Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
September-2018 Volume 16 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2018 Volume 16 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report

Hemophagocytic lymphohistiocytosis presenting with annular erythema multiforme‑like eruptions in a patient with angioimmunoblastic T cell lymphoma: A case report

  • Authors:
    • Liping Zhang
    • Chunguang Tong
    • Yaqi Tan
    • Shiguang Peng
    • Yanling He
    • Tianyou Wang
  • View Affiliations / Copyright

    Affiliations: Department of Hematology and Oncology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, P.R. China, Department of Dermatology, Beijing Chao‑Yang Hospital, Capital Medical University, Beijing 100020, P.R. China
  • Pages: 2060-2065
    |
    Published online on: July 6, 2018
       https://doi.org/10.3892/etm.2018.6420
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Angioimmunoblastic T cell lymphoma (AITL)‑­associated hemophagocytic lymphohistiocytosis (HLH) rarely occurs with annular erythema multiforme‑like rashes. The present case report describes a patient who was misdiagnosed with erythema multiforme at an early stage of the disease due to annular erythema multiforme‑like eruptions. However, antihistamine treatment was ineffective. The patient progressed rapidly with high fever, hepatosplenomegaly and pharyngitis. The number of copies of Epstein‑Barr virus DNA continuously increased. Accompanied by the swelling of lymph nodes, the blood cell count decreased. Further bone‑marrow examination and biopsy of the lymph nodes were conducted. The patient was eventually diagnosed with AITL‑associated HLH, and treated with etoposide together with cyclophosphamide, doxorubicin, vincristine and prednisolone. The patient was successfully treated with several courses of chemotherapy. In view of the fact that AITL‑associated HLH with annular erythema multiforme‑like rashes is relatively rare worldwide and is associated with a high mortality rate, the data on previous cases were reviewed with the hope of providing clinical bases for early diagnosis and treatment of AITL‑associated HLH.
View Figures

Figure 1

Figure 2

View References

1 

Al-Samkari H and Berliner N: Hemophagocytic lymphohistiocytosis. Annu Rev Pathol. 13:27–49. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Parikh SA, Kapoor P, Letendre L, Kumar S and Wolanskyj AP: Prognostic factors and outcomes of adults with hemophagocytic lymphohistiocytosis. Mayo Clin Proc. 89:484–492. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Gholam C, Grigoriadou S, Gilmour KC and Gaspar HB: Familial haemophagocytic lymphohistiocytosis: Advances in the genetic basis, diagnosis and management. Clin Exp Immunol. 163:271–283. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Henter JI, Elinder G, Soder O and Ost A: Incidence in Sweden and clinical features of familial hemophagocytic lymphohistiocytosis. Acta Paediatr Scand. 80:428–435. 1991. View Article : Google Scholar : PubMed/NCBI

5 

Ishii E, Ohga S, Tanimura M, Imashuku S, Sako M, Mizutani S and Miyazaki S: Clinical and epidemiologic studies of familial hemophagocytic lymphohistiocytosis in Japan. Med Pediatr Oncol. 30:276–283. 1998. View Article : Google Scholar : PubMed/NCBI

6 

Schram AM and Berliner N: How I treat hemophagocytic lymphohistiocytosis in the adult patient. Blood. 125:2908–2914. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Matsumura Y, Kuroda J, Shimura Y, Kiyota M, Yamamoto-Sugitani M, Kobayashi T, Matsumoto Y, Horiike S and Taniwaki M: Cyclosporine a and reduced-intensity conditioning allogeneic stem cell transplantation for relapsed angioimmunoblastic t cell lymphoma with hemophagocytic syndrome. Intern Med. 51:2785–2787. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Vella JE and El-Daly H: Hemophagocytic lymphohistiocytosis in a patient with angioimmunoblastic lymphoma: A case report and review of the literature. Int J Surg Pathol. 20:606–609. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Yu JT, Hwang WL, Wang RC and Teng CL: Reduced intensity conditioning allogeneic hematopoietic stem cell transplant could be beneficial to angioimmunoblastic T-cell lymphoma patients with hemophagocytic lymphohistiocytosis. Ann Hematol. 91:805–807. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Wu X, Zhao M, Pan B, Zhang J, Peng M, Wang L, Hao X, Huang X, Mu R, Guo W, et al: Complete blood count reference intervals for healthy Han Chinese adults. PLoS One. 10:e01196692015. View Article : Google Scholar : PubMed/NCBI

