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Article Open Access

Oxidative status of cardinal ligament in pelvic organ prolapse

  • Authors:
    • Gui Fang
    • Li Hong
    • Cheng Liu
    • Qing Yang
    • Qifan Zhang
    • Yang Li
    • Bingshu Li
    • Debin Wu
    • Wenying Wu
    • Hua Shi
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology Ultrasound, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Department of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China
    Copyright: © Fang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3293-3302
    |
    Published online on: August 21, 2018
       https://doi.org/10.3892/etm.2018.6633
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Abstract

Pelvic organ prolapse (POP) is a common and distressing health problem in adult women, but the pathophysiological mechanism is yet to be fully elucidated. Previous studies have indicated that oxidative stress may be associated with POP. Thus, the aim of the present study was to investigate the oxidative status of pelvic supportive tissue in POP and further demonstrate that oxidative stress is associated with the pathogenesis of POP. A total of 60 samples were collected from females undergoing hysterectomy for POP or cervical intraepithelial neoplasia (CIN). This included 16 females with POP II, 24 females with POP III‑IV (according to the POP‑Q system) and 20 females with CIN II‑III as the control group. Immunohistochemistry was utilized to measure the expression of oxidative biomarkers, 8‑hydroxydeoxyguanosine (8‑OHdG) and 4‑hydroxynonenal (4‑HNE). Major antioxidative enzymes, mitochondrial superoxide dismutase (MnSOD) and glutathione peroxidase 1 (GPx1) were measured through reverse transcription‑quantitative polymerase chain reaction, western blotting and enzyme activity assays. The results demonstrated that in the cardinal ligament, the expression of 8‑OHdG and 4‑HNE was higher in the POP III‑IV group compared with the POP II group and control group. The MnSOD and GPx1 protein level and enzyme activity were lower in the POP III‑IV group compared with the POP II or the control group, while the mRNA expression level of MnSOD and GPx1 was increased. In conclusion, oxidative damage is increased in the pelvic supportive ligament of female patients with POP and the antioxidative defense capacity is decreased. These results support previous findings that oxidative stress is involved in the pathogenesis of POP.
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1 

Samuelsson EC, Victor FT, Tibblin G and Svärdsudd KF: Signs of genital prolapse in a Swedish population of women 20 to 59 years of age and possible related factors. Am J Obstet Gynecol. 180:299–305. 1999. View Article : Google Scholar : PubMed/NCBI

2 

Wu JM, Kawasaki A, Hundley AF, Dieter AA, Myers ER and Sung VW: Predicting the number of women who will undergo incontinence and prolapse surgery, 2010 to 2050. Am J Obstet Gynecol. 205:230.e1–e5. 2011. View Article : Google Scholar

3 

Boyles SH, Weber AM and Meyn L: Procedures for pelvic organ prolapse in the United States, 1979–1997. Am J Obstet Gynecol. 188:108–115. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Shah AD, Kohli N, Rajan SS and Hoyte L: The age distribution, rates, and types of surgery for pelvic organ prolapse in the USA. Int Urogynecol J Pelvic Floor Dysfunct. 19:421–428. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Brown JS, Waetjen LE, Subak LL, Thom DH, Van den Eeden S and Vittinghoff E: Pelvic organ prolapse surgery in the United States, 1997. Am J Obstet Gynecol. 186:712–716. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Nikolova G, Lee H, Berkovitz S, Nelson S, Sinsheimer J, Vilain E and Rodríguez LV: Sequence variant in the laminin gamma1 (LAMC1) gene associated with familial pelvic organ prolapse. Hum Genet. 120:847–856. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Olsen AL, Smith VJ, Bergstrom JO, Colling JC and Clark AL: Epidemiology of surgically managed pelvic organ prolapse and urinary incontinence. Obstet Gynecol. 89:501–506. 1997. View Article : Google Scholar : PubMed/NCBI

8 

Zhu L, Lang J, Feng R, Chen J and Wong F: Estrogen receptor in pelvic floor tissues in patients with stress urinary incontinence. Int Urogynecol J Pelvic Floor Dysfunct. 15:340–343. 2004.PubMed/NCBI

