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Preliminary study on the effect of brazilin on biofilms of Staphylococcus aureus

  • Authors:
    • Dan Peng
    • Anlin Chen
    • Bin Shi
    • Xun Min
    • Tao Zhang
    • Zheling Dong
    • Huan Yang
    • Xianlian Chen
    • Yingbiao Tian
    • Zehui Chen
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China, Department of Clinical Laboratory, School of Laboratory Medicine, Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China, Department of Pharmacy, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China
    Copyright: © Peng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2108-2118
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    Published online on: July 4, 2018
       https://doi.org/10.3892/etm.2018.6403
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Abstract

Biofilms significantly enhance antibiotic resistance by inhibiting penetration of antibiotics and are shielded from the immune system via the formation of an extracellular polymeric matrix. Innovative and novel approaches are required for the inhibition of biofilm formation and treatment of biofilm‑associated infectious diseases. In the current study, a biofilm model of Staphylococcus aureus was established in vitro to explore inhibitory effects of brazilin (BN) on biofilm formation and to evaluate damaging effects of BN in the presence and absence of vancomycin (VCM) on the biofilm. Antibiofilm‑infection mechanisms of BN were observed. In these experiments, the clinical strain of S. aureus C‑4‑4 was isolated for biofilm formation. Crystal violet staining and fluorescence microscopy revealed that BN inhibited biofilm formation in vitro and the best effect was observed with two times the minimum inhibitory concentration of BN following 48 h incubation. Additionally, the results demonstrated that BN in combination with VCM enhanced the damage to biofilms, whereas VCM alone did not. The results of the reverse transcription‑quantitative polymerase chain reaction analyses demonstrated that BN downregulated gene expression of intercellular adhesion (ica)A and upregulated icaR and the quorum‑sensing (QS) system regulator accessory gene regulator A. In summary, BN inhibited S. aureus biofilm formation and destroyed biofilms, while simultaneously increasing permeability to VCM. BN was able to reduce production of the extracellular polymeric matrix and inhibited the QS system. These results support the use of BN as a novel drug and treatment strategy for S. aureus biofilm‑associated infections.
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View References

1 

Yu L, Hisatsune J, Hayashi I, Tatsukawa N, Sato'o Y, Mizumachi E, Kato F, Hirakawa H, Pier GB and Sugaia M: A Novel Repressor of the ica locus discovered in clinically isolated super-biofilm-elaborating Staphylococcus aureus. MBio. 8:pii:e02282. –16. 2017. View Article : Google Scholar

2 

Yoshii Y, Okuda KI, Yamada S, Nagakura M, Sugimoto S, Nagano T, Okabe T, Kojima H, Iwamoto T, Kuwano K and Mizunoe Y: Norgestimate inhibits staphylococcal biofilm formation and resensitizes methicillin-resistant Staphylococcus aureus to β-lactam antibiotics. NPJ Biofilms Microbiomes. 3:182017. View Article : Google Scholar : PubMed/NCBI

3 

Sollid JU, Furberg AS, Hanssen AM and Johannessen M: Staphylococcus aureus: Determinants of human carriage. Infect Genet Evol. 21:531–541. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Kong C, Chee CF, Richter K, Thomas N, Rahman Abd N and Nathan S: Suppression of Staphylococcus aureus biofilm formation and virulence by a benzimidazole derivative, UM-C162. Sci Rep. 8:27582018. View Article : Google Scholar : PubMed/NCBI

5 

Waryah CB, Wells K, Ulluwishewa D, Chen-Tan N, Gogoi-Tiwari J, Ravensdale J, Costantino P, Gökçen A, Vilcinskas A, Wiesner J and Mukkur T: In vitro antimicrobial efficacy of tobramycin against Staphylococcus aureus biofilms in combination with or without DNase I and/or Dispersin B: A preliminary investigation. Microb Drug Resist. 23:384–390. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Lázaro-Díez M, Remuzgo-Martínez S, Rodríguez-Mirones C, Acosta F, Icardo JM, Martínez-Martínez L and Ramos-Vivas J: Effects of subinhibitory concentrations of ceftaroline on methicillin-resistant Staphylococcus aureus (MRSA) biofilms. PLoS One. 11:e01475692016. View Article : Google Scholar : PubMed/NCBI

