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Plasma miR‑136 can be used to screen patients with knee osteoarthritis from healthy controls by targeting IL‑17

  • Authors:
    • Lei Wan
    • Qiang Zhao
    • Gang Niu
    • Tai Xiang
    • Cuilei Ding
    • Shijie Wang
  • View Affiliations / Copyright

    Affiliations: Department of Joint Surgery, Rizhao People's Hospital, Rizhao, Shandong 276800, P.R. China, Department of Bone Surgery, The Second People's Hospital of Rizhao City, Rizhao, Shandong 276800, P.R. China, Surgical Department, Rizhao People's Hospital, Rizhao, Shandong 276800, P.R. China, Department of Surgery, Rizhao People's Hospital, Rizhao, Shandong 276800, P.R. China, Department of Orthopedics, Rizhao People's Hospital, Rizhao, Shandong 276800, P.R. China
    Copyright: © Wan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3419-3424
    |
    Published online on: August 20, 2018
       https://doi.org/10.3892/etm.2018.6625
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Abstract

The current study mainly evaluated the plasma level of microRNA (miR)‑136 in knee osteoarthritis (KOA) patients and determined if miR‑136 could be used as a potential biomarker to screen KOA patients from healthy controls. It was demonstrated that plasma miR‑136 was significantly decreased in the plasma of KOA patients. Moreover, the reduction in plasma miR‑136 negatively correlated with the severity of KOA. Additionally, the increase in the serum interleukin (IL)‑17 level positively correlated with the severity of KOA. More importantly, dual luciferase assays and western blot assays indicated that IL‑17 was a target gene of miR‑136. Further analysis showed that plasma miR‑136 could be used as a biomarker to screen KOA patients from healthy controls. In summary, for the first time, the present study revealed that through targeting IL‑17, decreased plasma miR‑136 levels could be used as a potential biomarker to screen KOA patients from healthy controls.
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1 

Evaniew AL and Evaniew N: Knee osteoarthritis: Therapeutic alternatives in primary care. World J Orthop. 8:187–191. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Monfort J, Pujol J, Contreras-Rodriguez O, Llorente-Onaindia J, López-Solà M, Blanco-Hinojo L, Vergés J, Herrero M, Sánchez L, Ortiz H, et al: Effects of chondroitin sulfate on brain response to painful stimulation in knee osteoarthritis patients. A randomized, double-blind, placebo-controlled functional magnetic resonance imaging study. Med Clin (Barc). 148:539–547. 2017.(In English, Spanish).

3 

Niu J, Clancy M, Aliabadi P, Vasan R and Felson DT: Metabolic syndrome, its components, and knee osteoarthritis: The Framingham Osteoarthritis Study. Arthritis Rheumatol. 69:1194–1203. 2017. View Article : Google Scholar : PubMed/NCBI

4 

van Leeuwen DM, van de Bunt F, de Ruiter CJ, van Schoor NM, Deeg DJH and Emanuel KS: Functioning without cartilage: Older people with radiographic knee osteoarthritis who self-report no functional limitations do score lower on a performance battery. J Aging Phys Act. 25:570–575. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Rongen JJ, Rovers MM, van Tienen TG, Buma P and Hannink G: Increased risk for knee replacement surgery after arthroscopic surgery for degenerative meniscal tears: A multi-center longitudinal observational study using data from the osteoarthritis initiative. Osteoarthritis Cartilage. 25:23–29. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Oo WM, Linklater JM and Hunter DJ: Imaging in knee osteoarthritis. Curr Opin Rheumatol. 29:86–95. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Wang K, Xu J, Cai J, Zheng S, Han W, Antony B and Ding C: Serum levels of interleukin-17 and adiponectin are associated with infrapatellar fat pad volume and signal intensity alteration in patients with knee osteoarthritis. Arthritis Res Ther. 18:1932016. View Article : Google Scholar : PubMed/NCBI