9 

Buchsbaum GM, Chin M, Glantz C and Guzick D: Prevalence of urinary incontinence and associated risk factors in a cohort of nuns. Obstet Gynecol. 100:226–229. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Buchsbaum GM, Duecy EE, Kerr LA, Huang LS and Guzick DS: Urinary incontinence in nulliparous women and their parous sisters. Obstet Gynecol. 106:1253–1258. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Bump RC and Norton PA: Epidemiology and natural history of pelvic floor dysfunction. Obstet Gynecol Clin North Am. 25:723–746. 1998. View Article : Google Scholar : PubMed/NCBI

12 

George G, Joseph J and Ganjifrockwalaa F: Decreased total antioxidant levels and increased oxidative stress in South African type 2 diabetes mellitus patients. J Endocrinol Metab Diabetes South Africa. 22:21–25. 2017. View Article : Google Scholar

13 

Pham-Huy LA, He H and Pham-Huy C: Free radicals, antioxidants in disease and health. Int J Biomed Sci. 4:89–96. 2008.PubMed/NCBI

14 

Turrens JF: Mitochondrial formation of reactive oxygen species. J Physiol. 552:335–344. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Diplock AT: Antioxidants and disease prevention. Mol Aspects Med. 15:293–376. 1994. View Article : Google Scholar : PubMed/NCBI

16 

Tsai-Turton M and Luderer U: Opposing effects of glutathione depletion and follicle-stimulating hormone on reactive oxygen species and apoptosis in cultured preovulatory rat follicles. Endocrinology. 147:1224–1236. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Choy KW, Liu YM, Chu CY, Wang CC, Lui WT, Lee LL, Pang MW, Rogers MS and Yip SK: High isoprostane level in cardinal ligament-derived fibroblasts and urine sample of women with uterine prolapse. BJOG. 115:1179–1183. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Brigelius-Flohé R and Maiorino M: Glutathione peroxidases. Biochim Biophys Acta. 1830:3289–3303. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Akhtar MS, Lodhi LA, Ahmad I, Qureshi ZI and Muhammad G: Serum trace mineral variations in Nili-Ravi buffaloes suffering with prepartum vaginal prolapse in two different agro-ecological zones of Punjab, Pakistan. Theriogenology. 77:1328–1333. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Kim JY, Kim EJ, Jeon MJ, Kim H, Moon YJ and Bai SW: Association between the poly(ADP-ribose) polymerase-1 gene polymorphism and advanced pelvic organ prolapse. Menopause. 21:177–181. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Visco AG and Yuan L: Differential gene expression in pubococcygeus muscle from patients with pelvic organ prolapse. Am J Obstet Gynecol. 189:102–112. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Akhtar K, Broekelmann TJ, Miao M, Keeley FW, Starcher BC, Pierce RA, Mecham RP and Adair-Kirk TL: Oxidative and nitrosative modifications of tropoelastin prevent elastic fiber assembly in vitro. J Biol Chem. 285:37396–37404. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Fisher GJ, Wang ZQ, Datta SC, Varani J, Kang S and Voorhees JJ: Pathophysiology of premature skin aging induced by ultraviolet light. N Engl J Med. 337:1419–1429. 1997. View Article : Google Scholar : PubMed/NCBI

24 

Fisher GJ, Datta S, Wang Z, Li XY, Quan T, Chung JH, Kang S and Voorhees JJ: c-Jun-dependent inhibition of cutaneous procollagen transcription following ultraviolet irradiation is reversed by all-trans retinoic acid. J Clin Invest. 106:663–670. 2000. View Article : Google Scholar : PubMed/NCBI

25 

Siwik DA, Pagano PJ and Colucci WS: Oxidative stress regulates collagen synthesis and matrix metalloproteinase activity in cardiac fibroblasts. Am J Physiol Cell Physiol. 280:C53–C60. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Lang J, Zhu L, Sun Z and Chen J: Clinical study on collagen and stress urinary incontinence. Clin Exp Obstet Gynecol. 29:180–182. 2002.PubMed/NCBI

