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Article

Association of cytokine gene polymorphisms with osteoarthritis susceptibility

  • Authors:
    • Otilia Constantina Rogoveanu
    • Daniela Calina
    • Mihai Gabriel Cucu
    • Florin Burada
    • Anca Oana Docea
    • Simona Sosoi
    • Emilian Stefan
    • Mihai Ioana
    • Emilia Burada
  • View Affiliations / Copyright

    Affiliations: Department of Physical Medicine and Rehabilitation, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania, Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania, Human Genomics Laboratory, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania, Department of Toxicology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania, Clinic of Orthopaedics and Traumatology, Clinical Hospital CF2, 011464 Bucharest, Romania
  • Pages: 2659-2664
    |
    Published online on: July 18, 2018
       https://doi.org/10.3892/etm.2018.6477
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Abstract

Osteoarthritis (OA) is a multifactorial disease characterized by low‑grade inflammatory processes that are mediated initially by the cells and factors of the innate immune system. In addition to their key role in inflammation, cytokines contribute to the pathogenesis of OA through angiogenesis and chemotaxis. The purpose of the present case‑control study was to investigate a possible association of four cytokine single nucleotide polymorphisms (SNPs), IL‑4R ‑3223C>T (rs2057768), IL‑8 ‑251T>A (rs4073), IL‑10 ‑1082A>G (rs1800896) and TNF ‑A‑308G>A (rs1800629) with OA susceptibility. Genomic DNA was isolated from blood samples collected from 305 Romanian subjects (90 patients with OA and 215 controls) and the genotyping of the SNPs was performed by TaqMan allelic discrimination polymerase chain reaction using predesigned assays. Our data indicated a significant association for IL‑4R rs2057768 C>T SNP. The subjects that carried the CT genotype were at a higher risk for OA (OR 2.03, 95% CI: 1.21‑3.42, P=0.007) compared with those that had the CC genotype. Furthermore, the carriers of the T allele were at a 1.9 fold higher risk for OA (OR 1.92; 95% CI, 1.17‑3.17; P=0.009) in a dominant model. The association remained significant only for knee OA in the subgroups analysis. No correlations were observed between the other remaining SNPs and OA. The results suggested that the IL‑4R rs2057768 SNP could contribute to OA susceptibility in the Romanian population, providing novel evidence for the involvement of IL‑4/IL‑4R pair in the pathogenesis of OA.
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1 

Abramson SB and Attur M: Developments in the scientific understanding of osteoarthritis. Arthritis Res Ther. 11:2272009. View Article : Google Scholar : PubMed/NCBI

2 

Loeser RF, Goldring SR, Scanzello CR and Goldring MB: Osteoarthritis: A disease of the joint as an organ. Arthritis Rheum. 64:1697–1707. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Goldring MB and Goldring SR: Osteoarthritis. J Cell Physiol. 213:626–634. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Felson DT: An update on the pathogenesis and epidemiology of osteoarthritis. Radiol Clin North Am. 42:1–9, v. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Zhang Y and Jordan JM: Epidemiology of osteoarthritis. Clin Geriatr Med. 26:355–369. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Brooks P: Inflammation as an important feature of osteoarthritis. Bull World Health Organ. 81:689–690. 2003.PubMed/NCBI

