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Article

Impact of weight cycling on CTRP3 expression, adipose tissue inflammation and insulin sensitivity in C57BL/6J mice

  • Authors:
    • Xin Li
    • Li Jiang
    • Miao Yang
    • Yu‑Wen Wu
    • Jia‑Zhong Sun
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, P.R. China, Department of Internal Medicine, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, P.R. China
  • Pages: 2052-2059
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    Published online on: July 4, 2018
       https://doi.org/10.3892/etm.2018.6399
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Abstract

Impacts of weight cycling on C1q/tumor necrosis factor (TNF)‑related protein‑3 (CTRP3) expression, adipose tissue inflammation and insulin sensitivity in C57BL/6J mice were evaluated in the current study. A total of 30 male C57Bl/6J mice were divided randomly into three groups; normal control (n=10), high‑fat diet (OB, n=10) and weight cycling (WC, n=10), which were fed with high‑fat diet in the first and last 8 weeks and regular chow in between. Systemic glucose metabolic status and insulin sensitivity were detected by intraperitoneal glucose tolerance test and hyperinsulinemic‑euglycemic clamp, respectively. Blood levels of interleukin (IL)‑6 and TNF‑α were determined using ELISA. Relative CTRP3, IL‑6, TNF‑α and glucose transporter (GLUT)4 mRNA expression in adipose tissue was detected using reverse transcription‑quantitative polymerase chain reaction assays. Relative CTRP3, phosphatidylinositide 3‑kinases (PI3K) and protein kinase B (PKB; Ser473) protein expression were detected by western blot analysis. Area under the curve of glucose and glucose infusion rate of the WC group were significantly increased compared with the OB group (P<0.01). CTRP3 mRNA and protein levels of the WC group were significantly decreased by 20.3 and 23.1%, respectively, compared with the OB group (P<0.01). IL‑6 and TNF‑α protein plasma levels and gene expression in adipose tissue of the WC group were significantly increased compared with the OB group (P<0.01). Expression and phosphorylation of insulin signaling molecules PI3K and PKB (Ser473), respectively and GLUT4 gene expression in adipose tissue of the WC group were significantly decreased compared with the OB group (P<0.01). In conclusion, weight cycling impaired glucose metabolism and insulin sensitivity by decreasing CTRP3, PI3K, phosphorylated‑PKB (Ser473) and GLUT4 expression, and increasing IL‑6 and TNF‑α levels.
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View References

1 

Nathan DM: Diabetes: Advances in diagnosis and treatment. JAMA. 314:1052–1062. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Stanford KI, Middelbeek RJ and Goodyear LJ: Exercise effects on white adipose tissue: Beiging and metabolic adaptations. Diabetes. 64:2361–2368. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Chang YY and Chiou WB: Means yield to ends in weight loss: Focusing on ‘how’ vs ‘why’ aspects of losing weight can lead to poorer regulation of dietary practices. J Acad Nutr Diet. 115:1387–1391. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Bertz F, Brekke HK, Ellegård L, Rasmussen KM, Wennergren M and Winkvist A: Diet and exercise weight-loss trial in lactating overweight and obese women. Am J Clin Nutr. 96:698–705. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Melby CL, Paris HL, Foright RM and Peth J: Attenuating the biologic drive for weight regain following weight loss: Must what goes down always go back up? Nutrients. 9:pii: E468. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Bosy-Westphal A, Kahlhöfer J, Lagerpusch M, Skurk T and Müller MJ: Deep body composition phenotyping during weight cycling: Relevance to metabolic efficiency and metabolic risk. Obes Rev. 1 Suppl 16:S36–S44. 2015. View Article : Google Scholar

7 

Delahanty LM, Pan Q, Jablonski KA, Aroda VR, Watson KE, Bray GA, Kahn SE, Florez JC, Perreault L and Franks PW; Diabetes Prevention Program Research Group, : Effects of weight loss, weight cycling, and weight loss maintenance on diabetes incidence and change in cardiometabolic traits in the diabetes prevention program. Diabetes Care. 37:2738–2745. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Neamat-Allah J, Barrdahl M, Hüsing A, Katzke VA, Bachlechner U, Steffen A, Kaaks R, Schulze MB, Boeing H and Kühn T: Weight cycling and the risk of type 2 diabetes in the EPIC-Germany cohort. Diabetologia. 58:2718–2725. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Rhee EJ, Cho JH, Kwon H, Park SE, Park CY, Oh KW, Park SW and Lee WY: Increased risk of diabetes development in individuals with weight cycling over 4 years: The kangbuk samsung health study. Diabetes Res Clin Pract. 139:230–238. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Madigan CD, Pavey T, Daley AJ, Jolly K and Brown WJ: Is weight cycling associated with adverse health outcomes? A cohort study. Prev Med. 108:47–52. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Rogero MM and Calder PC: Obesity, inflammation, toll-like receptor 4 and fatty acids. Nutrients. 10:pii: E432. 2018. View Article : Google Scholar

