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Reduced hepcidin level features osteoporosis

  • Authors:
    • Bin Liu
    • Caihua Liu
    • Weifeng Zhong
    • Min Song
    • Shouqin Du
    • Jianli Su
  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine, the Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China, Department of Laboratory Medicine, People's Hospital of Qingdao Shibei District, Qingdao, Shandong 266033, P.R. China, Department of Hospital Infection Management, People's hospital of Zhangqiu District, Jinan, Shandong 250200, P.R. China, Department of Dermatoloogy, People's hospital of Zhangqiu District, Jinan, Shandong 250200, P.R. China, Department of Laboratory Medicine, People's hospital of Zhangqiu District, Jinan, Shandong 250200, P.R. China, Department of Laboratory Medicine, Qilu Hospital of Shandong University (Qingdao), Qingdao, Shandong 266035, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1963-1967
    |
    Published online on: July 5, 2018
       https://doi.org/10.3892/etm.2018.6410
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Abstract

Osteoporosis (OP) is a common serious skeletal disorder marked by increased risk of bone fracture due to fragility. OP has been taken to be a disease linked with abnormal calcium metabolism that alone is obviously insufficient to explain the development of OP. Iron overload has been associated with the development of OP and increasing studies have suggested the association. However, direct evidence for this has not been clinically established. To this end, using the Roche biochemical autoanalyzer, we detected the concentration of iron, soluble transferrin receptor 2 (TFR2), and hepcidin, a key peptide regulating iron homeostasis, in the sera from patients with OP. it was shown that the iron and TFR2 concentration was markedly higher than that of healthy control; whereas the concentration of hepcidin was markedly lower than that in control. In addition, to pilot explore the underlying mechanism by which hepcidin was downregulated, we present that hepcidin can directly interact with TFR2 using immunoprecipitation. The present study first established the direct biochemical evidence for the involvement of hepcidin in the pathogenesis of OP, indicating that the upregulation of hepcidin could be used as a novel alternative therapeutic strategy in the management of OP.
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Copy and paste a formatted citation
Spandidos Publications style
Liu B, Liu C, Zhong W, Song M, Du S and Su J: Reduced hepcidin level features osteoporosis. Exp Ther Med 16: 1963-1967, 2018.
APA
Liu, B., Liu, C., Zhong, W., Song, M., Du, S., & Su, J. (2018). Reduced hepcidin level features osteoporosis. Experimental and Therapeutic Medicine, 16, 1963-1967. https://doi.org/10.3892/etm.2018.6410
MLA
Liu, B., Liu, C., Zhong, W., Song, M., Du, S., Su, J."Reduced hepcidin level features osteoporosis". Experimental and Therapeutic Medicine 16.3 (2018): 1963-1967.
Chicago
Liu, B., Liu, C., Zhong, W., Song, M., Du, S., Su, J."Reduced hepcidin level features osteoporosis". Experimental and Therapeutic Medicine 16, no. 3 (2018): 1963-1967. https://doi.org/10.3892/etm.2018.6410
Copy and paste a formatted citation
x
Spandidos Publications style
Liu B, Liu C, Zhong W, Song M, Du S and Su J: Reduced hepcidin level features osteoporosis. Exp Ther Med 16: 1963-1967, 2018.
APA
Liu, B., Liu, C., Zhong, W., Song, M., Du, S., & Su, J. (2018). Reduced hepcidin level features osteoporosis. Experimental and Therapeutic Medicine, 16, 1963-1967. https://doi.org/10.3892/etm.2018.6410
MLA
Liu, B., Liu, C., Zhong, W., Song, M., Du, S., Su, J."Reduced hepcidin level features osteoporosis". Experimental and Therapeutic Medicine 16.3 (2018): 1963-1967.
Chicago
Liu, B., Liu, C., Zhong, W., Song, M., Du, S., Su, J."Reduced hepcidin level features osteoporosis". Experimental and Therapeutic Medicine 16, no. 3 (2018): 1963-1967. https://doi.org/10.3892/etm.2018.6410
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