7 

Feuillie C, Formosa-Dague C, Hays LM, Vervaecka O, Derclayea S, Brennanc MP, Fosterb TJ, Geogheganb JA and Dufrêne YF: Molecular interactions and inhibition of the staphylococcal biofilm-forming protein SdrC. Proc Natl Acad Sci USA. 114:3738–3743. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Howlin RP, Brayford MJ, Webb JS, Cooper JJ, Aiken SS and Stoodley P: Antibiotic-loaded synthetic Calcium sulfate beads for prevention of bacterial colonization and biofilm formation in periprosthetic infections. Antimicrob Agents Chemother. 59:111–120. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Koch G, Yepes A, Förstner KU, Wermser C, Stengel ST, Modamio J, Ohlsen K, Foster KR and Lopez D: Evolution of resistance to a last-resort antibiotic in Staphylococcus aureus via bacterial competition. Cell. 158:1060–1071. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Howden BP, Davies JK, Johnson PD, Stinear TP and Grayson ML: Reduced vancomycin susceptibility in Staphylococcus aureus, including vancomycin-intermediate and heterogeneous vancomycin-intermediate strains: Resistance mechanisms, laboratory detection, and clinical implications. Clin Microbiol Rev. 23:99–139. 2016. View Article : Google Scholar

11 

Kiedrowski MR and Horswill AR: New approaches for treating staphylococcal biofilm infections. Ann N Y Acad Sci. 1241:104–121. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Bhattacharya M, Wozniak DJ, Stoodley P and Hall-Stoodley L: Prevention and treatment of Staphylococcus aureus biofilms. Expert Rev Anti Infect Ther. 13:1499–1516. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Salem AH, Elkhatib WF and Noreddin AM: Pharmacodynamic assessment of vancomycin-rifampicin combination against methicillin resistant Staphylococcus aureus biofilm: A parametric response surface analysis. J Pharma Pharmacol. 63:73–79. 2011. View Article : Google Scholar

14 

Olson ME, Slater SR, Rupp ME and Fey PD: Rifampicin enhances activity of daptomycin and vancomycin against both a polysaccharide intercellular adhesin (PIA)-dependent and -independent Staphylococcus epidermidis biofilm. J Antimicrob Chemother. 65:2164–2171. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Fontaine BM, Nelson K, Lyles JT, Jariwala PB, García-Rodriguez JM, Quave CL and Weinert EE: Identification of ellagic acid rhamnoside as a bioactive component of a complex botanical extract with anti-biofilm activity. Front Microbiol. 8:4962017. View Article : Google Scholar : PubMed/NCBI

16 

Fu B, Wu Q, Dang M, Bai D, Guo Q, Shen L and Duan K: Inhibition of pseudomonas aeruginosa biofilm formation by traditional chinese medicinal herb herba patriniae. Biomed Res Int. 2017:95847032017. View Article : Google Scholar : PubMed/NCBI

17 

Luo J, Dong B, Wang K, Cai S, Liu T, Cheng X, Lei D and Chen Y, Li Y, Kong J and Chen Y: Baicalin inhibits biofilm formation, attenuates the quorum sensing-controlled virulence and enhances Pseudomonas aeruginosa clearance in a mouse peritoneal implant infection model. PLoS One. 12:e01768832017. View Article : Google Scholar : PubMed/NCBI

18 

García-Heredia A, García S, Merino-Mascorro JÁ, Feng P and Heredia N: Natural plant products inhibits growth and alters the swarming motility, biofilm formation, and expression of virulence genes in enteroaggregative and enterohemorrhagic Escherichia coli. Food Microbiol. 59:124–132. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Kim J, Lee HK, Chang TS, Kang KS and Hwang GS: Inhibitory effect of brazilin on osteoclast differentiation and its mechanism of action. Int Immunopharmacol. 29:628–634. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Gao XJ, Wang TC, Zhang ZC, Cao YG, Zhang NS and Guo MY: Brazilin plays an anti-inflammatory role with regulating Toll-like receptor 2 and TLR 2 downstream pathways in Staphylococcus aureus-induced mastitis in mice. Int Immunopharmacol. 27:130–137. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Dan P, Zhou X and Chen Z: Research progress on mechanism and treatment of Staphylococcus aureus biofilms. Molecular Biomedicine. 23:3745–3749. 2017.