12 

Persson PB and Persson Bondke A: Metabolism, obesity and the metabolic syndrome. Acta Physiol (Oxf). 13:e130962018. View Article : Google Scholar

13 

Tarantino G: Gut microbiome, obesity-related comorbidities, and low-grade chronic inflammation. J Clin Endocrinol Metab. 99:2343–2346. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Ryan DH and Jensen MD: What the new obesity guidelines will tell us. Curr Opin Endocrinol Diabetes Obes. 20:429–433. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Boutari C, Perakakis N and Mantzoros CS: Association of adipokines with development and progression of nonalcoholic fatty liver disease. Endocrinol Metab (Seoul). 33:33–43. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Andrade-Oliveira V, Câmara NO and Moraes-Vieira PM: Adipokines as drug targets in diabetes and underlying disturbances. J Diabetes Res. 2015:6816122015. View Article : Google Scholar : PubMed/NCBI

17 

Li Y, Wright GL and Peterson JM: C1q/TNF-related protein 3 (CTRP3) function and regulation. Compr Physiol. 7:863–878. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Peterson JM, Wei Z and Wong GW: C1q/TNF-related protein-3 (CTRP3), a novel adipokine that regulates hepatic glucose output. J Biol Chem. 285:39691–39701. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Yi W, Sun Y, Yuan Y, Lau WB, Zheng Q, Wang X, Wang Y, Shang X, Gao E, Koch WJ and Ma XL: C1q/tumor necrosis factor-related protein-3, a newly identified adipokine, is a novel antiapoptotic, proangiogenic, and cardioprotective molecule in the ischemic mouse heart. Circulation. 125:3159–3169. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Petersen PS, Wolf RM, Lei X, Peterson JM and Wong GW: Immunomodulatory roles of CTRP3 in endotoxemia and metabolic stress. Physiol Rep. 4:e127352016. View Article : Google Scholar : PubMed/NCBI

21 

Li X, Jiang L, Yang M, Wu YW, Sun JZ and Sun SX: CTRP3 improves the insulin sensitivityof 3T3-L1 adipocytes by inhibiting inflammation and ameliorating insulin signalling transduction. Endokrynol Pol. 65:252–258. 2014. View Article : Google Scholar : PubMed/NCBI

22 

List EO, Berryman DE, Wright-Piekarski J, Jara A, Funk K and Kopchick JJ: The effects of weight cycling on lifespan in male C57BL/6J mice. Int J Obes (Lond). 37:1088–1094. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Li X, Yuan L, Li J, Li H and Cheng S: Blockade of renin angiotensin system increased resistance to STZ-induced diabetes in rats with long-term high-fat diet. Exp Diabetes Res. 2012:6189232012. View Article : Google Scholar : PubMed/NCBI

24 

Barbosa-da-Silva S, Fraulob-Aquino JC, Lopes JR, Mandarim-de-Lacerda CA and Aguila MB: Weight cycling enhances adipose tissue inflammatory responses in male mice. PLoS One. 7:e398372012. View Article : Google Scholar : PubMed/NCBI

25 

Li X, Jiang L, Yang M, Wu YW, Sun SX and Sun JZ: Expression of CTRP3, a novel adipokine, in rats at different pathogenic stages of type 2 diabetes mellitus and the impacts of GLP-1 receptor agonist on it. J Diabetes Res. 2014:3985182014. View Article : Google Scholar : PubMed/NCBI

26 

Zhou S, Wang G and Zhang W: Effect of TLR4/MyD88 signaling pathway on sepsis-associated acute respiratory distress syndrome in rats, via regulation of macrophage activation and inflammatory response. Exp Ther Med. 15:3376–3384. 2018.PubMed/NCBI

