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Targeting lung cancer initiating cells by all‑trans retinoic acid‑loaded lipid‑PLGA nanoparticles with CD133 aptamers

  • Authors:
    • Yu Zhang
    • Juan Zhao
    • Jing Sun
    • Lu Huang
    • Qingfeng Li
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei 441000, P.R. China, Department of Pharmacy, Second Military Medical University, Shanghai 200433, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4639-4649
    |
    Published online on: September 19, 2018
       https://doi.org/10.3892/etm.2018.6762
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Abstract

Lung cancer initiating cells represent a specific subpopulation of lung cancer cells, which significantly contribute to the initiation, metastasis and recurrence of lung cancer. CD133, initially considered a marker of stem cells, is now considered as a marker for lung cancer initiating cells. All‑trans retinoic acid (RA) has been demonstrated to cause the differentiation, inhibition of proliferation, and apoptosis of cancer cells and cancer initiating cells. However, there have been no reports on the activity of RA against lung cancer initiating cells. In the present study, the activity of RA against lung cancer initiating cells was investigated by determining the cytotoxicity, and performing a tumorsphere assay and flow cytometry‑based analysis. In addition, to promote the therapeutic effect of RA in CD133+ lung cancer initiating cells, RA‑loaded lipid poly(lactic‑co‑glycolic acid) (PLGA) nanoparticles with CD133 aptamers (RA‑LPNPs‑CD133) were developed. The activity of RA and RA‑LPNPs‑CD133 against lung cancer initiating cells was also investigated. RA‑LPNPs‑CD133 had a size of 129.9 nm, and exhibited sustained release of RA during the 144‑h period. For the first time, to the best of our knowledge, the present study demonstrated that RA exerted potent activity towards CD133+ lung cancer initiating cells. The results also showed that RA‑LPNPs‑CD133 efficiently and specifically promoted the delivery of RA to CD133+ lung cancer initiating cells, exhibiting superior inhibitory effects against CD133+ lung cancer initiating cells compared with non‑targeted nanoparticles and RA. To the best of our knowledge, the present study is the first to report the promotion of RA delivery via nanoparticles to lung cancer initiating cells and achievement of a superior inhibitory effect against lung cancer initiating cells by the utilization of CD133 aptamers. Therefore, RA‑LPNPs‑CD133 represents a promising tool for the elimination of lung cancer initiating cells.
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View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2017. CA Cancer J Clin. 67:7–30. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Eramo A, Lotti F, Sette G, Pilozzi E, Biffoni M, Di Virgilio A, Conticello C, Ruco L, Peschle C and De Maria R: Identification and expansion of the tumorigenic lung cancer stem cell population. Cell Death Differ. 15:504–514. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Kim JJ and Tannock IF: Repopulation of cancer cells during therapy: An important cause of treatment failure. Nat Rev Cancer. 5:516–525. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Zakaria N, Satar NA, Halim Abu NH, Ngalim SH, Yusoff NM, Lin J and Yahaya BH: Targeting lung cancer stem cells: Research and clinical impacts. Front Oncol. 7:802017. View Article : Google Scholar : PubMed/NCBI

6 

Bertolini G, Roz L, Perego P, Tortoreto M, Fontanella E, Gatti L, Pratesi G, Fabbri A, Andriani F, Tinelli S, et al: Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment. Proc Natl Acad Sci USA. 106:16281–16286. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Siddikuzzaman Guruvayoorappan C and Berlin Grace VM: All trans retinoic acid and cancer. Immunopharmacol Immunotoxicol. 33:241–249. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Montesinos P, Bergua JM, Vellenga E, Rayón C, Parody R, de la Serna J, León A, Esteve J, Milone G, Debén G, et al: Differentiation syndrome in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline chemotherapy: Characteristics, outcome, and prognostic factors. Blood. 113:775–783. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Li RJ, Ying X, Zhang Y, Ju RJ, Wang XX, Yao HJ, Men Y, Tian W, Yu Y, Zhang L, et al: All-trans retinoic acid stealth liposomes prevent the relapse of breast cancer arising from the cancer stem cells. J Control Release. 149:281–291. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Karsy M, Albert L, Tobias ME, Murali R and Jhanwar-Uniyal M: All-trans retinoic acid modulates cancer stem cells of glioblastoma multiforme in an MAPK-dependent manner. Anticancer Res. 30:4915–4920. 2010.PubMed/NCBI

