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Article Open Access

Inhibition of RKIP aggravates thioacetamide‑induced acute liver failure in mice

Retraction in: /10.3892/etm.2023.12005
  • Authors:
    • Xing Lin
    • Jinbin Wei
    • Jinlan Nie
    • Facheng Bai
    • Xunshuai Zhu
    • Lang Zhuo
    • Zhongpeng Lu
    • Quanfang Huang
  • View Affiliations / Copyright

    Affiliations: Pharmaceutical College and Life Sciences Institute, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Department of Bioengineering, Institute of Bioengineering and Nanotechnology, Singapore 169483, Republic of Singapore, Department of Biochemistry, University of Arkansas Medical School, Little Rock, AR 72205‑7199, USA, Department of Pharmacy, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, Guangxi 530023, P.R. China
    Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2992-2998
    |
    Published online on: July 30, 2018
       https://doi.org/10.3892/etm.2018.6542
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Abstract

Accumulating evidence has indicated that Raf kinase inhibitor protein (RKIP) is involved in several intracellular signaling pathways; its abnormal expression is associated with tumor progression and metastasis in several human neoplasms. However, the role of RKIP in acute liver injury has remained elusive. In the present study, acute liver failure was induced by thioacetamide in mice, and locostatin was used to interfere with RKIP expression. It was found that RKIP expression was significantly inhibited by locostatin. Down‑regulation of RKIP expression resulted in severe liver injury and extensive release of alanine aminotransferase and aspartate aminotransferase. In addition, reduced RKIP expression significantly enhanced the levels of reactive oxygen species and the content of pro‑inflammatory factors such as tumor necrosis factor‑α as well as interleukin‑6 and ‑1β, and decreased the levels of nuclear factor E2‑related factor‑2 and heme oxygenase‑1. Furthermore, down‑regulation of RKIP promoted the activation of the nuclear factor‑κB and extracellular signal‑regulated kinase signaling pathways. In conclusion, the present study indicates an inverse correlation between RKIP level and the degree of hepatic injury, that is, a decrease in RKIP expression may exacerbate acute liver failure.
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1 

Berasain C, Castillo J, Perugorria MJ, Latasa MU, Prieto J and Avila MA: Inflammation and liver cancer: New molecular links. Ann N Y Acad Sci. 1155:206–221. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Kaminska B: MAPK signalling pathways as molecular targets for anti-inflammatory therapy-from molecular mechanisms to therapeutic benefits. Biochim Biophys Acta. 1754:253–262. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Deutschman CS, Haber BA, Andrejko K, Cressman DE, Harrison R, Elenko E and Taub R: Increased expression of cytokine-induced neutrophil chemoattractant in septic rat liver. Am J Physiol. 271:R593–R600. 1996.PubMed/NCBI

4 

Serre L, de Jesus Pereira K, Zelwer C, Bureaud N, Schoentgen F and Bénédetti H: Crystal structures of YBHB and YBCL from Escherichia coli, two bacterial homologues to a Raf kinase inhibitor protein. J Mol Biol. 310:617–634. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Granovsky AE and Rosner MR: Raf kinase inhibitory protein: A signal transduction modulator and metastasis suppressor. Cell Res. 18:452–457. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Keller ET: Metastasis suppressor genes: A role for raf kinase inhibitor protein (RKIP). Anticancer Drugs. 15:663–669. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Zhu S, Mc Henry KT, Lane WS and Fenteany G: A chemical inhibitor reveals the role of Raf kinase inhibitor protein in cell migration. Chem Biol. 12:981–991. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Demirel U, Yalnız M, Aygün C, Orhan C, Tuzcu M, Sahin K, Ozercan IH and Bahçecioğlu IH: Allopurinol ameliorates thioacetamide-induced acute liver failure by regulating cellular redox-sensitive transcription factors in rats. Inflammation. 35:1549–1557. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Li HZ, Gao Y, Zhao XL, Liu YX, Sun BC, Yang J and Yao Z: Effects of raf kinase inhibitor protein expression on metastasis and progression of human breast cancer. Mol Cancer Res. 7:832–840. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Shinomol GK and Muralidhara: Differential induction of oxidative impairments in brain regions of male mice following subchronic consumption of Khesari dhal (Lathyrus sativus) and detoxified Khesari dhal. Neurotoxicology. 28:798–806. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Lin X, Zhang S, Huang R, Tan S, Liang S, Wu X, Zhuo L and Huang Q: Protective effect of tormentic acid from Potentilla Chinensis against lipopolysaccharide/D-galactosamine induced fulminant hepatic failure in mice. Int Immunopharmacol. 19:365–372. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Keller ET, Fu Z and Brennan M: The role of Raf kinase inhibitor protein (RKIP) in health and disease. Biochem Pharmacol. 68:1049–1053. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Yeung K, Seitz T, Li S, Janosch P, McFerran B, Kaiser C, Fee F, Katsanakis KD, Rose DW, Mischak H, et al: Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP. Nature. 401:173–177. 1999. View Article : Google Scholar : PubMed/NCBI

