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Bioinformatics identification of potential candidate blood indicators for doxorubicin‑induced heart failure

  • Authors:
    • Guo‑Xing Wan
    • Li‑Hua Ji
    • Wen‑Bin Xia
    • Lan Cheng
    • Yong‑Gang Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Second Affiliated Hospital Shantou University Medical College, Shantou, Guangdong 515041, P.R. China
    Copyright: © Wan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2534-2544
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    Published online on: July 19, 2018
       https://doi.org/10.3892/etm.2018.6482
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Abstract

The care of individual patients requiring anthracyclines remains challenging as uncertainty persists on predictors of cardiotoxicity. The aim of the present study was to identify potential candidate blood indicators of doxorubicin‑induced heart failure. The gene expression profiles of GSE40447 and GSE9128 microarray data were downloaded from the Gene Expression Omnibus database to identify differentially expressed genes (DEGs) using the R/Limma package or GEO2R. Functional and pathway enrichment analysis on DEGs were performed using DAVID database. The cardiovascular disease (CVD)‑related DEGs were screen out based on the CardioGenBase database. The protein‑protein interaction (PPI) network was constructed with STRING database and visualized by using Cytoscape. Then, the CVD‑related DEGs were validated by intersection analysis with DEGs in GSE9128. The overlapping DEGs with a consistent expression pattern in GSE40447 and GSE9128 were identified as candidate indicators for doxorubicin‑induced heart failure. A total of 516 DEGs potentially associated with doxorubicin‑induced heart failure in GSE40447 were identified, which were mainly enriched in the gene ontology terms related to B cells, leukocytes, lymphocyte activation and B cell receptor signaling pathway. Of the DEGs, 42 were screened out as CVD‑related DEGs by using CardioGenBase. Seven genes with high connectivity degree were presented in the PPI network. Finally, 5/6 CVD‑related DEGs revealed by the intersection analysis were validated by GSE9128 and highlighted as candidate indicators of doxorubicin‑induced heart failure: CD163, CD28, SLC25A20, ANPEP and TLR5. Several genes, including the 5 previously mentioned, were proposed as potential candidate blood indicators for doxorubicin‑induced heart failure. Further experimental validations are greatly warranted for future clinical application.
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1 

Curigliano G, Cardinale D, Dent S, Criscitiello C, Aseyev O, Lenihan D and Cipolla CM: Cardiotoxicity of anticancer treatments: Epidemiology, detection, and management. CA Cancer J Clin. 66:309–325. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Shabalala S, Muller CJF, Louw J and Johnson R: Polyphenols, autophagy and doxorubicin-induced cardiotoxicity. Life Sci. 180:160–170. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Argun M, Üzüm K, Sönmez MF, Özyurt A, Derya K, Çilenk KT, Unalmış S, Pamukcu Ö, Baykan A, Narin F, et al: Cardioprotective effect of metformin against doxorubicin cardiotoxicity in rats. Anatol J Cardiol. 16:234–241. 2016.PubMed/NCBI

4 

McGowan JV, Chung R, Maulik A, Piotrowska I, Walker JM and Yellon DM: Anthracycline chemotherapy and cardiotoxicity. Cardiovasc Drugs Ther. 31:63–75. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Bahadir A, Kurucu N, Kadıoğlu M and Yenilme E: The role of nitric oxide in Doxorubicin-induced cardiotoxicity: Experimental study. Turk J Haematol. 31:68–74. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Bryant J, Picot J, Baxter L, Levitt G, Sullivan I and Clegg A: Use of cardiac markers to assess the toxic effects of anthracyclines given to children with cancer: A systematic review. Eur J Cancer. 43:1959–1966. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Conway A, McCarthy AL, Lawrence P and Clark RA: The prevention, detection and management of cancer treatment-induced cardiotoxicity: A meta-review. BMC Cancer. 15:3662015. View Article : Google Scholar : PubMed/NCBI