11 

Shinya S, Masaru A, Akira H, Eisaku H and Susumu O: Development of an assay of seven biochemical items, HbA1c, and hematocrit using a small amount of blood collected from the fingertip. Clin Chim Acta. 413:192–197. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Crowson CS, Rahman MU and Matteson EL: Which measure of inflammation to use? A comparison of erythrocyte sedimentation rate and C-reactive protein measurements from randomized clinical trials of golimumab in rheumatoid arthritis. J Rheumatol. 36:1606–1610. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Lo YM, Chan LY, Lo KW, Leung SF, Zhang J, Chan AT, Lee JC, Hjelm NM, Johnson PJ and Huang DP: Quantitative analysis of cell-free Epstein-Barr virus DNA in plasma of patients with nasopharyngeal carcinoma. Cancer Res. 59:1188–1191. 1999.PubMed/NCBI

14 

Gu AD, Mo HY, Xie YB, Peng RJ, Bei JX, Peng J, Li MY, Chen LZ, Feng QS, Jia WH and Zeng YX: Evaluation of a multianalyte profiling assay and an enzyme-linked immunosorbent assay for serological examination of Epstein-Barr virus-specific antibody responses in diagnosis of nasopharyngeal carcinoma. Clin Vaccine Immunol. 15:1684–1688. 2005. View Article : Google Scholar

15 

Oboshi W, Aki K, Tada T, Watanabe T, Yukimasa N, Ueno I, Saito K and Hosoi E: Flow cytometric evaluation of surface CD56 expression on activated natural killer cells as functional marker. J Med Invest. 63:199–203. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Valiathan R, Lewis JE, Melillo AB, Leonard S, Ali KH and Asthana D: Evaluation of a flow cytometry-based assay for natural killer cell activity in clinical settings. Scand J Immunol. 75:455–462. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Zu Y, Steinberg SM, Campo E, Hans CP, Weisenburger DD, Braziel RM, Delabie J, Gascoyne RD, Muller-Hermlink K, Pittaluga S, et al: Validation of tissue microarray immunohistochemistry staining and interpretation in diffuse large B-cell lymphoma. Leuk Lymphoma. 46:693–701. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Wang Y, Liu X and Chen Y: Adult systemic Epstein-Barr virus-positive T-cell lymphoproliferative disease: A case report. Exp Ther Med. 10:1025–1028. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Baer R, Bankier AT, Biggin MD, Deininger PL, Farrell PJ, Gibson TJ, Hatfull G, Hudson GS, Satchwell SC, Séguin C, et al: DNA sequence and expression of the B95-8 Epstein-Barr virus genome. Nature. 310:207–211. 1984. View Article : Google Scholar : PubMed/NCBI

20 

Khan G, Coates PJ, Kangro HO and Slavin G: Epstein Barr virus (EBV) encoded small RNAs: Targets for detection by in situ hybridisation with oligonucleotide probes. J Clin Pathol. 45:616–620. 1992. View Article : Google Scholar : PubMed/NCBI

21 

Smith KJ, Skelton HG III, Giblin WL and James WD: Cutaneous lesions of hemophagocytic syndrome in a patient with T-cell lymphoma and active Epstein-Barr infection. J Am Acad Dermatol. 25:919–924. 1991. View Article : Google Scholar : PubMed/NCBI

22 

Jordan MB, Allen CE, Weitzman S, Filipovich AH and McClain KL: How I treat hemophagocytic lymphohistiocytosis. Blood. 118:4041–4052. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Allen CE and McClain KL: Pathophysiology and epidemiology of hemophagocytic lymphohistiocytosis. Hematology Am Soc Hematol Educ Program. 2015:177–182. 2015.PubMed/NCBI

24 

Takahashi N, Chubachi A, Kume M, Hatano Y, Komatsuda A, Kawabata Y, Yanagiya N, Ichikawa Y, Miura AB and Miura I: A clinical analysis of 52 adult patients with hemophagocytic syndrome: The prognostic significance of the underlying diseases. Int J Hematol. 74:209–213. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Koh MJ, Sadarangani SP, Chan YC, Chan MY, Tan AM, Tan SH, Tay YK and Ng SB: Aggressive subcutaneous panniculitis-like T-cell lymphoma with hemophagocytosis in two children (subcutaneous panniculitis-like T-cell lymphoma). J Am Acad Dermatol. 61:875–881. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Castillo JJ, Beltran BE, Bibas M, Bower M, Collins JA, Cwynarski K, Diez-Martin JL, Hernandez-Ilizaliturri F, Horwitz SM, Montoto S, et al: Prognostic factors in patients with HIV-associated peripheral T-cell lymphoma: A multicenter study. Am J Hematol. 86:256–261. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Zettl A, Lee SS, Rüdiger T, Starostik P, Marino M, Kirchner T, Ott M, Müller-Hermelink HK and Ott G: Epstein-Barr virus-associated B-Cell lymphoproliferative disorders in angioimmunoblastic T-cell lymphoma and peripheral T cell lymphoma, unspecified. Am J Clin Pathol. 117:368–379. 2002. View Article : Google Scholar : PubMed/NCBI

