Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2018 Volume 16 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2018 Volume 16 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Type A aortic dissection in pregnant patients with fibrillin‑1 gene mutations: Two case reports and a literature review

  • Authors:
    • Yuanli Lei
    • Zhelong Jiang
    • Jiaozhen Chen
    • Dongsheng Wang
    • Guangliang Hong
    • Shouquan Chen
  • View Affiliations / Copyright

    Affiliations: Department of Emergency Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China, Department of Emergency Medicine, Hangzhou First People's Hospital, Nanjing Medical University, Hangzhou, Zhejiang 310000, P.R. China, Department of Electrocardiogram, Wenzhou People's Hospital, Wenzhou, Zhejiang 325000, P.R. China
    Copyright: © Lei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4407-4414
    |
    Published online on: September 19, 2018
       https://doi.org/10.3892/etm.2018.6761
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

In acute aortic dissection (AD) in pregnancy, increased cardiovascular stress due to pregnancy is an important factor leading to an emergent aortic event. It is rare but often results in a devastating event for both the pregnant patient and the foetus. Two cases of acute AD (Stanford type A) in pregnant females are presented in the present study. The patients were diagnosed via echocardiography, and the diagnosis was confirmed with computed tomography angiography prior to aortic surgery. Up to 50% of ADs in pregnancy occur in patients with fibrillin‑1 (FBN1) gene mutations. The FBN1 gene was sequenced in both patients, and notable, novel pathogenic mutations of FBN1 were identified in both patients. A literature review was also performed on available diagnostic imaging and other measurements regarding AD during pregnancy. The authors suggest that the relevant content may have important clinical implications in raising disease awareness, arranging test rationally and choosing an intervention method.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Immer FF, Bansi AG, Immer-Bansi AS, McDougall J, Zehr KJ, Schaff HV and Carrel TP: Aortic dissection in pregnancy: Analysis of risk factors and outcome. Ann Thorac Surg. 76:309–314. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Kim SW, Kim D and Hong JM: Acute aortic dissection in pregnancy with the marfan syndrome. Korean J Thorac Cardiovasc Surg. 47:291–293. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Kamel H, Roman MJ, Pitcher A and Devereux RB: Pregnancy and the risk of aortic dissection or rupture: A cohort-crossover analysis. Circulation. 134:527–533. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Thalmann M, Sodeck GH, Domanovits H, Grassberger M, Loewe C, Grimm M and Czerny M: Acute type A aortic dissection and pregnancy: A population-based study. Eur J Cardiothorac Surg. 39:e159–e163. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Banerjee A, Begaj I and Thorne S: Aortic dissection in pregnancy in England: An incidence study using linked national databases. BMJ Open. 5:e0083182015. View Article : Google Scholar : PubMed/NCBI

6 

Jovic TH, Aboelmagd T, Ramalingham G, Jones N and Nashef SA: Type A aortic dissection in pregnancy: Two operations yielding five healthy patients. Aorta (Stamford). 2:113–115. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Zhu JM, Ma WG, Peterss S, Wang LF, Qiao ZY, Ziganshin BA, Zheng J, Liu YM, Elefteriades JA and Sun LZ: Aortic dissection in pregnancy: Management strategy and outcomes. Ann Thorac Surg. 103:1199–1206. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Kim WH, Bae J, Choi SW, Lee JH, Kim CS, Cho HS and Lee SM: Stanford type A aortic dissection in a patient with Marfan syndrome during pregnancy: A case report. Korean J Anesthesiol. 69:76–79. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Mészáros I, Mórocz J, Szlávi J, Schmidt J, Tornóci L, Nagy L and Szép L: Epidemiology and clinicopathology of aortic dissection. Chest. 117:1271–1278. 2000. View Article : Google Scholar : PubMed/NCBI

10 

JCS Joint Working Group, . Guidelines for diagnosis and treatment of aortic aneurysm and aortic dissection (JCS 2011): Digest version. Circ J. 77:789–828. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Yang P, Zhang J, Li Y, Wang H and Zheng J: Maternal and fetal outcomes with aortic dissection in pregnant patients with Marfan syndrome. Zhonghua Fu Chan Ke Za Zhi. 50:334–340. 2015.(In Chinese). PubMed/NCBI

12 

Shinya S, Masaru A, Akira H, Eisaku H and Susumu O: Development of an assay of seven biochemical items, HbA1c, and hematocrit using a small amount of blood collected from the fingertip. Clin Chim Acta. 413:192–197. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Lei Y, Zheng MH, Huang W, Zhang J and Lu Y: Wet beriberi with multiple organ failure remarkably reversed by thiamine administration: A case report and literature review. Medicine (Baltimore). 97:e00102018. View Article : Google Scholar : PubMed/NCBI

14 

Lei Y, Xiao S, Chen S, Zhang H, Li H and Lu Y: N,N-dimethylformamide-induced acute hepatic failure: A case report and literature review. Exp Ther Med. 14:5659–5663. 2017.PubMed/NCBI

15 

Sakaguchi M, Kitahara H, Seto T, Furusawa T, Fukui D, Yanagiya N, Nishimura K and Amano J: Surgery for acute type A aortic dissection in pregnant patients with Marfan syndrome. Eur J Cardiothorac Surg. 28:280–285. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Master M and Day G: Acute aortic dissection in pregnancy in a woman with undiagnosed marfan syndrome. Case Rep Obstet Gynecol. 2012:4901692012.PubMed/NCBI

