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Article

Tetrandrine alleviates symptoms of rheumatoid arthritis in rats by regulating the expression of cyclooxygenase‑2 and inflammatory factors

  • Authors:
    • Xiang Li
    • Zhongxiu Wu
    • Bin He
    • Wei Zhong
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, Zaozhuang Municipal Hospital, Zaozhuang, Shandong 277101, P.R. China, Cadre Ward, Zaozhuang Municipal Hospital, Zaozhuang, Shandong 277101, P.R. China
  • Pages: 2670-2676
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    Published online on: July 20, 2018
       https://doi.org/10.3892/etm.2018.6498
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Abstract

The present study aimed to construct a rat model of rheumatoid arthritis (RA) to evaluate changes in pathology, the expression of inflammatory factors and regulation of signaling pathways. The protective effect of tetrandrine (Tet) on tissue lesions induced by RA was also investigated. A total of 60 Wistar rats (100‑200 g) were randomly divided into six groups (n=10 per group), namely a blank (NC) group, model group, methotrexate (MTX) group (3 mg/kg body weight), high‑dose Tet group (31.25 mg/kg body weight), medium‑dose Tet group (18.75 mg/kg body weight) and low‑dose Tet group (6.25 mg/kg body weight). A rat model of RA was induced via injection of 0.1 ml complete Freund's adjuvant into the right rear toe. Toe swelling rate, arthritis index and immune organ index were calculated. In addition, cyclooxygenase (COX)‑2 expression at the mRNA and protein level in the peripheral blood mononuclear cells (PBMCs) of rats were determined by reverse transcription‑quantitative polymerase chain reaction and western blot analysis, respectively. Serum concentrations of inflammatory factors were measured using enzyme‑linked immunosorbent assays. It was observed that treatment with Tet alleviated the severity of rear toe swelling associated with RA in rats. Furthermore, Tet exerted anti‑inflammatory and immunosuppressive effects in the rat model of RA. Tet also reduced the expression of COX‑2 in PBMCs and lowered the concentrations of inflammatory factors in the serum of RA rats. The present data indicate that Tet may exert pharmacological effects in the treatment of RA. The mechanism of action of Tet may be associated with the regulation of inflammatory factors and the inhibition of immune organs.
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1 

Sandoo A, Veldhuijzen van Zanten JJ, Metsios GS, Carroll D and Kitas GD: Vascular function and morphology in rheumatoid arthritis: A systematic review. Rheumatology (Oxford). 50:2125–2139. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Thomas E, Symmons DP, Brewster DH, Black RJ and Macfarlane GJ: National study of cause-specific mortality in rheumatoid arthritis, juvenile chronic arthritis, and other rheumatic conditions: A 20 year followup study. J Rheumatol. 30:958–965. 2003.PubMed/NCBI

3 

Lu Z and Zhong N: Internal medicine. 7th edition. Beijing: People's Medical Publishing House; pp. 8482008

4 

Koushik S, Joshi N, Nagaraju S, Mahmood S, Mudeenahally K, Padmavathy R, Jegatheesan SK, Mullangi R and Rajagopal S: PAD4: Pathophysiology, current therapeutics and future perspective in rheumatoid arthritis. Expert Opin Ther Targets. 21:433–447. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Worthington J, Barton A and John SL: The epidemiology of rheumatoid arthritis and the use of linkage and association studies to identify disease genes. The hereditary basis of rheumatic disease. Rikard Holmdahl: Birkhäuser Basel; Switzerland: pp. 1–28. 2006

6 

Smolen JS, Aletaha D and McInnes IB: Rheumatoid arthritis. Lancet. 388:2023–2038. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Venuturupalli S: Immune mechanisms and novel targets in rheumatoid arthritis. Immunol Allergy Clin North Am. 37:301–313. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Wolfe RM and Ang DC: Biologic therapies for autoimmune and connective tissue diseases. Immunol Allergy Clin North Am. 37:283–299. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Diaper R, Wong E and Metcalfe SA: The implications of biologic therapy for elective foot and ankle surgery in patients with rheumatoid arthritis. Foot (Edinb). 30:53–58. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Lampropoulos CE, Orfanos P, Manoussakis MN, Tzioufas AG, Moutsopoulos HM and Vlachoyiannopoulos PG: Treat-to-target biologic therapy in patients with rheumatoid arthritis is more efficacious and safe compared to delayed initiation of biologics: A real-world study. Clin Exp Rheumatol. 35:192–200. 2017.PubMed/NCBI