8 

Wang K, Xu J, Cai J, Zheng S, Yang X and Ding C: Serum levels of resistin and interleukin-17 are associated with increased cartilage defects and bone marrow lesions in patients with knee osteoarthritis. Mod Rheumatol. 27:339–344. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Suurmond J, Dorjée AL, Boon MR, Knol EF, Huizinga TW, Toes RE and Schuerwegh AJ: Mast cells are the main interleukin 17-positive cells in anticitrullinated protein antibody-positive and -negative rheumatoid arthritis and osteoarthritis synovium. Arthritis Res Ther. 13:R1502011. View Article : Google Scholar : PubMed/NCBI

10 

van Baarsen LG, Lebre MC, van der Coelen D, Aarrass S, Tang MW, Ramwadhdoebe TH, Gerlag DM and Tak PP: Heterogeneous expression pattern of interleukin 17A (IL-17A), IL-17F and their receptors in synovium of rheumatoid arthritis, psoriatic arthritis and osteoarthritis: Possible explanation for nonresponse to anti-IL-17 therapy? Arthritis Res Ther. 16:4262014. View Article : Google Scholar : PubMed/NCBI

11 

Southam L, Heath O, Chapman K and Loughlin J: Association analysis of the interleukin 17 genes IL17A and IL17F as potential osteoarthritis susceptibility loci. Ann Rheum Dis. 65:556–557. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Attur MG, Patel RN, Abramson SB and Amin AR: Interleukin-17 up-regulation of nitric oxide production in human osteoarthritis cartilage. Arthritis Rheum. 40:1050–1053. 1997. View Article : Google Scholar : PubMed/NCBI

13 

Honorati MC, Bovara M, Cattini L, Piacentini A and Facchini A: Contribution of interleukin 17 to human cartilage degradation and synovial inflammation in osteoarthritis. Osteoarthritis Cartilage. 10:799–807. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Hu W, Zhang W, Li F, Guo F and Chen A: miR-139 is up-regulated in osteoarthritis and inhibits chondrocyte proliferation and migration possibly via suppressing EIF4G2 and IGF1R. Biochem Biophys Res Commun. 474:296–302. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Lu X, Lin J, Jin J, Qian W and Weng X: Hsa-miR-15a exerts protective effects against osteoarthritis by targeting aggrecanase-2 (ADAMTS5) in human chondrocytes. Int J Mol Med. 37:509–516. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Borgonio Cuadra VM, González-Huerta NC, Romero-Córdoba S, Hidalgo-Miranda A and Miranda-Duarte A: Altered expression of circulating microRNA in plasma of patients with primary osteoarthritis and in silico analysis of their pathways. PLoS One. 9:e976902014. View Article : Google Scholar : PubMed/NCBI

17 

Jin R, Xu S, Lin X and Shen M: MiR-136 controls neurocytes apoptosis by regulating Tissue Inhibitor of Metalloproteinases-3 in spinal cord ischemic injury. Biomed Pharmacother. 94:47–54. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Yan M, Li X, Tong D, Han C, Zhao R, He Y and Jin X: miR-136 suppresses tumor invasion and metastasis by targeting RASAL2 in triple-negative breast cancer. Oncol Rep. 36:65–71. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, Christy W, Cooke TD, Greenwald R, Hochberg M, et al: Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum. 29:1039–1049. 1986. View Article : Google Scholar : PubMed/NCBI

20 

Kellgren JH and Lawrence JS: Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 16:494–502. 1957. View Article : Google Scholar : PubMed/NCBI

21 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Pas HI, Winters M, Haisma HJ, Koenis MJ, Tol JL and Moen MH: Stem cell injections in knee osteoarthritis: A systematic review of the literature. Br J Sports Med. 51:1125–1133. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Pihl K, Englund M, Lohmander LS, Jørgensen U, Nissen N, Schjerning J and Thorlund JB: Signs of knee osteoarthritis common in 620 patients undergoing arthroscopic surgery for meniscal tear. Acta Orthop. 88:90–95. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Gu R, Liu N, Luo S, Huang W, Zha Z and Yang J: MicroRNA-9 regulates the development of knee osteoarthritis through the NF-kappaB1 pathway in chondrocytes. Medicine (Baltimore). 95:e43152016. View Article : Google Scholar : PubMed/NCBI

