Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
October-2018 Volume 16 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2018 Volume 16 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Eugenol protects the transplanted heart against ischemia/reperfusion injury in rats by inhibiting the inflammatory response and apoptosis

  • Authors:
    • Wei Fen
    • Longyu Jin
    • Qianyi Xie
    • Lihua Huang
    • Zhibin Jiang
    • Ying Ji
    • Chunyun Li
    • Linfei Yang
    • Dianjun Wang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiothoracic Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China, Center for Medical Experiments, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China, Department of Pediatrics, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China
    Copyright: © Fen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3464-3470
    |
    Published online on: August 13, 2018
       https://doi.org/10.3892/etm.2018.6598
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to investigate the protective effect of eugenol on the transplanted heart and explore its mechanisms of action. Male Sprague‑Dawley rats were randomly divided into a sham group (n=10), a eugenol group (n=10 pairs, donors and recipients) and a control group (n=10 pairs, donors and recipients). The recipients in the eugenol group received an intraperitoneal injection of eugenol (20 mg/kg/day). The sham group and the control group received equal volumes of physiological saline by intraperitoneal injection. After 15 days the recipients in the control and eugenol groups underwent abdominal heterotopic heart transplantation, while the sham group received only a coeliotomy. The orthotopic hearts in the sham group and the heterotopic hearts in the eugenol and control groups, as well as the peripheral blood samples from all three groups were taken 3 h post operation for biochemical, histopathological, molecular and apoptosis analyses. Compared with the control group, the eugenol treatment significantly reduced the myocardial malondialdehyde content, serum cardiac troponin I, creatine kinase‑MB, tumor necresis factor‑α and interleukin‑6 levels (P<0.05) and significantly alleviated myocardial injury. Western blot analysis demonstrated that the protein expression of cleaved Poly (ADP‑ribose) polymerase 1, BAX and active caspase‑3 in the eugenol group were significantly decreased, while B‑cell lymphoma 2 expression was significantly increased compared with the control group (P<0.05). The myocardial apoptosis rate of the eugenol group was significantly decreased compared with the control group (P<0.05). In conclusion eugenol treatment significantly reduced myocardial injury and demonstrated protective effects for the transplanted heart.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Wang W, Hu SS, Kong LZ, Gao RL, Zhu ML, Wang WY, Wu ZS, Chen WW, Yang JG, Ma LY, et al: Summary of report on cardiovascular diseases in China, 2012. Biomed Environ Sci. 27:552–558. 2014.PubMed/NCBI

2 

Singh TP, Milliren CE, Almond CS and Graham D: Survival benefit from transplantation in patients listed for heart transplantation in the United States. J Am Coll Cardiol. 63:1169–1178. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Wang H, Zhang X, Zheng X, Lan Z, Shi J, Jiang J, Zwiep T, Li Q, Quan D, Zhang ZX and Min W: Prevention of allograft rejection in heart transplantation through concurrent gene silencing of TLR and Kinase signaling pathways. Sci Rep. 6:338692016. View Article : Google Scholar : PubMed/NCBI

4 

Gu H, Xie M, Xu L, Zheng X, Yang Y and Lv X: The protective role of interleukin-18 binding protein in a murine model of cardiac ischemia/reperfusion injury. Transpl Int. 28:1436–1444. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Tonsho M, Michel S, Ahmed Z, Alessandrini A and Madsen JC: Heart transplantation: Challenges facing the field. Cold Spring Harb Perspect Med. 4:a0156362014. View Article : Google Scholar : PubMed/NCBI

6 

Luciani GB, Forni A, Rigatelli G, Chiominto B, Cardaioli P, Mazzucco A and Faggian G: Myocardial protection in heart transplantation using blood cardioplegia: 12-year outcome of a prospective randomized trial. J Heart Lung Transplant. 30:29–36. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Wood KJ and Goto R: Mechanisms of rejection: Current perspectives. Transplantation. 93:1–10. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Pramod K, Ansari SH and Ali J: Eugenol: A natural compound with versatile pharmacological actions. Nat Prod Commun. 5:1999–2006. 2010.PubMed/NCBI

9 

Markowitz K, Moynihan M, Liu M and Kim S: Biologic properties of eugenol and zinc oxide-eugenol. A clinically oriented review. Oral Surg Oral Med Oral Pathol. 73:729–737. 1992. View Article : Google Scholar : PubMed/NCBI

10 

Pisano M, Pagnan G, Loi M, Mura ME, Tilocca MG, Palmieri G, Fabbri D, Dettori MA, Delogu G, Ponzoni M and Rozzo C: Antiproliferative and pro-apoptotic activity of eugenol-related biphenyls on malignant melanoma cells. Mol Cancer. 6:82007. View Article : Google Scholar : PubMed/NCBI