27 

Liapis A, Bakas P, Pafiti A, Frangos-Plemenos M, Arnoyannaki N and Creatsas G: Changes of collagen type III in female patients with genuine stress incontinence and pelvic floor prolapse. Eur J Obstet Gynecol Reprod Biol. 97:76–79. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Ewies AA, Al-Azzawi F and Thompson J: Changes in extracellular matrix proteins in the cardinal ligaments of post-menopausal women with or without prolapse: A computerized immunohistomorphometric analysis. Hum Reprod. 18:2189–2195. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Goepel C, Johanna Kantelhardt E, Karbe I, Stoerer S and Dittmer J: Changes of glycoprotein and collagen immunolocalization in the uterine artery wall of postmenopausal women with and without pelvic organ prolapse. Acta Histochem. 113:375–381. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Söderberg MW, Falconer C, Byström B, Malmström A and Ekman G: Young women with genital prolapse have a low collagen concentration. Acta Obstet Gynecol Scand. 83:1193–1198. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Cooke MS, Evans MD, Dizdaroglu M and Lunec J: Oxidative DNA damage: Mechanisms, mutation, and disease. FASEB J. 17:1195–1214. 2003. View Article : Google Scholar : PubMed/NCBI

32 

Lupachyk S, Shevalye H, Maksimchyk Y, Drel VR and Obrosova IG: PARP inhibition alleviates diabetes-induced systemic oxidative stress and neural tissue 4-hydroxynonenal adduct accumulation: Correlation with peripheral nerve function. Free Radic Biol Med. 50:1400–1409. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Yoritaka A, Hattori N, Uchida K, Tanaka M, Stadtman ER and Mizuno Y: Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease. Proc Natl Acad Sci USA. 93:pp. 2696–2701. 1996; View Article : Google Scholar : PubMed/NCBI

34 

Halliwell B: Why and how should we measure oxidative DNA damage in nutritional studies? How far have we come? Am J Clin Nutr. 72:1082–1087. 2000. View Article : Google Scholar : PubMed/NCBI

35 

Kasai H: Analysis of a form of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis. Mutat Res. 387:147–163. 1997. View Article : Google Scholar : PubMed/NCBI

36 

Alary J, Guéraud F and Cravedi JP: Fate of 4-hydroxynonenal in vivo: Disposition and metabolic pathways. Mol Aspects Med. 24:177–187. 2003. View Article : Google Scholar : PubMed/NCBI

37 

Dwivedi S, Sharma A, Patrick B, Sharma R and Awasthi YC: Role of 4-hydroxynonenal and its metabolites in signaling. Redox Rep. 12:4–10. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Oberley TD and Oberley LW: Antioxidant enzyme levels in cancer. Histol Histopathol. 12:525–535. 1997.PubMed/NCBI

39 

Wallace DC: Mitochondrial diseases in man and mouse. Science. 283:1482–1488. 1999. View Article : Google Scholar : PubMed/NCBI

40 

Arthur JR: The glutathione peroxidases. Cell Mol Life Sci. 57:1825–1835. 2000. View Article : Google Scholar : PubMed/NCBI

41 

DeLancey JO: Anatomie aspects of vaginal eversion after hysterectomy. Am J Obstet Gynecol. 166:1717–1728. 1992. View Article : Google Scholar : PubMed/NCBI

42 

Martin CM and O'Leary JJ: Histology of cervical intraepithelial neoplasia and the role of biomarkers. Best Pract Res Clin Obstet Gynaecol. 25:605–615. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Bump RC, Mattiasson A, Bø K, Brubaker LP, DeLancey JO, Klarskov P, Shull BL and Smith AR: The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunction. Am J Obstet Gynecol. 175:10–17. 1996. View Article : Google Scholar : PubMed/NCBI