28 

Zhou Y, Attygalle AD, Chuang SS, Diss T, Ye H, Liu H, Hamoudi RA, Munson P, Bacon CM, Dogan A and Du MQ: Angioimmunoblastic T-cell lymphoma: Histological progression associates with EBV and HHV6B viral load. Br J Haematol. 138:44–53. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Brown HA, Macon WR, Kurtin PJ and Gibson LE: Cutaneous involvement by angioimmunoblastic T-cell lymphoma with remarkable heterogeneous Epstein-Barr virus expression. J Cutan Pathol. 28:432–438. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Zerah ML and DeWitt CA: Cutaneous findings in hemophagocytic lymphohistiocytosis. Dermatology. 230:234–243. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Ariffin H, Lum SH, Cheok SA, Shekhar K, Ariffin WA, Chan LL and Lin HP: Haemophagocytic lymphohistiocytosis in Malaysian children. J Paediatr Child Health. 41:136–139. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Smith KJ, Skelton HG, Yeager J, Angritt P, Wagner K, James WD, Giblin WJ and Lupton GP: Cutaneous histopathologic, immunohistochemical, and clinical manifestations inpatients with hemophagocytic syndrome. Military medical consortium for applied retroviral research (MMCARR). Arch Dermatol. 128:193–200. 1992. View Article : Google Scholar : PubMed/NCBI

33 

Sakai H, Otsubo S, Miura T and Iizuka H: Hemophagocytic syndrome presenting with a facial erythema in a patient with systemic lupus erythematosus. J Am Acad Dermatol. 57:S111–S114. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Fardet L, Galicier L, Vignon-Pennamen MD, Regnier S, Noguera ME, de Labarthe A, Raffoux E, Martinez V, Buyse S, Viguier M, et al: Frequency, clinicalfeatures and prognosis of cutaneous manifestations in adult patients with reactive haemophagocytic syndrome. Br J Dermatol. 162:547–553. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang L, Tong C, Tan Y, Peng S, He Y and Wang T: Hemophagocytic lymphohistiocytosis presenting with annular erythema multiforme‑like eruptions in a patient with angioimmunoblastic T cell lymphoma: A case report. Exp Ther Med 16: 2060-2065, 2018.
APA
Zhang, L., Tong, C., Tan, Y., Peng, S., He, Y., & Wang, T. (2018). Hemophagocytic lymphohistiocytosis presenting with annular erythema multiforme‑like eruptions in a patient with angioimmunoblastic T cell lymphoma: A case report. Experimental and Therapeutic Medicine, 16, 2060-2065. https://doi.org/10.3892/etm.2018.6420
MLA
Zhang, L., Tong, C., Tan, Y., Peng, S., He, Y., Wang, T."Hemophagocytic lymphohistiocytosis presenting with annular erythema multiforme‑like eruptions in a patient with angioimmunoblastic T cell lymphoma: A case report". Experimental and Therapeutic Medicine 16.3 (2018): 2060-2065.
Chicago
Zhang, L., Tong, C., Tan, Y., Peng, S., He, Y., Wang, T."Hemophagocytic lymphohistiocytosis presenting with annular erythema multiforme‑like eruptions in a patient with angioimmunoblastic T cell lymphoma: A case report". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2060-2065. https://doi.org/10.3892/etm.2018.6420
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang L, Tong C, Tan Y, Peng S, He Y and Wang T: Hemophagocytic lymphohistiocytosis presenting with annular erythema multiforme‑like eruptions in a patient with angioimmunoblastic T cell lymphoma: A case report. Exp Ther Med 16: 2060-2065, 2018.
APA
Zhang, L., Tong, C., Tan, Y., Peng, S., He, Y., & Wang, T. (2018). Hemophagocytic lymphohistiocytosis presenting with annular erythema multiforme‑like eruptions in a patient with angioimmunoblastic T cell lymphoma: A case report. Experimental and Therapeutic Medicine, 16, 2060-2065. https://doi.org/10.3892/etm.2018.6420
MLA
Zhang, L., Tong, C., Tan, Y., Peng, S., He, Y., Wang, T."Hemophagocytic lymphohistiocytosis presenting with annular erythema multiforme‑like eruptions in a patient with angioimmunoblastic T cell lymphoma: A case report". Experimental and Therapeutic Medicine 16.3 (2018): 2060-2065.
Chicago
Zhang, L., Tong, C., Tan, Y., Peng, S., He, Y., Wang, T."Hemophagocytic lymphohistiocytosis presenting with annular erythema multiforme‑like eruptions in a patient with angioimmunoblastic T cell lymphoma: A case report". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2060-2065. https://doi.org/10.3892/etm.2018.6420
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team