11 

Mnafgui K, Kaanich F, Derbali A, Hamden K, Derbali F, Slama S, Allouche N and Elfeki A: Inhibition of key enzymes related to diabetes and hypertension by Eugenol in vitro and in alloxan-induced diabetic rats. Arch Physiol Biochem. 119:225–233. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Srinivasan S, Sathish G, Jayanthi M, Muthukumaran J, Muruganathan U and Ramachandran V: Ameliorating effect of eugenol on hyperglycemia by attenuating the key enzymes of glucose metabolism in streptozotocin-induced diabetic rats. Mol Cell Biochem. 385:159–168. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Nam H and Kim MM: Eugenol with antioxidant activity inhibits MMP-9 related to metastasis in human fibrosarcoma cells. Food Chem Toxicol. 55:106–112. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Peixotoneves D, Lealcardoso JH and Jaggar JH: Eugenol dilates rat cerebral arteries by inhibiting smooth musclecell voltage-dependent calcium channels. J Cardiovasc Pharmacol. 64:401–406. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Yogalakshmi B, Viswanathan P and Anuradha CV: Investigation of antioxidant, anti-inflammatory and DNA-protective properties of eugenol in thioacetamide-induced liver injury in rats. Toxicology. 268:204–212. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Mnafgui K, Hajji R, Derbali F, Gammoudi A, Khabbabi G, Ellefi H, Allouche N, Kadri A and Gharsallah N: Anti-inflammatory, antithrombotic and cardiac remodeling preventive effects of eugenol in isoproterenol-induced myocardial infarction in wistar rat. Cardiovasc Toxicol. 16:336–344. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Motteleb DM, Abd El, Selim SA and Mohamed AM: Differential effects of eugenol against hepatic inflammation and overall damage induced by ischemia/re-perfusion injury. J Immunotoxicol. 11:238–245. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Chen H, Xia Y, Zhu B, Hu X, Xu S, Chen L, Papadimos TJ, Wang W, Wang Q and Xu X: Measurement of the efficacy of 2% lipid in reversing bupivacaine- induced asystole in isolated rat hearts. BMC Anesthesiol. 14:602014. View Article : Google Scholar : PubMed/NCBI

19 

Gherardini G, Haegerstrand A, Matarasso A, Gurlek A, Evans GR and Lundeberg T: Cell adhesion and short-term patency in human endothelium preseeded 1.5-mm polytetrafluoroethylene vascular grafts: An experimental study. Plast Reconstr Surg. 99:472–478. 1997. View Article : Google Scholar : PubMed/NCBI

20 

Ono K and Lindsey ES: Improved technique of heart transplantation in rats. J Thorac Cardiovasc Surg. 57:225–229. 1969.PubMed/NCBI

21 

Wakayama K, Fukai M, Yamashita K, Kimura T, Hirokata G, Shibasaki S, Fukumori D, Haga S, Sugawara M, Suzuki T, et al: Successful transplantation of rat hearts subjected to extended cold preservation with a novel preservation solution. Transpl Int. 25:696–706. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Croal BL, Hillis GS, Gibson PH, Fazal MT, El-Shafei H, Gibson G, Jeffrey RR, Buchan KG, West D and Cuthbertson BH: Relationship between postoperative cardiac troponin i levels and outcome of cardiac surgery. Circulation. 114:1468–1475. 2007. View Article : Google Scholar

23 

Yuan Z, Li H, Qi Q, Gong W, Qian C, Dong R, Zang Y, Li J, Zhou M, Cai J, et al: Plasma levels of growth differentiation factor-15 are associated with myocardial injury in patients undergoing off-pump coronary artery bypass grafting. Sci Rep. 6:282212016. View Article : Google Scholar : PubMed/NCBI

24 

Lee S, Huang CS, Kawamura T, Shigemura N, Billiar TR, Nakao A and Toyoda Y: Histidine-tryptophan-ketoglutarate or celsior: Which is more suitable for cold preservation for cardiac grafts from older donors? Ann Thorac Surg. 91:755–763. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Rittoo D, Jones A, Lecky B and Neithercut D: Elevation of cardiac troponin T, but not cardiac troponin I, in patients with neuromuscular diseases: Implications for the diagnosis of myocardial infarction. J Am Coll Cardiol. 63:2411–2420. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Kuang J, Sun Y, Wang W, Ke H and Ye H: Myocardial apoptosis and injury of donor hearts kept in completely beating status with normothermic blood perfusion for transplants. Int J Clin Exp Med. 8:5767–5773. 2015.PubMed/NCBI

27 

Li Z, Galli U, Becker LE, Bruns H, Nickkolgh A, Hoffmann K, Karck M and Schemmer P: Sulforaphane protects hearts from early injury after experimental transplantation. Ann Transplant. 18:558–566. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Alamran FF and Shahkolahi M: Oxytocin ameliorates the immediate myocardial injury in heart transplant through down regulation of the neutrophil dependent myocardial apoptosis. Transplant Proc. 45:2506–2512. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Yamauchitakihara K, Ihara Y, Ogata A, Yoshizaki K, Azuma J and Kishimoto T: Hypoxic stress induces cardiac myocyte-derived interleukin-6. Circulation. 91:1520–1524. 1995. View Article : Google Scholar : PubMed/NCBI

