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Article

Dysregulated ICOS+ proinflammatory and suppressive regulatory T cells in patients with rheumatoid arthritis

  • Authors:
    • Hong‑Xia Wang
    • Xia Kang
    • Shuai Chu
    • Haixia Li
    • Xin Li
    • Xiaofeng Yin
    • Yu‑Rong Qiu
    • Weinan Lai
  • View Affiliations / Copyright

    Affiliations: Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Department of Rheumatology and Immunology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China
  • Pages: 3728-3734
    |
    Published online on: August 24, 2018
       https://doi.org/10.3892/etm.2018.6657
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Abstract

Regulatory T cells (Tregs) serve an important role in the pathogenesis of rheumatoid arthritis (RA) by regulating autoimmunity and inflammation. Humans and mice contain inducible T‑cell costimulator‑positive (ICOS+) Tregs, although their role in RA is unclear. A total of 33 patients with RA and 17 normal control (NC) subjects were examined. The proportion of ICOS+ Tregs in the peripheral blood and intracellular cytokine levels in these cells were assessed using flow cytometry. The percentage of ICOS+ Tregs increased in the cohort of patients with RA compared with the NCs. Such increases were much larger in patients with inactive RA compared with patients with active RA. Additionally, ICOS+ Tregs expressed multiple suppressive cytokines, including interleukin (IL)‑10, transforming growth factor‑β and IL‑35, but expressed low levels of IL‑17. Importantly, the expression of suppressive cytokines in ICOS+ Tregs from patients with active RA decreased, but IL‑17 expression noticeably increased compared with patients with inactive RA. The present findings suggested that ICOS+ Tregs may perform inflammatory and inhibitory functions, and abnormal ICOS+ Tregs numbers and functions may contribute to the pathogenesis of RA.
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1 

Firestein GS: Evolving concepts of rheumatoid arthritis. Nature. 423:356–361. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Del Junco DJ, Annegers JF, Coulam CB and Luthra HS: The relationship between rheumatoid arthritis and reproductive function. Br J Rheumatol. 1 Soppl 28:(33): 42–45. 1989.

3 

Picerno V, Ferro F, Adinolfi A, Valentini E, Tani C and Alunno A: One year in review: The pathogenesis of rheumatoid arthritis. Clin Exp Rheumatol. 33:551–558. 2015.PubMed/NCBI

4 

McInnes IB and Schett G: The pathogenesis of rheumatoid arthritis. N Engl J Med. 365:2205–2219. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Yue C, You X, Zhao L, Wang H, Tang F, Zhang F, Zhang X and He W: The effects of adalimumab and methotrexate treatment on peripheral Th17 cells and IL-17/IL-6 secretion in rheumatoid arthritis patients. Rheumatol Int. 30:1553–1557. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Lu TT, Zhu P, Li XY and Fan CM: Functional status of T helper cells in rheumatoid arthritis and effect of etanercept. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 24:495–497. 2008.(In Chinese). PubMed/NCBI

7 

Miossec P: Interleukin-17 in fashion, at last: Ten years after its description, its cellular source has been identified. Arthritis Rheum. 56:2111–2125. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Shahrara S, Huang Q, Mandelin AN II and Pope RM: TH-17 cells in rheumatoid arthritis. Arthritis Res Ther. 10:R932008. View Article : Google Scholar : PubMed/NCBI

9 

Campbell DJ: Control of regulatory T cell migration, function, and homeostasis. J Immunol. 195:2507–2513. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Byng-Maddick R and Ehrenstein MR: The impact of biological therapy on regulatory T cells in rheumatoid arthritis. Rheumatology (Oxford). 54:768–775. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Cooles FA, Isaacs JD and Anderson AE: Treg cells in rheumatoid arthritis: An update. Curr Rheumatol Rep. 15:3522013. View Article : Google Scholar : PubMed/NCBI

12 

Dong C, Juedes AE, Temann UA, Shresta S, Allison JP, Ruddle NH and Flavell RA: ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature. 409:97–101. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Busse M, Krech M, Meyer-Bahlburg A, Hennig C and Hansen G: ICOS mediates the generation and function of CD4+CD25+Foxp3+ regulatory T cells conveying respiratory tolerance. J Immunol. 189:1975–1982. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Herman AE, Freeman GJ, Mathis D and Benoist C: CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion. J Exp Med. 199:1479–1489. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Chen Y, Shen S, Gorentla BK, Gao J and Zhong XP: Murine regulatory T cells contain hyperproliferative and death-prone subsets with differential ICOS expression. J Immunol. 188:1698–1707. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Ito T, Hanabuchi S, Wang YH, Park WR, Arima K, Bover L, Qin FX, Gilliet M and Liu YJ: Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery. Immunity. 28:870–880. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Kohyama M, Sugahara D, Sugiyama S, Yagita H, Okumura K and Hozumi N: Inducible costimulator-dependent IL-10 production by regulatory T cells specific for self-antigen. Proc Natl Acad Sci USA. 101:pp. 4192–4197. 2004; View Article : Google Scholar : PubMed/NCBI

