Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
August-2018 Volume 16 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2018 Volume 16 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Effects of graft preconditioning on γ‑irradiated deep frozen tendon allografts used in anterior cruciate ligament reconstruction

  • Authors:
    • Xiaozuo Zheng
    • Wei Xu
    • Juyuan Gu
    • Yang Hu
    • Meijuan Cui
    • Yu‑E Feng
    • Shijun Gao
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China, The Second Department of Intensive Care Unit, Children's Hospital of Hebei Province, Shijiazhuang, Hebei 050000, P.R. China, Department of Medical Records, Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China
    Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1338-1342
    |
    Published online on: June 21, 2018
       https://doi.org/10.3892/etm.2018.6338
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Preconditioning of the grafts prior to implantation into the knee is considered to reduce the loss of tension caused by graft viscoelasticity after anterior cruciate ligament reconstruction. The present study analyzed the impacts of different preconditioning forces on the biomechanical properties of the γ‑irradiated deep frozen tendon allografts. A total of 36 tendon grafts were randomly divided into three groups and were preconditioned at 80 N (group 1), 160 N (group 2) and 320 N (group 3) for 10 min. Subsequently, the grafts were gradually completely relaxed for 1 min and subsequently received 25 cyclic loads of 0‑80 N. Afterwards, the grafts were loaded to 80 N, which was maintained for 30 min. Finally, load was gradually increased until ultimate failure at maximum load (UFML) was obtained. There were significant differences in the stiffness and UFML values between the 3 groups (all P<0.05). The graft stiffness in group 3 significantly increased compared with the other 2 groups, and the stiffness of group 2 grafts increased compared with group 1. The UFML in group 3 was significantly lower compared with groups 1 and 2, while there was no significant difference between groups 1 and 2. In the present study, the results suggested that increasing the initial tension could effectively reduce the loss of stiffness due to viscoelasticity for the γ‑irradiated deep frozen allogeneic tendon grafts. However, overloaded initial tension decreased the tensile strength.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Jiang C, Chen G, Chen P, Li W, Zhang H and Zhang W: Double-bundle revision anterior cruciate ligament reconstruction is effective in rescuing failed primary reconstruction and re-introducing patients to physical exercise. Exp Ther Med. 15:2074–2080. 2018.PubMed/NCBI

2 

Chia ZY, Chee JN, Bin-Abd-Razak HR, Lie DT and Chang PC: A comparative study of anterior cruciate ligament reconstruction with double, single, or selective bundle techniques. J Orthop Surg (Hong Kong). 26:23094990187731242018. View Article : Google Scholar : PubMed/NCBI

3 

Jaglowski JR, Williams BT, Turnbull TL, LaPrade RF and Wijdicks CA: High-load preconditioning of soft tissue grafts: An in vitro biomechanical bovine tendon model. Knee Surg Sports Traumatol Arthrosc. 24:895–902. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Blythe A, Tasker T and Zioupos P: ACL graft constructs: In-vitro fatigue testing highlights the occurrence of irrecoverable lengthening and the need for adequate (pre)conditioning to avert the recurrence of knee instability. Technol Health Care. 14:335–347. 2006.PubMed/NCBI

5 

Elias JJ, Kilambi S and Ciccone WJ II: Tension level during preconditioning influences hamstring tendon graft properties. Am J Sports Med. 37:334–348. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Elias JJ, Rai SP and Ciccone WJ II: In vitro comparison of tension and stiffness between hamstring tendon and patella tendon grafts. J Orthop Res. 26:1506–1511. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Nurmi JT, Kannus P, Sievänen H, Järvelä T, Järvinen M and Järvinen TL: Interference screw fixation of soft tissue grafts in anterior cruciate ligament reconstruction: part 2: Effect of preconditioning on graft tension during and after screw insertion. Am J Sports Med. 32:418–424. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Arneja S, McConkey MO, Mulpuri K, Chin P, Gilbart MK, Regan WD and Leith JM: Graft tensioning in anterior cruciate ligament reconstruction: A systematic review of randomized controlled trials. Arthroscopy. 25:200–207. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Numazaki H, Tohyama H, Nakano H, Kikuchi S and Yasuda K: The effect of initial graft tension in anterior cruciate ligament reconstruction on the mechanical behaviors of the femur-graft-tibia complex during cyclic loading. Am J Sports Med. 30:800–805. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Figueroa D, Calvo R, Vaisman A, Meleán P and Figueroa F: Effect of tendon tensioning: An in vitro study in porcine extensor tendons. Knee. 17:245–258. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Guillard C, Lintz F, Odri GA, Vogeli D, Colin F, Collon S, Chappard D, Gouin F and Robert H: Effects of graft pretensioning in anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc. 20:2208–2213. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Yoshiya S, Andrish JT, Manley MT and Bauer TW: Graft tension in anterior cruciate ligament reconstruction. An in vivo study in dogs. Am J Sports Med. 15:464–470. 1987. View Article : Google Scholar : PubMed/NCBI

