑132 (MG group), pyrrolidine dithiocarbamic acid (PDTC group) or normal saline (MI group) for 28 days. The expression of nuclear factor‑κB (NF‑κB) p65, interleukin 1β (IL‑1β) and matrix metalloproteinase 2 (MMP‑2), as well as the total volume of collagen and the ratio of type I/III collagen were then detected. Total collagen, including type I and III collagen, and the ratio of type I/III collagen were significantly increased in MI rats compared with those in the sham group (P<0.01), while it was significantly decreased in the PDTC and MG groups compared with that in the MI group (P<0.01). A similar trend was identified for the expression of NF‑κB, IL‑1β and MMP‑2, which was significantly increased in the MI group compared with that in the sham group (P<0.01), while it was significantly decreased in the MG and PDTC groups compared with that in the MI group (P<0.01). In conclusion, MG‑132 was demonstrated to improve post‑MI tissue remodeling, and the mechanism may be associated with the inhibition of NF‑κB activation and the downregulation of inflammatory cytokines, such as IL‑1β.
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Copy and paste a formatted citation
Spandidos Publications style
Wu X, Chen Z, Yang Y, Dong Y, Liu H, Kuang S and Luo K: Impact of proteasome inhibitor MG‑132 on expression of NF‑κB, IL‑1β and histological remodeling after myocardial infarction. Exp Ther Med 16: 1365-1372, 2018.
APA
Wu, X., Chen, Z., Yang, Y., Dong, Y., Liu, H., Kuang, S., & Luo, K. (2018). Impact of proteasome inhibitor MG‑132 on expression of NF‑κB, IL‑1β and histological remodeling after myocardial infarction. Experimental and Therapeutic Medicine, 16, 1365-1372. https://doi.org/10.3892/etm.2018.6308
MLA
Wu, X., Chen, Z., Yang, Y., Dong, Y., Liu, H., Kuang, S., Luo, K."Impact of proteasome inhibitor MG‑132 on expression of NF‑κB, IL‑1β and histological remodeling after myocardial infarction". Experimental and Therapeutic Medicine 16.2 (2018): 1365-1372.
Chicago
Wu, X., Chen, Z., Yang, Y., Dong, Y., Liu, H., Kuang, S., Luo, K."Impact of proteasome inhibitor MG‑132 on expression of NF‑κB, IL‑1β and histological remodeling after myocardial infarction". Experimental and Therapeutic Medicine 16, no. 2 (2018): 1365-1372. https://doi.org/10.3892/etm.2018.6308
Copy and paste a formatted citation
x
Spandidos Publications style
Wu X, Chen Z, Yang Y, Dong Y, Liu H, Kuang S and Luo K: Impact of proteasome inhibitor MG‑132 on expression of NF‑κB, IL‑1β and histological remodeling after myocardial infarction. Exp Ther Med 16: 1365-1372, 2018.
APA
Wu, X., Chen, Z., Yang, Y., Dong, Y., Liu, H., Kuang, S., & Luo, K. (2018). Impact of proteasome inhibitor MG‑132 on expression of NF‑κB, IL‑1β and histological remodeling after myocardial infarction. Experimental and Therapeutic Medicine, 16, 1365-1372. https://doi.org/10.3892/etm.2018.6308
MLA
Wu, X., Chen, Z., Yang, Y., Dong, Y., Liu, H., Kuang, S., Luo, K."Impact of proteasome inhibitor MG‑132 on expression of NF‑κB, IL‑1β and histological remodeling after myocardial infarction". Experimental and Therapeutic Medicine 16.2 (2018): 1365-1372.
Chicago
Wu, X., Chen, Z., Yang, Y., Dong, Y., Liu, H., Kuang, S., Luo, K."Impact of proteasome inhibitor MG‑132 on expression of NF‑κB, IL‑1β and histological remodeling after myocardial infarction". Experimental and Therapeutic Medicine 16, no. 2 (2018): 1365-1372. https://doi.org/10.3892/etm.2018.6308
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