11 

Han D, Rodriguez-Bravo V, Charytonowicz E, Demicco E, Domingo-Domenech J, Maki RG and Cordon-Cardo C: Targeting sarcoma tumor-initiating cells through differentiation therapy. Stem Cell Res. 21:117–123. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Li B, Gao MH, Chu XM, Teng L, Lv CY, Yang P and Yin QF: The synergistic antitumor effects of all-trans retinoic acid and C-phycocyanin on the lung cancer A549 cells in vitro and in vivo. Eur J Pharmacol. 749:107–114. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Greve G, Schiffmann I and Lübbert M: Epigenetic priming of non-small cell lung cancer cell lines to the antiproliferative and differentiating effects of all-trans retinoic acid. J Cancer Res Clin Oncol. 141:2171–2180. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Li HX, Zhao W, Shi Y, Li YN, Zhang LS, Zhang HQ and Wang D: Retinoic acid amide inhibits JAK/STAT pathway in lung cancer which leads to apoptosis. Tumour Biol. 36:8671–8678. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Chen D, Xie F, Sun D, Yin C, Gao J and Zhong Y: Nanomedicine-mediated combination drug therapy in tumor. Open Pharmaceutical Sci J. 4:1–10. 2017. View Article : Google Scholar

16 

Xie FY, Xu WH, Yin C, Zhang GQ, Zhong YQ and Gao J: Nanomedicine strategies for sustained, controlled, and targeted treatment of cancer stem cells of the digestive system. World J Gastrointest Oncol. 8:735–744. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Gao J, Feng SS and Guo Y: Nanomedicine against multidrug resistance in cancer treatment. Nanomedicine (Lond). 7:465–468. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Cristiano MC, Cosco D, Celia C, Tudose A, Mare R, Paolino D and Fresta M: Anticancer activity of all-trans retinoic acid-loaded liposomes on human thyroid carcinoma cells. Colloids Surf B Biointerfaces. 150:408–416. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Gao J, Xia Y, Chen H, Yu Y, Song J, Li W, Qian W, Wang H, Dai J and Guo Y: Polymer-lipid hybrid nanoparticles conjugated with anti-EGF receptor antibody for targeted drug delivery to hepatocellular carcinoma. Nanomedicine (Lond). 9:279–293. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Kapoor DN, Bhatia A, Kaur R, Sharma R, Kaur G and Dhawan S: PLGA: A unique polymer for drug delivery. Ther Deliv. 6:41–58. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Gao J, Chen H, Song H, Su X, Niu F, Li W, Li B, Dai J, Wang H and Guo Y: Antibody-targeted immunoliposomes for cancer treatment. Mini Rev Med Chem. 13:2026–2035. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Gao J, Feng SS and Guo Y: Antibody engineering promotes nanomedicine for cancer treatment. Nanomedicine (Lond). 5:1141–1145. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Wang J, Wu Z, Pan G, Ni J, Xie F, Jiang B, Wei L, Gao J and Zou W: Enhanced doxorubicin delivery to hepatocellular carcinoma cells via CD147 antibody-conjugated immunoliposomes. Nanomedicine. 14:1949–1691. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Herr JK, Smith JE, Medley CD, Shangguan D and Tan W: Aptamer-conjugated nanoparticles for selective collection and detection of cancer cells. Anal Chem. 78:2918–2924. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Xiao Z and Farokhzad OC: Aptamer-functionalized nanoparticles for medical applications: Challenges and opportunities. ACS Nano. 6:3670–3676. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Auffan M, Rose J, Bottero JY, Lowry GV, Jolivet JP and Wiesner MR: Towards a definition of inorganic nanoparticles from an environmental, health and safety perspective. Nat Nanotechnol. 4:634–641. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Cushing BL, Kolesnichenko VL and O'Connor CJ: Recent advances in the liquid-phase syntheses of inorganic nanoparticles. Chem Rev. 104:3893–3946. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Mamot C, Ritschard R, Wicki A, Stehle G, Dieterle T, Bubendorf L, Hilker C, Deuster S, Herrmann R and Rochlitz C: Tolerability, safety, pharmacokinetics, and efficacy of doxorubicin-loaded anti-EGFR immunoliposomes in advanced solid tumours: A phase 1 dose-escalation study. Lancet Oncol. 13:1234–1241. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Miller K, Cortes J, Hurvitz SA, Krop IE, Tripathy D, Verma S, Riahi K, Reynolds JG, Wickham TJ, Molnar I and Yardley DA: HERMIONE: A randomized Phase 2 trial of MM-302 plus trastuzumab versus chemotherapy of physician's choice plus trastuzumab in patients with previously treated, anthracycline-naïve, HER2-positive, locally advanced/metastatic breast cancer. BMC Cancer. 16:3522016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Zhao J, Sun J, Huang L and Li Q: Targeting lung cancer initiating cells by all‑trans retinoic acid‑loaded lipid‑PLGA nanoparticles with CD133 aptamers. Exp Ther Med 16: 4639-4649, 2018.
APA
Zhang, Y., Zhao, J., Sun, J., Huang, L., & Li, Q. (2018). Targeting lung cancer initiating cells by all‑trans retinoic acid‑loaded lipid‑PLGA nanoparticles with CD133 aptamers. Experimental and Therapeutic Medicine, 16, 4639-4649. https://doi.org/10.3892/etm.2018.6762
MLA
Zhang, Y., Zhao, J., Sun, J., Huang, L., Li, Q."Targeting lung cancer initiating cells by all‑trans retinoic acid‑loaded lipid‑PLGA nanoparticles with CD133 aptamers". Experimental and Therapeutic Medicine 16.6 (2018): 4639-4649.
Chicago
Zhang, Y., Zhao, J., Sun, J., Huang, L., Li, Q."Targeting lung cancer initiating cells by all‑trans retinoic acid‑loaded lipid‑PLGA nanoparticles with CD133 aptamers". Experimental and Therapeutic Medicine 16, no. 6 (2018): 4639-4649. https://doi.org/10.3892/etm.2018.6762
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Zhao J, Sun J, Huang L and Li Q: Targeting lung cancer initiating cells by all‑trans retinoic acid‑loaded lipid‑PLGA nanoparticles with CD133 aptamers. Exp Ther Med 16: 4639-4649, 2018.
APA
Zhang, Y., Zhao, J., Sun, J., Huang, L., & Li, Q. (2018). Targeting lung cancer initiating cells by all‑trans retinoic acid‑loaded lipid‑PLGA nanoparticles with CD133 aptamers. Experimental and Therapeutic Medicine, 16, 4639-4649. https://doi.org/10.3892/etm.2018.6762
MLA
Zhang, Y., Zhao, J., Sun, J., Huang, L., Li, Q."Targeting lung cancer initiating cells by all‑trans retinoic acid‑loaded lipid‑PLGA nanoparticles with CD133 aptamers". Experimental and Therapeutic Medicine 16.6 (2018): 4639-4649.
Chicago
Zhang, Y., Zhao, J., Sun, J., Huang, L., Li, Q."Targeting lung cancer initiating cells by all‑trans retinoic acid‑loaded lipid‑PLGA nanoparticles with CD133 aptamers". Experimental and Therapeutic Medicine 16, no. 6 (2018): 4639-4649. https://doi.org/10.3892/etm.2018.6762
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