27 

Dankel SN, Degerud EM, Borkowski K, Fjære E, Midtbø LK, Haugen C, Solsvik MH, Lavigne AM, Liaset B, Sagen JV, et al: Weight cycling promotes fat gain and altered clock gene expression in adipose tissue in C57BL/6J mice. Am J Physiol Endocrinol Metab. 306:E210–E224. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Tsai S, Clemente-Casares X, Revelo XS, Winer S and Winer DA: Are obesity-related insulin resistance and type 2 diabetes autoimmune diseases? Diabetes. 64:1886–1897. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Neeland IJ, Poirier P and Després JP: Cardiovascular and metabolic heterogeneity of obesity: Clinical challenges and implications for management. Circulation. 137:1391–1406. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Strohacker K and McFarlin BK: Influence of obesity, physical inactivity, and weight cycling on chronic inflammation. Front Biosci (Elite Ed). 2:98–104. 2010.PubMed/NCBI

32 

Salinardi TC, Batra P, Roberts SB, Urban LE, Robinson LM, Pittas AG, Lichtenstein AH, Deckersbach T, Saltzman E and Das SK: Lifestyle intervention reduces body weight and improves cardiometabolic risk factors in worksites. Am J Clin Nutr. 97:667–676. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Wolf RM, Steele KE, Peterson LA, Magnuson TH, Schweitzer MA and Wong GW: Lower circulating C1q/TNF-related protein-3 (CTRP3) levels are associated with obesity: A cross-sectional study. PLoS One. 10:e01339552015. View Article : Google Scholar : PubMed/NCBI

34 

Catenacci VA, Pan Z, Ostendorf D, Brannon S, Gozansky WS, Mattson MP, Martin B, MacLean PS, Melanson EL and Donahoo Troy W: A randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity. Obesity (Silver Spring). 24:1874–1883. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Madero M, Arriaga JC, Jalal D, Rivard C, McFann K, Pérez-Méndez O, Vázquez A, Ruiz A, Lanaspa MA, Jimenez CR, et al: The effect of two energy-restricted diets, a low-fructose diet versus a moderate natural fructose diet, on weight loss and metabolic syndrome parameters: A randomized controlled trial. Metabolism. 60:1551–1559. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Kodama S, Horikawa C, Fujihara K, Yoshizawa S, Yachi Y, Tanaka S, Ohara N, Matsunaga S, Yamada T, Hanyu O and Sone H: Quantitative relationship between body weight gain in adulthood and incident type 2 diabetes: A meta-analysis. Obes Rev. 15:202–214. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Mehta T, Smith DL Jr, Muhammad J and Casazza K: Impact of weight cycling on risk of morbidity and mortality. Obes Rev. 15:870–881. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Abraham TM, Pencina KM, Pencina MJ and Fox CS: Trends in diabetes incidence: The framingham heart study. Diabetes Care. 38:482–487. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Mackie GM, Samocha-Bonet D and Tam CS: Does weight cycling promote obesity and metabolic risk factors? Obes Res Clin Pract. 11:131–139. 2017. View Article : Google Scholar : PubMed/NCBI

40 

Zhang Y, Yatsuya H, Li Y, Chiang C, Hirakawa Y, Kawazoe N, Tamakoshi K, Toyoshima H and Aoyama A: Long-term weight-change slope, weight fluctuation and risk of type 2 diabetes mellitus in middle-aged Japanese men and women: Findings of aichi workers' cohort study. Nutr Diabetes. 7:e2522017. View Article : Google Scholar : PubMed/NCBI

41 

Stevens VL, Jacobs EJ, Sun J, Patel AV, McCullough ML, Teras LR and Gapstur SM: Weight cycling and mortality in a large prospective US study. Am J Epidemiol. 175:785–792. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Anderson EK, Gutierrez DA, Kennedy A and Hasty AH: Weight cycling increases T-cell accumulation in adipose tissue and impairs systemic glucose tolerance. Diabetes. 62:3180–3188. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Hoevenaars FP, Keijer J, Swarts HJ, Snaas-Alders S, Bekkenkamp-Grovenstein M and van Schothorst EM: Effects of dietary history on energy metabolism and physiological parameters in C57BL/6J mice. Exp Physiol. 98:1053–1062. 2013. View Article : Google Scholar : PubMed/NCBI

44 

Cappellano G, Morandi EM, Rainer J, Grubwieser P, Heinz K, Wolfram D, Bernhard D, Lobenwein S, Pierer G and Ploner C: Human macrophages preferentially infiltrate the superficial adipose tissue. Int J Mol Sci. 19:E14042018. View Article : Google Scholar : PubMed/NCBI

