Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
October-2018 Volume 16 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2018 Volume 16 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

SPARCL1 suppresses the proliferation and migration of human ovarian cancer cells via the MEK/ERK signaling

  • Authors:
    • Yan Ma
    • Yuan Xu
    • Li Li
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, Third Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China
  • Pages: 3195-3201
    |
    Published online on: August 7, 2018
       https://doi.org/10.3892/etm.2018.6575
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Ovarian cancer is the most lethal gynecological malignancy worldwide and is one of the five leading causes of cancer‑associated mortality in women. There is an urgent requirement to obtain a greater understanding of the molecular mechanism underlying ovarian cancer progression in order to identify novel drug targets and biomarkers. Secreted protein acidic and rich in cysteine‑like protein 1 (SPARCL1) has been suggested as a candidate tumor suppressor in various types of human cancers. However, the potential role of SPARCL1 for ovarian cancer has not yet been clearly established. In the present study, lower protein expression levels of SPARCL1 were detected in ovarian cancer tissues when compared with adjacent normal tissues. Overexpression of SPARCL1 significantly suppressed the proliferation and migration of cells from the ovarian cancer cell line SKOV‑3, whereas knockdown of SPARCL1 significantly increased cell growth and migration. Furthermore, the results revealed that SPARCL1 overexpression significantly suppressed the activation of the mitogen‑activated protein kinase kinase (MEK)/extracellular signal‑related kinase (ERK) signaling pathway. Collectively, these results indicated that SPARCL1 may suppress the proliferation and migration of ovarian cancer cells by downregulating signaling via the MEK/ERK pathway.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Chen C, Wu J, Zhu P, Xu C and Yao L: Investigating isoquinoline derivatives for inhibition of inhibitor of apoptosis proteins for ovarian cancer treatment. Drug Des Devel Ther. 11:2697–2707. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Zhang W, Su J, Xu H, Yu S, Liu Y, Zhang Y, Sun L, Yue Y and Zhou X: Dicumarol inhibits PDK1 and targets multiple malignant behaviors of ovarian cancer cells. PLoS One. 12:e01796722017. View Article : Google Scholar : PubMed/NCBI

3 

Li Q, Gao JF and Qi BL: PDCD1 strengthens the sensitivity of ovarian cancer to cisplatin chemotherapy by promoting apoptosis. J BUON. 22:746–756. 2017.PubMed/NCBI

4 

Zhao Y, Cui L, Pan Y, Shao D, Zheng X, Zhang F, Zhang H, He K and Chen L: Berberine inhibits the chemotherapy-induced repopulation by suppressing the arachidonic acid metabolic pathway and phosphorylation of FAK in ovarian cancer. Cell Prolif. 50:e123932017. View Article : Google Scholar

5 

Zhao SJ, Jiang YQ, Xu NW, Li Q, Zhang Q, Wang SY, Li J, Wang YH, Zhang YL, Jiang SH, et al: SPARCL1 suppresses osteosarcoma metastasis and recruits macrophages by activation of canonical WNT/β-catenin signaling through stabilization of the WNT-receptor complex. Oncogene. 37:1049–1061. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Ye H, Wang WG, Cao J and Hu XC: SPARCL1 suppresses cell migration and invasion in renal cell carcinoma. Mol Med Rep. 16:7784–7790. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Xiang Y, Qiu Q, Jiang M, Jin R, Lehmann BD, Strand DW, Jovanovic B, DeGraff DJ, Zheng Y, Yousif DA, et al: Yi Y: SPARCL1 suppresses metastasis in prostate cancer. Mol Oncol. 7:1019–1030. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Wu DM, Shi J, Liu T, Deng SH, Han R and Xu Y: Integrated analysis reveals down-regulation of SPARCL1 is correlated with cervical cancer development and progression. Cancer Biomark. 21:355–365. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Liu X, Gao Y, Zhao B, Li X, Lu Y, Zhang J, Li D, Li L and Yin F: Discovery of microarray-identified genes associated with ovarian cancer progression. Int J Oncol. 46:2467–2478. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Jiang G, Yang D, Wang L, Zhang X, Xu H, Miao Y, Wang E and Zhang Y: A novel biomarker ARMc8 promotes the malignant progression of ovarian cancer. Hum Pathol. 46:1471–1479. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Josahkian JA, Saggioro FP, Vidotto T, Ventura HT, Candido Dos Reis FJ, de Sousa CB, Tiezzi DG, de Andrade JM, Koti M and Squire JA: Increased STAT1 expression in high grade serous ovarian cancer is associated with a better outcome. Int J Gynecol Cancer. 28:459–465. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Wei W, Li Y, Lv S, Zhang C and Tian Y: PARP-1 may be involved in angiogenesis in epithelial ovarian cancer. Oncol Lett. 12:4561–4567. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Cao F, Wang K, Zhu R, Hu YW, Fang WZ and Ding HZ: Clinicopathological significance of reduced SPARCL1 expression in human breast cancer. Asian Pac J Cancer Prev. 14:195–200. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Hurley PJ, Hughes RM, Simons BW, Huang J, Miller RM, Shinder B, Haffner MC, Esopi D, Kimura Y, Jabbari J, et al: Androgen-regulated SPARCL1 in the tumor microenvironment inhibits metastatic progression. Cancer Res. 75:4322–4334. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Hurley PJ, Marchionni L, Simons BW, Ross AE, Peskoe SB, Miller RM, Erho N, Vergara IA, Ghadessi M, Huang Z, et al: Secreted protein, acidic and rich in cysteine-like 1 (SPARCL1) is down regulated in aggressive prostate cancers and is prognostic for poor clinical outcome. Proc Natl Acad Sci USA. 109:14977–14982. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Jakharia A, Borkakoty B and Singh S: Expression of SPARC like protein 1 (SPARCL1), extracellular matrix-associated protein is down regulated in gastric adenocarcinoma. J Gastrointest Oncol. 7:278–283. 2016.PubMed/NCBI

