Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
November-2018 Volume 16 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2018 Volume 16 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

The relationship between inflammatory factor expression and blood pressure and urinary protein in the placenta of gestational hypertension rats

  • Authors:
    • Xue-Qin Jia
    • Su Xu
    • Mei-Rong Tian
    • Yu-Yan Ma
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics, Qilu Hospital of Shandong University, Jinan, Shandong 250010, P.R. China, Department of Obstetrics, The Lanshan District Maternal and Child Care Service Centre of Rizhao, Rizhao, Shandong 276812, P.R. China, Department Obstetrics, Taian City Central Hospital, Taian, Shandong 271000, P.R. China
    Copyright: © Jia et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3793-3798
    |
    Published online on: August 30, 2018
       https://doi.org/10.3892/etm.2018.6668
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The association between inflammatory factor expression and blood pressure with urinary protein in the placenta of pregnant women with pregnancy-induced hypertension (PIH) was investigated to provide a new vision for the clinical prevention and treatment of PIH. Rats were used as animal models and were randomly divided into three groups (control, hypertension and treatment groups) on day 15 of pregnancy with 20 rats in each group. The 10% hypoxia-induced PIH group was induced with administration of an anti-hypertensive drug, and the treatment group was giventreprostinil for one week after the 10% hypoxia-induced PIH. On the 21st day, the experiment was terminated and the placenta was taken to measure the mRNA and protein expression levels of IL-6 and TNF-α, respectively. Pearson's correlation analysis demonstrated the correlation between IL-6 and TNF-α with blood pressure and urinary protein. The blood pressure and urinary protein concentrations in the hypertension group were significantly higher than that in the control group, and the expression levels of IL-6 and TNF-α in the hypertension group were significantly higher (P<0.05). The treatment group significantly reduced inflammatory cytokines and blood pressure and urinary protein levels (P<0.05). Pearson's correlation analysis showed that IL-6 and TNF-α were positively correlated with blood pressure and urinary protein concentration. The blood pressure and urinary protein concentration in PIH rats and the expression levels of IL-6 and TNF-α were significantly higher, and IL-6 and TNF-α were positively correlated with blood pressure and urine protein concentration.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Sibai BM: Diagnosis and management of gestational hypertension and preeclampsia. Obstet Gynecol. 102:181–192. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Buchbinder A, Sibai BM, Caritis S, Macpherson C, Hauth J, Lindheimer MD, Klebanoff M, Vandorsten P, Landon M, Paul R, et al: National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units: Adverse perinatal outcomes are significantly higher in severe gestational hypertension than in mild preeclampsia. Am J Obstet Gynecol. 186:66–71. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Barton JR, O'brien JM, Bergauer NK, Jacques DL and Sibai BM: Mild gestational hypertension remote from term: Progression and outcome. Am J Obstet Gynecol. 184:979–983. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Salonen Ros H, Lichtenstein P, Lipworth L and Cnattingius S: Genetic effects on the liability of developing pre-eclampsia and gestational hypertension. Am J Med Genet. 91:256–260. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Naeye RL and Friedman EA: Causes of perinatal death associated with gestational hypertension and proteinuria. Am J Obstet Gynecol. 133:8–10. 1979. View Article : Google Scholar : PubMed/NCBI

6 

Koopmans CM, Bijlenga D, Groen H, Vijgen SM, Aarnoudse JG, Bekedam DJ, van den Berg PP, de Boer K, Burggraaff JM, Bloemenkamp KW, et al HYPITAT study group, : Induction of labour versus expectant monitoring for gestational hypertension or mild pre-eclampsia after 36 weeks' gestation (HYPITAT): A multicentre, open-label randomised controlled trial. Lancet. 374:979–988. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Ros HS, Cnattingius S and Lipworth L: Comparison of risk factors for preeclampsia and gestational hypertension in a population-based cohort study. Am J Epidemiol. 147:1062–1070. 1998. View Article : Google Scholar : PubMed/NCBI

8 

Hermida RC, Ayala DE, Mojón A, Fernández JR, Alonso I, Silva I, Ucieda R and Iglesias M: Blood pressure patterns in normal pregnancy, gestational hypertension, and preeclampsia. Hypertension. 36:149–158. 2000. View Article : Google Scholar : PubMed/NCBI

9 

Vambergue A, Nuttens MC, Goeusse P, Biausque S, Lepeut M and Fontaine P: Pregnancy induced hypertension in women with gestational carbohydrate intolerance: The diagest study. Eur J Obstet Gynecol Reprod Biol. 102:31–35. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Redman CWG and Sargent IL: Pre-eclampsia, the placenta and the maternal systemic inflammatory response - A review. Placenta. 24 Suppl A:S21–S27. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Roberts JM and Redman CWG: Pre-eclampsia: More than pregnancy-induced hypertension. Lancet. 341:1447–1451. 1993. View Article : Google Scholar : PubMed/NCBI

