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Article

Reversible splenial lesion syndrome associated with acute Mycoplasma pneumoniae‑associated encephalitis: A report of four cases and literature review

  • Authors:
    • Xiaoyu Dong
    • Shuyan Cong
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China
  • Pages: 2152-2159
    |
    Published online on: July 2, 2018
       https://doi.org/10.3892/etm.2018.6387
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Abstract

Reversible splenial lesion syndrome (RESLES) is a rare clinico‑radiological syndrome that is defined as reversible lesions that involve the splenium of the corpus callosum (SCC). RESLES has been reported in patients with a broad spectrum of diseases and conditions, including infections, hypoglycemia and poisoning. The present report described four RESLES cases triggered by Mycoplasma pneumoniae (M. pneumoniae) and discussed the associated diagnostic challenges. Four cases of acute M. pneumoniae‑associated encephalitis that displayed RESLES were reviewed. The clinical presentations were nonspecific in these patients. However, magnetic resonance imaging (MRI) revealed consistent lesions in the SCC with a hyperintensity in diffusion‑weighted imaging (DWI) and hypointensities in T1WI, which disappeared after a variable lapse. Treatment with azithromycin or combined treatment with immunomodulatory agents if necessary led to a good prognosis. The present findings indicated that radiological diagnosis of RESLES should be considered in patients with M. pneumoniae‑associated encephalitis. Furthermore, serum Mycoplasma antibody is important for the diagnosis of M. pneumoniae‑associated encephalitis.
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Copy and paste a formatted citation
Spandidos Publications style
Dong X and Cong S: Reversible splenial lesion syndrome associated with acute Mycoplasma pneumoniae‑associated encephalitis: A report of four cases and literature review. Exp Ther Med 16: 2152-2159, 2018.
APA
Dong, X., & Cong, S. (2018). Reversible splenial lesion syndrome associated with acute Mycoplasma pneumoniae‑associated encephalitis: A report of four cases and literature review. Experimental and Therapeutic Medicine, 16, 2152-2159. https://doi.org/10.3892/etm.2018.6387
MLA
Dong, X., Cong, S."Reversible splenial lesion syndrome associated with acute Mycoplasma pneumoniae‑associated encephalitis: A report of four cases and literature review". Experimental and Therapeutic Medicine 16.3 (2018): 2152-2159.
Chicago
Dong, X., Cong, S."Reversible splenial lesion syndrome associated with acute Mycoplasma pneumoniae‑associated encephalitis: A report of four cases and literature review". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2152-2159. https://doi.org/10.3892/etm.2018.6387
Copy and paste a formatted citation
x
Spandidos Publications style
Dong X and Cong S: Reversible splenial lesion syndrome associated with acute Mycoplasma pneumoniae‑associated encephalitis: A report of four cases and literature review. Exp Ther Med 16: 2152-2159, 2018.
APA
Dong, X., & Cong, S. (2018). Reversible splenial lesion syndrome associated with acute Mycoplasma pneumoniae‑associated encephalitis: A report of four cases and literature review. Experimental and Therapeutic Medicine, 16, 2152-2159. https://doi.org/10.3892/etm.2018.6387
MLA
Dong, X., Cong, S."Reversible splenial lesion syndrome associated with acute Mycoplasma pneumoniae‑associated encephalitis: A report of four cases and literature review". Experimental and Therapeutic Medicine 16.3 (2018): 2152-2159.
Chicago
Dong, X., Cong, S."Reversible splenial lesion syndrome associated with acute Mycoplasma pneumoniae‑associated encephalitis: A report of four cases and literature review". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2152-2159. https://doi.org/10.3892/etm.2018.6387
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