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Effect of montelukast on the expression of CD4+CD25+ regulatory T cells in children with acute bronchial asthma

  • Authors:
    • Xiaoting Qu
    • Yuan Chen
    • Chaoyang Yin
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, Shangluo Central Hospital, Shangluo, Shaanxi 726000, P.R. China, Department of Pediatrics, Ankang City Central Hospital of Shaanxi Province, Ankang, Shaanxi 725000, P.R. China
    Copyright: © Qu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2381-2386
    |
    Published online on: July 19, 2018
       https://doi.org/10.3892/etm.2018.6485
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Abstract

The aim of this study was to investigate the effect of montelukast on the expression of CD4+CD25+ regulatory T cells in children with acute bronchial asthma. Fifty-six child patients with acute bronchial asthma treated in the Department of Pneumology at the Shangluo Central Hospital were selected and randomly divided into the control group (n=28) and treatment group (n=28). The control group was treated with the conventional therapy of bronchial asthma, while the treatment group received montelukast on the basis of the control group for 7 days. The clinical symptoms, lung function and proportion of CD4+CD25+ regulatory T cells in peripheral T lymphocyte subsets in patients in the two groups were observed. Moreover, the levels of inflammatory factors and immunoglobulin E (IgE) in peripheral blood in both groups were detected. The effective treatment rate in the treatment group was significantly higher than that in the control group (P<0.05), and the forced expiratory volume in 1 sec/forced vital capacity (FEV1/FVC), peak expiratory flow (PEF) and 25% peak expiratory flow (PEF25) in the treatment group were significantly higher than those in the control group (P<0.05). The proportions of CD4+CD25+ regulatory T cells in the two groups after drug therapy were significantly increased. The proportion and content per unit volume of peripheral CD4+CD25+ regulatory T cells in the treatment group were obviously higher than those in the control group (P<0.01). After treatment, the levels of interleukin-4 (IL-4), IL-5 and IL-6 in peripheral blood in the two groups were significantly decreased. However, the levels of transferrin-γ (TFN-γ) and IL-10 were significantly increased (P<0.01). The IgE level in the treatment group was also significantly higher than that in the control group (P<0.01). In conclusion, montelukast can regulate the T helper 1 (Th1)/Th2 balance, increase the expression of CD4+CD25+ regulatory T cells, and improve the airway inflammation caused by acute bronchial asthma and the clinical symptoms and lung function of patients with acute bronchial asthma.
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Copy and paste a formatted citation
Spandidos Publications style
Qu X, Chen Y and Yin C: Effect of montelukast on the expression of CD4+CD25+ regulatory T cells in children with acute bronchial asthma. Exp Ther Med 16: 2381-2386, 2018.
APA
Qu, X., Chen, Y., & Yin, C. (2018). Effect of montelukast on the expression of CD4+CD25+ regulatory T cells in children with acute bronchial asthma. Experimental and Therapeutic Medicine, 16, 2381-2386. https://doi.org/10.3892/etm.2018.6485
MLA
Qu, X., Chen, Y., Yin, C."Effect of montelukast on the expression of CD4+CD25+ regulatory T cells in children with acute bronchial asthma". Experimental and Therapeutic Medicine 16.3 (2018): 2381-2386.
Chicago
Qu, X., Chen, Y., Yin, C."Effect of montelukast on the expression of CD4+CD25+ regulatory T cells in children with acute bronchial asthma". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2381-2386. https://doi.org/10.3892/etm.2018.6485
Copy and paste a formatted citation
x
Spandidos Publications style
Qu X, Chen Y and Yin C: Effect of montelukast on the expression of CD4+CD25+ regulatory T cells in children with acute bronchial asthma. Exp Ther Med 16: 2381-2386, 2018.
APA
Qu, X., Chen, Y., & Yin, C. (2018). Effect of montelukast on the expression of CD4+CD25+ regulatory T cells in children with acute bronchial asthma. Experimental and Therapeutic Medicine, 16, 2381-2386. https://doi.org/10.3892/etm.2018.6485
MLA
Qu, X., Chen, Y., Yin, C."Effect of montelukast on the expression of CD4+CD25+ regulatory T cells in children with acute bronchial asthma". Experimental and Therapeutic Medicine 16.3 (2018): 2381-2386.
Chicago
Qu, X., Chen, Y., Yin, C."Effect of montelukast on the expression of CD4+CD25+ regulatory T cells in children with acute bronchial asthma". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2381-2386. https://doi.org/10.3892/etm.2018.6485
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