17 

Kohli E, Jwayyed S, Giorgio G and Bhalla MC: Acute type a aortic dissection in a 36-week pregnant patient. Case Rep Emerg Med. 2013:3906702013.PubMed/NCBI

18 

Regalado ES, Guo DC, Estrera AL, Buja LM and Milewicz DM: Acute aortic dissections with pregnancy in women with ACTA2 mutations. Am J Med Genet A. 164A:1–112. 2014.PubMed/NCBI

19 

Li X, Zhang HY, Han FZ, Yu CJ, Fan XP, Fan RX and Zhuang J: Surgical management of pregnancy-associated acute Stanford type A aortic dissection: Analysis of 5 cases. Nan Fang Yi Ke Da Xue Xue Bao. 37:1555–1558. 2017.(In Chinese). PubMed/NCBI

20 

Barrus A, Afshar S, Sani S, LaBounty TG, Padilla C, Farber MK, Rudikoff AG and Conte Hernandez A: Acute type A aortic dissection and successful surgical repair in a woman at 21 weeks gestational pregnancy with maternal and fetal survival: A case report. J Cardiothorac Vasc Anesth. 32:1487–1493. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Patel PA, Fernando RJ, MacKay EJ, Yoon J, Gutsche JT, Patel S, Shah R, Dashiell J, Weiss SJ, Goeddel L, et al: Acute type A aortic dissection in pregnancy-diagnostic and therapeutic challenges in a multidisciplinary setting. J Cardiothorac Vasc Anesth. 32:1991–1997. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Yang Y: The value of echocardiography in diagnosis and treatment of aortic dissection. J Cardiovasc Surg (Electron Ed). 2:61–63. 2013.

23 

Mayumi T, Yoshida M, Tazuma S, Furukawa A, Nishii O, Shigematsu K, Azuhata T, Itakura A, Kamei S, Kondo H, et al: The practice guidelines for primary care of acute abdomen 2015. Jpn J Radiol. 34:80–115. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Shiga T, Wajima Z, Apfel CC, Inoue T and Ohe Y: Diagnostic accuracy of transesophageal echocardiography, helical computed tomography, and magnetic resonance imaging for suspected thoracic aortic dissection: Systematic review and meta-analysis. Arch Intern Med. 166:1350–1356. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Zhao H, Wen D, Duan W, An R, Li J and Zheng M: Identification of CTA-based predictive findings for temporary and permanent neurological dysfunction after repair in acute type A aortic dissection. Sci Rep. 8:97402018. View Article : Google Scholar : PubMed/NCBI

26 

Yang S, Li X, Chao B, Wu L, Cheng Z, Duan Y, Wu D, Zhan Y, Chen J, Liu B, et al: Abdominal aortic intimal flap motion characterization in acute aortic dissection: Assessed with retrospective ECG-gated thoracoabdominal aorta dual-source CT angiography. PLoS One. 9:e876642014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lei Y, Jiang Z, Chen J, Wang D, Hong G and Chen S: Type A aortic dissection in pregnant patients with fibrillin‑1 gene mutations: Two case reports and a literature review. Exp Ther Med 16: 4407-4414, 2018.
APA
Lei, Y., Jiang, Z., Chen, J., Wang, D., Hong, G., & Chen, S. (2018). Type A aortic dissection in pregnant patients with fibrillin‑1 gene mutations: Two case reports and a literature review. Experimental and Therapeutic Medicine, 16, 4407-4414. https://doi.org/10.3892/etm.2018.6761
MLA
Lei, Y., Jiang, Z., Chen, J., Wang, D., Hong, G., Chen, S."Type A aortic dissection in pregnant patients with fibrillin‑1 gene mutations: Two case reports and a literature review". Experimental and Therapeutic Medicine 16.6 (2018): 4407-4414.
Chicago
Lei, Y., Jiang, Z., Chen, J., Wang, D., Hong, G., Chen, S."Type A aortic dissection in pregnant patients with fibrillin‑1 gene mutations: Two case reports and a literature review". Experimental and Therapeutic Medicine 16, no. 6 (2018): 4407-4414. https://doi.org/10.3892/etm.2018.6761
Copy and paste a formatted citation
x
Spandidos Publications style
Lei Y, Jiang Z, Chen J, Wang D, Hong G and Chen S: Type A aortic dissection in pregnant patients with fibrillin‑1 gene mutations: Two case reports and a literature review. Exp Ther Med 16: 4407-4414, 2018.
APA
Lei, Y., Jiang, Z., Chen, J., Wang, D., Hong, G., & Chen, S. (2018). Type A aortic dissection in pregnant patients with fibrillin‑1 gene mutations: Two case reports and a literature review. Experimental and Therapeutic Medicine, 16, 4407-4414. https://doi.org/10.3892/etm.2018.6761
MLA
Lei, Y., Jiang, Z., Chen, J., Wang, D., Hong, G., Chen, S."Type A aortic dissection in pregnant patients with fibrillin‑1 gene mutations: Two case reports and a literature review". Experimental and Therapeutic Medicine 16.6 (2018): 4407-4414.
Chicago
Lei, Y., Jiang, Z., Chen, J., Wang, D., Hong, G., Chen, S."Type A aortic dissection in pregnant patients with fibrillin‑1 gene mutations: Two case reports and a literature review". Experimental and Therapeutic Medicine 16, no. 6 (2018): 4407-4414. https://doi.org/10.3892/etm.2018.6761
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team