44 

Santulli P, Borghese B, Lemaréchal H, Leconte M, Millischer AE, Batteux F, Chapron C and Borderie D: Increased serum oxidative stress markers in women with uterine leiomyoma. PLoS One. 8:e720692013. View Article : Google Scholar : PubMed/NCBI

45 

Scutiero G, Iannone P, Bernardi G, Bonaccorsi G, Spadaro S, Volta CA, Greco P and Nappi L: Oxidative stress and endometriosis: A systematic review of the literature. Oxid Med Cell Longev. 2017:72652382017. View Article : Google Scholar : PubMed/NCBI

46 

Lugogo NL, Bappanad D and Kraft M: Obesity, metabolic dysregulation and oxidative stress in asthma. Biochim Biophys Acta. 1810:1120–1126. 2011. View Article : Google Scholar : PubMed/NCBI

47 

Dikalov SI and Ungvari Z: Role of mitochondrial oxidative stress in hypertension. Am J Physiol Heart Circ Physiol. 305:H1417–H1427. 2013. View Article : Google Scholar : PubMed/NCBI

48 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

49 

Takacs P, Gualtieri M, Nassiri M, Candiotti K and Medina CA: Vaginal smooth muscle cell apoptosis is increased in women with pelvic organ prolapse. Int Urogynecol J Pelvic Floor Dysfunct. 19:1559–1564. 2008. View Article : Google Scholar : PubMed/NCBI

50 

Takacs P, Nassiri M, Gualtieri M, Candiotti K and Medina CA: Uterosacral ligament smooth muscle cell apoptosis is increased in women with uterine prolapse. Reprod Sci. 16:447–452. 2009. View Article : Google Scholar : PubMed/NCBI

51 

Kim EJ, Chung N, Park SH, Lee KH, Kim SW, Kim JY, Bai SW and Jeon MJ: Involvement of oxidative stress and mitochondrial apoptosis in the pathogenesis of pelvic organ prolapse. J Urol. 189:588–594. 2013. View Article : Google Scholar : PubMed/NCBI

52 

Li S, Tan HY, Wang N, Zhang ZJ, Lao L, Wong CW and Feng Y: The role of oxidative stress and antioxidants in liver diseases. Int J Mol Sci. 16:26087–26124. 2015. View Article : Google Scholar : PubMed/NCBI

53 

Perl A: Oxidative stress in the pathology and treatment of systemic lupus erythematosus. Nat Rev Rheumatol. 9:674–686. 2013. View Article : Google Scholar : PubMed/NCBI

54 

Lindblom R, Higgins G, Coughlan M and de Haan JB: Targeting mitochondria and reactive oxygen Species-driven pathogenesis in diabetic nephropathy. Rev Diabet Stud. 12:134–156. 2015. View Article : Google Scholar : PubMed/NCBI

55 

Nita M and Grzybowski A: The role of the reactive oxygen species and oxidative stress in the pathomechanism of the Age-related ocular diseases and other pathologies of the anterior and posterior eye segments in adults. Oxid Med Cell Longev. 2016:31647342016. View Article : Google Scholar : PubMed/NCBI

56 

Styskal J, Van Remmen H, Richardson A and Salmon AB: Oxidative stress and diabetes: What can we learn about insulin resistance from antioxidant mutant mouse models? Free Radic Biol Med. 52:46–58. 2012. View Article : Google Scholar : PubMed/NCBI

57 

Baas AS and Berk BC: Differential activation of mitogen-activated protein kinases by H2O2 and O2- in vascular smooth muscle cells. Circ Res. 77:29–36. 1995. View Article : Google Scholar : PubMed/NCBI

58 

Ushio-Fukai M, Alexander RW, Akers M and Griendling KK: p38 Mitogen-activated protein kinase is a critical component of the redox-sensitive signaling pathways activated by angiotensin II. Role in vascular smooth muscle cell hypertrophy. J Biol Chem. 273:15022–15029. 1998. View Article : Google Scholar : PubMed/NCBI

