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Cilostazol on the expression of ICAM‑1, VCAM-1and inflammatory factors in plasma in patients with thromboangiitis obliterans

  • Authors:
    • Fuchen Song
    • Bo Ji
    • Ting Chen
  • View Affiliations / Copyright

    Affiliations: Department of Vascular Surgery, Affiliated Hospital of Shandong University ofTraditional Chinese Medicine, Jinan, Shandong 250011, P.R. China, Department of Ophtalmology, Affiliated Hospital of Shandong University ofTraditional Chinese Medicine, Jinan, Shandong 250011, P.R. China
    Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2349-2354
    |
    Published online on: July 11, 2018
       https://doi.org/10.3892/etm.2018.6436
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Abstract

The effects of cilostazol on the expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and inflammatory factors in plasma in patients with thromboangiitis obliterans (TAO) were studied. Plasma viscosity, fibrinogen, total cholesterol (TC) and triglyceride (TG) were detected for the healthy control, TAO and cilostazol groups, respectively. Results showed that compared with those in the control group, the plasma viscosity, fibrinogen, TC and TG levels in TAO group were significantly increased. By contrast, compared with those in TAO group, the plasma viscosity, fibrinogen, TC and TG levels in the cilostazol group were significantly decreased. ELISA results revealed that ICAM-1 and VCAM-1 expression levels in TAO group were obviously increased compared with those in control group. ICAM-1 and VCAM-1 expression levels in cilostazol group were obviously decreased compared with those in TAO group. According to RT-PCR, the mRNA expression levels of IL-1β, IL-6 and TNF-α in TAO group were significantly higher than those in control group, while the levels in cilostazol group were significantly decreased compared with those in TAO group. In addition, RT-PCR and western blotting proved that expression of both mRNA and protein of ICAM-1 and VCAM-1 in TAO group was significantly increased and obviously decreased after administration of cilostazol. The results of analysis of variance showed that the differences of ICAM-1 and VCAM-1 expression was statistically significant among the control, TAO and cilostazol groups (p<0.01). Cilostazol can significantly reduce the TAO-induced abnormal increase in ICAM-1, VCAM-1 and inflammatory factor expression in plasma in patients. It was proven that cilostazol has a good anti-TAO effect.
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Copy and paste a formatted citation
Spandidos Publications style
Song F, Ji B and Chen T: Cilostazol on the expression of ICAM‑1, VCAM-1and inflammatory factors in plasma in patients with thromboangiitis obliterans. Exp Ther Med 16: 2349-2354, 2018.
APA
Song, F., Ji, B., & Chen, T. (2018). Cilostazol on the expression of ICAM‑1, VCAM-1and inflammatory factors in plasma in patients with thromboangiitis obliterans. Experimental and Therapeutic Medicine, 16, 2349-2354. https://doi.org/10.3892/etm.2018.6436
MLA
Song, F., Ji, B., Chen, T."Cilostazol on the expression of ICAM‑1, VCAM-1and inflammatory factors in plasma in patients with thromboangiitis obliterans". Experimental and Therapeutic Medicine 16.3 (2018): 2349-2354.
Chicago
Song, F., Ji, B., Chen, T."Cilostazol on the expression of ICAM‑1, VCAM-1and inflammatory factors in plasma in patients with thromboangiitis obliterans". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2349-2354. https://doi.org/10.3892/etm.2018.6436
Copy and paste a formatted citation
x
Spandidos Publications style
Song F, Ji B and Chen T: Cilostazol on the expression of ICAM‑1, VCAM-1and inflammatory factors in plasma in patients with thromboangiitis obliterans. Exp Ther Med 16: 2349-2354, 2018.
APA
Song, F., Ji, B., & Chen, T. (2018). Cilostazol on the expression of ICAM‑1, VCAM-1and inflammatory factors in plasma in patients with thromboangiitis obliterans. Experimental and Therapeutic Medicine, 16, 2349-2354. https://doi.org/10.3892/etm.2018.6436
MLA
Song, F., Ji, B., Chen, T."Cilostazol on the expression of ICAM‑1, VCAM-1and inflammatory factors in plasma in patients with thromboangiitis obliterans". Experimental and Therapeutic Medicine 16.3 (2018): 2349-2354.
Chicago
Song, F., Ji, B., Chen, T."Cilostazol on the expression of ICAM‑1, VCAM-1and inflammatory factors in plasma in patients with thromboangiitis obliterans". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2349-2354. https://doi.org/10.3892/etm.2018.6436
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