7 

Robinson WH, Lepus CM, Wang Q, Raghu H, Mao R, Lindstrom TM and Sokolove J: Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis. Nat Rev Rheumatol. 12:580–592. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP and Fahmi H: Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol. 7:33–42. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Malemud CJ: Biologic basis of osteoarthritis: State of the evidence. Curr Opin Rheumatol. 27:289–294. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Yang F, Hu A, Zhao D, Guo L, Yang L, Wang B, Tian F, Liu B, Huang S and Xie H: An insertion/deletion polymorphism at the microRNA-122 binding site in the interleukin-1alpha 3′-untranslated region is associated with a risk for osteoarthritis. Mol Med Rep. 12:6199–6206. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Mapp PI and Walsh DA: Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis. Nat Rev Rheumatol. 8:390–398. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Mabey T and Honsawek S: Cytokines as biochemical markers for knee osteoarthritis. World J Orthop. 6:95–105. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Burada F, Dumitrescu T, Nicoli R, Ciurea ME, Angelescu C, Mixich F and Ioana M: IL-1RN +2018T>C polymorphism is correlated with colorectal cancer. Mol Biol Rep. 40:2851–2857. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Forster T, Chapman K and Loughlin J: Common variants within the interleukin 4 receptor alpha gene (IL4R) are associated with susceptibility to osteoarthritis. Hum Genet. 114:391–395. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Limer KL, Tosh K, Bujac SR, McConnell R, Doherty S, Nyberg F, Zhang W, Doherty M, Muir KR and Maciewicz RA: Attempt to replicate published genetic associations in a large, well-defined osteoarthritis case-control population (the GOAL study). Osteoarthritis Cartilage. 17:782–789. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Vargiolu M, Silvestri T, Bonora E, Dolzani P, Pulsatelli L, Addimanda O, Mancarella L, Punzi L, Fioravanti A, Facchini A, Romeo G, et al: Interleukin-4/interleukin-4 receptor gene polymorphisms in hand osteoarthritis. Osteoarthritis Cartilage. 18:810–816. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Yigit S, Inanir A, Tekcan A, Tural E, Ozturk GT, Kismali G and Karakus N: Significant association of interleukin-4 gene intron 3 VNTR polymorphism with susceptibility to knee osteoarthritis. Gene. 537:6–9. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Hämäläinen S, Solovieva S, Vehmas T, Leino-Arjas P and Hirvonen A: Variations in the TNFalpha gene and their interactions with the IL4R and IL10 genes in relation to hand osteoarthritis. BMC Musculoskelet Disord. 15:3112014. View Article : Google Scholar : PubMed/NCBI

19 

He Y, Liang X, Wu X, Meng C, Wu B, Fu D, Jin S, Yang S and Wang H: Association between interleukin 8 −251 A/T and +781 C/T polymorphisms and osteoarthritis risk. Immunol Lett. 162:207–211. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Lv C, Xu X, Wang J, Zhang Z, Zhang D, Guo C, Geng C and Sun Y: Combined effect of cytokine gene polymorphisms on end-stage knee osteoarthritis from Chinese Han population. Rheumatol Int. 32:3625–3629. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Riyazi N, Kurreeman FA, Huizinga TW, Dekker FW, Stoeken-Rijsbergen G and Kloppenburg M: The role of interleukin 10 promoter polymorphisms in the susceptibility of distal interphalangeal osteoarthritis. J Rheumatol. 32:1571–1575. 2005.PubMed/NCBI

22 

Fytili P, Giannatou E, Karachalios T, Malizos K and Tsezou A: Interleukin-10G and interleukin-10R microsatellite polymorphisms and osteoarthritis of the knee. Clin Exp Rheumatol. 23:621–627. 2005.PubMed/NCBI

23 

Kroeger KM, Carville KS and Abraham LJ: The −308 tumor necrosis factor-alpha promoter polymorphism effects transcription. Mol Immunol. 34:391–399. 1997. View Article : Google Scholar : PubMed/NCBI

24 

Uglialoro AM, Turbay D, Pesavento PA, Delgado JC, McKenzie FE, Gribben JG, Hartl D, Yunis EJ and Goldfeld AE: Identification of three new single nucleotide polymorphisms in the human tumor necrosis factor-alpha gene promoter. Tissue Antigens. 52:359–367. 1998. View Article : Google Scholar : PubMed/NCBI

25 

Sezgin M, Barlas IO, Ankarali HC, Altintaş ZM, Türkmen E, Gökdoğan T, Sahin G and Erdal M: Tumour necrosis factor alpha −308G/A gene polymorphism: Lack of association with knee osteoarthritis in a Turkish population. Clin Exp Rheumatol. 26:763–768. 2008.PubMed/NCBI