59 

Ushio-Fukai M, Alexander RW, Akers M, Yin Q, Fujio Y, Walsh K and Griendling KK: Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells. J Biol Chem. 274:22699–22704. 1999. View Article : Google Scholar : PubMed/NCBI

60 

Sundaresan M, Yu ZX, Ferrans VJ, Irani K and Finkel T: Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science. 270:296–299. 1995. View Article : Google Scholar : PubMed/NCBI

61 

Zafari AM, Ushio-Fukai M, Akers M, Yin Q, Shah A, Harrison DG, Taylor WR and Griendling KK: Role of NADH/NADPH oxidase-derived H2O2 in angiotensin II-induced vascular hypertrophy. Hypertension. 32:488–495. 1998. View Article : Google Scholar : PubMed/NCBI

62 

Ushio-Fukai M, Zafari AM, Fukui T, Ishizaka N and Griendling KK: p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells. J Biol Chem. 271:23317–23321. 1996. View Article : Google Scholar : PubMed/NCBI

63 

Ballinger SW, Patterson C, Yan CN, Doan R, Burow DL, Young CG, Yakes FM, Van Houten B, Ballinger CA, Freeman BA and Runge MS: Hydrogen peroxide- and peroxynitrite-induced mitochondrial DNA damage and dysfunction in vascular endothelial and smooth muscle cells. Circ Res. 86:960–966. 2000. View Article : Google Scholar : PubMed/NCBI

64 

Kiningham KK, Oberley TD, Lin S, Mattingly CA and St Clair DK: Overexpression of manganese superoxide dismutase protects against mitochondrial-initiated poly(ADP-ribose) polymerase-mediated cell death. FASEB J. 13:1601–1610. 1999. View Article : Google Scholar : PubMed/NCBI

65 

Lin MT and Beal MF: Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature. 443:787–795. 2006. View Article : Google Scholar : PubMed/NCBI

66 

Čáp M, Váchová L and Palková Z: Reactive oxygen species in the signaling and adaptation of multicellular microbial communities. Oxid Med Cell Longev. 2012:9767532012. View Article : Google Scholar : PubMed/NCBI

67 

Scherz-Shouval R and Elazar Z: Regulation of autophagy by ROS: Physiology and pathology. Trends Biochem Sci. 36:30–38. 2011. View Article : Google Scholar : PubMed/NCBI

68 

Vernon PJ and Tang D: Eat-me: Autophagy, phagocytosis, and reactive oxygen species signaling. Antioxid Redox Signal. 18:677–691. 2013. View Article : Google Scholar : PubMed/NCBI

69 

Owens MW, Milligan SA, Jourd'heuil D and Grisham MB: Effects of reactive metabolites of oxygen and nitrogen on gelatinase A activity. Am J Physiol. 273:L445–L450. 1997.PubMed/NCBI

70 

Viappiani S, Nicolescu AC, Holt A, Sawicki G, Crawford BD, León H, van Mulligen T and Schulz R: Activation and modulation of 72kDa matrix metalloproteinase-2 by peroxynitrite and glutathione. Biochem Pharmacol. 77:826–834. 2009. View Article : Google Scholar : PubMed/NCBI

71 

Kim NN, Villegas S, Summerour SR and Villarreal FJ: Regulation of cardiac fibroblast extracellular matrix production by bradykinin and nitric oxide. J Mol Cell Cardiol. 31:457–466. 1999. View Article : Google Scholar : PubMed/NCBI

72 

Liang CC, Huang HY and Chang SD: Gene expression and immunoreactivity of elastolytic enzymes in the uterosacral ligaments from women with uterine prolapse. Reprod Sci. 19:354–359. 2012. View Article : Google Scholar : PubMed/NCBI

73 

Donnini S, Monti M, Roncone R, Morbidelli L, Rocchigiani M, Oliviero S, Casella L, Giachetti A, Schulz R and Ziche M: Peroxynitrite inactivates human-tissue inhibitor of metalloproteinase-4. FEBS Lett. 582:1135–1140. 2008. View Article : Google Scholar : PubMed/NCBI