30 

Liu Q, Li J, Jubair S, Wang D, Luo Y, Fan D and Janicki JS: Sparstolonin B attenuates hypoxia-induced apoptosis, necrosis and inflammation in cultured rat left ventricular tissue slices. Cardiovasc Drugs Ther. 28:433–439. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Kaczorowski DJ, Nakao A, Mollen KP, Vallabhaneni R, Sugimoto R, Kohmoto J, Tobita K, Zuckerbraun BS, McCurry KR, Murase N and Billiar TR: Toll-like receptor 4 mediates the early inflammatory response after cold ischemia/reperfusion. Transplantation. 84:1279–1287. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Reil JC, Gilles S, Zahler S, Brandl A, Drexler H, Hültner L, Matrisian LM, Welsch U and Becker BF: Insights from knock-out models concerning postischemic release of TNFalpha from isolated mouse hearts. J Mol Cell Cardiol. 42:133–141. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Carden DL and Granger DN: Pathophysiology of ischaemia-reperfusion injury. J Pathol. 190:255–266. 2000. View Article : Google Scholar : PubMed/NCBI

34 

Itoh S, Kimura N, Axtell RC, Velotta JB, Gong Y, Wang X, Kajiwara N, Nambu A, Shimura E, Adachi H, et al: Interleukin-17 accelerates allograft rejection by suppressing regulatory T cell expansion. Circulation. 124 11 Suppl:S187–S196. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Sang HL, Lee S, Noda K, Kawamura T, Tanaka Y, Shigemura N, Nakao A and Toyoda Y: Adenosine injection prior to cardioplegia enhances preservation of senescent hearts in rat heterotopic heart transplantation. Eur J Cardiothorac Surg. 43:1202–1208. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Fen W, Jin L, Xie Q, Huang L, Jiang Z, Ji Y, Li C, Yang L and Wang D: Eugenol protects the transplanted heart against ischemia/reperfusion injury in rats by inhibiting the inflammatory response and apoptosis. Exp Ther Med 16: 3464-3470, 2018.
APA
Fen, W., Jin, L., Xie, Q., Huang, L., Jiang, Z., Ji, Y. ... Wang, D. (2018). Eugenol protects the transplanted heart against ischemia/reperfusion injury in rats by inhibiting the inflammatory response and apoptosis. Experimental and Therapeutic Medicine, 16, 3464-3470. https://doi.org/10.3892/etm.2018.6598
MLA
Fen, W., Jin, L., Xie, Q., Huang, L., Jiang, Z., Ji, Y., Li, C., Yang, L., Wang, D."Eugenol protects the transplanted heart against ischemia/reperfusion injury in rats by inhibiting the inflammatory response and apoptosis". Experimental and Therapeutic Medicine 16.4 (2018): 3464-3470.
Chicago
Fen, W., Jin, L., Xie, Q., Huang, L., Jiang, Z., Ji, Y., Li, C., Yang, L., Wang, D."Eugenol protects the transplanted heart against ischemia/reperfusion injury in rats by inhibiting the inflammatory response and apoptosis". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3464-3470. https://doi.org/10.3892/etm.2018.6598
Copy and paste a formatted citation
x
Spandidos Publications style
Fen W, Jin L, Xie Q, Huang L, Jiang Z, Ji Y, Li C, Yang L and Wang D: Eugenol protects the transplanted heart against ischemia/reperfusion injury in rats by inhibiting the inflammatory response and apoptosis. Exp Ther Med 16: 3464-3470, 2018.
APA
Fen, W., Jin, L., Xie, Q., Huang, L., Jiang, Z., Ji, Y. ... Wang, D. (2018). Eugenol protects the transplanted heart against ischemia/reperfusion injury in rats by inhibiting the inflammatory response and apoptosis. Experimental and Therapeutic Medicine, 16, 3464-3470. https://doi.org/10.3892/etm.2018.6598
MLA
Fen, W., Jin, L., Xie, Q., Huang, L., Jiang, Z., Ji, Y., Li, C., Yang, L., Wang, D."Eugenol protects the transplanted heart against ischemia/reperfusion injury in rats by inhibiting the inflammatory response and apoptosis". Experimental and Therapeutic Medicine 16.4 (2018): 3464-3470.
Chicago
Fen, W., Jin, L., Xie, Q., Huang, L., Jiang, Z., Ji, Y., Li, C., Yang, L., Wang, D."Eugenol protects the transplanted heart against ischemia/reperfusion injury in rats by inhibiting the inflammatory response and apoptosis". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3464-3470. https://doi.org/10.3892/etm.2018.6598
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team