22 

Nirmal NP and Panichayupakaranant P: Antioxidant, antibacterial, and anti-inflammatory activities of standardized brazilin-rich Caesalpinia sappan extract. Pharm Biol. 53:1339–1343. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Yan Y, Chen YC, Lin YH, Guo J, Niu ZR, Li L, Wang SB, Fang LH and Du GH: Brazilin isolated from the heartwood of Caesalpinia sappan L induces endothelium-dependent and-independent relaxation of rat aortic rings. Acta Pharmacol Sin. 36:1318–1326. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Clinical and Laboratory Standards Institute: Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard, 9th ed CLSI document M7-A9. Clinical and Laboratory Standards Institute; Wayne, PA: 2012

25 

Shi SF, Jia JF, Guo XK, Zhao YP, Chen DS, Guo YY and Zhang XL: Reduced Staphylococcus aureus biofilm formation in the presence of chitosan-coated iron oxide nanoparticles. Int J Nanomedicine. 11:6499–6506. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Balasubramanian S, Othman EM, Kampik D, Stopper H, Hentschel U, Ziebuhr1 W, Oelschlaeger1 TA and Abdelmohsen UR: Marine sponge-derived Streptomyces sp. SBT343 extract inhibits Staphylococcal biofilm formation. Front Microbiol. 8:2362017. View Article : Google Scholar : PubMed/NCBI

28 

Sugimoto S, Sato F, Miyakawa R, Chiba A, Onodera S, Hori S and Mizunoe Y: Broad impact of extracellular DNA on biofilm formation by clinically isolated Methicillin-resistant and-sensitive strains of Staphylococcus aureus. Sci Rep. 8:22542018. View Article : Google Scholar : PubMed/NCBI

29 

Singh AK, Prakash P, Achra A, Singh GP, Das A and Singh RK: Standardization and classification of in vitro biofilm formation by clinical isolates of Staphylococcus aureus. J Glob Infect Dis. 9:93–101. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Brooks JL and Jefferson KK: Staphylococcal biofilms: Quest for the magic bullet. Adv Appl Microbiol. 81:63–87. 2012. View Article : Google Scholar : PubMed/NCBI

31 

van Hal SJ, Lodise TP and Paterson DL: The clinical significance of vancomycin minimum inhibitory concentration in Staphylococcus aureus infections: A systematic review and meta-analysis. Clin Infect Dis. 54:755–771. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Chen Y, Liu T, Wang K, Hou C, Cai S, Huang Y, Du Z, Huang H, Kong J and Chen Y: Baicalein inhibits Staphylococcus aureus biofilm formation and the quorum sensing system in vitro. PLoS One. 11:e01534682016. View Article : Google Scholar : PubMed/NCBI

33 

O'gara JP: Ica and beyond: Biofilm mechanisms and regulation in Staphylococcus epidermidis and Staphylococcus aureus. FEMS Microbiol Lett. 270:179–188. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Figueiredo AMS, Ferreira FA, Beltrame CO and Côrtes MF: The role of biofilms in persistent infections and factors involved in ica-independent biofilm development and gene regulation in Staphylococcus aureus. Crit Rev Microbiol. 43:602–620. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Ma R, Qiu S, Jiang Q, Sun H, Xue T, Cai G and Sun B: AI-2 quorum sensing negatively regulates rbf expression and biofilm formation in Staphylococcus aureus. Int J Med Microbiol. 307:257–267. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Gupta A and Mishra S, Singh S and Mishra S: Prevention of IcaA regulated poly N-acetyl glucosamine formation in Staphylococcus aureus biofilm through new-drug like inhibitors: In silico approach and MD simulation study. Microb Pathog. 110:659–669. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Skurnik D, Cywes-Bentley C and Pier GB: The exceptionally broad-based potential of active and passive vaccination targeting the conserved microbial surface polysaccharide PNAG. Expert Rev Vaccines. 15:1041–1053. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Formosa-Dague C, Feuillie C, Beaussart A, Derclaye S, Kucharíková S, Lasa I, Van Dijck P and Dufrêne YF: Sticky matrix: Adhesion mechanism of the staphylococcal polysaccharide intercellular adhesin. ACS Nano. 10:3443–3452. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Doulgeraki AI, Di Ciccio P, Ianieri A and Nychas GE: Methicillin-resistant food-related Staphylococcus aureus: A review of current knowledge and biofilm formation for future studies and applications. Res Microbiol. 168:1–15. 2017. View Article : Google Scholar : PubMed/NCBI

