Open Access

Integrated analysis of key mRNAs and lncRNAs in osteoarthritis

  • Authors:
    • Lei Chen
    • Yingqi Zhang
    • Zhitao Rao
    • Jincheng Zhang
    • Yeqing Sun
  • View Affiliations

  • Published online on: June 27, 2018     https://doi.org/10.3892/etm.2018.6360
  • Pages: 1841-1849
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Osteoarthritis (OA) is the most common type of arthritis, observed mainly in the population aged >65 years. However, the mechanism underlying the development and progression of OA has remained largely elusive. The present study aimed to identify differentially expressed mRNAs and lncRNAs in OA. By analyzing the GSE48556 and GSE82107 datasets, a total of 202 up‑ and 434 downregulated mRNAs were identified in OA. Gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis indicated that differently expressed genes were mainly involved in regulating antigen processing and presentation, interspecies interaction between organisms, immune response, transcription and signal transduction. In addition, a series of long non‑coding (lnc)RNAs were differently expressed in OA. To provide novel data on the molecular mechanisms and functional roles of these lncRNAs in OA, a co‑expression analysis was performed, which revealed that the dysregulated lncRNAs were associated with transcription, signal transduction, immune response and cell adhesion. In addition, certain key genes in protein‑protein interaction networks were identified. The present study provided useful information for exploring potential candidate biomarkers for the diagnosis and prognosis of OA, as well as novel drug targets.
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September-2018
Volume 16 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Chen L, Zhang Y, Rao Z, Zhang J and Sun Y: Integrated analysis of key mRNAs and lncRNAs in osteoarthritis. Exp Ther Med 16: 1841-1849, 2018
APA
Chen, L., Zhang, Y., Rao, Z., Zhang, J., & Sun, Y. (2018). Integrated analysis of key mRNAs and lncRNAs in osteoarthritis. Experimental and Therapeutic Medicine, 16, 1841-1849. https://doi.org/10.3892/etm.2018.6360
MLA
Chen, L., Zhang, Y., Rao, Z., Zhang, J., Sun, Y."Integrated analysis of key mRNAs and lncRNAs in osteoarthritis". Experimental and Therapeutic Medicine 16.3 (2018): 1841-1849.
Chicago
Chen, L., Zhang, Y., Rao, Z., Zhang, J., Sun, Y."Integrated analysis of key mRNAs and lncRNAs in osteoarthritis". Experimental and Therapeutic Medicine 16, no. 3 (2018): 1841-1849. https://doi.org/10.3892/etm.2018.6360