17 

Bendik I, Schraml P and Ludwig CU: Characterization of MAST9/Hevin, a SPARC-like protein, that is down-regulated in non-small cell lung cancer. Cancer Res. 58:626–629. 1998.PubMed/NCBI

18 

Naschberger E, Liebl A, Schellerer VS, Schutz M, Britzen-Laurent N, Kolbel P, Schaal U, Haep L, Regensburger D, Wittmann T, et al: Matricellular protein SPARCL1 regulates tumor microenvironment-dependent endothelial cell heterogeneity in colorectal carcinoma. J Clin Invest. 126:4187–4204. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Zhang H, Widegren E, Wang DW and Sun XF: SPARCL1: A potential molecule associated with tumor diagnosis, progression and prognosis of colorectal cancer. Tumour Biol. 32:1225–1231. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Chi F, Wu R, Jin X, Jiang M and Zhu X: HER2 induces cell proliferation and invasion of non-small-cell lung cancer by upregulating COX-2 expression via MEK/ERK signaling pathway. Onco Targets Ther. 9:2709–2716. 2016.PubMed/NCBI

21 

Li K, Guo Q, Yang J, Chen H, Hu K, Zhao J, Zheng S, Pang X, Zhou S, Dang Y and Li L: FOXD3 is a tumor suppressor of colon cancer by inhibiting EGFR-Ras-Raf-MEK-ERK signal pathway. Oncotarget. 8:5048–5056. 2017.PubMed/NCBI

22 

Shen MJ, Xu LJ, Yang L, Tsai Y, Keng PC and Chen Y, Lee SO and Chen Y: Radiation alters PD-L1/NKG2D ligand levels in lung cancer cells and leads to immune escape from NK cell cytotoxicity via IL-6-MEK/Erk signaling pathway. Oncotarget. 8:80506–80520. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Wang J, Guo X, Xie C and Jiang J: KIF15 promotes pancreatic cancer proliferation via the MEK-ERK signalling pathway. Br J Cancer. 117:245–255. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Wang Y, Xiao H, Wu H, Yao C, He H, Wang C and Li W: G protein subunit alpha q regulates gastric cancer growth via the p53/p21 and MEK/ERK pathways. Oncol Rep. 37:1998–2006. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Yang K, Gao K, Hu G, Wen Y, Lin C and Li X: CTGF enhances resistance to 5-FU-mediating cell apoptosis through FAK/MEK/ERK signal pathway in colorectal cancer. Onco Targets Ther. 9:7285–7295. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Yang L, Shen M, Xu LJ, Yang X, Tsai Y, Keng PC, Chen Y and Lee SO: Enhancing NK cell-mediated cytotoxicity to cisplatin-resistant lung cancer cells via MEK/Erk signaling inhibition. Sci Rep. 7:79582017. View Article : Google Scholar : PubMed/NCBI

27 

Zhang C, Yu P, Zhu L, Zhao Q, Lu X and Bo S: Blockade of alpha7 nicotinic acetylcholine receptors inhibit nicotine-induced tumor growth and vimentin expression in non-small cell lung cancer through MEK/ERK signaling way. Oncol Rep. 38:3309–3318. 2017.PubMed/NCBI

28 

Shen X and Kramer RH: Adhesion-mediated squamous cell carcinoma survival through ligand-independent activation of epidermal growth factor receptor. Am J Pathol. 165:1315–1329. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Bai RX, Wang WP, Zhao PW and Li CB: Ghrelin attenuates the growth of HO-8910 ovarian cancer cells through the ERK pathway. Braz J Med Biol Res. 49:e50432016. View Article : Google Scholar

