Open Access

Silencing FOXC1 inhibits growth and migration of human oral squamous cell carcinoma cells

  • Authors:
    • Zhongjun Liu
    • Shuaimei Xu
    • Hongxing Chu
    • Yu Lu
    • Peiyan Yuan
    • Xiongqun Zeng
  • View Affiliations

  • Published online on: August 20, 2018     https://doi.org/10.3892/etm.2018.6627
  • Pages: 3369-3376
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Forkhead box C1 (FOXC1) is a transcription factor that serves an important role in regulating tumorigenesis and cancer progression. However, the expression and functional role of FOXC1 in oral squamous cell carcinoma (OSCC) remains unclear. FOXC1 protein expression was determined using immunohistochemical staining of OSCC tissues and normal tissues. Cell Counting Kit‑8, colony formation, migration and 5‑ethynyl‑2'‑deoxyuridine assays were performed to investigate the role and underlying mechanism of action of FOXC1 in OSCC. A consistent increase in the immunoreactive intensity of FOXC1 in OSCC tissues as compared with that in adjacent normal tissues was demonstrated. Knockdown of FOXC1 impaired cell growth and colony formation by inhibiting cell proliferation and reducing cyclin B1 and cyclin D1 levels in OSCC cells. FOXC1‑silenced OSCC cells exhibited decreased migration compared with that demonstrated by the control cells, accompanied by a downregulation of matrix metalloproteinase (MMP)‑2 and MMP‑9. Collectively, the results of the present study demonstrated that FOXC1 functions as an oncogene in OSCC and may be an important therapeutic target and predictive biomarker for OSCC.
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October-2018
Volume 16 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Liu Z, Xu S, Chu H, Lu Y, Yuan P and Zeng X: Silencing FOXC1 inhibits growth and migration of human oral squamous cell carcinoma cells. Exp Ther Med 16: 3369-3376, 2018
APA
Liu, Z., Xu, S., Chu, H., Lu, Y., Yuan, P., & Zeng, X. (2018). Silencing FOXC1 inhibits growth and migration of human oral squamous cell carcinoma cells. Experimental and Therapeutic Medicine, 16, 3369-3376. https://doi.org/10.3892/etm.2018.6627
MLA
Liu, Z., Xu, S., Chu, H., Lu, Y., Yuan, P., Zeng, X."Silencing FOXC1 inhibits growth and migration of human oral squamous cell carcinoma cells". Experimental and Therapeutic Medicine 16.4 (2018): 3369-3376.
Chicago
Liu, Z., Xu, S., Chu, H., Lu, Y., Yuan, P., Zeng, X."Silencing FOXC1 inhibits growth and migration of human oral squamous cell carcinoma cells". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3369-3376. https://doi.org/10.3892/etm.2018.6627