74 

Mayne ST: Antioxidant nutrients and chronic disease: Use of biomarkers of exposure and oxidative stress status in epidemiologic research. J Nutr. 133 Suppl 3:933S–940S. 2003. View Article : Google Scholar : PubMed/NCBI

75 

Kulms D, Zeise E, Poeppelmann B and Schwarz T: DNA damage, death receptor activation and reactive oxygen species contribute to ultraviolet radiation-induced apoptosis in an essential and independent way. Oncogene. 21:5844–5851. 2002. View Article : Google Scholar : PubMed/NCBI

76 

Kaneko T, Tahara S and Matsuo M: Non-linear accumulation of 8-hydroxy-2′-deoxyguanosine, a marker of oxidized DNA damage, during aging. Mutat Res. 316:277–285. 1996. View Article : Google Scholar : PubMed/NCBI

77 

Awasthi YC, Sharma R, Sharma A, Yadav S, Singhal SS, Chaudhary P and Awasthi S: Self-regulatory role of 4-hydroxynonenal in signaling for stress-induced programmed cell death. Free Radic Biol Med. 45:111–118. 2008. View Article : Google Scholar : PubMed/NCBI

78 

Cheng JZ, Singhal SS, Saini M, Singhal J, Piper JT, Van Kuijk F, Zimniak P, Awasthi YC and Awasthi S: Effects of mGST A4 transfection on 4-hydroxynonenal-mediated apoptosis and differentiation of K562 human erythroleukemia cells. Arch Biochem Biophys. 372:29–36. 1999. View Article : Google Scholar : PubMed/NCBI

79 

Li J, Sharma R, Patrick B, Sharma A, Jeyabal PV, Reddy PM, Saini MK, Dwivedi S, Dhanani S, Ansari NH, et al: Regulation of CD95 (Fas) expression and Fas-mediated apoptotic signaling in HLE B-3 cells by 4-hydroxynonenal. Biochemistry. 45:12253–12264. 2006. View Article : Google Scholar : PubMed/NCBI

80 

Sharma R, Brown D, Awasthi S, Yang Y, Sharma A, Patrick B, Saini MK, Singh SP, Zimniak P, Singh SV and Awasthi YC: Transfection with 4-hydroxynonenal-metabolizing glutathione S-transferase isozymes leads to phenotypic transformation and immortalization of adherent cells. Eur J Biochem. 271:1690–1701. 2004. View Article : Google Scholar : PubMed/NCBI

81 

Sharma R, Sharma A, Dwivedi S, Zimniak P, Awasthi S and Awasthi YC: 4-Hydroxynonenal self-limits fas-mediated DISC-independent apoptosis by promoting export of Daxx from the nucleus to the cytosol and its binding to Fas. Biochemistry. 47:143–156. 2008. View Article : Google Scholar : PubMed/NCBI

82 

Chaudhary P, Sharma R, Sharma A, Vatsyayan R, Yadav S, Singhal SS, Rauniyar N, Prokai L, Awasthi S and Awasthi YC: Mechanisms of 4-hydroxy-2-nonenal induced pro-and anti-apoptotic signaling. Biochemistry. 49:6263–6275. 2010. View Article : Google Scholar : PubMed/NCBI

83 

Forgione MA, Weiss N, Heydrick S, Cap A, Klings ES, Bierl C, Eberhardt RT, Farber HW and Loscalzo J: Cellular glutathione peroxidase deficiency and endothelial dysfunction. Am J Physiol Heart Circ Physiol. 282:H1255–H1261. 2002. View Article : Google Scholar : PubMed/NCBI

84 

Thu VT, Kim HK, Ha SH, Yoo JY, Park WS, Kim N, Oh GT and Han J: Glutathione peroxidase 1 protects mitochondria against hypoxia/reoxygenation damage in mouse hearts. Pflugers Arch. 460:55–68. 2010. View Article : Google Scholar : PubMed/NCBI

