Open Access

Fluorescent contrast agents for tumor surgery (Review)

  • Authors:
    • Qi Xiao
    • Tianming Chen
    • Shilin Chen
  • View Affiliations

  • Published online on: July 4, 2018     https://doi.org/10.3892/etm.2018.6401
  • Pages: 1577-1585
  • Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cancer is a leading cause of cases of mortality worldwide. The most effective method to cure solid tumors is surgery. Every year, >50% of cancer patients receive surgery to remove solid tumors. Surgery may increase the cure rate of most solid tumors by 4-11 fold. Surgery has many challenges, including identifying small lesions, locating metastases and confirming complete tumor removal. Fluorescence guidance describes a new approach to improve surgical accuracy. Near‑infrared fluorescence imaging allows for real‑time early diagnosis and intraoperative imaging of lesion tissue. The results of previous preclinical studies in the field of near‑infrared fluorescence imaging are promising. This review provides examples introducing the three kinds of fluorescent dyes: The passive fluorescent dye indocyanine green, which has been approved by the Food and Drug Administration for clinical use in the USA, the fluorescent prodrug 5‑aminolevulinic acid, a porphyrin precursor in the heme synthesis, and biomarker‑targeted fluorescent dyes, which allow conjugation to different target sites.
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September-2018
Volume 16 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Xiao Q, Chen T and Chen S: Fluorescent contrast agents for tumor surgery (Review). Exp Ther Med 16: 1577-1585, 2018
APA
Xiao, Q., Chen, T., & Chen, S. (2018). Fluorescent contrast agents for tumor surgery (Review). Experimental and Therapeutic Medicine, 16, 1577-1585. https://doi.org/10.3892/etm.2018.6401
MLA
Xiao, Q., Chen, T., Chen, S."Fluorescent contrast agents for tumor surgery (Review)". Experimental and Therapeutic Medicine 16.3 (2018): 1577-1585.
Chicago
Xiao, Q., Chen, T., Chen, S."Fluorescent contrast agents for tumor surgery (Review)". Experimental and Therapeutic Medicine 16, no. 3 (2018): 1577-1585. https://doi.org/10.3892/etm.2018.6401