Hemophagocytic lymphohistiocytosis presenting with annular erythema multiforme‑like eruptions in a patient with angioimmunoblastic T cell lymphoma: A case report

  • Authors:
    • Liping Zhang
    • Chunguang Tong
    • Yaqi Tan
    • Shiguang Peng
    • Yanling He
    • Tianyou Wang
  • View Affiliations

  • Published online on: July 6, 2018     https://doi.org/10.3892/etm.2018.6420
  • Pages: 2060-2065
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Abstract

Angioimmunoblastic T cell lymphoma (AITL)‑­associated hemophagocytic lymphohistiocytosis (HLH) rarely occurs with annular erythema multiforme‑like rashes. The present case report describes a patient who was misdiagnosed with erythema multiforme at an early stage of the disease due to annular erythema multiforme‑like eruptions. However, antihistamine treatment was ineffective. The patient progressed rapidly with high fever, hepatosplenomegaly and pharyngitis. The number of copies of Epstein‑Barr virus DNA continuously increased. Accompanied by the swelling of lymph nodes, the blood cell count decreased. Further bone‑marrow examination and biopsy of the lymph nodes were conducted. The patient was eventually diagnosed with AITL‑associated HLH, and treated with etoposide together with cyclophosphamide, doxorubicin, vincristine and prednisolone. The patient was successfully treated with several courses of chemotherapy. In view of the fact that AITL‑associated HLH with annular erythema multiforme‑like rashes is relatively rare worldwide and is associated with a high mortality rate, the data on previous cases were reviewed with the hope of providing clinical bases for early diagnosis and treatment of AITL‑associated HLH.
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September-2018
Volume 16 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhang L, Tong C, Tan Y, Peng S, He Y and Wang T: Hemophagocytic lymphohistiocytosis presenting with annular erythema multiforme‑like eruptions in a patient with angioimmunoblastic T cell lymphoma: A case report. Exp Ther Med 16: 2060-2065, 2018
APA
Zhang, L., Tong, C., Tan, Y., Peng, S., He, Y., & Wang, T. (2018). Hemophagocytic lymphohistiocytosis presenting with annular erythema multiforme‑like eruptions in a patient with angioimmunoblastic T cell lymphoma: A case report. Experimental and Therapeutic Medicine, 16, 2060-2065. https://doi.org/10.3892/etm.2018.6420
MLA
Zhang, L., Tong, C., Tan, Y., Peng, S., He, Y., Wang, T."Hemophagocytic lymphohistiocytosis presenting with annular erythema multiforme‑like eruptions in a patient with angioimmunoblastic T cell lymphoma: A case report". Experimental and Therapeutic Medicine 16.3 (2018): 2060-2065.
Chicago
Zhang, L., Tong, C., Tan, Y., Peng, S., He, Y., Wang, T."Hemophagocytic lymphohistiocytosis presenting with annular erythema multiforme‑like eruptions in a patient with angioimmunoblastic T cell lymphoma: A case report". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2060-2065. https://doi.org/10.3892/etm.2018.6420