8 

Senkus E and Jassem J: Cardiovascular effects of systemic cancer treatment. Cancer Treat Rev. 37:300–311. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Bai AD, Agarwal A, Steinberg M, Showler A, Burry L, Tomlinson GA, Bell CM and Morris AM: Clinical predictors and clinical prediction rules to estimate initial patient risk for infective endocarditis in Staphylococcus aureus bacteraemia: A systematic review and meta-analysis. Clin Microbiol Infect. 23:900–906. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Lotrionte M, Biondi-Zoccai G, Abbate A, Lanzetta G, D'Ascenzo F, Malavasi V, Peruzzi M, Frati G and Palazzoni G: Review and meta-analysis of incidence and clinical predictors of anthracycline cardiotoxicity. Am J Cardiol. 112:1980–1984. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Jain D, Russell RR, Schwartz RG, Panjrath GS and Aronow W: Cardiac complications of cancer therapy: Pathophysiology, identification, prevention, treatment, and future directions. Curr Cardiol Rep. 19:362017. View Article : Google Scholar : PubMed/NCBI

12 

Cardinale D and Sandri MT: Role of biomarkers in chemotherapy-induced cardiotoxicity. Prog Cardiovasc Dis. 53:121–129. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Dolci A, Dominici R, Cardinale D, Sandri MT and Panteghini M: Biochemical markers for prediction of chemotherapy-induced cardiotoxicity: Systematic review of the literature and recommendations for use. Am J Clin Pathol. 130:688–695. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Fallah-Rad N, Walker JR, Wassef A, Lytwyn M, Bohonis S, Fang T, Tian G, Kirkpatrick ID, Singal PK, Krahn M, et al: The utility of cardiac biomarkers, tissue velocity and strain imaging, and cardiac magnetic resonance imaging in predicting early left ventricular dysfunction in patients with human epidermal growth factor receptor II-positive breast cancer treated with adjuvant trastuzumab therapy. J Am Coll Cardiol. 57:2263–2270. 2011. View Article : Google Scholar : PubMed/NCBI

15 

McCaffrey TA, Tziros C, Lewis J, Katz R, Siegel R, Weglicki W, Kramer J, Mak IT, Toma I, Chen L, et al: Genomic profiling reveals the potential role of TCL1A and MDR1 deficiency in chemotherapy-induced cardiotoxicity. Int J Biol Sci. 9:350–360. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Cappuzzello C, Napolitano M, Arcelli D, Melillo G, Melchionna R, Di Vito L, Carlini D, Silvestri L, Brugaletta S, Liuzzo G, et al: Gene expression profiles in peripheral blood mononuclear cells of chronic heart failure patients. Physiol Genomics. 38:233–240. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Gautier L, Cope L, Bolstad BM and Irizarry RA: Affy-analysis of Affymetrix GeneChip data at the probe level. Bioinformatics. 20:307–315. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Troyanskaya O, Cantor M, Sherlock G, Brown P, Hastie T, Tibshirani R, Botstein D and Altman RB: Missing value estimation methods for DNA microarrays. Bioinformatics. 17:520–525. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U and Speed TP: Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics. 4:249–264. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W and Smyth GK: Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43:e472015. View Article : Google Scholar : PubMed/NCBI

21 

Huang da W, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Nayar PG, Murugesan R, Mary BPD and Ahmed SS: CardioGenBase: A literature based Multi-Omics database for major cardiovascular diseases. PLoS One. 10:e1431882015.

