Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
October-2018 Volume 16 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2018 Volume 16 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report

Echinocandins for Pneumocystis jirovecii pneumonia in non‑HIV patients: A case report

  • Authors:
    • Hui‑Bin Huang
    • Jing‑Min Peng
    • Bin Du
  • View Affiliations / Copyright

    Affiliations: Medical Intensive Care Unit, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, P.R. China
  • Pages: 3227-3232
    |
    Published online on: August 7, 2018
       https://doi.org/10.3892/etm.2018.6587
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

For the past two decades, echinocandins have shown prophylactic and therapeutic efficacy in patients with Pneumocystis jirovecii pneumonia (PJP), due to their ability to inhibit the synthesis of β‑1, 3‑glucan, a major component of the cell wall of P. jirovecii. The present study reported two cases of human immunodeficiency virus (HIV)‑negative patients who received echinocandins as a salvage therapy at Peking Union Medical College Hospital (Beijing, China), both of whom exhibited good responses to treatment. In both cases, polymerase chain reaction of sputum or bronchoalveolar lavage specimens became negative following treatment. The present study also performed a literature search to identify non‑HIV patients with PJP who previously received echinocandins. The results of the present study suggested that echinocandins maybe promising therapeutic agents in the treatment of non‑HIV patients with PJP, particularly in combination with trimethoprim‑sulfamethoxazole. Therefore, the results warrant a randomized controlled trial.
View Figures

Figure 1

View References

1 

Li MC, Lee NY, Lee CC, Lee HC, Chang CM and Ko WC: Pneumocystis jiroveci pneumonia in immunocompromised patients: Delayed diagnosis and poor outcomes in 2014,non-HIV-infected individuals. J Microbiol Immunol Infect. 47:42–47. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Mansharamani NG, Garland R, Delaney D and Koziel H: Management and outcome patterns for adult pneumocystis carinii pneumonia, 1985 to 1995: Comparison of HIV-associated cases to other immunocompromised states. Chest. 118:704–711. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Miller RF, Allen E, Copas A, Singer M and Edwards SG: Improved survival for HIV infected patients with severe pneumocystis jirovecii pneumonia is independent of highly active antiretroviral therapy. Thorax. 61:716–721. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Yale SH and Limper AH: Pneumocystis carinii pneumonia in patients without acquired immunodeficiency syndrome: Associated illness and prior corticosteroid therapy. Mayo Clin Proc. 71:5–13. 1996. View Article : Google Scholar : PubMed/NCBI

5 

Weng L, Huang X, Chen L, Feng LQ, Jiang W, Hu XY, Peng JM, Wang CY, Zhan QY and Du B: Prognostic factors for severe Pneumocystis jirovecipneumonia of non-HIV patients in intensive care unit: A bicentric retrospective study. BMC Infectious Dis. 16:5282016. View Article : Google Scholar

6 

Monnet X, Vidal-Petiot E, Osman D, Hamzaoui O, Durrbach A, Goujard C, Miceli C, Bourée P and Richard C: Critical care management and outcome of severe Pneumocystis pneumonia in patients with and without HIV infection. Crit Care. 12:R282008. View Article : Google Scholar : PubMed/NCBI

7 

Boonsarngsuk V, Sirilak S and Kiatboonsri S: Acute respiratory failure due to pneumocystis pneumonia: Outcome and prognostic factors. Int J Infect Dis. 13:59–66. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Zhang JC, Dai JY, Fan J and Wu XP: The treatment of pneumocystis Carinii pneumonia with caspofungin in elderly patients: A case report and literature review. Zhonghua Jie He He Hu Xi Za Zhi. 29:4632006.(In Chinese). PubMed/NCBI

9 

Annaloro C, Volpe AD, Usardi P and Lambertenghi Deliliers G: Caspofungin treatment of Pneumocystis pneumonia during conditioning for bone marrow transplantation. Eur J Clin Microbiol Infect Dis. 25:52–54. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Beltz K, Kramm CM, Laws HJ, Schroten H, Wessalowski R and Göbel U: Combined trimethoprim and caspofungin treatment for severe pneumocystis jiroveci pneumonia in a five year old boy with acute lymphoblastic leukemia. Klin Pädiatr. 218:177–179. 2006. View Article : Google Scholar

11 

Kamboj M, Weinstock D and Sepkowitz KA: Progression of pneumocystis jiroveci pneumonia in patients receiving echinocandin therapy. Clin Infect Dis. 43:e92–e94. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Takeda K, Morioka D, Kumamoto T, Matsuo K, Tanaka K, Endo I, Togo S and Shimada H: A survival case of ABO-incompatible liver transplantation complicated with severe preoperative infection and subsequent overwhelming postsplenectomy infection. Transplant Proc. 41:3941–3944. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Zhang W, Wang GF, Nie LG, et al: Clinical characteristics of Pneumocystis pneumonia during chemotherapy and radiotherapy in lung cancer patients. J Prac Oncol. 27:175–179. 2012.

