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Sericin enhances the insulin‑PI3K/AKT signaling pathway in the liver of a type 2 diabetes rat model

  • Authors:
    • Chengjun Song
    • Donghui Liu
    • Songhe Yang
    • Luyang Cheng
    • Enhong Xing
    • Zhihong Chen
  • View Affiliations / Copyright

    Affiliations: Department of Human Anatomy, Chengde Medical University, Chengde, Hebei 067000, P.R. China, Department of Immunology, Chengde Medical University, Chengde, Hebei 067000, P.R. China, Department of Clinical Laboratory, Affiliated Hospital of Chengde Medical University, Chengde, Hebei 067000, P.R. China
    Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3345-3352
    |
    Published online on: August 17, 2018
       https://doi.org/10.3892/etm.2018.6615
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Abstract

The aim of the current study was to investigate the regulatory effect of sericin on the hepatic insulin‑­phosphoinositide 3‑kinase (PI3K)/protein kinase B (AKT) signaling pathway in a type 2 diabetes rat model. Male Sprague Dawley rats were randomly divided into four groups: Control group, diabetic model group, high‑dose sericin group and low‑dose sericin group, with 12 rats in each group. Fasting blood glucose was detected by the glucose oxidase method, and hepatic glycogen was determined by periodic acid‑Schiff staining. The morphology of the liver was observed by hematoxylin and eosin staining. Immunohistochemical staining, western blotting and reverse transcription‑quantitative polymerase chain reaction were used to determine the protein and mRNA expression levels of insulin receptor (IR), IR substrate‑1 (IRS‑1), PI3K and AKT. Compared with the control group, the blood glucose of the diabetic model group was significantly increased (P<0.05). The glycogen content and the expression levels of IR, IRS‑1, PI3K and AKT in the diabetic model group were significantly lower (P<0.05), and the liver morphological structure of the diabetic model group exhibited obvious pathological changes compared with the control group. Compared with the diabetic model group, the blood glucose of the high‑ and low‑dose sericin groups was significantly reduced, while the glycogen content and the expression levels of IR, IRS‑1, PI3K and AKT in the sericin treatment groups were significantly increased (P<0.05). Additionally, the liver pathological changes of high‑dose and low‑dose sericin groups were markedly reduced. Sericin may enhance the signaling transduction effect of insulin by upregulating the expression levels of key factors (IR, IRS‑1, PI3K and AKT) in the liver insulin‑PI3K/AKT signaling pathway, thus promoting glucose transport and liver glycogen synthesis, and further reducing blood glucose.
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1 

Chattopadhyay T, Singh RR, Gupta S and Surolia A: Bone morphogenetic protein-7 (BMP-7) augments insulin sensitivity in mice with type II diabetes mellitus by potentiating PI3K/AKT pathway. Biofactors. 43:195–209. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Chaudhury A, Duvoor C, Reddy Dendi VS, Kraleti S, Chada A, Ravilla R, Marco A, Shekhawat NS, Montales MT, Kuriakose K, et al: Clinical review of antidiabetic drugs: Implications for type 2 diabetes mellitus management. Front Endocrinol (Lausanne). 8:62017.PubMed/NCBI

3 

Horita S, Nakamura M, Suzuki M, Satoh N, Suzuki A and Seki G: Selective insulin resistance in the kidney. Biomed Res Int. 2016:58251702016. View Article : Google Scholar : PubMed/NCBI

4 

Gao YF, Zhang MN, Wang TX, Wu TC, Ai RD and Zhang ZS: Hypoglycemic effect of D-chiro-inositol in type 2 diabetes mellitus rats through the PI3K/Akt signaling pathway. Mol Cell Endocrinol. 433:26–34. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Hou XL, Wang WQ, Shi CY, Tong Q and Fang JG: Research progress in pharmacological effects of dihydromyricelin. Chinese Traditional and Herbal Drugs. 46:603–609. 2015.