23 

Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, Simonovic M, Roth A, Santos A, Tsafou KP, et al: STRING v10: Protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 43(Database Issue): D447–D452. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Kohl M, Wiese S and Warscheid B: Cytoscape: Software for visualization and analysis of biological networks. Methods Mol Biol. 696:291–303. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Etzerodt A and Moestrup SK: CD163 and inflammation: Biological, diagnostic, and therapeutic aspects. Antioxid Redox Signal. 18:2352–2363. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Landis RC, Philippidis P, Domin J, Boyle JJ and Haskard DO: Haptoglobin genotype-dependent anti-inflammatory signaling in CD163(+) macrophages. Int J Inflam. 2013:9803272013. View Article : Google Scholar : PubMed/NCBI

27 

Zhong SM, Qin YH, Li ZC and Wei YS: Clinical value of detecting serum soluble CD163 level in patients with atrial fibrillation. Nan Fang Yi Ke Da Xue Xue Bao. 36:1406–1409. 2016.(In Chinese). PubMed/NCBI

28 

Zou LY, Peng CQ, Li CZ, Zhao CL, Zhu JM, Liu JL and Zhang CX: Association between hemoglobin scavenger receptor CD163 expression and coronary atherosclerotic severity in patients with coronary heart disease. Zhonghua Xin Xue Guan Bing Za Zhi. 37:605–609. 2009.(In Chinese). PubMed/NCBI

29 

Ptaszynska-Kopczynska K, Marcinkiewicz-Siemion M, Lisowska A, Waszkiewicz E, Witkowski M, Jasiewicz M, Miklasz P, Jakim P, Galar B, Musial WJ and Kaminski KA: Alterations of soluble TWEAK and CD163 concentrations in patients with chronic heart failure. Cytokine. 80:7–12. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Aruffo A and Seed B: Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system. Proc Natl Acad Sci USA. 84:8573–8577. 1987. View Article : Google Scholar : PubMed/NCBI

31 

Porciello N and Tuosto L: CD28 costimulatory signals in T lymphocyte activation: Emerging functions beyond a qualitative and quantitative support to TCR signalling. Cytokine Growth Factor Rev. 28:11–19. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Sulzgruber P, Koller L, Winter MP, Richter B, Blum S, Korpak M, Hulsmann M, Goliasch G, Wojta J and Niessner A: The impact of CD4+CD28null T-lymphocytes on atrial fibrillation and mortality in patients with chronic heart failure. Thromb Haemost. 117:349–356. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Dumitriu IE, Araguás ET, Baboonian C and Kaski JC: CD4+ CD28 null T cells in coronary artery disease: When helpers become killers. Cardiovasc Res. 81:11–19. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Kyaw T, Tipping P, Toh BH and Bobik A: Killer cells in atherosclerosis. Eur J Pharmacol. 816:67–75. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Kyaw T, Peter K, Li Y, Tipping P, Toh BH and Bobik A: Cytotoxic lymphocytes and atherosclerosis: Significance, mechanisms and therapeutic challenges. Br J Pharmacol. 174:3956–3972. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Piggott K, Biousse V, Newman NJ, Goronzy JJ and Weyand CM: Vascular damage in giant cell arteritis. Autoimmunity. 42:596–604. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Garib FY and Rizopulu AP: T-regulatory cells as part of strategy of immune evasion by pathogens. Biochemistry (Mosc). 80:957–971. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Zhu L, Zou LJ, Hua R and Li B: Association of single-nucleotide polymorphisms in toll-like receptor 5 gene with rheumatic heart disease in Chinese Han population. Int J Cardiol. 145:129–130. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Koupenova M, Mick E, Mikhalev E, Benjamin EJ, Tanriverdi K and Freedman JE: Sex differences in platelet toll-like receptors and their association with cardiovascular risk factors. Arterioscler Thromb Vasc Biol. 35:1030–1037. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Mahapatra S, Ananth A, Baugh N, Damian M and Enns GM: Triheptanoin: A rescue therapy for cardiogenic shock in carnitine-acylcarnitine translocase deficiency. JIMD Rep. 39:19–23. 2018. View Article : Google Scholar : PubMed/NCBI

