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Microarray data analysis to identify differentially expressed genes and biological pathways associated with asthma

  • Authors:
    • Shanshan Qi
    • Guanghui Liu
    • Xiang Dong
    • Nan Huang
    • Wenjing Li
    • Hao Chen
  • View Affiliations / Copyright

    Affiliations: Department of Allergy, Wuhan No. 1 Hospital, Wuhan, Hubei 430022, P.R. China, Department of Allergy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China
    Copyright: © Qi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1613-1620
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    Published online on: June 28, 2018
       https://doi.org/10.3892/etm.2018.6366
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Abstract

The present study aimed to identify differentially expressed genes (DEGs) and biological processes (BPs) associated with asthma. DEGs between allergic asthma and healthy controls were screened from GSE15823. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed using Database for Annotation, Visualization and Integrated Discovery. A protein‑protein interaction network was constructed, followed by module mining and functional analysis. Additionally, GSE41649 was downloaded to validate the reliability of the results. In GSE41649, DEGs were identified and compared with key DEGs identified in GSE15823. A total of 43 upregulated and 275 downregulated DEGs were obtained from GSE15823. Upregulated DEGs, such as nitric oxide synthase 2 (NOS2), were enriched in BPs related to oxidation reduction. Downregulated DEGs, such as chemokine (C‑C motif) ligand 19 (CCL21) and Cys‑X‑Cys ligand (CXCL9), were enriched in immune response‑related BPs. Protein tyrosine phosphatase receptor type C (PTPRC), CCL21, and CXCL9 were identified as hub genes. The DEGs in module 1 were significantly involved in the chemokine signaling pathway (P<0.05). The expression of the key genes obtained in GSE15823 demonstrated the same variation directions in the two datasets. The immune response, oxidants and nitric oxide metabolic pathways may have important roles in the progression of asthma. DEGs of PTPRC, CCL21, CXCL9 and NOS2 may be the potential targets for asthma diagnosis and treatment.
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View References

1 

Maddox L and Schwartz DA: The pathophysiology of asthma. Annu Rev Med. 53:477–498. 2002. View Article : Google Scholar : PubMed/NCBI

2 

Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald JM, Gibson P, Ohta K, O'Byrne P, Pedersen SE, et al: Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J. 31:143–178. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Koehoorn M, Tamburic L, McLeod CB, Demers P, Lynd L and Kennedy SM: Population-based surveillance of asthma among workers in British Columbia, Canada. Chronic Dis Inj Can. 33:88–94. 2013.PubMed/NCBI

4 

Lai C, Beasley R, Crane J, Foliaki S, Shah J and Weiland S: International Study of Asthma and Allergies in Childhood Phase Three Study Group: Global variation in the prevalence and severity of asthma symptoms: Phase three of the international study of asthma and allergies in childhood (ISAAC). Thorax. 64:476–483. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Leutholtz BC and Ripoll I: Exercise and disease management. 2nd edition. CRC Press; Boca Raton, FL: 2011

6 

Reponen T, Lockey J, Bernstein DI, Vesper SJ, Levin L, Hershey Khurana GK, Zheng S, Ryan P, Grinshpun SA, Villareal M and Lemasters G: Infant origins of childhood asthma associated with specific molds. J Allergy Clin Immunol. 130:639–644.e5. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Torgerson DG, Ampleford EJ, Chiu GY, Gauderman WJ, Gignoux CR, Graves PE, Himes BE, Levin AM, Mathias RA, Hancock DB, et al: Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet. 43:887–892. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Ober C and Hoffjan S: Asthma genetics 2006: The long and winding road to gene discovery. Genes Immun. 7:95–100. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Wang G, Liu CT, Wang ZL, Jiang LL, Yan CL and Luo FM: Antisense oligonucleotides-induced local blockade of T-bet expression leads to airway inflammation in rats1. Acta Pharmacol Sin. 27:561–567. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Laprise C, Sladek R, Ponton A, Bernier MC, Hudson TJ and Laviolette M: Functional classes of bronchial mucosa genes that are differentially expressed in asthma. BMC genomics. 5:212004. View Article : Google Scholar : PubMed/NCBI

11 

Moore JH, Asselbergs FW and Williams SM: Bioinformatics challenges for genome-wide association studies. Bioinformatics. 26:445–455. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Vaillancourt VT, Bordeleau M, Laviolette M and Laprise C: From expression pattern to genetic association in asthma and asthma-related phenotypes. BMC Res Notes. 5:6302012. View Article : Google Scholar : PubMed/NCBI