6 

Gandhi GR, Jothi G, Antony PJ, Balakrishna K, Paulraj MG, Ignacimuthu S, Stalin A and Al-Dhabi NA: Gallic acid attenuates high-fat diet fed-streptozotocin-induced insulin resistance via partial agonism of PPARgamma in experimental type 2 diabetic rats and enhances glucose uptake through translocation and activation of GLUT4 in PI3K/p-Akt signaling pathway. Eur J Pharmacol. 745:201–216. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Liu TY, Shi CX, Gao R, Sun HJ, Xiong XQ, Ding L, Chen Q, Li YH, Wang JJ, Kang YM and Zhu GQ: Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes. Clin Sci (Lond). 129:839–850. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Chang S: Progress in studying the relationship between PDK/Akt signal access and insulin resistance. Zhong Yi Yao Dao Bao. 14:113–116. 2008.

9 

Ahrén B, Masmiquel L, Kumar H, Sargin M, Karsbøl JD, Jacobsen SH and Chow F: Efficacy and safety of once-weekly semaglutide versus once-daily sitagliptin as an add-on to metformin, thiazolidinediones, or both, in patients with type 2 diabetes (SUSTAIN 2): A 56-week, double-blind, phase 3a, randomised trial. Lancet Diabetes Endocrinol. 5:341–354. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Type 2 diabetes and metformin. First choice for monotherapy: Weak evidence of efficacy but well-known and acceptable adverse effects. Prescrire Int. 23:269–272. 2014.PubMed/NCBI

11 

Chen H, Zhu LJ, Min SJ and Hu GL: Structure, property and utilization of silk sericin. Journal of Functional Polymers. 14:344–347. 2001.

12 

Takasu Y, Yamada H, Tamura T, Sezutsu H, Mita K and Tsubouchi K: Identification and characterization of a novel sericin gene expressed in the anterior middle silk gland of the silkworm Bombyx mori. Insect Biochem Mol Biol. 37:1234–1240. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Aramwit P, Siritientong T and Srichana T: Potential applications of silk sericin, a natural protein from textile industry by-products. Waste Manag Res. 30:217–224. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Okazaki Y, Kakehi S, Xu Y, Tsujimoto K, Sasaki M, Ogawa H and Kato N: Consumption of sericin reduces serum lipids, ameliorates glucose tolerance and elevates serum adiponectin in rats fed a high-fat diet. Biosci Biotechnol Biochem. 74:1534–1538. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Limpeanchob N, Trisat K, Duangjai A, Tiyaboonchai W, Pongcharoen S and Sutheerawattananonda M: Sericin reduces serum cholesterol in rats and cholesterol uptake into Caco-2 cells. J Agric Food Chem. 58:12519–12522. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Chen Z, He Y, Song C, Dong Z, Su Z and Xue J: Sericin can reduce hippocampal neuronal apoptosis by activating the Akt signal transduction pathway in a rat model of diabetes mellitus. Neural Regen Res. 7:197–201. 2012.PubMed/NCBI

17 

Song CJ, Yang ZJ, Tang QF and Chen ZH: Effects of sericin on the testicular growth hormone/insulin-like growth factor-1 axis in a rat model of type 2 diabetes. Int J Clin Exp Med. 8:10411–10419. 2015.PubMed/NCBI

18 

Hao WJ, Li JY, Jiang H, Li YH, Shen Z, Hou JJ, Xiong J and Li XR: Advantages of purified high-fat and high-glucose diet. Wei Sheng Yan Jiu. 46:143–147. 2017.

19 

Li N, Liu Q, Li XJ, Bai XH, Liu YY, Jin ZY, Jing YX, Yan ZY and Chen JX: Establishment and evaluation of a rat model of type 2 diabetes associated with depression. Zhongguo Ying Yong Sheng Li Xue Za. 31:23–26. 2015.(In Chinese).