13 

Peña E, Martínez MA, Calvo B, Palanca D and Doblaré M: A finite element simulation of the effect of graft stiffness and graft tensioning in ACL reconstruction. Clin Biomech (Bristol, Avon). 20:636–644. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Guo L, Chen H, Luo JM, Yang L, Gu LC and Fu DJ: An arthroscopic second-look study on the effect of remnant preservation on synovialization of bone-patellar tendon-bone allograft in anterior cruciate ligament reconstruction. Arthroscopy. 32:868–877. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Carter TR and Rabago MT: Allograft anterior cruciate ligament reconstruction in patients younger than 25 years. J Knee Surg. 29:322–328. 2016.PubMed/NCBI

16 

Tian S, Wang B, Liu L, Wang Y, Ha C, Li Q, Yang X and Sun K: Irradiated hamstring tendon allograft versus autograft for anatomic double-bundle anterior cruciate ligament reconstruction: midterm clinical outcomes. Am J Sports Med. 44:2579–2588. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Curran AR, Adams DJ, Gill JL, Steiner ME and Scheller AD: The biomechanical effects of low-dose irradiation on bone-patellar tendon-bone allografts. Am J Sports Med. 32:1131–1135. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Vyas D, Rabuck SJ and Harner CD: Allograft anterior cruciate ligament reconstruction: Indications, techniques, and outcomes. J Orthop Sports Phys The. 42:196–207. 2012. View Article : Google Scholar

19 

Marrale J, Morrissey MC and Haddad FS: A literature review of autograft and allograft anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc. 15:690–704. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Shaerf DA, Pastides PS, Sarraf KM and Willis-Owen CA: Anterior cruciate ligament reconstruction best practice: A review of graft choice. World J Orthop. 5:23–29. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Zheng X, Li T, Wang J, Dong J and Gao S: Medial collateral ligament reconstruction using bone-patellar tendon-bone allograft for chronic medial knee instability combined with multi-ligament injuries: A new technique. J Orthop Surg Res. 11:852016. View Article : Google Scholar : PubMed/NCBI

22 

Schwartz HE, Matava MJ, Proch FS, Butler CA, Ratcliffe A, Levy M and Butler DL: The effect of gamma irradiation on anterior cruciate ligament allograft biomechanical and biochemical properties in the caprine model at time zero and at 6 months after surgery. Am J Sports Med. 34:1747–1755. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Fideler BM, Vangsness CT Jr, Lu B, Orlando C and Moore T: Gamma irradiation: Effects on biomechanical properties of human bone-patellar tendon-bone allografts. Am J Sports Med. 23:643–646. 1995. View Article : Google Scholar : PubMed/NCBI

24 

Ren D, Sun K, Tian S, Yang X, Zhang C, Wang W, Huang H, Zhang J and Deng Y: Effects of gamma irradiation and repetitive freeze-thaw cycles on the biomechanical properties of human flexor digitorum superficialis tendons. J Biomech. 45:252–256. 2012. View Article : Google Scholar : PubMed/NCBI

