Intravenous morphine titration vs. oral hydrocodone/acetaminophen for adults with lower extremity displaced fracture in an emergency department setting: A randomized controlled trial

  • Authors:
    • Zhengqi Pan
    • Yongjian Qi
    • Yinxian Wen
    • Liaobin Chen
  • View Affiliations

  • Published online on: August 14, 2018     https://doi.org/10.3892/etm.2018.6606
  • Pages: 3674-3679
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The objective of the present study was to test the hypothesis that intravenous morphine titration provides superior analgesia to oral hydrocodone/acetaminophen for patients with lower extremity displaced fracture in an emergency department (ED) setting. A prospective, randomized clinical trial of ED patients suffering acute lower extremity displaced fracture pain was performed with a total of 206 participants included. After application of exclusion criteria, the cohort comprised 166 patients, 85 of which were randomly allocated to the oral hydrocodone/acetaminophen (5 mg/500 mg) group and 81 to the intravenous morphine titration (every 5 min by 3‑mg increments) group. The main outcome was the visual analogue scale (VAS) at different time‑points after the first dose of analgesic was administered. Secondary outcomes included the VAS change during the skeletal traction operation and short‑term adverse events. The results demonstrated that the initial VSA of the participants was similar at the baseline on arrival at the ED (P=0.2582). At the time‑points of 5, 15, 30 min after the first dose of analgesic administered, the intravenous morphine titration group exhibited a greater VAS reduction compared with that in the oral hydrocodone/acetaminophen group (P<0.01). The differences between the 2 groups were not statistically significant at 1 h or thereafter. The incidence of short‑term adverse events was similar between the 2 groups but sedation, whose incidence in the morphine group was markedly increased, may not be arbitrarily attributed to adverse events. It was concluded that, compared with oral hydrocodone/acetaminophen, intravenous morphine titration provided a rapid and sufficient pain relief and equivalent short‑term adverse events for patients with lower extremity displaced fracture in an ED setting.
View Figures
View References

Related Articles

Journal Cover

October-2018
Volume 16 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Pan Z, Qi Y, Wen Y and Chen L: Intravenous morphine titration vs. oral hydrocodone/acetaminophen for adults with lower extremity displaced fracture in an emergency department setting: A randomized controlled trial. Exp Ther Med 16: 3674-3679, 2018.
APA
Pan, Z., Qi, Y., Wen, Y., & Chen, L. (2018). Intravenous morphine titration vs. oral hydrocodone/acetaminophen for adults with lower extremity displaced fracture in an emergency department setting: A randomized controlled trial. Experimental and Therapeutic Medicine, 16, 3674-3679. https://doi.org/10.3892/etm.2018.6606
MLA
Pan, Z., Qi, Y., Wen, Y., Chen, L."Intravenous morphine titration vs. oral hydrocodone/acetaminophen for adults with lower extremity displaced fracture in an emergency department setting: A randomized controlled trial". Experimental and Therapeutic Medicine 16.4 (2018): 3674-3679.
Chicago
Pan, Z., Qi, Y., Wen, Y., Chen, L."Intravenous morphine titration vs. oral hydrocodone/acetaminophen for adults with lower extremity displaced fracture in an emergency department setting: A randomized controlled trial". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3674-3679. https://doi.org/10.3892/etm.2018.6606