20 

Santos EL, Dias BH, Andrade AC, Pascoal AM, Vasconcelos Filho FE, Medeiros Fd and Guimarães SB: Effects of acupuncture and electroacupuncture on estradiol-induced inflammation and oxidative stress in health rodents. Acta Cir Bras. 28:582–588. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Silachev DN, Usatikova EA, Pevzner IB, Zorova LD, Babenko VA, Gulyaev MV, Pirogov YA, Plotnikov EY and Zorov DB: Effect of anesthetics on efficiency of remote ischemic preconditioning. Biochemistry. Biokhimiia (Mosc). 82:1006–1016. 2017. View Article : Google Scholar

22 

Vollmar B, Janata J, Yamauchi JI and Menger MD: Attenuation of microvascular reperfusion injury in rat pancreas transplantation by L-arginine. Transplantation. 67:950–955. 1999. View Article : Google Scholar : PubMed/NCBI

23 

Kura RR, Kilari EK and Shaik M: Influence of aprepitant on the pharmacodynamics and pharmacokinetics of gliclazide in rats and rabbits. PeerJ. 6:e47982018. View Article : Google Scholar : PubMed/NCBI

24 

Wang NN, Liu F, Xu X, Zhang SW, Nie R, Yin DD, Liu GQ and Wang GJ: Establishment and preliminary application of fluorescence quantitative RT-PCR detection method for tambus virus. Zhong Guo Shou Yi Ke Xue. 45:15–19. 2015.

25 

Chahardah-Cherik SM, Gheibizadeh MP, Jahani SP and Cheraghian BP: The relationship between health literacy and health promoting behaviors in patients with type 2 diabetes. Int J Commun Based Nurs Midwifery. 6:65–75. 2018.

26 

Papier K, D'Este C, Bain C, Banwell C, Seubsman S, Sleigh A and Jordan S: Consumption of sugar-sweetened beverages and type 2 diabetes incidence in Thai adults: Results from an 8-year prospective study. Nutr Diabetes. 7:e2832017. View Article : Google Scholar : PubMed/NCBI

27 

Whiting DR, Guariguata L, Weil C and Shaw J: IDF diabetes atlas: Global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract. 94:311–321. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Gautam S and Banerjee M: The macrophage Ox-LDL receptor, CD36 and its association with type II diabetes mellitus. Mol Genet Metab. 102:389–398. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Hu X, Wang S, Xu J, Wang DB, Chen Y and Yang GZ: Triterpenoid saponins from Stauntonia chinensis ameliorate insulin resistance via the AMP-activated protein kinase and IR/IRS-1/PI3K/Akt pathways in insulin-resistant HepG2 cells. Int J Mol Sci. 15:10446–10458. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Lu J, Chen LN and Ma X: PI3K/Akt signaling pathway and insulin resistance related diseases. Guo Wai Yi Xue (Yi Xue Di Li Fen Ce). 33:127–131. 2012.(In Chinese).

31 

Winnay JN, Dirice E, Liew CW, Kulkarni RN and Kahn CR: p85α deficiency protects β-cells from endoplasmic reticulum stress-induced apoptosis. Proc Natl Acad Sci USA. 111:1192–1197. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Nelson VL, Jiang YP, Dickman KG, Ballou LM and Lin RZ: Adipose tissue insulin resistance due to loss of PI3K p110alpha leads to decreased energy expenditure and obesity. Am J Physiol Endocrinol Metab. 306:E1205–E1216. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Qu W, Hao L, Chen Y and Zhou S: Effect of chronic ethanol intake on insulin receptor, insulin receptor subsrate-1 and phosphoinositide 3-kinase mRNA expression in skeletal muscle of rats. Wei Sheng Yan Jiu. 36:172–175. 2007.(In Chinese). PubMed/NCBI

34 

Zhang Y, Hai J, Cao M, Zhang Y, Pei S, Wang J and Zhang Q: Silibinin ameliorates steatosis and insulin resistance during non-alcoholic fatty liver disease development partly through targeting IRS-1/PI3K/Akt pathway. Int Immunopharmacol. 17:714–720. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Wu QP, Xiao C, Yang XB and Zhang JM: Hypoglycemic effects of components extracted from edible and medicinal fungi and their mechanisms of action. Acta Edulis Fungi. 16:80–86. 2009.

