Analysis on the level of IL-6, IL-21, AMH in patients with auto-immunity premature ovarian failure and study of correlation

Sun,Shulan; Chen,Hong; Zheng,Xiaoxia; Ma,Chuanyan; Yue,Ruiqin

doi:10.3892/etm.2018.6592

Analysis on the level of IL-6, IL-21, AMH in patients with auto-immunity premature ovarian failure and study of correlation

Authors:
- Shulan Sun
- Hong Chen
- Xiaoxia Zheng
- Chuanyan Ma
- Ruiqin Yue
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Affiliations: Department of Gynaecology, Binzhou City Center Hospital, Binzhou, Shandong 251700, P.R. China, Department of Obstetrics, Binzhou City Center Hospital, Binzhou, Shandong 251700, P.R. China, Department of Gynaecology, The Second People's Hospital of Liaocheng, Linqing, Shandong 252600, P.R. China
Published online on: August 10, 2018 https://doi.org/10.3892/etm.2018.6592
Pages: 3395-3398

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Abstract

Expression of interleukin-6 (IL-6), interleukin-21 (IL-21) and anti-müllerian hormone (AMH) in premature ovarian failure (POF) patients were observed to explore the correlation of each indicator and its significance in POF. One hundred and forty-two patients diagnosed with POF in Binzhou City Center Hospital from June 2014 to December 2015 were selected as the observation group. At the same time, another 140 healthy women were selected as the control group. The serum levels of IL-6, IL-2l, AMH, follicle stimulating hormone (FSH) and luteinizing hormone (LH), estradiol (E2), testosterone (T) and basal antral follicle count (AFC), and mean ovarian volume (MOV) were determined and compared; correlation analysis of IL-6, IL-2l and AMH with other indicators was performed. Compared to the control group, the serum levels of IL-6, IL-21, FSH and LH in the observation group were significantly higher (P<0.05), while E2, T, AMH levels in the serum, AFC and MOV were significantly lower (P<0.05). Spearman's correlation analysis showed that IL-6, IL-21 was positively correlated with FSH and LH (P<0.05), but negatively correlated with E2, T and MOV (P<0.05). AMH was negatively correlated with FSH and LH, but positively correlated with E2, T and MOV. Our results showed that the expression of IL-6, IL-21 and AMH were related to the occurrence and development of POF, IL-6, IL-21 and AMH can be used as the primary screening indexes for POF patients.