85 

Jang YC, Pérez VI, Song W, Lustgarten MS, Salmon AB, Mele J, Qi W, Liu Y, Liang H, Chaudhuri A, et al: Overexpression of Mn superoxide dismutase does not increase life span in mice. J Gerontol A Biol Sci Med Sci. 64:1114–1125. 2009. View Article : Google Scholar : PubMed/NCBI

86 

Zhang Y, Zhang HM, Shi Y, Lustgarten M, Li Y, Qi W, Zhang BX and Van Remmen H: Loss of manganese superoxide dismutase leads to abnormal growth and signal transduction in mouse embryonic fibroblasts. Free Radic Biol Med. 49:1255–1262. 2010. View Article : Google Scholar : PubMed/NCBI

87 

Kwak HB, Lee Y, Kim JH, Van Remmen H, Richardson AG and Lawler JM: MnSOD overexpression reduces fibrosis and Pro-apoptotic signaling in the aging mouse heart. J Gerontol A Biol Sci Med Sci. 70:533–544. 2015. View Article : Google Scholar : PubMed/NCBI

88 

Eldridge A, Fan M, Woloschak G, Grdina DJ, Chromy BA and Li J: Manganese superoxide dismutase interacts with a large scale of cellular and mitochondrial proteins in low-dose radiation-induced adaptive radioprotection. Free Radic Biol Med. 53:1838–1847. 2012. View Article : Google Scholar : PubMed/NCBI

89 

Smolik AC, Bengez-Pudja L, Cheng I and Mascotti DP: Characterization of E. coli manganese superoxide dismutase binding to RNA and DNA. Biochim Biophys Acta. 1844:2251–2256. 2014. View Article : Google Scholar : PubMed/NCBI

90 

Holley AK, Dhar SK, Xu Y and St Clair DK: Manganese superoxide dismutase: Beyond life and death. Amino Acids. 42:139–158. 2012. View Article : Google Scholar : PubMed/NCBI

91 

Silva JP, Shabalina IG, Dufour E, Petrovic N, Backlund EC, Hultenby K, Wibom R, Nedergaard J, Cannon B and Larsson NG: SOD2 overexpression: Enhanced mitochondrial tolerance but absence of effect on UCP activity. EMBO J. 24:4061–4070. 2005. View Article : Google Scholar : PubMed/NCBI

92 

Motoori S, Majima HJ, Ebara M, Kato H, Hirai F, Kakinuma S, Yamaguchi C, Ozawa T, Nagano T, Tsujii H and Saisho H: Overexpression of mitochondrial manganese superoxide dismutase protects against radiation-induced cell death in the human hepatocellular carcinoma cell line HLE. Cancer Res. 61:5382–5388. 2001.PubMed/NCBI

93 

Suzuki K, Murtuza B, Sammut IA, Latif N, Jayakumar J, Smolenski RT, Kaneda Y, Sawa Y, Matsuda H and Yacoub MH: Heat shock protein 72 enhances manganese superoxide dismutase activity during myocardial ischemia-reperfusion injury, associated with mitochondrial protection and apoptosis reduction. Circulation. 106 12 Suppl 1:I270–I276. 2002.PubMed/NCBI

94 

Boreham MK, Wai CY, Miller RT, Schaffer JI and Word RA: Morphometric properties of the posterior vaginal wall in women with pelvic organ prolapse. Am J Obstet Gynecol. 187:1501–1509. 2002. View Article : Google Scholar : PubMed/NCBI

95 

Boreham MK, Wai CY, Miller RT, Schaffer JI and Word R: Morphometric analysis of smooth muscle in the anterior vaginal wall of women with pelvic organ prolapse. Am J Obstet Gynecol. 187:56–63. 2002. View Article : Google Scholar : PubMed/NCBI

96 

Gabriel B, Denschlag D, Göbel H, Fittkow C, Werner M, Gitsch G and Watermann D: Uterosacral ligament in postmenopausal women with or without pelvic organ prolapse. Int Urogynecol J Pelvic Floor Dysfunct. 16:475–479. 2005. View Article : Google Scholar : PubMed/NCBI

