Open Access

Protective effects of primary neural stem cell treatment in ischemic stroke models

  • Authors:
    • Xiaowen Yu
    • Xiaoqing Wang
    • Shuxiong Zeng
    • Xiping Tuo
  • View Affiliations

  • Published online on: July 18, 2018     https://doi.org/10.3892/etm.2018.6466
  • Pages: 2219-2228
  • Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Strokes are a major cause of neurological disability. Stem cell replacement therapy is a potential novel strategy of treating patients that have experienced strokes. The present study examined the protective role of neural stem cell (NSC) administration in oxygen‑glucose deprivation (OGD) injury and ischemic stroke animal models. Primary cultured embryonic NSCs and brain microvascular endothelial cells were indirectly co‑cultured for in vitro testing. A rat model of embolic middle cerebral artery occlusion (MCAO) was used to assess the morphological and functional changes that occur following treatment with NSCs. The role of the phosphoinositide 3‑kinase/protein kinase b/glycogen synthase kinase 3β (PI3K/Akt/GSK‑3β) signaling pathway in the neuroprotective effects of NSC treatment was also determined. It was demonstrated in vivo and in vitro that NSC administration may attenuate the brain injury caused by stroke. Furthermore, the results suggest that activation of PI3k/Akt/GSK‑3β signaling pathway serves a role in attenuating OGD injury. Inflammation, synaptic remodeling and autophagy may be improved following NSC treatment and behavioral testing suggests that treatment with NSCs improves functional recovery in rats following MCAO.
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September-2018
Volume 16 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Yu X, Wang X, Zeng S and Tuo X: Protective effects of primary neural stem cell treatment in ischemic stroke models. Exp Ther Med 16: 2219-2228, 2018
APA
Yu, X., Wang, X., Zeng, S., & Tuo, X. (2018). Protective effects of primary neural stem cell treatment in ischemic stroke models. Experimental and Therapeutic Medicine, 16, 2219-2228. https://doi.org/10.3892/etm.2018.6466
MLA
Yu, X., Wang, X., Zeng, S., Tuo, X."Protective effects of primary neural stem cell treatment in ischemic stroke models". Experimental and Therapeutic Medicine 16.3 (2018): 2219-2228.
Chicago
Yu, X., Wang, X., Zeng, S., Tuo, X."Protective effects of primary neural stem cell treatment in ischemic stroke models". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2219-2228. https://doi.org/10.3892/etm.2018.6466