45 

Ludgero-Correia A Jr, Aguila MB, Mandarim-de-Lacerda CA and Faria TS: Effects of high-fat diet on plasma lipids, adiposity, and inflammatory markers in ovariectomized C57BL/6 mice. Nutrition. 28:316–323. 2012. View Article : Google Scholar : PubMed/NCBI

46 

Mechanick JI, Zhao S and Garvey WT: The adipokine-cardiovascular-lifestyle network: Translation to clinical practice. J Am Coll Cardiol. 68:1785–1803. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Fasshauer M and Blüher M: Adipokines in health and disease. Trends Pharmacol Sci. 36:461–470. 2015. View Article : Google Scholar : PubMed/NCBI

48 

Engin A: Adiponectin-resistance in obesity. Adv Exp Med Biol. 960:415–441. 2017. View Article : Google Scholar : PubMed/NCBI

49 

Achari AE and Jain SK: Adiponectin, a therapeutic target for obesity, diabetes, and endothelial dysfunction. Int J Mol Sci. 18:E13212017. View Article : Google Scholar : PubMed/NCBI

50 

Khan M and Joseph F: Adipose tissue and adipokines: The association with and application of adipokines in obesity. Scientifica (Cairo). 2014:3285922014.PubMed/NCBI

51 

Kopp A, Bala M, Weigert J, Büchler C, Neumeier M, Aslanidis C, Schölmerich J and Schäffler A: Effects of the new adiponectin paralogous protein CTRP-3 and of LPS on cytokine release from monocytes of patients with type 2 diabetes mellitus. Cytokine. 49:51–57. 2010. View Article : Google Scholar : PubMed/NCBI

52 

Zand H, Morshedzadeh N and Naghashian F: Signaling pathways linking inflammation to insulin resistance. Diabetes Metab Syndr. 1 Suppl 11:S307–S309. 2017. View Article : Google Scholar

53 

De Felice FG and Ferreira ST: Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease. Diabetes. 63:2262–2272. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li X, Jiang L, Yang M, Wu YW and Sun JZ: Impact of weight cycling on CTRP3 expression, adipose tissue inflammation and insulin sensitivity in C57BL/6J mice. Exp Ther Med 16: 2052-2059, 2018.
APA
Li, X., Jiang, L., Yang, M., Wu, Y., & Sun, J. (2018). Impact of weight cycling on CTRP3 expression, adipose tissue inflammation and insulin sensitivity in C57BL/6J mice. Experimental and Therapeutic Medicine, 16, 2052-2059. https://doi.org/10.3892/etm.2018.6399
MLA
Li, X., Jiang, L., Yang, M., Wu, Y., Sun, J."Impact of weight cycling on CTRP3 expression, adipose tissue inflammation and insulin sensitivity in C57BL/6J mice". Experimental and Therapeutic Medicine 16.3 (2018): 2052-2059.
Chicago
Li, X., Jiang, L., Yang, M., Wu, Y., Sun, J."Impact of weight cycling on CTRP3 expression, adipose tissue inflammation and insulin sensitivity in C57BL/6J mice". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2052-2059. https://doi.org/10.3892/etm.2018.6399
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Jiang L, Yang M, Wu YW and Sun JZ: Impact of weight cycling on CTRP3 expression, adipose tissue inflammation and insulin sensitivity in C57BL/6J mice. Exp Ther Med 16: 2052-2059, 2018.
APA
Li, X., Jiang, L., Yang, M., Wu, Y., & Sun, J. (2018). Impact of weight cycling on CTRP3 expression, adipose tissue inflammation and insulin sensitivity in C57BL/6J mice. Experimental and Therapeutic Medicine, 16, 2052-2059. https://doi.org/10.3892/etm.2018.6399
MLA
Li, X., Jiang, L., Yang, M., Wu, Y., Sun, J."Impact of weight cycling on CTRP3 expression, adipose tissue inflammation and insulin sensitivity in C57BL/6J mice". Experimental and Therapeutic Medicine 16.3 (2018): 2052-2059.
Chicago
Li, X., Jiang, L., Yang, M., Wu, Y., Sun, J."Impact of weight cycling on CTRP3 expression, adipose tissue inflammation and insulin sensitivity in C57BL/6J mice". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2052-2059. https://doi.org/10.3892/etm.2018.6399
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