Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2018 Volume 16 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2018 Volume 16 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Response of regulatory T cells to classic heat stroke in mice

  • Authors:
    • Jie Hu
    • Hong‑Jun Kang
    • Chao Liu
    • Pan Hu
    • Meng‑Meng Yang
    • Fei‑Hu Zhou
  • View Affiliations / Copyright

    Affiliations: Critical Care Medicine, Chinese PLA General Hospital, Beijing 100853, P.R. China
    Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4609-4615
    |
    Published online on: September 19, 2018
       https://doi.org/10.3892/etm.2018.6766
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Systemic inflammatory response syndrome (SIRS) is an important process associated with the pathogenesis of multiple organ failure resulting from heat stroke (HS). Alterations in the levels of circulating cytokines during the progression of SIRS have been well established. However, only a small number of studies have demonstrated the responses of lymphocytes during HS, and no studies have investigated immune‑regulatory cells, such as regulatory T cells (Tregs). Tregs have been revealed to be important in numerous inflammation‑associated diseases, and have exhibited promising therapeutic effects in both experimental and clinical trials. In the present study, the splenic Treg response in a classic HS mouse model was investigated, and the results demonstrated that total numbers of splenic Tregs were significantly decreased at 0, 24 and 72 h time intervals post‑heat stress. Furthermore, the immunosuppressive capacity of splenic Tregs on cluster of differentiation (CD)4+T cell expansion was revealed to be suppressed following heat stress. In addition, HS was demonstrated to downregulate the expression levels of surface inhibitory molecules (CD39, CD73 and cytotoxic T‑lymphocyte associated protein 4), as well as anti‑inflammatory cytokines [interleukin (IL)‑10, transforming growth factor‑β and IL‑35], in Tregs. It was hypothesized that the aforementioned Treg responses may contribute to SIRS during HS. To the best of our knowledge, the present study is the first study to investigate the response of Tregs to HS, and the results demonstrated that there were significant alterations regarding to the total number, and function, of splenic Tregs, as well as the expression levels of inhibitory surface molecules and secretory cytokines. These results may highlight a novel mechanism underlying the pathogenesis of HS, as well as identify a potential therapeutic target for SIRS in patients suffering from HS.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Leon LR and Helwig BG: Heat stroke: Role of the systemic inflammatory response. J Appl Physiol (1985). 109:1980–1988. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Leon LR and Bouchama A: Heat stroke. Compr Physiol. 5:611–647. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Hammami MM, Bouchama A, Shail E, Aboul-Enein HY and Al-Sedairy S: Lymphocyte subsets and adhesion molecules expression in heatstroke and heat stress. J Appl Physiol (1985). 84:1615–1621. 1998. View Article : Google Scholar : PubMed/NCBI

4 

van der Veeken J, Gonzalez AJ, Cho H, Arvey A, Hemmers S, Leslie CS and Rudensky AY: Memory of inflammation in regulatory T cells. Cell. 166:977–990. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Belkaid Y and Rouse BT: Natural regulatory T cells in infectious disease. Nat Immunol. 6:353–360. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Leon LR, DuBose DA and Mason CW: Heat stress induces a biphasic thermoregulatory response in mice. Am J Physiol Regul Integr Comp Physiol. 288:R197–R204. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Hu J, Zhang L, Wang N, Ding R, Cui S, Zhu F, Xie Y, Sun X, Wu D, Hong Q, et al: Mesenchymal stem cells attenuate ischemic acute kidney injury by inducing regulatory T cells through splenocyte interactions. Kidney Int. 84:521–531. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Csóka B, Németh ZH, Törő G, Koscsó B, Kókai E, Robson SC, Enjyoji K, Rolandelli RH, Erdélyi K, Pacher P and Haskó G: CD39 improves survival in microbial sepsis by attenuating systemic inflammation. FASEB J. 29:25–36. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Haskó G, Csóka B, Koscsó B, Chandra R, Pacher P, Thompson LF, Deitch EA, Spolarics Z, Virág L, Gergely P, et al: Ecto-5′-nucleotidase (CD73) decreases mortality and organ injury in sepsis. J Immunol. 187:4256–4267. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Schmetterer KG, Neunkirchner A and Pickl WF: Naturally occurring regulatory T cells: Markers, mechanisms, and manipulation. FASEB J. 26:2253–2276. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Huang H, Xu R, Lin F, Bao C, Wang S, Ji C, Li K, Jin L, Mu J, Wang Y, et al: High circulating CD39(+) regulatory T cells predict poor survival for sepsis patients. Int J Infect Dis. 30:57–63. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Tatura R, Zeschnigk M, Hansen W, Steinmann J, Vidigal PG, Hutzler M, Pastille E, Westendorf AM, Buer J and Kehrmann J: Relevance of Foxp3(+) regulatory T cells for early and late phases of murine sepsis. Immunology. 146:144–156. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Huo R, Wang L, Wang X, Zhao Y, Wang Y, Zhao X, Chang L, Liu SL, Tong D, Zhang H and Huang Y: Removal of regulatory T cells prevents secondary chronic infection but increases the mortality of subsequent sub-acute infection in sepsis mice. Oncotarget. 7:10962–10975. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Chen X, Feng Y, Shen X, Pan G, Fan G, Gao X, Han J and Zhu Y: Anti-sepsis protection of Xuebijing injection is mediated by differential regulation of pro- and anti-inflammatory Th17 and T regulatory cells in a murine model of polymicrobial sepsis. J Ethnopharmacol. 211:358–365. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Khamri W, Abeles RD, Hou TZ, Anderson AE, El-Masry A, Triantafyllou E, Bernsmeier C, Larsen FS, Singanayagam A, Kudo N, et al: Increased expression of cytotoxic T-lymphocyte-associated protein 4 by T cells, induced by B7 in Sera, reduces adaptive immunity in patients with acute liver failure. Gastroenterology. 153:263–276.e8. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T, Miyara M, Fehervari Z, Nomura T and Sakaguchi S: CTLA-4 control over Foxp3+ regulatory T cell function. Science. 322:271–275. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Chang KC, Burnham CA, Compton SM, Rasche DP, Mazuski RJ, McDonough JS, Unsinger J, Korman AJ, Green JM and Hotchkiss RS: Blockade of the negative co-stimulatory molecules PD-1 and CTLA-4 improves survival in primary and secondary fungal sepsis. Crit Care. 17:R852013. View Article : Google Scholar : PubMed/NCBI

