Open Access

Plasma miR‑136 can be used to screen patients with knee osteoarthritis from healthy controls by targeting IL‑17

  • Authors:
    • Lei Wan
    • Qiang Zhao
    • Gang Niu
    • Tai Xiang
    • Cuilei Ding
    • Shijie Wang
  • View Affiliations

  • Published online on: August 20, 2018     https://doi.org/10.3892/etm.2018.6625
  • Pages: 3419-3424
  • Copyright: © Wan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The current study mainly evaluated the plasma level of microRNA (miR)‑136 in knee osteoarthritis (KOA) patients and determined if miR‑136 could be used as a potential biomarker to screen KOA patients from healthy controls. It was demonstrated that plasma miR‑136 was significantly decreased in the plasma of KOA patients. Moreover, the reduction in plasma miR‑136 negatively correlated with the severity of KOA. Additionally, the increase in the serum interleukin (IL)‑17 level positively correlated with the severity of KOA. More importantly, dual luciferase assays and western blot assays indicated that IL‑17 was a target gene of miR‑136. Further analysis showed that plasma miR‑136 could be used as a biomarker to screen KOA patients from healthy controls. In summary, for the first time, the present study revealed that through targeting IL‑17, decreased plasma miR‑136 levels could be used as a potential biomarker to screen KOA patients from healthy controls.
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October-2018
Volume 16 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wan L, Zhao Q, Niu G, Xiang T, Ding C and Wang S: Plasma miR‑136 can be used to screen patients with knee osteoarthritis from healthy controls by targeting IL‑17. Exp Ther Med 16: 3419-3424, 2018
APA
Wan, L., Zhao, Q., Niu, G., Xiang, T., Ding, C., & Wang, S. (2018). Plasma miR‑136 can be used to screen patients with knee osteoarthritis from healthy controls by targeting IL‑17. Experimental and Therapeutic Medicine, 16, 3419-3424. https://doi.org/10.3892/etm.2018.6625
MLA
Wan, L., Zhao, Q., Niu, G., Xiang, T., Ding, C., Wang, S."Plasma miR‑136 can be used to screen patients with knee osteoarthritis from healthy controls by targeting IL‑17". Experimental and Therapeutic Medicine 16.4 (2018): 3419-3424.
Chicago
Wan, L., Zhao, Q., Niu, G., Xiang, T., Ding, C., Wang, S."Plasma miR‑136 can be used to screen patients with knee osteoarthritis from healthy controls by targeting IL‑17". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3419-3424. https://doi.org/10.3892/etm.2018.6625