12 

Majumdar S, Dasguptha H, Bhattacharya K and Bhattacharya A: A study of placenta in normal and hypertensive pregnancies. J Anat Soc India. 54:1–9. 2005.http://medind.nic.in/jae/t05/i2/jaet05i2p34.pdf

13 

Xiong X, Demianczuk NN, Saunders LD, Wang FL and Fraser WD: Impact of preeclampsia and gestational hypertension on birth weight by gestational age. Am J Epidemiol. 155:203–209. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Seely EW and Solomon CG: Insulin resistance and its potential role in pregnancy-induced hypertension. J Clin Endocrinol Metab. 88:2393–2398. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Sgambati E, Marini M, Zappoli Thyrion GD, Parretti E, Mello G, Orlando C, Simi L, Tricarico C, Gheri G and Brizzi E: VEGF expression in the placenta from pregnancies complicated by hypertensive disorders. BJOG. 111:564–570. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Peraçoli JC, Rudge MVC and Peraçoli MTS: Tumor necrosis factor-alpha in gestation and puerperium of women with gestational hypertension and pre-eclampsia. Am J Reprod Immunol. 57:177–185. 2007. View Article : Google Scholar : PubMed/NCBI

17 

LaMarca BD, Ryan MJ, Gilbert JS, Murphy SR and Granger JP: Inflammatory cytokines in the pathophysiology of hypertension during preeclampsia. Curr Hypertens Rep. 9:480–485. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Sargent IL, Borzychowski AM and Redman CWG: NK cells and human pregnancy - An inflammatory view. Trends Immunol. 27:399–404. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Hermida RC, Ayala DE, Mojón A, Fernández JR, Silva I, Ucieda R and Iglesias M: Blood pressure excess for the early identification of gestational hypertension and preeclampsia. Hypertension. 31:83–89. 1998. View Article : Google Scholar : PubMed/NCBI

20 

Borzychowski AM, Sargent IL and Redman CWG: Inflammation and pre-eclampsiaSeminars in Fetal and Neonatal Medicine. 11. WB Saunders; Philadelphia: pp. 309–316. 2006, View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Jia X, Xu S, Tian M and Ma Y: The relationship between inflammatory factor expression and blood pressure and urinary protein in the placenta of gestational hypertension rats. Exp Ther Med 16: 3793-3798, 2018.
APA
Jia, X., Xu, S., Tian, M., & Ma, Y. (2018). The relationship between inflammatory factor expression and blood pressure and urinary protein in the placenta of gestational hypertension rats. Experimental and Therapeutic Medicine, 16, 3793-3798. https://doi.org/10.3892/etm.2018.6668
MLA
Jia, X., Xu, S., Tian, M., Ma, Y."The relationship between inflammatory factor expression and blood pressure and urinary protein in the placenta of gestational hypertension rats". Experimental and Therapeutic Medicine 16.5 (2018): 3793-3798.
Chicago
Jia, X., Xu, S., Tian, M., Ma, Y."The relationship between inflammatory factor expression and blood pressure and urinary protein in the placenta of gestational hypertension rats". Experimental and Therapeutic Medicine 16, no. 5 (2018): 3793-3798. https://doi.org/10.3892/etm.2018.6668
Copy and paste a formatted citation
x
Spandidos Publications style
Jia X, Xu S, Tian M and Ma Y: The relationship between inflammatory factor expression and blood pressure and urinary protein in the placenta of gestational hypertension rats. Exp Ther Med 16: 3793-3798, 2018.
APA
Jia, X., Xu, S., Tian, M., & Ma, Y. (2018). The relationship between inflammatory factor expression and blood pressure and urinary protein in the placenta of gestational hypertension rats. Experimental and Therapeutic Medicine, 16, 3793-3798. https://doi.org/10.3892/etm.2018.6668
MLA
Jia, X., Xu, S., Tian, M., Ma, Y."The relationship between inflammatory factor expression and blood pressure and urinary protein in the placenta of gestational hypertension rats". Experimental and Therapeutic Medicine 16.5 (2018): 3793-3798.
Chicago
Jia, X., Xu, S., Tian, M., Ma, Y."The relationship between inflammatory factor expression and blood pressure and urinary protein in the placenta of gestational hypertension rats". Experimental and Therapeutic Medicine 16, no. 5 (2018): 3793-3798. https://doi.org/10.3892/etm.2018.6668
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team