Association of cytokine gene polymorphisms with osteoarthritis susceptibility

  • Authors:
    • Otilia Constantina Rogoveanu
    • Daniela Calina
    • Mihai Gabriel Cucu
    • Florin Burada
    • Anca Oana Docea
    • Simona Sosoi
    • Emilian Stefan
    • Mihai Ioana
    • Emilia Burada
  • View Affiliations

  • Published online on: July 18, 2018     https://doi.org/10.3892/etm.2018.6477
  • Pages: 2659-2664
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Osteoarthritis (OA) is a multifactorial disease characterized by low‑grade inflammatory processes that are mediated initially by the cells and factors of the innate immune system. In addition to their key role in inflammation, cytokines contribute to the pathogenesis of OA through angiogenesis and chemotaxis. The purpose of the present case‑control study was to investigate a possible association of four cytokine single nucleotide polymorphisms (SNPs), IL‑4R ‑3223C>T (rs2057768), IL‑8 ‑251T>A (rs4073), IL‑10 ‑1082A>G (rs1800896) and TNF ‑A‑308G>A (rs1800629) with OA susceptibility. Genomic DNA was isolated from blood samples collected from 305 Romanian subjects (90 patients with OA and 215 controls) and the genotyping of the SNPs was performed by TaqMan allelic discrimination polymerase chain reaction using predesigned assays. Our data indicated a significant association for IL‑4R rs2057768 C>T SNP. The subjects that carried the CT genotype were at a higher risk for OA (OR 2.03, 95% CI: 1.21‑3.42, P=0.007) compared with those that had the CC genotype. Furthermore, the carriers of the T allele were at a 1.9 fold higher risk for OA (OR 1.92; 95% CI, 1.17‑3.17; P=0.009) in a dominant model. The association remained significant only for knee OA in the subgroups analysis. No correlations were observed between the other remaining SNPs and OA. The results suggested that the IL‑4R rs2057768 SNP could contribute to OA susceptibility in the Romanian population, providing novel evidence for the involvement of IL‑4/IL‑4R pair in the pathogenesis of OA.
View Figures
View References

Related Articles

Journal Cover

September-2018
Volume 16 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Rogoveanu OC, Calina D, Cucu MG, Burada F, Docea AO, Sosoi S, Stefan E, Ioana M and Burada E: Association of cytokine gene polymorphisms with osteoarthritis susceptibility. Exp Ther Med 16: 2659-2664, 2018
APA
Rogoveanu, O.C., Calina, D., Cucu, M.G., Burada, F., Docea, A.O., Sosoi, S. ... Burada, E. (2018). Association of cytokine gene polymorphisms with osteoarthritis susceptibility. Experimental and Therapeutic Medicine, 16, 2659-2664. https://doi.org/10.3892/etm.2018.6477
MLA
Rogoveanu, O. C., Calina, D., Cucu, M. G., Burada, F., Docea, A. O., Sosoi, S., Stefan, E., Ioana, M., Burada, E."Association of cytokine gene polymorphisms with osteoarthritis susceptibility". Experimental and Therapeutic Medicine 16.3 (2018): 2659-2664.
Chicago
Rogoveanu, O. C., Calina, D., Cucu, M. G., Burada, F., Docea, A. O., Sosoi, S., Stefan, E., Ioana, M., Burada, E."Association of cytokine gene polymorphisms with osteoarthritis susceptibility". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2659-2664. https://doi.org/10.3892/etm.2018.6477