13 

Chamberland A, Madore AM, Tremblay K, Laviolette M and Laprise C: A comparison of two sets of microarray experiments to define allergic asthma expression pattern. Exp Lung Res. 35:399–410. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, November 1986. Am Rev Respir Dis. 136:225–244. 1987.PubMed/NCBI

15 

Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U and Speed TP: Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics. 4:249–264. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Gautier L, Cope L, Bolstad BM and Irizarry RA: affy-analysis of Affymetrix GeneChip data at the probe level. Bioinformatics. 20:307–315. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Dubitzky W, Wolkenhauer O, Yokota H and Cho KH: Student'st-TestEncyclopedia of Systems Biology. Springer; New York, NY: pp. 2023–2025. 2013, View Article : Google Scholar

18 

da Huang W, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene ontology: Tool for the unification of biology. The Gene Ontology Consortium. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Kanehisa M and Goto S: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28:27–30. 2000. View Article : Google Scholar : PubMed/NCBI

21 

Franceschini A, Szklarczyk D, Frankild S, Kuhn M, Simonovic M, Roth A, Lin J, Minguez P, Bork P, von Mering C and Jensen LJ: STRING v9.1: Protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res. 41:(Database Issue). D808–D815. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Stuart JM, Segal E, Koller D and Kim SK: A gene-coexpression network for global discovery of conserved genetic modules. science. 302:249–255. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Bader GD and Hogue CW: An automated method for finding molecular complexes in large protein interaction networks. BMC Bioinformatics. 4:22003. View Article : Google Scholar : PubMed/NCBI

25 

Wark PA, Johnston SL, Bucchieri F, Powell R, Puddicombe S, Laza-Stanca V, Holgate ST and Davies DE: Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. J Exp Med. 201:937–947. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Differentiation CO: Protein tyrosine phosphatase receptor type C. Springer; New York, NY: 2012

27 

Trowbridge IS, Ostergaard HL and Johnson P: CD45: A leukocyte-specific member of the protein tyrosine phosphatase family. Biochim Biophys Acta. 1095:46–56. 1991. View Article : Google Scholar : PubMed/NCBI

28 

Hermiston ML, Xu Z and Weiss A: CD45: A critical regulator of signaling thresholds in immune cells. Annu Rev Immunol. 21:107–137. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Matsumoto K, Bochner BS, Wakiguchi H and Kurashige T: Altered expression of CD11b and CD62L after cross-linking of CD45 isoforms on human eosinophils. Int Arch Allergy Immunol. 117 Suppl 1:S34–S39. 1998. View Article : Google Scholar

30 

Blaylock MG, Lipworth BJ, Dempsey OJ, Duncan CJ, Lee DK, Lawrie A, Douglas JG and Walsh GM: Eosinophils from patients with asthma express higher levels of the pan-leucocyte receptor CD45 and the isoform CD45RO. Clin Exp Allergy. 33:936–941. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Walsh GM: Advances in the immunobiology of eosinophils and their role in disease. Crit Rev Clin Lab Sci. 36:453–496. 1999. View Article : Google Scholar : PubMed/NCBI

32 

Nguyen KD, Vanichsarn C, Fohner A and Nadeau KC: Selective deregulation in chemokine signaling pathways of CD4+CD25(hi)CD127(lo)/(−) regulatory T cells in human allergic asthma. J Allergy Clin Immunol. 123:933–939.e10. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Yamashita N, Tashimo H, Matsuo Y, Ishida H, Yoshiura K, Sato K, Yamashita N, Kakiuchi T and Ohta K: Role of CCL21 and CCL19 in allergic inflammation in the ovalbumin-specific murine asthmatic model. J Allergy Clin Immunol. 117:1040–1046. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Lambrecht BN, Peleman RA, Bullock GR and Pauwels RA: Sensitization to inhaled antigen by intratracheal instillation of dendritic cells. Clin Exp Allergy. 30:214–224. 2000. View Article : Google Scholar : PubMed/NCBI

35 

Takamura K, Fukuyama S, Nagatake T, Kim DY, Kawamura A, Kawauchi H and Kiyono H: Regulatory role of lymphoid chemokine CCL19 and CCL21 in the control of allergic rhinitis. J Immunol. 179:5897–5906. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Xu B, Aoyama K, Kusumoto M, Matsuzawa A, Butcher EC, Michie SA, Matsuyama T and Takeuchi T: Lack of lymphoid chemokines CCL19 and CCL21 enhances allergic airway inflammation in mice. Int Immunol. 19:775–784. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Meller S, Lauerma AI, Kopp FM, Winterberg F, Anthoni M, Müller A, Gombert M, Haahtela A, Alenius H, Rieker J, et al: Chemokine responses distinguish chemical-induced allergic from irritant skin inflammation: Memory T cells make the difference. J Allergy Immuno. 119:1470–1480. 2007. View Article : Google Scholar

