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Lund exhaust on hemodynamic parameters and inflammatory mediators in patients undergoing cardiac valve replacement under cardiopulmonary bypass

  • Authors:
    • Jihong Zhu
    • Weimin Zhang
    • Guoying Shen
    • Xin Yu
    • Jige Guo
    • Taidi Zhong
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Sir Run Run Shaw Hospital of Zhejiang University, Hangzhou, Zhejiang 310016, P.R. China, Heart Center, Sir Run Run Shaw Hospital of Zhejiang University, Hangzhou, Zhejiang 310016, P.R. China, Out-patient Department, Sir Run Run Shaw Hospital of Zhejiang University, Hangzhou, Zhejiang 310016, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1747-1752
    |
    Published online on: June 26, 2018
       https://doi.org/10.3892/etm.2018.6354
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Abstract

The effect of Lund exhaust technique on hemodynamics and inflammatory mediators in patients undergoing cardiac valve replacement under cardiopulmonary bypass was evaluated. A total of 60 patients with heart disease undergoing elective heart valve replacement under elective cardiopulmonary bypass were randomly divided into Lund exhaust group (group A) and control group (group B), with 30 patients in each group. Group A underwent Lund exhaust during cardiopulmonary bypass, while group B was identical to group A except for not using the Lund exhaust technique during cardiopulmonary bypass. The hemodynamic parameters at different time-points showed that the indexes of MAP, PASP, CO, CI, PCWP, CVP and SVR in T1, T2, T3 and T4 moments between group A and group B were statistically significant (p<0.05). There was no statistical significance in IL-6, IL-8, IL-10, TNF-α and TIMP-1 between group A and group B patients at the T0 moment (p>0.05). The levels of IL-6, IL-8, IL-10, TNF-α and TIMP-1 in group B patients at T1, T2, T3 and T4 moments were statistically significant compared with those in group A (p<0.05). The IL-6, IL-8, TNF-α indexes of group B patients were statistically significant at the T5 moment compared with those in group A (p<0.05). The IL-10 and TIMP-1 of two groups were not statistically significant at the T5 moment. The operating time, CPB time, aortic clamp time, intraoperative blood loss, postoperative tube time, ICU stay time, hospital stay time and pulmonary infection of patients in group A were significantly less than those in group B. In conclusion, Lund exhaust technology can significantly reduce the fluctuation of hemodynamics, decrease the expression of inflammatory factors, improve lung function, and is conducive to the rehabilitation of patients.
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Copy and paste a formatted citation
Spandidos Publications style
Zhu J, Zhang W, Shen G, Yu X, Guo J and Zhong T: Lund exhaust on hemodynamic parameters and inflammatory mediators in patients undergoing cardiac valve replacement under cardiopulmonary bypass. Exp Ther Med 16: 1747-1752, 2018.
APA
Zhu, J., Zhang, W., Shen, G., Yu, X., Guo, J., & Zhong, T. (2018). Lund exhaust on hemodynamic parameters and inflammatory mediators in patients undergoing cardiac valve replacement under cardiopulmonary bypass. Experimental and Therapeutic Medicine, 16, 1747-1752. https://doi.org/10.3892/etm.2018.6354
MLA
Zhu, J., Zhang, W., Shen, G., Yu, X., Guo, J., Zhong, T."Lund exhaust on hemodynamic parameters and inflammatory mediators in patients undergoing cardiac valve replacement under cardiopulmonary bypass". Experimental and Therapeutic Medicine 16.3 (2018): 1747-1752.
Chicago
Zhu, J., Zhang, W., Shen, G., Yu, X., Guo, J., Zhong, T."Lund exhaust on hemodynamic parameters and inflammatory mediators in patients undergoing cardiac valve replacement under cardiopulmonary bypass". Experimental and Therapeutic Medicine 16, no. 3 (2018): 1747-1752. https://doi.org/10.3892/etm.2018.6354
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu J, Zhang W, Shen G, Yu X, Guo J and Zhong T: Lund exhaust on hemodynamic parameters and inflammatory mediators in patients undergoing cardiac valve replacement under cardiopulmonary bypass. Exp Ther Med 16: 1747-1752, 2018.
APA
Zhu, J., Zhang, W., Shen, G., Yu, X., Guo, J., & Zhong, T. (2018). Lund exhaust on hemodynamic parameters and inflammatory mediators in patients undergoing cardiac valve replacement under cardiopulmonary bypass. Experimental and Therapeutic Medicine, 16, 1747-1752. https://doi.org/10.3892/etm.2018.6354
MLA
Zhu, J., Zhang, W., Shen, G., Yu, X., Guo, J., Zhong, T."Lund exhaust on hemodynamic parameters and inflammatory mediators in patients undergoing cardiac valve replacement under cardiopulmonary bypass". Experimental and Therapeutic Medicine 16.3 (2018): 1747-1752.
Chicago
Zhu, J., Zhang, W., Shen, G., Yu, X., Guo, J., Zhong, T."Lund exhaust on hemodynamic parameters and inflammatory mediators in patients undergoing cardiac valve replacement under cardiopulmonary bypass". Experimental and Therapeutic Medicine 16, no. 3 (2018): 1747-1752. https://doi.org/10.3892/etm.2018.6354
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