25 

DiBartola AC, Everhart JS, Kaeding CC, Magnussen RA and Flanigan DC: Maximum load to failure of high dose versus low dose gamma irradiation of anterior cruciate ligament allografts: A meta-analysis. Knee. 23:755–762. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Suggs J, Wang C and Li G: The effect of graft stiffness on knee joint biomechanics after ACL reconstruction-a 3D computational simulation. Clin Biomech (Bristol, Avon). 18:35–43. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Woo SL, Hollis JM, Adams DJ, Lyon RM and Takai S: Tensile properties of the human femur-anterior cruciate ligament-tibia complex. The effects of specimen age and orientation. Am J Sports Med. 19:217–225. 1991. View Article : Google Scholar : PubMed/NCBI

28 

Noyes FR and Grood ES: The strength of the anterior cruciate ligament in humans and Rhesus monkeys. J Bone Joint Surg Am. 58:1074–1082. 1976. View Article : Google Scholar : PubMed/NCBI

29 

Jackson DW, Corsetti J and Simon TM: Biologic incorporation of allograft anterior cruciate ligament replacements. Clin Orthop Relat Res. 324:126–133. 1996. View Article : Google Scholar

30 

Gorschewsky O, Browa A, Vogel U and Stauffer E: Clinico-histologic comparison of allogenic and autologous bone-tendon-bone using one-third of the patellar tendon in reconstruction of the anterior cruciate ligament. Unfallchirurg. 105:703–714. 2002.(In German). View Article : Google Scholar : PubMed/NCBI

31 

Mikami S, Yasuda K, Katsuragi R, Aoki Y, Minami A and Tohyama H: Reduction of initial tension in the in situ frozen anterior cruciate ligament. Clin Orthop Relat Res. 419:207–213. 2004. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zheng X, Xu W, Gu J, Hu Y, Cui M, Feng YE and Gao S: Effects of graft preconditioning on γ‑irradiated deep frozen tendon allografts used in anterior cruciate ligament reconstruction. Exp Ther Med 16: 1338-1342, 2018.
APA
Zheng, X., Xu, W., Gu, J., Hu, Y., Cui, M., Feng, Y., & Gao, S. (2018). Effects of graft preconditioning on γ‑irradiated deep frozen tendon allografts used in anterior cruciate ligament reconstruction. Experimental and Therapeutic Medicine, 16, 1338-1342. https://doi.org/10.3892/etm.2018.6338
MLA
Zheng, X., Xu, W., Gu, J., Hu, Y., Cui, M., Feng, Y., Gao, S."Effects of graft preconditioning on γ‑irradiated deep frozen tendon allografts used in anterior cruciate ligament reconstruction". Experimental and Therapeutic Medicine 16.2 (2018): 1338-1342.
Chicago
Zheng, X., Xu, W., Gu, J., Hu, Y., Cui, M., Feng, Y., Gao, S."Effects of graft preconditioning on γ‑irradiated deep frozen tendon allografts used in anterior cruciate ligament reconstruction". Experimental and Therapeutic Medicine 16, no. 2 (2018): 1338-1342. https://doi.org/10.3892/etm.2018.6338
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng X, Xu W, Gu J, Hu Y, Cui M, Feng YE and Gao S: Effects of graft preconditioning on γ‑irradiated deep frozen tendon allografts used in anterior cruciate ligament reconstruction. Exp Ther Med 16: 1338-1342, 2018.
APA
Zheng, X., Xu, W., Gu, J., Hu, Y., Cui, M., Feng, Y., & Gao, S. (2018). Effects of graft preconditioning on γ‑irradiated deep frozen tendon allografts used in anterior cruciate ligament reconstruction. Experimental and Therapeutic Medicine, 16, 1338-1342. https://doi.org/10.3892/etm.2018.6338
MLA
Zheng, X., Xu, W., Gu, J., Hu, Y., Cui, M., Feng, Y., Gao, S."Effects of graft preconditioning on γ‑irradiated deep frozen tendon allografts used in anterior cruciate ligament reconstruction". Experimental and Therapeutic Medicine 16.2 (2018): 1338-1342.
Chicago
Zheng, X., Xu, W., Gu, J., Hu, Y., Cui, M., Feng, Y., Gao, S."Effects of graft preconditioning on γ‑irradiated deep frozen tendon allografts used in anterior cruciate ligament reconstruction". Experimental and Therapeutic Medicine 16, no. 2 (2018): 1338-1342. https://doi.org/10.3892/etm.2018.6338
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team