38 

Tworek D, Kuna P, Młynarski W, Górski P, Pietras T and Antczak A: MIG (CXCL9), IP-10 (CXCL10) and I-TAC (CXCL11) concentrations after nasal allergen challenge in patients with allergic rhinitis. Arch Med Sci. 9:849–853. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Sackesen C, Ercan H, Dizdar E, Soyer O, Gumus P, Tosun BN, Büyüktuncer Z, Karabulut E, Besler T and Kalayci O: A comprehensive evaluation of the enzymatic and nonenzymatic antioxidant systems in childhood asthma. J Allergy Clin Immunol. 122:78–85. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Andreadis AA, Hazen SL, Comhair SA and Erzurum SC: Oxidative and nitrosative events in asthma. Free Radic Biol Med. 35:213–225. 2003. View Article : Google Scholar : PubMed/NCBI

41 

Nadeem A, Raj HG and Chhabra SK: Increased oxidative stress and altered levels of antioxidants in chronic obstructive pulmonary disease. Inflammation. 29:23–32. 2005. View Article : Google Scholar : PubMed/NCBI

42 

Ghosh S and Erzurum SC: Nitric oxide metabolism in asthma pathophysiology. Biochim Biophys Acta. 1810:1008–1016. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Alderton WK, Cooper CE and Knowles RG: Nitric oxide synthases: Structure, function and inhibition. Biochem J. 357:593–615. 2001. View Article : Google Scholar : PubMed/NCBI

44 

Salam MT, Bastain TM, Rappaport EB, Islam T, Berhane K, Gauderman WJ and Gilliland FD: Genetic variations in nitric oxide synthase and arginase influence exhaled nitric oxide levels in children. Allergy. 66:412–419. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Dweik RA: Nitric oxide, hypoxia, and superoxide: The good, the bad, and the ugly! Thorax. 60:265–267. 2005. View Article : Google Scholar : PubMed/NCBI

46 

Prescott E, Lange P and Vestbo J: Effect of gender on hospital admissions for asthma and prevalence of self-reported asthma: A prospective study based on a sample of the general population. Copenhagen City Heart Study Group. Thorax. 52:287–289. 1997. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Qi S, Liu G, Dong X, Huang N, Li W and Chen H: Microarray data analysis to identify differentially expressed genes and biological pathways associated with asthma. Exp Ther Med 16: 1613-1620, 2018.
APA
Qi, S., Liu, G., Dong, X., Huang, N., Li, W., & Chen, H. (2018). Microarray data analysis to identify differentially expressed genes and biological pathways associated with asthma. Experimental and Therapeutic Medicine, 16, 1613-1620. https://doi.org/10.3892/etm.2018.6366
MLA
Qi, S., Liu, G., Dong, X., Huang, N., Li, W., Chen, H."Microarray data analysis to identify differentially expressed genes and biological pathways associated with asthma". Experimental and Therapeutic Medicine 16.3 (2018): 1613-1620.
Chicago
Qi, S., Liu, G., Dong, X., Huang, N., Li, W., Chen, H."Microarray data analysis to identify differentially expressed genes and biological pathways associated with asthma". Experimental and Therapeutic Medicine 16, no. 3 (2018): 1613-1620. https://doi.org/10.3892/etm.2018.6366
Copy and paste a formatted citation
x
Spandidos Publications style
Qi S, Liu G, Dong X, Huang N, Li W and Chen H: Microarray data analysis to identify differentially expressed genes and biological pathways associated with asthma. Exp Ther Med 16: 1613-1620, 2018.
APA
Qi, S., Liu, G., Dong, X., Huang, N., Li, W., & Chen, H. (2018). Microarray data analysis to identify differentially expressed genes and biological pathways associated with asthma. Experimental and Therapeutic Medicine, 16, 1613-1620. https://doi.org/10.3892/etm.2018.6366
MLA
Qi, S., Liu, G., Dong, X., Huang, N., Li, W., Chen, H."Microarray data analysis to identify differentially expressed genes and biological pathways associated with asthma". Experimental and Therapeutic Medicine 16.3 (2018): 1613-1620.
Chicago
Qi, S., Liu, G., Dong, X., Huang, N., Li, W., Chen, H."Microarray data analysis to identify differentially expressed genes and biological pathways associated with asthma". Experimental and Therapeutic Medicine 16, no. 3 (2018): 1613-1620. https://doi.org/10.3892/etm.2018.6366
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