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Review Open Access

Cycloastragenol: An exciting novel candidate for age‑associated diseases (Review)

  • Authors:
    • Yongjie Yu
    • Limin Zhou
    • Yajun Yang
    • Yuyu Liu
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, Guangdong Medical University, Zhanjiang, Guangdong 524023, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2175-2182
    |
    Published online on: July 20, 2018
       https://doi.org/10.3892/etm.2018.6501
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Abstract

Cycloastragenol (CAG) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus (Fisch.) Bunge. An increasing body of evidence has indicated that CAG has a wide spectrum of pharmacological functions, which are attracting attention in the research community. The aim of the present review paper was to review and elucidate the advanced study of CAG. The focus was on advanced studies of CAG in English and Chinese databases; the literature was collected and reviewed to summarize the latest efficacy, pharmacokinetics and adverse reactions of CAG. Extensive pharmacological effects have been attributed to CAG, including telomerase activation, telomere elongation, anti‑inflammatory and anti‑oxidative properties; CAG has also been reported to improve lipid metabolism. Clinical research has demonstrated that CAG activates telomerase in humans and ameliorates various biomarkers. CAG is absorbed through the intestinal epithelium via passive diffusion and undergoes first‑pass hepatic metabolism. Within a certain dose range, oral CAG is relatively safe; however, underlying mechanisms associated with CAG are not clear, and thus, we should be aware of potential adverse reactions associated with CAG. According to existing studies and clinical trials, CAG is safe and has broad application prospects. However, further studies are required to fully understand its efficacy and potential adverse reactions, and to ensure the proper use of CAG is applied to treat diseases clinically.
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Copy and paste a formatted citation
Spandidos Publications style
Yu Y, Zhou L, Yang Y and Liu Y: Cycloastragenol: An exciting novel candidate for age‑associated diseases (Review). Exp Ther Med 16: 2175-2182, 2018.
APA
Yu, Y., Zhou, L., Yang, Y., & Liu, Y. (2018). Cycloastragenol: An exciting novel candidate for age‑associated diseases (Review). Experimental and Therapeutic Medicine, 16, 2175-2182. https://doi.org/10.3892/etm.2018.6501
MLA
Yu, Y., Zhou, L., Yang, Y., Liu, Y."Cycloastragenol: An exciting novel candidate for age‑associated diseases (Review)". Experimental and Therapeutic Medicine 16.3 (2018): 2175-2182.
Chicago
Yu, Y., Zhou, L., Yang, Y., Liu, Y."Cycloastragenol: An exciting novel candidate for age‑associated diseases (Review)". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2175-2182. https://doi.org/10.3892/etm.2018.6501
Copy and paste a formatted citation
x
Spandidos Publications style
Yu Y, Zhou L, Yang Y and Liu Y: Cycloastragenol: An exciting novel candidate for age‑associated diseases (Review). Exp Ther Med 16: 2175-2182, 2018.
APA
Yu, Y., Zhou, L., Yang, Y., & Liu, Y. (2018). Cycloastragenol: An exciting novel candidate for age‑associated diseases (Review). Experimental and Therapeutic Medicine, 16, 2175-2182. https://doi.org/10.3892/etm.2018.6501
MLA
Yu, Y., Zhou, L., Yang, Y., Liu, Y."Cycloastragenol: An exciting novel candidate for age‑associated diseases (Review)". Experimental and Therapeutic Medicine 16.3 (2018): 2175-2182.
Chicago
Yu, Y., Zhou, L., Yang, Y., Liu, Y."Cycloastragenol: An exciting novel candidate for age‑associated diseases (Review)". Experimental and Therapeutic Medicine 16, no. 3 (2018): 2175-2182. https://doi.org/10.3892/etm.2018.6501
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