Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
September-2018 Volume 16 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2018 Volume 16 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Combined antitumor effects of P‑5m octapeptide and 5‑fluorouracil on a murine model of H22 hepatoma ascites

Corrigendum in: /10.3892/etm.2018.6971
  • Authors:
    • Xiao Han
    • Liping An
    • Dongmei Yan
    • Hiroshi Matsuura
    • Weiguang Ding
    • Mengchuan Zhang
    • Guangyu Xu
    • Ying Sun
    • Guangxin Yuan
    • Manli Wang
    • Nanxi Zhao
    • Jingbo Sun
    • Xun Zhu
    • Peige Du
  • View Affiliations / Copyright

    Affiliations: Department of Microbial and Biochemical Pharmacy, College of Pharmaceutical Science, Beihua University, Changchun, Jilin 132013, P.R. China, Department of Immunology, Norman Bethune College of Medicine, Jilin University, Changchun, Jilin 130021, P.R. China, Department of Physiology, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan
    Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1586-1592
    |
    Published online on: July 6, 2018
       https://doi.org/10.3892/etm.2018.6422
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study has demonstrated that P-5m octapeptide (P-5m) has therapeutic potential in metastatic human hepatocarcinoma, possibly through the modulation of matrix metalloproteinase‑2 expression. The purpose of the present study was to evaluate the antitumor effect of P‑5m combined with 5‑fluorouracil (5‑Fu) on the treatment of hepatoma 22 (H22) hepatocarcinoma malignant ascites in a mouse model. The inhibitory effect on the growth of mouse ascites tumors was monitored by measuring body weight gain, survival time, ascites volume, numbers of tumor cells, DNA synthesis and peritoneal capillary permeability analysis. The present data revealed a significant reduction in ascites volume and cell count in mice that were treated with P‑5m plus 5‑Fu. Furthermore, the median survival time in mice in the combination group was prolonged compared with the disease control group. Moreover, a significant reduction in the total H22 ascites cell count in mice from the combination group was observed when compared with the disease control group. P‑5m plus 5‑Fu was able to induce the cell cycle arrest and inhibit the peritoneal capillary permeability of the mice. To conclude, the present study indicated that P‑5m may have therapeutic potential in ascites caused by hepatocellular carcinoma.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Ayantunde AA and Parsons SL: Pattern and prognostic factors in patients with malignant ascites: A retrospective study. Ann Oncol. 18:945–949. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Barni S, Cabiddu M, Ghilardi M and Petrelli F: A novel perspective for an orphan problem: Old and new drugs for the medical management of malignant ascites. Crit Rev Oncol Hematol. 79:144–153. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Coupe NA, Cox K, Clark K, Boyer M and Stockler M: Outcomes of permanent peritoneal ports for the management of recurrent malignant ascites. J Palliat Med. 16:938–940. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Woopen H and Sehouli J: Current and future options in the treatment of malignant ascites in ovarian cancer. Anticancer Res. 29:3353–3359. 2009.PubMed/NCBI

5 

Chung M and Kozuch P: Treatment of malignant ascites. Curr Treat Options Oncol. 9:215–233. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Akgol G, Yildiz C, Karakus S, Koc M, Dogan M, Turan M and Karadayi K: The effects of intraperitoneal chemotherapeutic agents on adhesion formation. European J Gynaecol Oncol. 37:781–785. 2016.

7 

Cashin PH, Mahteme H, Graf W, Karlsson H, Larsson R and Nygren P: Activity ex vivo of cytotoxic drugs in patient samples of peritoneal carcinomatosis with special focus on colorectal cancer. BMC Cancer. 13:4352013. View Article : Google Scholar : PubMed/NCBI

8 

Parson EN, Lentz S, Russell G, Shen P, Levine EA and Stewart JH IV: Outcomes after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal surface dissemination from ovarian neoplasms. Am J Surg. 202:481–486. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Guarneri V, Piacentini F, Barbieri E and Conte PF: Achievements and unmet needs in the management of advanced ovarian cancer. Gynecol Oncol. 117:152–158. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Oh SY, Kwon HC, Lee S, Lee DM, Yoo HS, Kim SH, Jang JS, Kim MC, Jeong JS and Kim HJ: A Phase II study of oxaliplatin with low-dose leucovorin and bolus and continuous infusion 5-fluorouracil (modified FOLFOX-4) for gastric cancer patients with malignant ascites. Jpn J Clin Oncol. 37:930–935. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Van der Speeten K, Stuart OA, Mahteme H and Sugarbaker PH: Pharmacology of perioperative 5-fluorouracil. J Surg Oncol. 102:730–735. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Wyllie E and Wyllie R: Routine laboratory monitoring for serious adverse effects of antiepileptic medications: The controversy. Epilepsia. 32 Suppl 5:S74–S79. 1991.PubMed/NCBI