25 

Ko JY, Lee MS, Lian WS, Weng WT, Sun YC, Chen YS and Wang FS: MicroRNA-29a counteracts synovitis in knee osteoarthritis pathogenesis by targeting VEGF. Sci Rep. 7:35842017. View Article : Google Scholar : PubMed/NCBI

26 

He J, Zhao J, Peng X, Shi X, Zong S and Zeng G: Molecular mechanism of MiR-136-5p targeting NF-κB/A20 in the IL-17-mediated inflammatory response after spinal cord injury. Cell Physiol Biochem. 44:1224–1241. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Peng X, Shi X, Zhao J, He J, Li K, Cen Z, Wu Y, Zong S and Zeng G: The effects of miR-136-5p-mediated regulation of A20 in astrocytes from cultured spinal cord cultured cells in vitro. Cell Physiol Biochem. 41:1596–1604. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Retraction note: Mast cells are the main interleukin 17-positive cells in anticitrullinated protein antibody-positive and -negative rheumatoid arthritis and osteoarthritis synovium. Arthritis Res Ther. 17:3542015. View Article : Google Scholar : PubMed/NCBI

29 

Chen B, Deng Y, Tan Y, Qin J and Chen LB: Association between severity of knee osteoarthritis and serum and synovial fluid interleukin 17 concentrations. J Int Med Res. 42:138–144. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Deligne C, Casulli S, Pigenet A, Bougault C, Campillo-Gimenez L, Nourissat G, Berenbaum F, Elbim C and Houard X: Differential expression of interleukin-17 and interleukin-22 in inflamed and non-inflamed synovium from osteoarthritis patients. Osteoarthritis Cartilage. 23:1843–1852. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wan L, Zhao Q, Niu G, Xiang T, Ding C and Wang S: Plasma miR‑136 can be used to screen patients with knee osteoarthritis from healthy controls by targeting IL‑17. Exp Ther Med 16: 3419-3424, 2018.
APA
Wan, L., Zhao, Q., Niu, G., Xiang, T., Ding, C., & Wang, S. (2018). Plasma miR‑136 can be used to screen patients with knee osteoarthritis from healthy controls by targeting IL‑17. Experimental and Therapeutic Medicine, 16, 3419-3424. https://doi.org/10.3892/etm.2018.6625
MLA
Wan, L., Zhao, Q., Niu, G., Xiang, T., Ding, C., Wang, S."Plasma miR‑136 can be used to screen patients with knee osteoarthritis from healthy controls by targeting IL‑17". Experimental and Therapeutic Medicine 16.4 (2018): 3419-3424.
Chicago
Wan, L., Zhao, Q., Niu, G., Xiang, T., Ding, C., Wang, S."Plasma miR‑136 can be used to screen patients with knee osteoarthritis from healthy controls by targeting IL‑17". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3419-3424. https://doi.org/10.3892/etm.2018.6625
Copy and paste a formatted citation
x
Spandidos Publications style
Wan L, Zhao Q, Niu G, Xiang T, Ding C and Wang S: Plasma miR‑136 can be used to screen patients with knee osteoarthritis from healthy controls by targeting IL‑17. Exp Ther Med 16: 3419-3424, 2018.
APA
Wan, L., Zhao, Q., Niu, G., Xiang, T., Ding, C., & Wang, S. (2018). Plasma miR‑136 can be used to screen patients with knee osteoarthritis from healthy controls by targeting IL‑17. Experimental and Therapeutic Medicine, 16, 3419-3424. https://doi.org/10.3892/etm.2018.6625
MLA
Wan, L., Zhao, Q., Niu, G., Xiang, T., Ding, C., Wang, S."Plasma miR‑136 can be used to screen patients with knee osteoarthritis from healthy controls by targeting IL‑17". Experimental and Therapeutic Medicine 16.4 (2018): 3419-3424.
Chicago
Wan, L., Zhao, Q., Niu, G., Xiang, T., Ding, C., Wang, S."Plasma miR‑136 can be used to screen patients with knee osteoarthritis from healthy controls by targeting IL‑17". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3419-3424. https://doi.org/10.3892/etm.2018.6625
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