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MGCD0103 induces apoptosis and simultaneously increases the expression of NF‑κB and PD‑L1 in classical Hodgkin's lymphoma

  • Authors:
    • Renhong Huang
    • Xiaowei Zhang
    • Zhijun Min
    • Abdelbari Sophia Shadia
    • Shun'e Yang
    • Xiaojian Liu
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, P.R. China, Department of Medical Oncology, Shanghai Cancer Center, Fudan University, Shanghai 200031, P.R. China, Department of Lymphoma, The Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3827-3834
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    Published online on: September 3, 2018
       https://doi.org/10.3892/etm.2018.6677
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Abstract

At present there is no consensus on the treatment of classical Hodgkin's lymphoma (CHL) following relapse. The aim of the present study was to access the class I‑selective histone deacetylase (HDAC) inhibitor (HDACI) MGCD0103 on the expression levels of Bcl‑2, nuclear factor (NF)‑κB and programmed death‑ligand 1 (PD‑L1) in CHL, to explore the possible therapeutic value of MGCD0103 in combined relative target drugs for patients with CHL. In L1236 and L428 cell lines, apoptosis and cell cycle stage were identified using flow cytometry, and the effects of HDACI on CHL were assessed in terms of Bcl‑2, NF‑κB and PD‑L1 expression levels, which were detected by western blotting and co‑focusing experiments. The results demonstrated that MGCD0103 could induce cell apoptosis and cell cycle arrest, down‑regulate Bcl‑2 and increase NF‑κB and PD‑L1 expression levels in L1236 and L428 cell lines. MGCD0103 decreases Bcl‑2 levels and upregulates PD‑L1, which indicates that the combined use of HDACIs and a PD‑L1 inhibitor in theory may improve treatment outcomes in patients with CHL. MGCD0103 may also up‑regulate NF‑κB, which seems to induce resistance towards anti‑apoptotic drugs. Clinical trials combining HDACIs with NF‑κB and/or PD‑L1 inhibitors should be designed to further improve treatment outcomes for patients with CHL.
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Copy and paste a formatted citation
Spandidos Publications style
Huang R, Zhang X, Min Z, Shadia A, Yang S and Liu X: MGCD0103 induces apoptosis and simultaneously increases the expression of NF‑κB and PD‑L1 in classical Hodgkin's lymphoma. Exp Ther Med 16: 3827-3834, 2018.
APA
Huang, R., Zhang, X., Min, Z., Shadia, A., Yang, S., & Liu, X. (2018). MGCD0103 induces apoptosis and simultaneously increases the expression of NF‑κB and PD‑L1 in classical Hodgkin's lymphoma. Experimental and Therapeutic Medicine, 16, 3827-3834. https://doi.org/10.3892/etm.2018.6677
MLA
Huang, R., Zhang, X., Min, Z., Shadia, A., Yang, S., Liu, X."MGCD0103 induces apoptosis and simultaneously increases the expression of NF‑κB and PD‑L1 in classical Hodgkin's lymphoma". Experimental and Therapeutic Medicine 16.5 (2018): 3827-3834.
Chicago
Huang, R., Zhang, X., Min, Z., Shadia, A., Yang, S., Liu, X."MGCD0103 induces apoptosis and simultaneously increases the expression of NF‑κB and PD‑L1 in classical Hodgkin's lymphoma". Experimental and Therapeutic Medicine 16, no. 5 (2018): 3827-3834. https://doi.org/10.3892/etm.2018.6677
Copy and paste a formatted citation
x
Spandidos Publications style
Huang R, Zhang X, Min Z, Shadia A, Yang S and Liu X: MGCD0103 induces apoptosis and simultaneously increases the expression of NF‑κB and PD‑L1 in classical Hodgkin's lymphoma. Exp Ther Med 16: 3827-3834, 2018.
APA
Huang, R., Zhang, X., Min, Z., Shadia, A., Yang, S., & Liu, X. (2018). MGCD0103 induces apoptosis and simultaneously increases the expression of NF‑κB and PD‑L1 in classical Hodgkin's lymphoma. Experimental and Therapeutic Medicine, 16, 3827-3834. https://doi.org/10.3892/etm.2018.6677
MLA
Huang, R., Zhang, X., Min, Z., Shadia, A., Yang, S., Liu, X."MGCD0103 induces apoptosis and simultaneously increases the expression of NF‑κB and PD‑L1 in classical Hodgkin's lymphoma". Experimental and Therapeutic Medicine 16.5 (2018): 3827-3834.
Chicago
Huang, R., Zhang, X., Min, Z., Shadia, A., Yang, S., Liu, X."MGCD0103 induces apoptosis and simultaneously increases the expression of NF‑κB and PD‑L1 in classical Hodgkin's lymphoma". Experimental and Therapeutic Medicine 16, no. 5 (2018): 3827-3834. https://doi.org/10.3892/etm.2018.6677
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