13 

Jang JH, Kim MY, Lee JW, Kim SC and Cho JH: Enhancement of the cancer targeting specificity of buforin IIb by fusion with an anionic peptide via a matrix metalloproteinases-cleavable linker. Peptides. 32:895–899. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Lo A, Lin CT and Wu HC: Hepatocellular carcinoma cell-specific peptide ligand for targeted drug delivery. Mol Cancer Ther. 7:579–589. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Xiao W, Wang Y, Lau EY, Luo J, Yao N, Shi C, Meza L, Tseng H, Maeda Y, Kumaresan P, et al: The use of one-bead one-compound combinatorial library technology to discover high-affinity αvβ3 integrin and cancer targeting arginine-glycine-aspartic acid ligands with a built-in handle. Mol Cancer Ther. 9:2714–2723. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Yao Z, Lu R, Jia J, Zhao P, Yang J, Zheng M, Lu J, Jin M, Yang H and Gao W: The effect of tripeptide tyroserleutide (YSL) on animal models of hepatocarcinoma. Peptides. 27:1167–1172. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Kawasaki M, Maeda T, Hanasawa K, Ohkubo I and Tani T: Effect of His-Gly-Lys motif derived from domain 5 of high molecular weight kininogen on suppression of cancer metastasis both in vitro and in vivo. J Biol Chem. 278:49301–49307. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Han X, Yan DM, Zhao XF, Matsuura H, Ding WG, Li P, Jiang S, Du BR, Du PG and Zhu X: GHGKHKNK octapeptide (P-5m) inhibits metastasis of HCCLM3 cell lines via regulation of MMP-2 expression in in vitro and in vivo studies. Molecules. 17:1357–1372. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Yamaguchi N and Kiick KL: Polysaccharide-poly (ethylene glycol) star copolymer as a scaffold for the production of bioactive hydrogels. Biomacromolecules. 6:1921–1930. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Zhang J, Wang X and Lu H: Amifostine increases cure rate of cisplatin on ascites hepatoma 22 via selectively protecting renal thioredoxin reductase. Cancer Lett. 260:127–136. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Santos FM, Latorre AO, Hueza IM, Sanches DS, Lippi LL, Gardner DR and Spinosa HS: Increased antitumor efficacy by the combined administration of swainsonine and cisplatin in vivo. Phytomedicine. 18:1096–1101. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Ghosh P, Sur P and Bag SP: Enhancement of antitumor effects of a new boron compound combined with ultrasound on the mouse ascites tumor. Med Chem. 8:1026–1031. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Li C and Ren LQ: Replication of Animal Models of Human Diseases. People's Medical Publishing House; Beijing: pp. 612008, (In Chinese).

24 

Su ZQ, Liu YH, Guo HZ, Sun CY, Xie JH, Li YC, Chen JN, Lai XP, Su ZR and Chen HM: Effect-enhancing and toxicity-reducing activity of usnic acid in ascitic tumor-bearing mice treated with bleomycin. Int Immunopharmacol. 46:146–155. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Ujioka T, Matsuura K, Tanaka N and Okamura H: Involvement of ovarian kinin-kallikrein system in the pathophysiology of ovarian hyperstimulation syndrome: Studies in a rat model. Hum Reprod. 13:3009–3015. 1998. View Article : Google Scholar : PubMed/NCBI

26 

Morel G: Internalization and nuclear localization of peptide hormones. Biochem Pharmacol. 47:63–76. 1994. View Article : Google Scholar : PubMed/NCBI

27 

Finch AR, Caunt CJ, Armstrong SP and McArdle CA: Agonist-induced internalization and downregulation of gonadotropin-releasing hormone receptors. Am J Physiol Cell Physiol. 297:C591–C600. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Kim GD, Rhee GS, Chung HM, Chee KM and Kim GJ: Cytotoxicity of 5-fluorouracil: Effect on endothelial differentiation via cell cycle inhibition in mouse embryonic stem cells. Toxicol In Vitro. 23:719–727. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Chen XX, Lai MD, Zhang YL and Huang Q: Less cytotoxicity to combination therapy of 5-fluorouracil and cisplatin than 5-fluorouracil alone in human colon cancer cell lines. World J Gastroenterol. 8:841–846. 2002. View Article : Google Scholar : PubMed/NCBI