36 

Tao MX, Wang F, Liu J, Cheng GY and Jin BQ: Hypoglycemic Effect of Pleurotus citrinopileats Polysaccharide. Food Sci. 30:227–230. 2009.

37 

Kuai M, Li Y, Sun X, Ma Z, Lin C, Jing Y, Lu Y, Chen Q, Wu X, Kong X and Bian H: A novel formula Sang-Tong-Jian improves glycometabolism and ameliorates insulin resistance by activating PI3K/AKT pathway in type 2 diabetic KKAy mice. Biomed Pharmacother. 84:1585–1594. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Bodmer M, Meier C, Krähenbühl S, Jick SS and Meier CR: Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia: A nested case-control analysis. Diabetes Care. 31:2086–2091. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Li SZ: Compendium of Materia Medica. Beijing: People's Health Publishing House; pp. 1–1052. 1985

40 

Zhang HP, Zhu LJ and Hu H: Studies on the properties of L-asparaginase immobilized on sericin protein powder. Bulletin of Sericulture. 34:16–19. 2003.

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Copy and paste a formatted citation
Spandidos Publications style
Song C, Liu D, Yang S, Cheng L, Xing E and Chen Z: Sericin enhances the insulin‑PI3K/AKT signaling pathway in the liver of a type 2 diabetes rat model. Exp Ther Med 16: 3345-3352, 2018.
APA
Song, C., Liu, D., Yang, S., Cheng, L., Xing, E., & Chen, Z. (2018). Sericin enhances the insulin‑PI3K/AKT signaling pathway in the liver of a type 2 diabetes rat model. Experimental and Therapeutic Medicine, 16, 3345-3352. https://doi.org/10.3892/etm.2018.6615
MLA
Song, C., Liu, D., Yang, S., Cheng, L., Xing, E., Chen, Z."Sericin enhances the insulin‑PI3K/AKT signaling pathway in the liver of a type 2 diabetes rat model". Experimental and Therapeutic Medicine 16.4 (2018): 3345-3352.
Chicago
Song, C., Liu, D., Yang, S., Cheng, L., Xing, E., Chen, Z."Sericin enhances the insulin‑PI3K/AKT signaling pathway in the liver of a type 2 diabetes rat model". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3345-3352. https://doi.org/10.3892/etm.2018.6615
Copy and paste a formatted citation
x
Spandidos Publications style
Song C, Liu D, Yang S, Cheng L, Xing E and Chen Z: Sericin enhances the insulin‑PI3K/AKT signaling pathway in the liver of a type 2 diabetes rat model. Exp Ther Med 16: 3345-3352, 2018.
APA
Song, C., Liu, D., Yang, S., Cheng, L., Xing, E., & Chen, Z. (2018). Sericin enhances the insulin‑PI3K/AKT signaling pathway in the liver of a type 2 diabetes rat model. Experimental and Therapeutic Medicine, 16, 3345-3352. https://doi.org/10.3892/etm.2018.6615
MLA
Song, C., Liu, D., Yang, S., Cheng, L., Xing, E., Chen, Z."Sericin enhances the insulin‑PI3K/AKT signaling pathway in the liver of a type 2 diabetes rat model". Experimental and Therapeutic Medicine 16.4 (2018): 3345-3352.
Chicago
Song, C., Liu, D., Yang, S., Cheng, L., Xing, E., Chen, Z."Sericin enhances the insulin‑PI3K/AKT signaling pathway in the liver of a type 2 diabetes rat model". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3345-3352. https://doi.org/10.3892/etm.2018.6615
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