11 

Xu XH, Gan YC, Xu GB, Chen T, Zhou H, Tang JF, Gu Y, Xu F, Xie YY, Zhao XY and Xu RZ: Tetrandrine citrate eliminates imatinib-resistant chronic myeloid leukemia cells in vitro and in vivo by inhibiting Bcr-Abl/β-catenin axis. J Zhejiang Univ Sci B. 13:867–874. 2012. View Article : Google Scholar : PubMed/NCBI

12 

He BC, Gao JL, Zhang BQ, Luo Q, Shi Q, Kim SH, Huang E, Gao Y, Yang K, Wagner ER, et al: Tetrandrine inhibits Wnt/β-catenin signaling and suppresses tumor growth of human colorectal cancer. Mol Pharmacol. 79:211–219. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Hou Y, Guo T, Wu C and He X: Effect of tetrandrine combined with epirubicin on the growth of human breast carcinoma multidrug resistance cell line. Yakugaku Zasshi. 128:663–666. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Chen Y, Tsai YH and Tseng SH: The potential of tetrandrine as a protective agent for ischemic stroke. Molecules. 16:8020–8032. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Xie W and Du L: Diabetes is an inflammatory disease: Evidence from traditional Chinese medicines. Diabetes Obes Metab. 13:289–301. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Idec-Sadkowska I, Andrzejak R, Antonowicz-Juchniewicz J and Kaczmarek-Wdowiak B: Trials of casual treatment of silicosis. Med Pr. 57:271–280. 2006.(In Polish). PubMed/NCBI

17 

Perera PK, Peng C, Xue L, Li Y and Han C: Ex vivo and in vivo effect of Chinese herbal pill Yi Shen Juan Bi (YJB) on experimental arthritis. J Ethnopharmacol. 134:171–175. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Lin B, Zhang H, Zhao XX, Rahman K, Wang Y, Ma XQ, Zheng CJ, Zhang QY, Han T and Qin LP: Inhibitory effects of the root extract of Litsea cubeba (lour.) pers. on adjuvant arthritis in rats. J Ethnopharmacol. 147:327–334. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Davies NM and Jamali F: COX-2 selective inhibitors cardiac toxicity: Getting to the heart of the matter. J Pharm Pharm Sci. 7:332–336. 2004.PubMed/NCBI

20 

Steiniger B and van der Meide PH: High-dose interferon-gamma alters the distribution of B lymphocytes and macrophages in rat spleen and lymph nodes. Immunology. 78:461–467. 1993.PubMed/NCBI

21 

Koshy L, Anju AL, Harikrishnan S, Kutty VR, Jissa VT, Kurikesu I, Jayachandran P, Jayakumaran Nair A, Gangaprasad A, Nair GM and Sudhakaran PR: Evaluating genomic DNA extraction methods from human whole blood using endpoint and real-time PCR assays. Mol Biol Rep. 44:97–108. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Ge S, Cui L and Wang P: Research progress on pharmacological effects of tetrandrine. Chin Traditional Herbal Drugs. 31:W004–W006. 2000.

24 

Bhagya N and Chandrashekar KR: Tetrandrine-A molecule of wide bioactivity. Phytochemistry. 125:5–13. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Rao MR: Effects of tetrandrine on cardiac and vascular remodeling. Acta Pharmacol Sin. 23:1075–1085. 2002.PubMed/NCBI

26 

Li DG, Wang ZR and Lu HM: Pharmacology of tetrandrine and its therapeutic use in digestive diseases. World J Gastroenterol. 7:627–629. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Liu T, Liu X and Li W: Tetrandrine, a Chinese plant-derived alkaloid, is a potential candidate for cancer chemotherapy. Oncotarget. 7:40800–40815. 2016.PubMed/NCBI