40 

Pamp SJ, Frees D, Engelmann S, Hecker M and Ingmer H: Spx is a global effector impacting stress tolerance and biofilm formation in Staphylococcus aureus. J Bacteriol. 188:4861–4870. 2006. View Article : Google Scholar : PubMed/NCBI

41 

Kinkel TL, Roux CM, Dunman PM and Fang FC: The Staphylococcus aureus SrrAB two-component system promotes resistance to nitrosative stress and hypoxia. MBio. 4:e00696–e13. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Coelho LR, Souza RR, Ferreira FA, Guimarães MA, Ferreira-Carvalho BT and Figueiredo AM: Agr RNAIII divergently regulates glucose-induced biofilm formation in clinical isolates of Staphylococcus aureus. Microbiology. 154:3480–3490. 2008. View Article : Google Scholar : PubMed/NCBI

43 

Atwood DN, Beenken KE, Loughran AJ, Meeker DG, Lantz TL, Graham JW, Spencer HJ and Smeltzer MS: XerC contributes to diverse forms of Staphylococcus aureus infection via agr-dependent and agr-independent pathway. Infect Immun. 84:1214–1225. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Le KY and Otto M: Quorum-sensing regulation in staphylococci-an overview. Front Microbiol. 6:11742015. View Article : Google Scholar : PubMed/NCBI

45 

Boles BR and Horswill AR: Agr-mediated dispersal of Staphylococcus aureus biofilms. PLoS Pathog. 4:e10000522008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Peng D, Chen A, Shi B, Min X, Zhang T, Dong Z, Yang H, Chen X, Tian Y, Chen Z, Chen Z, et al: Preliminary study on the effect of brazilin on biofilms of Staphylococcus aureus. Exp Ther Med 16: 2108-2118, 2018.
APA
Peng, D., Chen, A., Shi, B., Min, X., Zhang, T., Dong, Z. ... Chen, Z. (2018). Preliminary study on the effect of brazilin on biofilms of Staphylococcus aureus. Experimental and Therapeutic Medicine, 16, 2108-2118. https://doi.org/10.3892/etm.2018.6403
MLA
Peng, D., Chen, A., Shi, B., Min, X., Zhang, T., Dong, Z., Yang, H., Chen, X., Tian, Y., Chen, Z."Preliminary study on the effect of brazilin on biofilms of Staphylococcus aureus". Experimental and Therapeutic Medicine 16.3 (2018): 2108-2118.
Chicago
Peng, D., Chen, A., Shi, B., Min, X., Zhang, T., Dong, Z., Yang, H., Chen, X., Tian, Y., Chen, Z."Preliminary study on the effect of brazilin on biofilms of Staphylococcus aureus". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2108-2118. https://doi.org/10.3892/etm.2018.6403
Copy and paste a formatted citation
x
Spandidos Publications style
Peng D, Chen A, Shi B, Min X, Zhang T, Dong Z, Yang H, Chen X, Tian Y, Chen Z, Chen Z, et al: Preliminary study on the effect of brazilin on biofilms of Staphylococcus aureus. Exp Ther Med 16: 2108-2118, 2018.
APA
Peng, D., Chen, A., Shi, B., Min, X., Zhang, T., Dong, Z. ... Chen, Z. (2018). Preliminary study on the effect of brazilin on biofilms of Staphylococcus aureus. Experimental and Therapeutic Medicine, 16, 2108-2118. https://doi.org/10.3892/etm.2018.6403
MLA
Peng, D., Chen, A., Shi, B., Min, X., Zhang, T., Dong, Z., Yang, H., Chen, X., Tian, Y., Chen, Z."Preliminary study on the effect of brazilin on biofilms of Staphylococcus aureus". Experimental and Therapeutic Medicine 16.3 (2018): 2108-2118.
Chicago
Peng, D., Chen, A., Shi, B., Min, X., Zhang, T., Dong, Z., Yang, H., Chen, X., Tian, Y., Chen, Z."Preliminary study on the effect of brazilin on biofilms of Staphylococcus aureus". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2108-2118. https://doi.org/10.3892/etm.2018.6403
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