97 

Ozdegirmenci O, Karslioglu Y, Dede S, Karadeniz S, Haberal A, Gunhan O and Celasun B: Smooth muscle fraction of the round ligament in women with pelvic organ prolapse: A computer-based morphometric analysis. Int Urogynecol J Pelvic Floor Dysfunct. 16:39–43. 2005. View Article : Google Scholar : PubMed/NCBI

98 

Bermingham EN, Hesketh JE, Sinclair BR, Koolaard JP and Roy NC: Selenium-enriched foods are more effective at increasing glutathione peroxidase (GPx) activity compared with selenomethionine: A meta-analysis. Nutrients. 6:4002–4031. 2014. View Article : Google Scholar : PubMed/NCBI

99 

Kwak HB, Song W and Lawler JM: Exercise training attenuates age-induced elevation in Bax/Bcl-2 ratio, apoptosis, and remodeling in the rat heart. FASEB J. 20:791–793. 2006. View Article : Google Scholar : PubMed/NCBI

100 

Kwak HB, Kim JH, Joshi K, Yeh A, Martinez DA and Lawler JM: Exercise training reduces fibrosis and matrix metalloproteinase dysregulation in the aging rat heart. FASEB J. 25:1106–1117. 2011. View Article : Google Scholar : PubMed/NCBI

101 

Lawler JM, Kwak HB, Kim JH and Suk MH: Exercise training inducibility of MnSOD protein expression and activity is retained while reducing prooxidant signaling in the heart of senescent rats. Am J Physiol Regul Integr Comp Physiol. 296:R1496–R1502. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Fang G, Hong L, Liu C, Yang Q, Zhang Q, Li Y, Li B, Wu D, Wu W, Shi H, Shi H, et al: Oxidative status of cardinal ligament in pelvic organ prolapse. Exp Ther Med 16: 3293-3302, 2018.
APA
Fang, G., Hong, L., Liu, C., Yang, Q., Zhang, Q., Li, Y. ... Shi, H. (2018). Oxidative status of cardinal ligament in pelvic organ prolapse. Experimental and Therapeutic Medicine, 16, 3293-3302. https://doi.org/10.3892/etm.2018.6633
MLA
Fang, G., Hong, L., Liu, C., Yang, Q., Zhang, Q., Li, Y., Li, B., Wu, D., Wu, W., Shi, H."Oxidative status of cardinal ligament in pelvic organ prolapse". Experimental and Therapeutic Medicine 16.4 (2018): 3293-3302.
Chicago
Fang, G., Hong, L., Liu, C., Yang, Q., Zhang, Q., Li, Y., Li, B., Wu, D., Wu, W., Shi, H."Oxidative status of cardinal ligament in pelvic organ prolapse". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3293-3302. https://doi.org/10.3892/etm.2018.6633
Copy and paste a formatted citation
x
Spandidos Publications style
Fang G, Hong L, Liu C, Yang Q, Zhang Q, Li Y, Li B, Wu D, Wu W, Shi H, Shi H, et al: Oxidative status of cardinal ligament in pelvic organ prolapse. Exp Ther Med 16: 3293-3302, 2018.
APA
Fang, G., Hong, L., Liu, C., Yang, Q., Zhang, Q., Li, Y. ... Shi, H. (2018). Oxidative status of cardinal ligament in pelvic organ prolapse. Experimental and Therapeutic Medicine, 16, 3293-3302. https://doi.org/10.3892/etm.2018.6633
MLA
Fang, G., Hong, L., Liu, C., Yang, Q., Zhang, Q., Li, Y., Li, B., Wu, D., Wu, W., Shi, H."Oxidative status of cardinal ligament in pelvic organ prolapse". Experimental and Therapeutic Medicine 16.4 (2018): 3293-3302.
Chicago
Fang, G., Hong, L., Liu, C., Yang, Q., Zhang, Q., Li, Y., Li, B., Wu, D., Wu, W., Shi, H."Oxidative status of cardinal ligament in pelvic organ prolapse". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3293-3302. https://doi.org/10.3892/etm.2018.6633
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