Effect of exercise on bone in poorly controlled type 1 diabetes mediated by the ActRIIB/Smad signaling pathway

  • Authors:
    • Jin Yang
    • Lijun Sun
    • Xiushan Fan
    • Bo Yin
    • Yiting Kang
    • Liang Tang
    • Shucheng An
  • View Affiliations

  • Published online on: August 13, 2018     https://doi.org/10.3892/etm.2018.6601
  • Pages: 3686-3693
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Abstract

Myostatin (MSTN) is not only a key negative regulator of skeletal muscle secretion, however is also an endocrine factor that is transmitted to bone. To investigate the effect and possible mechanism of weight‑bearing treadmill running on bone with poorly controlled Type 1 diabetes, rats were randomly divided into three groups: Normal control (NC), diabetic mellitus (DM) and diabetic exercise training groups (DM‑WTR). The DM‑WTR rats were trained with weight‑bearing running. The results demonstrated that the levels of serum insulin, body weight, bone mass, muscle mass, grip strength, and serum calcium in the DM‑WTR rats were significantly increased, whereas the levels of blood glucose, alkaline phosphatase, and tartrate‑resistant acid phosphatase were markedly reduced in the DM‑WTR rats compared with the DM rats. Weight‑bearing running inhibited streptozocin (STZ)‑induced MSTN mRNA and protein expression in the diabetic rats. The mRNA and protein expression levels of activin type IIB receptor and mothers against decapentaplegic homolog 2/3 and its phosphorylation in femur DM‑WTR rats were reduced compared with DM rats. In addition, weight‑bearing running enhanced the STZ‑induced Wnt and β‑catenin expression levels and reduced the STZ‑induced glycogen synthase kinase (GSK)‑3β expression in diabetic rats' femora. In conclusion, the results suggested that weight‑bearing running could partially ameliorate STZ‑induced femur atrophy via MSTN downregulation, and this may be associated with the inactivation of Activin A Receptor Type 2B/Smad2/3 signaling pathways and the activation of the Wnt/GSK3β/β‑catenin signaling pathway. Further studies are needed to verify these conclusions.
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October-2018
Volume 16 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Yang J, Sun L, Fan X, Yin B, Kang Y, Tang L and An S: Effect of exercise on bone in poorly controlled type 1 diabetes mediated by the ActRIIB/Smad signaling pathway. Exp Ther Med 16: 3686-3693, 2018
APA
Yang, J., Sun, L., Fan, X., Yin, B., Kang, Y., Tang, L., & An, S. (2018). Effect of exercise on bone in poorly controlled type 1 diabetes mediated by the ActRIIB/Smad signaling pathway. Experimental and Therapeutic Medicine, 16, 3686-3693. https://doi.org/10.3892/etm.2018.6601
MLA
Yang, J., Sun, L., Fan, X., Yin, B., Kang, Y., Tang, L., An, S."Effect of exercise on bone in poorly controlled type 1 diabetes mediated by the ActRIIB/Smad signaling pathway". Experimental and Therapeutic Medicine 16.4 (2018): 3686-3693.
Chicago
Yang, J., Sun, L., Fan, X., Yin, B., Kang, Y., Tang, L., An, S."Effect of exercise on bone in poorly controlled type 1 diabetes mediated by the ActRIIB/Smad signaling pathway". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3686-3693. https://doi.org/10.3892/etm.2018.6601