28 

Xie QM, Tang HF, Chen JQ and Bian RL: Pharmacological actions of tetrandrine in inflammatory pulmonary diseases. Acta Pharmacol Sin. 23:1107–1113. 2002.PubMed/NCBI

29 

Hsu YC, Chiu YT, Cheng CC, Wu CF, Lin YL and Huang YT: Antifibrotic effects of tetrandrine on hepatic stellate cells and rats with liver fibrosis. J Gastroenterol Hepatol. 22:99–111. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Chan CM, Chan YW, Lau CH, Lau TW, Lau KM, Lam FC, Che CT, Leung PC, Fung KP, Lau CB and Ho YY: Influence of an anti-diabetic foot ulcer formula and its component herbs on tissue and systemic glucose homeostasis. J Ethnopharmacol. 109:10–20. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Lai JH: Immunomodulatory effects and mechanisms of plant alkaloid tetrandrine in autoimmune diseases. Acta Pharmacol Sin. 23:1093–1101. 2002.PubMed/NCBI

32 

Hu GX, Hu Y, Fang DC and Jiang MX: Hemodynamic effects of tetrandrine in conscious rats. Zhongguo Yao Li Xue Bao. 8:325–328. 1987.(In Chinese). PubMed/NCBI

33 

Ho LJ and Lai JH: Chinese herbs as immunomodulators and potential disease-modifying antirheumatic drugs in autoimmune disorders. Curr Drug Metab. 5:181–192. 2004. View Article : Google Scholar : PubMed/NCBI

34 

Caplazi P, Baca M, Barck K, Carano RA, DeVoss J, Lee WP, Bolon B and Diehl L: Mouse models of rheumatoid arthritis. Vet Pathol. 52:819–826. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Chieng LO, Madhavan K and Vanni S: Pooled data analysis on anterior versus posterior approach for rheumatoid arthritis at the craniovertebral junction. Neurosurg Focus. 38:E182015. View Article : Google Scholar : PubMed/NCBI

36 

Olumuyiwa-Akeredolu OO and Pretorius E: Platelet and red blood cell interactions and their in rheumatoid arthritis. Rheumatol Int. 35:1955–1964. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Kerola AM, Kauppi MJ, Nieminen T, Rantalaiho V, Kautiainen H, Kerola T, Virta LJ, Pohjolainen T and Puolakka K: Psychiatric and cardiovascular comorbidities as causes of long-term work disability among individuals with recent-onset rheumatoid arthritis. Scand J Rheumatol. 44:87–92. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Murata K, Yoshitomi H, Furu M, Ishikawa M, Shibuya H, Ito H and Matsuda S: MicroRNA-451 down-regulates neutrophil chemotaxis via p38 MAPK. Arthritis Rheumatol. 66:549–559. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Matsuno H, Yudoh K, Katayama R, Nakazawa F, Uzuki M, Sawai T, Yonezawa T, Saeki Y, Panayi GS, Pitzalis C and Kimura T: The role of TNF-alpha in the pathogenesis of inflammation and joint destruction in rheumatoid arthritis (RA): A study using a human RA/SCID mouse chimera. Rheumatology (Oxford). 41:329–337. 2002. View Article : Google Scholar : PubMed/NCBI

40 

Walker JG, Ahern MJ, Coleman M, Weedon H, Papangelis V, Beroukas D, Roberts-Thomson PJ and Smith MD: Expression of Jak3, STAT1, STAT4, and STAT6 in inflammatory arthritis: Unique Jak3 and STAT4 expression in dendritic cells in seropositive rheumatoid arthritis. Ann Rheum Dis. 65:149–156. 2006. View Article : Google Scholar : PubMed/NCBI

41 

Smolen JS, Agarwal SK, Ilivanova E, Xu XL, Miao Y, Zhuang Y, Nnane I, Radziszewski W, Greenspan A, Beutler A and Baker D: A randomised phase II study evaluating the efficacy and safety of subcutaneously administered ustekinumab and guselkumab in patients with active rheumatoid arthritis despite treatment with methotrexate. Ann Rheum Dis. 76:831–839. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Serag E, l-Dien MM, Abdou AG, Asaad NY, Abd El-Wahed MM and Kora MA: Intratumoral FOXP3+ regulatory T cells in diffuse large B-cell lymphoma. Appl Immunohistochem Mol Morphol. Feb 9–2016.(Epub ahead of print).