30 

Bartholomeusz C, Itamochi H, Nitta M, Saya H, Ginsberg MH and Ueno NT: Antitumor effect of E1A in ovarian cancer by cytoplasmic sequestration of activated ERK by PEA15. Oncogene. 25:79–90. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Chang MC, Chen CA, Chen PJ, Chiang YC, Chen YL, Mao TL, Lin HW, Lin Chiang WH and Cheng WF: Mesothelin enhances invasion of ovarian cancer by inducing MMP-7 through MAPK/ERK and JNK pathways. Biochem J. 442:293–302. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Fujisawa T, Joshi BH and Puri RK: IL-13 regulates cancer invasion and metastasis through IL-13Rα2 via ERK/AP-1 pathway in mouse model of human ovarian cancer. Int J Cancer. 131:344–356. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Ohta T, Isobe M, Takahashi T, Saitoh-Sekiguchi M, Motoyama T and Kurachi H: The Akt and ERK activation by platinum-based chemotherapy in ovarian cancer is associated with favorable patient outcome. Anticancer Res. 29:4639–4647. 2009.PubMed/NCBI

34 

Song H, Wei M, Liu W, Shen S, Li J and Wang L: Cisplatin induced apoptosis of ovarian cancer A2780s cells by activation of ERK/p53/PUMA signals. Histol Histopathol. 33:73–79. 2018.PubMed/NCBI

35 

Su S, Lin X, Ding N, Zhang H, Zhang Q, Ding Y, Hou X and Tian Y: Effects of PARP-1 inhibitor and ERK inhibitor on epithelial mesenchymal transitions of the ovarian cancer SKOV3 cells. Pharmacol Rep. 68:1225–1229. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Vergara D, Simeone P, Toraldo D, Del Boccio P, Vergaro V, Leporatti S, Pieragostino D, Tinelli A, De Domenico S, Alberti S, et al: Resveratrol downregulates Akt/GSK and ERK signalling pathways in OVCAR-3 ovarian cancer cells. Mol Biosyst. 8:1078–1087. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Wang W, Ren F, Wu Q, Jiang D, Li H and Shi H: MicroRNA-497 suppresses angiogenesis by targeting vascular endothelial growth factor A through the PI3K/AKT and MAPK/ERK pathways in ovarian cancer. Oncol Rep. 32:2127–2133. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Al-Ayoubi A, Tarcsafalvi A, Zheng H, Sakati W and Eblen ST: ERK activation and nuclear signaling induced by the loss of cell/matrix adhesion stimulates anchorage-independent growth of ovarian cancer cells. J Cell Biochem. 105:875–884. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Dang JH, Jin ZJ, Liu XJ, Hu D, Wang J, Luo Y and Li LL: Metformin in combination with cisplatin inhibits cell viability and induces apoptosis of human ovarian cancer cells by inactivating ERK 1/2. Oncol Lett. 14:7557–7564. 2017.PubMed/NCBI

40 

Chan DW, Hui WW, Cai PC, Liu MX, Yung MM, Mak CS, Leung TH, Chan KK and Ngan HY: Targeting GRB7/ERK/FOXM1 signaling pathway impairs aggressiveness of ovarian cancer cells. PLoS One. 7:e525782012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ma Y, Xu Y and Li L: SPARCL1 suppresses the proliferation and migration of human ovarian cancer cells via the MEK/ERK signaling. Exp Ther Med 16: 3195-3201, 2018.
APA
Ma, Y., Xu, Y., & Li, L. (2018). SPARCL1 suppresses the proliferation and migration of human ovarian cancer cells via the MEK/ERK signaling. Experimental and Therapeutic Medicine, 16, 3195-3201. https://doi.org/10.3892/etm.2018.6575
MLA
Ma, Y., Xu, Y., Li, L."SPARCL1 suppresses the proliferation and migration of human ovarian cancer cells via the MEK/ERK signaling". Experimental and Therapeutic Medicine 16.4 (2018): 3195-3201.
Chicago
Ma, Y., Xu, Y., Li, L."SPARCL1 suppresses the proliferation and migration of human ovarian cancer cells via the MEK/ERK signaling". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3195-3201. https://doi.org/10.3892/etm.2018.6575
Copy and paste a formatted citation
x
Spandidos Publications style
Ma Y, Xu Y and Li L: SPARCL1 suppresses the proliferation and migration of human ovarian cancer cells via the MEK/ERK signaling. Exp Ther Med 16: 3195-3201, 2018.
APA
Ma, Y., Xu, Y., & Li, L. (2018). SPARCL1 suppresses the proliferation and migration of human ovarian cancer cells via the MEK/ERK signaling. Experimental and Therapeutic Medicine, 16, 3195-3201. https://doi.org/10.3892/etm.2018.6575
MLA
Ma, Y., Xu, Y., Li, L."SPARCL1 suppresses the proliferation and migration of human ovarian cancer cells via the MEK/ERK signaling". Experimental and Therapeutic Medicine 16.4 (2018): 3195-3201.
Chicago
Ma, Y., Xu, Y., Li, L."SPARCL1 suppresses the proliferation and migration of human ovarian cancer cells via the MEK/ERK signaling". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3195-3201. https://doi.org/10.3892/etm.2018.6575
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team