41 

Choong K, Clarke JT, Cutz E, Pollit RJ and Olpin SE: Lethal cardiac tachyarrhythmia in a patient with neonatal carnitine-acylcarnitine translocase deficiency. Pediatr Dev Pathol. 4:573–579. 2001. View Article : Google Scholar : PubMed/NCBI

42 

Rubio-Gozalbo ME, Bakker JA, Waterham HR and Wanders RJ: Carnitine-acylcarnitine translocase deficiency, clinical, biochemical and genetic aspects. Mol Aspects Med. 25:521–532. 2004. View Article : Google Scholar : PubMed/NCBI

43 

Danziger RS: Aminopeptidase N in arterial hypertension. Heart Fail Rev. 13:293–298. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Pereira FE, Cronin C, Ghosh M, Zhou SY, Agosto M, Subramani J, Wang R, Shen JB, Schacke W, Liang B, et al: CD13 is essential for inflammatory trafficking and infarct healing following permanent coronary artery occlusion in mice. Cardiovasc Res. 100:74–83. 2013. View Article : Google Scholar : PubMed/NCBI

45 

Sánchez-Agesta Ortega R, Arias de Saavedra-Alías JM, Liébana-Cañada A, Sánchez-Muñoz B, Martínez-Martos JM and Ramírez-Expósito MJ: Circulating aminopeptidase activities in men and women with essential hypertension. Curr Med Chem. 20:4935–4945. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Buehler A, van Zandvoort MA, Stelt BJ, Hackeng TM, Schrans-Stassen BH, Bennaghmouch A, Hofstra L, Cleutjens JP, Duijvestijn A, Smeets MB, et al: cNGR: A novel homing sequence for CD13/APN targeted molecular imaging of murine cardiac angiogenesis in vivo. Arterioscler Thromb Vasc Biol. 26:2681–2687. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wan GX, Ji LH, Xia WB, Cheng L and Zhang YG: Bioinformatics identification of potential candidate blood indicators for doxorubicin‑induced heart failure. Exp Ther Med 16: 2534-2544, 2018.
APA
Wan, G., Ji, L., Xia, W., Cheng, L., & Zhang, Y. (2018). Bioinformatics identification of potential candidate blood indicators for doxorubicin‑induced heart failure. Experimental and Therapeutic Medicine, 16, 2534-2544. https://doi.org/10.3892/etm.2018.6482
MLA
Wan, G., Ji, L., Xia, W., Cheng, L., Zhang, Y."Bioinformatics identification of potential candidate blood indicators for doxorubicin‑induced heart failure". Experimental and Therapeutic Medicine 16.3 (2018): 2534-2544.
Chicago
Wan, G., Ji, L., Xia, W., Cheng, L., Zhang, Y."Bioinformatics identification of potential candidate blood indicators for doxorubicin‑induced heart failure". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2534-2544. https://doi.org/10.3892/etm.2018.6482
Copy and paste a formatted citation
x
Spandidos Publications style
Wan GX, Ji LH, Xia WB, Cheng L and Zhang YG: Bioinformatics identification of potential candidate blood indicators for doxorubicin‑induced heart failure. Exp Ther Med 16: 2534-2544, 2018.
APA
Wan, G., Ji, L., Xia, W., Cheng, L., & Zhang, Y. (2018). Bioinformatics identification of potential candidate blood indicators for doxorubicin‑induced heart failure. Experimental and Therapeutic Medicine, 16, 2534-2544. https://doi.org/10.3892/etm.2018.6482
MLA
Wan, G., Ji, L., Xia, W., Cheng, L., Zhang, Y."Bioinformatics identification of potential candidate blood indicators for doxorubicin‑induced heart failure". Experimental and Therapeutic Medicine 16.3 (2018): 2534-2544.
Chicago
Wan, G., Ji, L., Xia, W., Cheng, L., Zhang, Y."Bioinformatics identification of potential candidate blood indicators for doxorubicin‑induced heart failure". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2534-2544. https://doi.org/10.3892/etm.2018.6482
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