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Effects of graft preconditioning on γ‑irradiated deep frozen tendon allografts used in anterior cruciate ligament reconstruction

  • Authors:
    • Xiaozuo Zheng
    • Wei Xu
    • Juyuan Gu
    • Yang Hu
    • Meijuan Cui
    • Yu‑E Feng
    • Shijun Gao

  • View Affiliations

  • Published online on: June 21, 2018     https://doi.org/10.3892/etm.2018.6338
  • Pages: 1338-1342

  • Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Preconditioning of the grafts prior to implantation into the knee is considered to reduce the loss of tension caused by graft viscoelasticity after anterior cruciate ligament reconstruction. The present study analyzed the impacts of different preconditioning forces on the biomechanical properties of the γ‑irradiated deep frozen tendon allografts. A total of 36 tendon grafts were randomly divided into three groups and were preconditioned at 80 N (group 1), 160 N (group 2) and 320 N (group 3) for 10 min. Subsequently, the grafts were gradually completely relaxed for 1 min and subsequently received 25 cyclic loads of 0‑80 N. Afterwards, the grafts were loaded to 80 N, which was maintained for 30 min. Finally, load was gradually increased until ultimate failure at maximum load (UFML) was obtained. There were significant differences in the stiffness and UFML values between the 3 groups (all P<0.05). The graft stiffness in group 3 significantly increased compared with the other 2 groups, and the stiffness of group 2 grafts increased compared with group 1. The UFML in group 3 was significantly lower compared with groups 1 and 2, while there was no significant difference between groups 1 and 2. In the present study, the results suggested that increasing the initial tension could effectively reduce the loss of stiffness due to viscoelasticity for the γ‑irradiated deep frozen allogeneic tendon grafts. However, overloaded initial tension decreased the tensile strength.
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August-2018
Volume 16 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zheng X, Xu W, Gu J, Hu Y, Cui M, Feng YE and Gao S: Effects of graft preconditioning on γ‑irradiated deep frozen tendon allografts used in anterior cruciate ligament reconstruction. Exp Ther Med 16: 1338-1342, 2018
APA
Zheng, X., Xu, W., Gu, J., Hu, Y., Cui, M., Feng, Y., & Gao, S. (2018). Effects of graft preconditioning on γ‑irradiated deep frozen tendon allografts used in anterior cruciate ligament reconstruction. Experimental and Therapeutic Medicine, 16, 1338-1342. https://doi.org/10.3892/etm.2018.6338
MLA
Zheng, X., Xu, W., Gu, J., Hu, Y., Cui, M., Feng, Y., Gao, S."Effects of graft preconditioning on γ‑irradiated deep frozen tendon allografts used in anterior cruciate ligament reconstruction". Experimental and Therapeutic Medicine 16.2 (2018): 1338-1342.
Chicago
Zheng, X., Xu, W., Gu, J., Hu, Y., Cui, M., Feng, Y., Gao, S."Effects of graft preconditioning on γ‑irradiated deep frozen tendon allografts used in anterior cruciate ligament reconstruction". Experimental and Therapeutic Medicine 16, no. 2 (2018): 1338-1342. https://doi.org/10.3892/etm.2018.6338