18 

Gotsman I, Grabie N, Gupta R, Dacosta R, MacConmara M, Lederer J, Sukhova G, Witztum JL, Sharp AH and Lichtman AH: Impaired regulatory T-cell response and enhanced atherosclerosis in the absence of inducible costimulatory molecule. Circulation. 114:2047–2055. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Nistala K and Wedderburn LR: Th17 and regulatory T cells: Rebalancing pro-and anti-inflammatory forces in autoimmune arthritis. Rheumatology (Oxford). 48:602–606. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Niu Q, Cai B, Huang ZC, Shi YY and Wang LL: Disturbed Th17/Treg balance in patients with rheumatoid arthritis. Rheumatol Int. 32:2731–2736. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Wang W, Shao S, Jiao Z, Guo M, Xu H and Wang S: The Th17/Treg imbalance and cytokine environment in peripheral blood of patients with rheumatoid arthritis. Rheumatol Int. 32:887–893. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO III, Birnbaum NS, Burmester GR, Bykerk VP, Cohen MD, et al: 2010 rheumatoid arthritis classification criteria: An american college of rheumatology/european league against rheumatism collaborative initiative. Ann Rheum Dis. 69:1580–1588. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Prevoo ML, van't Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB and van Riel PL: Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum. 38:44–48. 1995. View Article : Google Scholar : PubMed/NCBI

24 

Sakaguchi S, Yamaguchi T, Nomura T and Ono M: Regulatory T cells and immune tolerance. Cell. 133:775–787. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Bedoya SK, Lam B, Lau K and Larkin J III: Th17 cells in immunity and autoimmunity. Clin Dev Immunol. 2013:9867892013. View Article : Google Scholar : PubMed/NCBI

26 

Kirkham BW, Lassere MN, Edmonds JP, Juhasz KM, Bird PA, Lee CS, Shnier R and Portek IJ: Synovial membrane cytokine expression is predictive of joint damage progression in rheumatoid arthritis: A two-year prospective study (the DAMAGE study cohort). Arthritis Rheum. 54:1122–1131. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, Cross R, Sehy D, Blumberg RS and Vignali DA: The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature. 450:566–569. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Wing K and Sakaguchi S: Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol. 11:7–13. 2010. View Article : Google Scholar : PubMed/NCBI

29 

van Amelsfort JM, Jacobs KM, Bijlsma JW, Lafeber FP and Taams LS: CD4(+)CD25(+) regulatory T cells in rheumatoid arthritis: Differences in the presence, phenotype, and function between peripheral blood and synovial fluid. Arthritis Rheum. 50:2775–2785. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Pan F, Xiang H, Yan J, Hong L, Zhang L, Liu Y, Feng X and Cai C: Dendritic cells from rheumatoid arthritis patient peripheral blood induce Th17 cell differentiation via miR-363/Integrin αv/TGF-β axis. Scand J Immunol. 85:441–449. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Vocanson M, Rozieres A, Hennino A, Poyet G, Gaillard V, Renaudineau S, Achachi A, Benetiere J, Kaiserlian D, Dubois B and Nicolas JF: Inducible costimulator (ICOS) is a marker for highly suppressive antigen-specific T cells sharing features of TH17/TH1 and regulatory T cells. J Allergy Clin Immunol. 126:280–289. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang HX, Kang X, Chu S, Li H, Li X, Yin X, Qiu YR and Lai W: Dysregulated ICOS+ proinflammatory and suppressive regulatory T cells in patients with rheumatoid arthritis. Exp Ther Med 16: 3728-3734, 2018.
APA
Wang, H., Kang, X., Chu, S., Li, H., Li, X., Yin, X. ... Lai, W. (2018). Dysregulated ICOS+ proinflammatory and suppressive regulatory T cells in patients with rheumatoid arthritis. Experimental and Therapeutic Medicine, 16, 3728-3734. https://doi.org/10.3892/etm.2018.6657
MLA
Wang, H., Kang, X., Chu, S., Li, H., Li, X., Yin, X., Qiu, Y., Lai, W."Dysregulated ICOS+ proinflammatory and suppressive regulatory T cells in patients with rheumatoid arthritis". Experimental and Therapeutic Medicine 16.4 (2018): 3728-3734.
Chicago
Wang, H., Kang, X., Chu, S., Li, H., Li, X., Yin, X., Qiu, Y., Lai, W."Dysregulated ICOS+ proinflammatory and suppressive regulatory T cells in patients with rheumatoid arthritis". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3728-3734. https://doi.org/10.3892/etm.2018.6657
Copy and paste a formatted citation
x
Spandidos Publications style
Wang HX, Kang X, Chu S, Li H, Li X, Yin X, Qiu YR and Lai W: Dysregulated ICOS+ proinflammatory and suppressive regulatory T cells in patients with rheumatoid arthritis. Exp Ther Med 16: 3728-3734, 2018.
APA
Wang, H., Kang, X., Chu, S., Li, H., Li, X., Yin, X. ... Lai, W. (2018). Dysregulated ICOS+ proinflammatory and suppressive regulatory T cells in patients with rheumatoid arthritis. Experimental and Therapeutic Medicine, 16, 3728-3734. https://doi.org/10.3892/etm.2018.6657
MLA
Wang, H., Kang, X., Chu, S., Li, H., Li, X., Yin, X., Qiu, Y., Lai, W."Dysregulated ICOS+ proinflammatory and suppressive regulatory T cells in patients with rheumatoid arthritis". Experimental and Therapeutic Medicine 16.4 (2018): 3728-3734.
Chicago
Wang, H., Kang, X., Chu, S., Li, H., Li, X., Yin, X., Qiu, Y., Lai, W."Dysregulated ICOS+ proinflammatory and suppressive regulatory T cells in patients with rheumatoid arthritis". Experimental and Therapeutic Medicine 16, no. 4 (2018): 3728-3734. https://doi.org/10.3892/etm.2018.6657
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