43 

Liu JY, Feng CP, Li X, Chang MC, Meng JL and Xu LJ: Immunomodulatory and antioxidative activity of Cordyceps militaris polysaccharides in mice. Int J Biol Macromol. 86:594–598. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Yu L, Yang B, Wang J, Zhao L, Luo W, Jiang Q and Yang J: Time course change of COX2-PGI2/TXA2 following global cerebral ischemia reperfusion injury in rat hippocampus. Behav Brain Funct. 10:422014. View Article : Google Scholar : PubMed/NCBI

45 

Yoon HY, Lee EG, Lee H, Cho IJ, Choi YJ, Sung MS, Yoo HG and Yoo WH: Kaempferol inhibits IL-1β-induced proliferation of rheumatoid arthritis synovial fibroblasts and the production of COX-2, PGE2 and MMPs. Int J Mol Med. 32:971–977. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Yorifuji M, Sawaji Y, Endo K, Kosaka T and Yamamoto K: Limited efficacy of COX-2 inhibitors on nerve growth factor and metalloproteinases expressions in human synovial fibroblasts. J Orthop Sci. 21:381–388. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Choy EH and Panayi GS: Cytokine pathways and joint inflammation in rheumatoid arthritis. N Engl J Med. 344:907–916. 2001. View Article : Google Scholar : PubMed/NCBI

48 

Choi EM and Hwang JK: Effects of methanolic extract and fractions from Litsea cubeba bark on the production of inflammatory mediators in RAW264.7 cells. Fitoterapia. 75:141–148. 2004. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li X, Wu Z, He B and Zhong W: Tetrandrine alleviates symptoms of rheumatoid arthritis in rats by regulating the expression of cyclooxygenase‑2 and inflammatory factors. Exp Ther Med 16: 2670-2676, 2018.
APA
Li, X., Wu, Z., He, B., & Zhong, W. (2018). Tetrandrine alleviates symptoms of rheumatoid arthritis in rats by regulating the expression of cyclooxygenase‑2 and inflammatory factors. Experimental and Therapeutic Medicine, 16, 2670-2676. https://doi.org/10.3892/etm.2018.6498
MLA
Li, X., Wu, Z., He, B., Zhong, W."Tetrandrine alleviates symptoms of rheumatoid arthritis in rats by regulating the expression of cyclooxygenase‑2 and inflammatory factors". Experimental and Therapeutic Medicine 16.3 (2018): 2670-2676.
Chicago
Li, X., Wu, Z., He, B., Zhong, W."Tetrandrine alleviates symptoms of rheumatoid arthritis in rats by regulating the expression of cyclooxygenase‑2 and inflammatory factors". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2670-2676. https://doi.org/10.3892/etm.2018.6498
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Wu Z, He B and Zhong W: Tetrandrine alleviates symptoms of rheumatoid arthritis in rats by regulating the expression of cyclooxygenase‑2 and inflammatory factors. Exp Ther Med 16: 2670-2676, 2018.
APA
Li, X., Wu, Z., He, B., & Zhong, W. (2018). Tetrandrine alleviates symptoms of rheumatoid arthritis in rats by regulating the expression of cyclooxygenase‑2 and inflammatory factors. Experimental and Therapeutic Medicine, 16, 2670-2676. https://doi.org/10.3892/etm.2018.6498
MLA
Li, X., Wu, Z., He, B., Zhong, W."Tetrandrine alleviates symptoms of rheumatoid arthritis in rats by regulating the expression of cyclooxygenase‑2 and inflammatory factors". Experimental and Therapeutic Medicine 16.3 (2018): 2670-2676.
Chicago
Li, X., Wu, Z., He, B., Zhong, W."Tetrandrine alleviates symptoms of rheumatoid arthritis in rats by regulating the expression of cyclooxygenase‑2 and inflammatory factors". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2670-2676. https://doi.org/10.3892/etm.2018.6498
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