30 

Liang SR, Hu GR, Fang LJ, Huang SJ, Li JS, Zhao MY and Meng MJ: CpG oligodeoxynucleotides enhance chemosensitivity of 5-fluorouracil in HepG2 human hepatoma cells via downregulation of the antiapoptotic factors survivin and livin. Cancer Cell Int. 13:1062013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Han X, An L, Yan D, Matsuura H, Ding W, Zhang M, Xu G, Sun Y, Yuan G, Wang M, Wang M, et al: Combined antitumor effects of P‑5m octapeptide and 5‑fluorouracil on a murine model of H22 hepatoma ascites Corrigendum in /10.3892/etm.2018.6971. Exp Ther Med 16: 1586-1592, 2018.
APA
Han, X., An, L., Yan, D., Matsuura, H., Ding, W., Zhang, M. ... Du, P. (2018). Combined antitumor effects of P‑5m octapeptide and 5‑fluorouracil on a murine model of H22 hepatoma ascites Corrigendum in /10.3892/etm.2018.6971. Experimental and Therapeutic Medicine, 16, 1586-1592. https://doi.org/10.3892/etm.2018.6422
MLA
Han, X., An, L., Yan, D., Matsuura, H., Ding, W., Zhang, M., Xu, G., Sun, Y., Yuan, G., Wang, M., Zhao, N., Sun, J., Zhu, X., Du, P."Combined antitumor effects of P‑5m octapeptide and 5‑fluorouracil on a murine model of H22 hepatoma ascites Corrigendum in /10.3892/etm.2018.6971". Experimental and Therapeutic Medicine 16.3 (2018): 1586-1592.
Chicago
Han, X., An, L., Yan, D., Matsuura, H., Ding, W., Zhang, M., Xu, G., Sun, Y., Yuan, G., Wang, M., Zhao, N., Sun, J., Zhu, X., Du, P."Combined antitumor effects of P‑5m octapeptide and 5‑fluorouracil on a murine model of H22 hepatoma ascites Corrigendum in /10.3892/etm.2018.6971". Experimental and Therapeutic Medicine 16, no. 3 (2018): 1586-1592. https://doi.org/10.3892/etm.2018.6422
Copy and paste a formatted citation
x
Spandidos Publications style
Han X, An L, Yan D, Matsuura H, Ding W, Zhang M, Xu G, Sun Y, Yuan G, Wang M, Wang M, et al: Combined antitumor effects of P‑5m octapeptide and 5‑fluorouracil on a murine model of H22 hepatoma ascites Corrigendum in /10.3892/etm.2018.6971. Exp Ther Med 16: 1586-1592, 2018.
APA
Han, X., An, L., Yan, D., Matsuura, H., Ding, W., Zhang, M. ... Du, P. (2018). Combined antitumor effects of P‑5m octapeptide and 5‑fluorouracil on a murine model of H22 hepatoma ascites Corrigendum in /10.3892/etm.2018.6971. Experimental and Therapeutic Medicine, 16, 1586-1592. https://doi.org/10.3892/etm.2018.6422
MLA
Han, X., An, L., Yan, D., Matsuura, H., Ding, W., Zhang, M., Xu, G., Sun, Y., Yuan, G., Wang, M., Zhao, N., Sun, J., Zhu, X., Du, P."Combined antitumor effects of P‑5m octapeptide and 5‑fluorouracil on a murine model of H22 hepatoma ascites Corrigendum in /10.3892/etm.2018.6971". Experimental and Therapeutic Medicine 16.3 (2018): 1586-1592.
Chicago
Han, X., An, L., Yan, D., Matsuura, H., Ding, W., Zhang, M., Xu, G., Sun, Y., Yuan, G., Wang, M., Zhao, N., Sun, J., Zhu, X., Du, P."Combined antitumor effects of P‑5m octapeptide and 5‑fluorouracil on a murine model of H22 hepatoma ascites Corrigendum in /10.3892/etm.2018.6971". Experimental and Therapeutic Medicine 16, no. 3 (2018): 1586-1592. https://doi.org/10.3892/etm.2018.6422
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team