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1	Beke A, Piko H, Haltrich I, Csomor J, Matolcsy A, Fekete G, Rigo J and Karcagi V: Molecular cytogenetic analysis of Xq critical regions in premature ovarian failure. Mol Cytogenet. 6:622013. View Article : Google Scholar : PubMed/NCBI
2	Goswami D and Conway GS: Premature ovarian failure. Horm Res. 68:196–202. 2007.PubMed/NCBI
3	Ghassemzadeh A, Farzadi L and Beyhaghi E: Premature ovarian failure risk factors in an Iranian population. Int J Gen Med. 5:335–338. 2012.PubMed/NCBI
4	Conway GS, Kaltsas G, Patel A, Davies MC and Jacobs HS: Characterization of idiopathic premature ovarian failure. Fertil Steril. 65:337–341. 1996. View Article : Google Scholar : PubMed/NCBI
5	Wittenberger MD, Hagerman RJ, Sherman SL, McConkie-Rosell A, Welt CK, Rebar RW, Corrigan EC, Simpson JL and Nelson LM: The FMR1 premutation and reproduction. Fertil Steril. 87:456–465. 2007. View Article : Google Scholar : PubMed/NCBI
6	Zhuang YB: IL-2, IL-6 expression in autoimmune premature ovarian failure and its clinical significance. Chin J Contemp Med. 15:46–47. 2015.
7	Sawalha AH, Kaufman KM, Kelly JA, Adler AJ, Aberle T, Kilpatrick J, Wakeland EK, Li QZ, Wandstrat AE, Karp DR, et al: Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus. Ann Rheum Dis. 67:458–461. 2008. View Article : Google Scholar : PubMed/NCBI
8	Knauff EA, Eijkemans MJ, Lambalk CB, ten Kate-Booij MJ, Hoek A, Beerendonk CC, Laven JS, Goverde AJ, Broekmans FJ, Themmen AP, et al; Dutch Premature Ovarian Failure Consortium, . Anti-Mullerian hormone, inhibin B, and antral follicle count in young women with ovarian failure. J Clin Endocrinol Metab. 94:786–792. 2009. View Article : Google Scholar : PubMed/NCBI
9	Vital Reyes VS, Téllez Velasco S, Hinojosa Cruz JC, Ortiz Romero Mde J, Chavarría Olarte ME and Reyes Fuentes A: Serum levels of IL-1beta, IL-6 and TNF-alpha in infertile patients with ovarian dysfunction. Ginecol Obstet Mex. 73:604–610. 2005.(In Spanish). PubMed/NCBI
10	Chernyshov VP, Radysh TV, Gura IV, Tatarchuk TP and Khominskaya ZB: Immune disorders in women with premature ovarian failure in initial period. Am J Reprod Immunol. 46:220–225. 2001. View Article : Google Scholar : PubMed/NCBI
11	Dayer JM and Choy E: Therapeutic targets in rheumatoid arthritis: The interleukin-6 receptor. Rheumatology (Oxford). 49:15–24. 2010. View Article : Google Scholar : PubMed/NCBI
12	Dienz O, Eaton SM, Bond JP, Neveu W, Moquin D, Noubade R, Briso EM, Charland C, Leonard WJ, Ciliberto G, et al: The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4⁺ T cells. J Exp Med. 206:69–78. 2009. View Article : Google Scholar : PubMed/NCBI
13	Youinou P and Jamin C: The weight of interleukin-6 in B cell-related autoimmune disorders. J Autoimmun. 32:206–210. 2009. View Article : Google Scholar : PubMed/NCBI
14	De Benedetti F: Targeting interleukin-6 in pediatric rheumatic diseases. Curr Opin Rheumatol. 21:533–537. 2009. View Article : Google Scholar : PubMed/NCBI
15	Spolski R and Leonard WJ: Interleukin-21: Basic biology and implications for cancer and autoimmunity. Annu Rev Immunol. 26:57–79. 2008. View Article : Google Scholar : PubMed/NCBI
16	Niu X, He D, Zhang X, Yue T, Li N, Zhang JZ, Dong C and Chen G: IL-21 regulates Th17 cells in rheumatoid arthritis. Hum Immunol. 71:334–341. 2010. View Article : Google Scholar : PubMed/NCBI
17	Coulam CB, Kempers RD and Randall RV: Premature ovarian failure: Evidence for the autoimmune mechanism. Fertil Steril. 36:238–240. 1981. View Article : Google Scholar : PubMed/NCBI
18	Zeng R, Spolski R, Casas E, Zhu W, Levy DE and Leonard WJ: The molecular basis of IL-21-mediated proliferation. Blood. 109:4135–4142. 2007. View Article : Google Scholar : PubMed/NCBI
19	Nurieva R, Yang XO, Martinez G, Zhang Y, Panopoulos AD, Ma L, Schluns K, Tian Q, Watowich SS, Jetten AM, et al: Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature. 448:480–483. 2007. View Article : Google Scholar : PubMed/NCBI
20	La Marca A, Stabile G, Artenisio AC and Volpe A: Serum anti-Mullerian hormone throughout the human menstrual cycle. Hum Reprod. 21:3103–3107. 2006. View Article : Google Scholar : PubMed/NCBI
21	Li HW, Lee VC, Lau EY, Yeung WS, Ho PC and Ng EH: Role of baseline antral follicle count and anti-Mullerian hormone in prediction of cumulative live birth in the first in vitro fertilisation cycle: A retrospective cohort analysis. PLoS One. 8:e610952013. View Article : Google Scholar : PubMed/NCBI
22	Méduri G, Massin N, Guibourdenche J, Bachelot A, Fiori O, Kuttenn F, Misrahi M and Touraine P: Serum anti-Müllerian hormone expression in women with premature ovarian failure. Hum Reprod. 22:117–123. 2007. View Article : Google Scholar : PubMed/NCBI