Type A aortic dissection in pregnant patients with fibrillin‑1 gene mutations: Two case reports and a literature review

Lei,Yuanli; Jiang,Zhelong; Chen,Jiaozhen; Wang,Dongsheng; Hong,Guangliang; Chen,Shouquan

doi:10.3892/etm.2018.6761

Type A aortic dissection in pregnant patients with fibrillin‑1 gene mutations: Two case reports and a literature review

Authors:
- Yuanli Lei
- Zhelong Jiang
- Jiaozhen Chen
- Dongsheng Wang
- Guangliang Hong
- Shouquan Chen
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Affiliations: Department of Emergency Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China, Department of Emergency Medicine, Hangzhou First People's Hospital, Nanjing Medical University, Hangzhou, Zhejiang 310000, P.R. China, Department of Electrocardiogram, Wenzhou People's Hospital, Wenzhou, Zhejiang 325000, P.R. China
Published online on: September 19, 2018 https://doi.org/10.3892/etm.2018.6761
Pages: 4407-4414
Copyright: © Lei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In acute aortic dissection (AD) in pregnancy, increased cardiovascular stress due to pregnancy is an important factor leading to an emergent aortic event. It is rare but often results in a devastating event for both the pregnant patient and the foetus. Two cases of acute AD (Stanford type A) in pregnant females are presented in the present study. The patients were diagnosed via echocardiography, and the diagnosis was confirmed with computed tomography angiography prior to aortic surgery. Up to 50% of ADs in pregnancy occur in patients with fibrillin‑1 (FBN1) gene mutations. The FBN1 gene was sequenced in both patients, and notable, novel pathogenic mutations of FBN1 were identified in both patients. A literature review was also performed on available diagnostic imaging and other measurements regarding AD during pregnancy. The authors suggest that the relevant content may have important clinical implications in raising disease awareness, arranging test rationally and choosing an intervention method.

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