Efficacy and tolerability of interferon‑free regimen for patients with genotype‑1 HCV infection

Takeda,Kosuke; Noguchi,Ryuichi; Namisaki,Tadashi; Moriya,Kei; Akahane,Takemi; Kitade,Mitsuteru; Kawaratani,Hideto; Shimozato,Naotaka; Kaji,Kosuke; Takaya,Hiroaki; Sawada,Yasuhiko; Seki,Kenichiro; Fujinaga,Yukihisa; Tsuji,Yuki; Kubo,Takuya; Sato,Shinya; Saikawa,Soichiro; Nakanishi,Keisuke; Furukawa,Masanori; Kitagawa,Koh; Ozutsumi,Takahiro; Kaya,Daisuke; Mitoro,Akira; Mashitani,Tsuyoshi; Okura,Yasushi; Yamao,Junichi; Yoshiji,Hitoshi

doi:10.3892/etm.2018.6481

September-2018 Volume 16 Issue 3

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September-2018 Volume 16 Issue 3

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Article

Efficacy and tolerability of interferon‑free regimen for patients with genotype‑1 HCV infection

Authors:
- Kosuke Takeda
- Ryuichi Noguchi
- Tadashi Namisaki
- Kei Moriya
- Takemi Akahane
- Mitsuteru Kitade
- Hideto Kawaratani
- Naotaka Shimozato
- Kosuke Kaji
- Hiroaki Takaya
- Yasuhiko Sawada
- Kenichiro Seki
- Yukihisa Fujinaga
- Yuki Tsuji
- Takuya Kubo
- Shinya Sato
- Soichiro Saikawa
- Keisuke Nakanishi
- Masanori Furukawa
- Koh Kitagawa
- Takahiro Ozutsumi
- Daisuke Kaya
- Akira Mitoro
- Tsuyoshi Mashitani
- Yasushi Okura
- Junichi Yamao
- Hitoshi Yoshiji
View Affiliations / Copyright

Affiliations: Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara 634‑8522, Japan, Department of Endoscopy, Nara Medical University, Kashihara, Nara 634‑8522, Japan
Pages: 2743-2750
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Published online on: July 19, 2018

https://doi.org/10.3892/etm.2018.6481
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Abstract

Depression is a major reason for interferon (IFN) therapy cessation. IFN‑free direct‑acting antiviral (DAA) therapy for depression is not well‑documented. Thus, four different IFN‑free regimens were assessed in genotype‑1 hepatitis C virus (HCV) patients with depression. Overall, 287 HCV genotype‑1 patients who received combination therapies with IFN‑free DAAs of daclatasvir/asunaprevir (DCV/ASV) (n=84), sofosbuvir/ledipasvir (SOF/LDV) (n=95), ombitasvir/paritaprevir/ritonavir (OBV/PTV/r) (n=74), and elbasvir/grazoprevir (EBR/GZR) (n=34) were included. Treatment‑induced depression as a complication of HCV therapy in IFN‑free DAA regimens was assessed. The severity of depression was evaluated using the Beck Depression Inventory‑II (BDI‑II) questionnaire. It was demonstrated that all four DAA regimens achieved similar high efficacy in Japanese patients with HCV genotype‑1 infection. Moreover, in seven patients with depression who received the 24‑week DCV/ASV treatment regimen, the BDI‑II scores significantly increased at week 4 as compared with pretreatment values; furthermore, they decreased below baseline at week 12 despite the rapid decline of serum HCV levels after the initiation of DCV/ASV therapy. The BDI‑II scores gradually decreased during therapy in the remaining 77 DCV/ASV‑treated patients without depression. The BDI‑II scores showed a significant decrease from baseline to the end of treatment with 12‑week regimens, including SOF/LDV and EBR/GZR. The 12‑week DAA regimen of SOF/LDV and EBR/GZR can be safely used with high efficacy in patients with genotype‑1 HCV infection, including those with depression.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

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Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Efficacy and tolerability of interferon‑free regimen for patients with genotype‑1 HCV infection

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