14 

Li H, Huang H and He H: Successful treatment of severe Pneumocystis pneumonia in an immunosuppressed patient using caspofungin combined with clindamycin: A case report and literature review. BMC Pulm Med. 16:1442016. View Article : Google Scholar : PubMed/NCBI

15 

Kim T, Hong HL, Lee YM, Sung H, Kim SH, Choi SH, Kim YS, Woo JH and Lee SO: Is caspofungin really an effective treatment for pneumocystis jirovecii pneumonia in immunocompromised patients without human immunodeficiency virus infection? Experiences at a single center and a literature review. Scand J Infect Dis. 45:484–488. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Tu GW, Ju MJ, Xu M, Rong RM, He YZ, Xue ZG, Zhu TY and Luo Z: Combination of caspofungin and low-dose trimethoprim/sulfamethoxazole for the treatment of severe pneumocystis jirovecii pneumonia in renal transplant recipients. Nephrology (Carlton). 18:736–742. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Jiang XQ, Fang L, Mei XD, Wang XJ and Bao MH: Pneumocystis jiroveci pneumonia in patients with non-Hodgkin's lymphoma after Rituximab-containing regimen: Two cases of report and literature review. J Thorac Dis. 5:E162–E166. 2013.PubMed/NCBI

18 

Mu XD, Que CL, He B, Wang GF and Li HC: Caspofungin in salvage treatment of severe pneumocystis pneumonia: Case report and literature review. Chin Med J (Engl). 122:996–999. 2009.PubMed/NCBI

19 

Hof H and Schnülle P: Pneumocystis jiroveci pneumonia in a patient with Wegener's granulomatosis treated efficiently with caspofungin. Mycoses. 1 Suppl:S65–S67. 2008. View Article : Google Scholar

20 

Utili R, Durante-mangoni E, Basilico C, Mattei A, Ragone E and Grossi P: Efficacy of caspofungin addition to trimethoprim-sulfamethoxazole treatment for severe pneumocystis pneumonia in solid organ transplant recipients. Transplantation. 84:685–688. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Schmatz DM, Romancheck MA, Pittarelli LA, Schwartz RE, Fromtling RA, Nollstadt KH, Vanmiddlesworth FL, Wilson KE and Turner MJ: Treatment of pneumocystis carinii pneumonia with 1,3-beta-glucan synthesis inhibitors. Proc Natl Acad Sci USA. 87:5950–5954. 1990. View Article : Google Scholar : PubMed/NCBI

22 

Armstrongjames D, Stebbing J, John L, Murungi A, Bower M, Gazzard B and Nelson M: A trial of caspofungin salvage treatment in PCP pneumonia. Thorax. 66:537–538. 2011. View Article : Google Scholar

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Smego RA Jr, Nagar S, Maloba B and Popara M: A Meta-analysis of salvage therapy for pneumocystis carinii pneumonia. Arch Intern Med. 161:1529–1533. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Kim T, Kim SH, Park KH, Cho OH, Sung H, Kim MN, Choi SH, Jeong JY, Woo JH, Kim YS and Lee SO: Clindamycin-primaquine versus pentamidine for the second-line treatment of pneumocystis pneumonia. J Infect Chemother. 15:343–346. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Powles MA, Liberator P, Anderson J, Karkhanis Y, Dropinski JF, Bouffard FA, Balkovec JM, Fujioka H, Aikawa M, McFadden D and Schmatz D: Efficacy of MK-991 (L-743,872), a semisynthetic pneumocandin, in murine models of Pneumocystis carinii. Antimicrob Agents Chemother. 42:1985–1989. 1998.PubMed/NCBI

27 

Thomas CF Jr and Limper AH: Current insights into the biology and pathogenesis of Pneumocystis pneumonia. Nat Rev Microbiol. 5:298–308. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Lobo ML, Esteves F, De SB, de Sousa B, Cardoso F, Cushion MT, Antunes F and Matos O: Therapeutic potential of caspofungin combined with trimethoprim-sulfamethoxazole for pneumocystis pneumonia: A pilot study in mice. PLoS One. 8:e706192013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Huang HB, Peng JM and Du B: Echinocandins for Pneumocystis jirovecii pneumonia in non‑HIV patients: A case report. Exp Ther Med 16: 3227-3232, 2018.
APA
Huang, H., Peng, J., & Du, B. (2018). Echinocandins for Pneumocystis jirovecii pneumonia in non‑HIV patients: A case report. Experimental and Therapeutic Medicine, 16, 3227-3232. https://doi.org/10.3892/etm.2018.6587
MLA
Huang, H., Peng, J., Du, B."Echinocandins for Pneumocystis jirovecii pneumonia in non‑HIV patients: A case report". Experimental and Therapeutic Medicine 16.4 (2018): 3227-3232.
Chicago
Huang, H., Peng, J., Du, B."Echinocandins for Pneumocystis jirovecii pneumonia in non‑HIV patients: A case report". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3227-3232. https://doi.org/10.3892/etm.2018.6587
Copy and paste a formatted citation
x
Spandidos Publications style
Huang HB, Peng JM and Du B: Echinocandins for Pneumocystis jirovecii pneumonia in non‑HIV patients: A case report. Exp Ther Med 16: 3227-3232, 2018.
APA
Huang, H., Peng, J., & Du, B. (2018). Echinocandins for Pneumocystis jirovecii pneumonia in non‑HIV patients: A case report. Experimental and Therapeutic Medicine, 16, 3227-3232. https://doi.org/10.3892/etm.2018.6587
MLA
Huang, H., Peng, J., Du, B."Echinocandins for Pneumocystis jirovecii pneumonia in non‑HIV patients: A case report". Experimental and Therapeutic Medicine 16.4 (2018): 3227-3232.
Chicago
Huang, H., Peng, J., Du, B."Echinocandins for Pneumocystis jirovecii pneumonia in non‑HIV patients: A case report". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3227-3232. https://doi.org/10.3892/etm.2018.6587
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team