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Evaluation of drug release from paclitaxel + hirudin‑eluting balloons and the resulting vascular reactivity in healthy pigs

  • Authors:
    • Xian Wang
    • Hongmei Li
    • Xiaoting Sun
    • Xiaohang Wang
    • Gangyin Wang
  • View Affiliations / Copyright

    Affiliations: Institute for Cardiovascular Disease, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3425-3432
    |
    Published online on: August 23, 2018
       https://doi.org/10.3892/etm.2018.6653
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Abstract

This study explored drug release from paclitaxel + hirudin‑eluting balloons in a healthy pig coronary artery model and objectively evaluated the vascular reactivity after balloon intervention. A total of 12 healthy white pigs were used for the analysis of drug release from the experimental balloon. The observational time‑points included immediately following implantation and day 7, 30, and 80 after surgery. At each time‑point, two pigs were treated with the paclitaxel + hirudin‑eluting balloon and one with the B. Braun paclitaxel‑eluting balloon (control). Quantitative coronary angiography (QCA) of the target vessel was performed before and after balloon treatment. One pig died before the designated experimental endpoint, and no abnormal clinical signs or tissue lesions were observed in the other pigs. QCA showed different degrees of spasms after balloon treatment, all of which recovered shortly thereafter without intervention. The blood vessel lumens were all open and without dissection or angioma. Drug content determination showed that the experimental balloon performed better than the control balloon with regard to drug release, vascular absorption and expulsion rate. The paclitaxel + hirudin‑eluting balloon catheter was easy to manipulate. The drug release from the experimental balloon was stable and resulted in good vascular reactivity. The safety and efficacy of the experimental balloon were not worse than the paclitaxel‑eluting balloon that is currently on the market.
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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Li H, Sun X, Wang X and Wang G: Evaluation of drug release from paclitaxel + hirudin‑eluting balloons and the resulting vascular reactivity in healthy pigs. Exp Ther Med 16: 3425-3432, 2018.
APA
Wang, X., Li, H., Sun, X., Wang, X., & Wang, G. (2018). Evaluation of drug release from paclitaxel + hirudin‑eluting balloons and the resulting vascular reactivity in healthy pigs. Experimental and Therapeutic Medicine, 16, 3425-3432. https://doi.org/10.3892/etm.2018.6653
MLA
Wang, X., Li, H., Sun, X., Wang, X., Wang, G."Evaluation of drug release from paclitaxel + hirudin‑eluting balloons and the resulting vascular reactivity in healthy pigs". Experimental and Therapeutic Medicine 16.4 (2018): 3425-3432.
Chicago
Wang, X., Li, H., Sun, X., Wang, X., Wang, G."Evaluation of drug release from paclitaxel + hirudin‑eluting balloons and the resulting vascular reactivity in healthy pigs". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3425-3432. https://doi.org/10.3892/etm.2018.6653
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Li H, Sun X, Wang X and Wang G: Evaluation of drug release from paclitaxel + hirudin‑eluting balloons and the resulting vascular reactivity in healthy pigs. Exp Ther Med 16: 3425-3432, 2018.
APA
Wang, X., Li, H., Sun, X., Wang, X., & Wang, G. (2018). Evaluation of drug release from paclitaxel + hirudin‑eluting balloons and the resulting vascular reactivity in healthy pigs. Experimental and Therapeutic Medicine, 16, 3425-3432. https://doi.org/10.3892/etm.2018.6653
MLA
Wang, X., Li, H., Sun, X., Wang, X., Wang, G."Evaluation of drug release from paclitaxel + hirudin‑eluting balloons and the resulting vascular reactivity in healthy pigs". Experimental and Therapeutic Medicine 16.4 (2018): 3425-3432.
Chicago
Wang, X., Li, H., Sun, X., Wang, X., Wang, G."Evaluation of drug release from paclitaxel + hirudin‑eluting balloons and the resulting vascular reactivity in healthy pigs". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3425-3432. https://doi.org/10.3892/etm.2018.6653
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