14 

Hu L, Li L, Xu D, Xia X, Pi R, Xu D, Wang W, Du H, Song E and Song Y: Protective effects of neohesperidin dihydrochalcone against carbon tetrachloride-induced oxidative damage in vivo and in vitro. Chem Biol Interact. 213:51–59. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Park JH, Kum YS, Lee TI, Kim SJ, Lee WR, Kim BI, Kim HS, Kim KH and Park KK: Melittin attenuates liver injury in thioacetamide-treated mice through modulating inflammation and fibrogenesis. Exp Biol Med (Maywood). 236:1306–1313. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Jaiswal AK: Nrf2 signaling in coordinated activation of antioxidant gene expression. Free Radic Biol Med. 36:1199–1207. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Na H, Kim E, Jung J, Lee H, Hyun J and Surh Y: (−)-Epigallocatechin gallate induces Nrf2-mediated antioxidant enzyme expression via activation of PI3K and ERK in human mammary epithelial cells. Arch Biochem Biophys. 476:171–177. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Xu W, Hellerbrand C, Köhler UA, Bugnon P, Kan YW, Werner S and Beyer TA: The Nrf2 transcription factor protects from toxin-induced liver injury and fibrosis. Lab Invest. 88:1068–1078. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Nakahira K, Takahashi T, Shimizu H, Maeshima K, Uehara K, Fujii H, Nakatsuka H, Yokoyama M, Akagi R and Morita K: Protective role of heme oxygenase-1 induction in carbon tetrachloride-induced hepatotoxicity. Biochem Pharmacol. 66:1091–1105. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Kaur G, Athar M and Alam MS: Eugenol precludes cutaneous chemical carcinogenesis in mouse by preventing oxidative stress and inflammation and by inducing apoptosis. Mol Carcinog. 49:290–301. 2010.PubMed/NCBI

21 

Boutros T, Chevet E and Metrakos P: Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: Roles in cell growth, death, and cancer. Pharmacol Rev. 60:261–310. 2008. View Article : Google Scholar : PubMed/NCBI

22 

McCubrey JA, Lahair MM and Franklin RA: Reactive oxygen species-induced activation of the MAP kinase signaling pathways. Antioxid Redox Signal. 8:1775–1789. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Chan ED and Riches DW: IFN-gamma + LPS induction of iNOS is modulated by ERK, JNK/SAPK, and p38(mapk) in a mouse macrophage cell line. Am J Physiol Cell Physiol. 280:C441–C450. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Yeung K, Janosch P, McFerran B, Rose DW, Mischak H, Sedivy JM and Kolch W: Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein. Mol Cell Biol. 20:3079–3085. 2000. View Article : Google Scholar : PubMed/NCBI

25 

Fu Z, Smith PC, Zhang L, Rubin MA, Dunn RL, Yao Z and Keller ET: Effects of raf kinase inhibitor protein expression on suppression of prostate cancer metastasis. J Natl Cancer Inst. 95:878–889. 2003. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lin X, Wei J, Nie J, Bai F, Zhu X, Zhuo L, Lu Z and Huang Q: Inhibition of RKIP aggravates thioacetamide‑induced acute liver failure in mice Retraction in /10.3892/etm.2023.12005. Exp Ther Med 16: 2992-2998, 2018.
APA
Lin, X., Wei, J., Nie, J., Bai, F., Zhu, X., Zhuo, L. ... Huang, Q. (2018). Inhibition of RKIP aggravates thioacetamide‑induced acute liver failure in mice Retraction in /10.3892/etm.2023.12005. Experimental and Therapeutic Medicine, 16, 2992-2998. https://doi.org/10.3892/etm.2018.6542
MLA
Lin, X., Wei, J., Nie, J., Bai, F., Zhu, X., Zhuo, L., Lu, Z., Huang, Q."Inhibition of RKIP aggravates thioacetamide‑induced acute liver failure in mice Retraction in /10.3892/etm.2023.12005". Experimental and Therapeutic Medicine 16.4 (2018): 2992-2998.
Chicago
Lin, X., Wei, J., Nie, J., Bai, F., Zhu, X., Zhuo, L., Lu, Z., Huang, Q."Inhibition of RKIP aggravates thioacetamide‑induced acute liver failure in mice Retraction in /10.3892/etm.2023.12005". Experimental and Therapeutic Medicine 16, no. 4 (2018): 2992-2998. https://doi.org/10.3892/etm.2018.6542
Copy and paste a formatted citation
x
Spandidos Publications style
Lin X, Wei J, Nie J, Bai F, Zhu X, Zhuo L, Lu Z and Huang Q: Inhibition of RKIP aggravates thioacetamide‑induced acute liver failure in mice Retraction in /10.3892/etm.2023.12005. Exp Ther Med 16: 2992-2998, 2018.
APA
Lin, X., Wei, J., Nie, J., Bai, F., Zhu, X., Zhuo, L. ... Huang, Q. (2018). Inhibition of RKIP aggravates thioacetamide‑induced acute liver failure in mice Retraction in /10.3892/etm.2023.12005. Experimental and Therapeutic Medicine, 16, 2992-2998. https://doi.org/10.3892/etm.2018.6542
MLA
Lin, X., Wei, J., Nie, J., Bai, F., Zhu, X., Zhuo, L., Lu, Z., Huang, Q."Inhibition of RKIP aggravates thioacetamide‑induced acute liver failure in mice Retraction in /10.3892/etm.2023.12005". Experimental and Therapeutic Medicine 16.4 (2018): 2992-2998.
Chicago
Lin, X., Wei, J., Nie, J., Bai, F., Zhu, X., Zhuo, L., Lu, Z., Huang, Q."Inhibition of RKIP aggravates thioacetamide‑induced acute liver failure in mice Retraction in /10.3892/etm.2023.12005". Experimental and Therapeutic Medicine 16, no. 4 (2018): 2992-2998. https://doi.org/10.3892/etm.2018.6542
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