26 

Muñoz-Valle JF, Oregόn-Romero E, Rangel-Villalobos H, Martínez-Bonilla GE, Castañeda-Saucedo E, Salgado-Goytia L, Leyva-Vázquez MA, Illades-Aguiar B, Alarcón-Romero Ldel C, Espinoza-Rojo M and Parra-Rojas I: High expression of TNF alpha is associated with −308 and −238 TNF alpha polymorphisms in knee osteoarthritis. Clin Exp Med. 14:61–67. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Ji B, Shi J, Cheng X, Zhou J, Zhou Q, Cao C and Pang J: Association analysis of two candidate polymorphisms in the tumour necrosis factor-alpha gene with osteoarthritis in a Chinese population. Int Orthop. 37:2061–2063. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Han L, Song JH, Yoon JH, Park YG, Lee SW, Choi YJ, Nam SW, Lee JY and Park WS: TNF-α and TNF-β Polymorphisms are Associated with Susceptibility to Osteoarthritis in a Korean Population. Korean J Pathol. 46:30–37. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Kou S and Wu Y: Meta-analysis of tumor necrosis factor alpha −308 polymorphism and knee osteoarthritis risk. BMC Musculoskelet Disord. 15:3732014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Rogoveanu OC, Calina D, Cucu MG, Burada F, Docea AO, Sosoi S, Stefan E, Ioana M and Burada E: Association of cytokine gene polymorphisms with osteoarthritis susceptibility. Exp Ther Med 16: 2659-2664, 2018.
APA
Rogoveanu, O.C., Calina, D., Cucu, M.G., Burada, F., Docea, A.O., Sosoi, S. ... Burada, E. (2018). Association of cytokine gene polymorphisms with osteoarthritis susceptibility. Experimental and Therapeutic Medicine, 16, 2659-2664. https://doi.org/10.3892/etm.2018.6477
MLA
Rogoveanu, O. C., Calina, D., Cucu, M. G., Burada, F., Docea, A. O., Sosoi, S., Stefan, E., Ioana, M., Burada, E."Association of cytokine gene polymorphisms with osteoarthritis susceptibility". Experimental and Therapeutic Medicine 16.3 (2018): 2659-2664.
Chicago
Rogoveanu, O. C., Calina, D., Cucu, M. G., Burada, F., Docea, A. O., Sosoi, S., Stefan, E., Ioana, M., Burada, E."Association of cytokine gene polymorphisms with osteoarthritis susceptibility". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2659-2664. https://doi.org/10.3892/etm.2018.6477
Copy and paste a formatted citation
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Spandidos Publications style
Rogoveanu OC, Calina D, Cucu MG, Burada F, Docea AO, Sosoi S, Stefan E, Ioana M and Burada E: Association of cytokine gene polymorphisms with osteoarthritis susceptibility. Exp Ther Med 16: 2659-2664, 2018.
APA
Rogoveanu, O.C., Calina, D., Cucu, M.G., Burada, F., Docea, A.O., Sosoi, S. ... Burada, E. (2018). Association of cytokine gene polymorphisms with osteoarthritis susceptibility. Experimental and Therapeutic Medicine, 16, 2659-2664. https://doi.org/10.3892/etm.2018.6477
MLA
Rogoveanu, O. C., Calina, D., Cucu, M. G., Burada, F., Docea, A. O., Sosoi, S., Stefan, E., Ioana, M., Burada, E."Association of cytokine gene polymorphisms with osteoarthritis susceptibility". Experimental and Therapeutic Medicine 16.3 (2018): 2659-2664.
Chicago
Rogoveanu, O. C., Calina, D., Cucu, M. G., Burada, F., Docea, A. O., Sosoi, S., Stefan, E., Ioana, M., Burada, E."Association of cytokine gene polymorphisms with osteoarthritis susceptibility". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2659-2664. https://doi.org/10.3892/etm.2018.6477
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