19 

Savio LEB, de Andrade Mello P, Figliuolo VR, de Avelar Almeida TF, Santana PT, Oliveira SDS, Silva CLM, Feldbrügge L, Csizmadia E, Minshall RD, et al: CD39 limits P2X7 receptor inflammatory signaling and attenuates sepsis-induced liver injury. J Hepatol. 67:716–726. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Wei X, Zhang J, Gu Q, Huang M, Zhang W, Guo J and Zhou X: Reciprocal expression of IL-35 and IL-10 defines two distinct effector Treg subsets that are required for maintenance of immune tolerance. Cell Rep. 21:1853–1869. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Li M, Eckl J, Geiger C, Schendel DJ and Pohla H: A novel and effective method to generate human porcine-specific regulatory T cells with high expression of IL-10, TGF-β1 and IL-35. Sci Rep. 7:39742017. View Article : Google Scholar : PubMed/NCBI

22 

Fujio K, Yamamoto K and Okamura T: Overview of LAG-3-expressing, IL-10-producing regulatory T Cells. Curr Top Microbiol Immunol. 410:29–45. 2017.PubMed/NCBI

23 

Toyama M, Kudo D, Aoyagi T, Miyasaka T, Ishii K, Kanno E, Kaku M, Kushimoto S and Kawakami K: Attenuated accumulation of T cells and reduced production of interleukin 10 lead to the exacerbation of tissue injury in a mouse model of acute respiratory distress syndrome. Microbiol Immunol. 62:111–123. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Gao M, Liu LX, Wu FL, Zhang X, Li YY, Shi T, Li DZ and Han TT: The changes of Th17/Treg and related cytokines: IL-17, IL-23, IL-10, and TGF-β in respiratory syncytial virus bronchiolitis rat model. Iran J Allergy Asthma Immunol. 16:386–395. 2017.PubMed/NCBI

25 

Li F, Ji L, Wang W, Hua F, Zhan Y, Zou S, Yuan L, Ke Y, Min Z, Song D, et al: Insufficient secretion of IL-10 by Tregs compromised its control on over-activated CD4+ T effector cells in newly diagnosed adult immune thrombocytopenia patients. Immunol Res. 61:269–280. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Mohammadnia-Afrouzi M, Hosseini AZ, Khalili A, Abediankenari S, Amari A, Aghili B and Nataj HH: Altered microRNA Expression and immunosuppressive cytokine production by regulatory T cells of ulcerative colitis patients. Immunol Invest. 45:63–74. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Singh K, Kadesjö E, Lindroos J, Hjort M, Lundberg M, Espes D, Carlsson PO, Sandler S and Thorvaldson L: Interleukin-35 administration counteracts established murine type 1 diabetes-possible involvement of regulatory T cells. Sci Rep. 5:126332015. View Article : Google Scholar : PubMed/NCBI

28 

Tran DQ: TGF-β: The sword, the wand, and the shield of FOXP3(+) regulatory T cells. J Mol Cell Biol. 4:29–37. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Qiao YC, Shen J, Hong XZ, Liang L, Bo CS, Sui Y and Zhao HL: Changes of regulatory T cells, transforming growth factor-beta and interleukin-10 in patients with type 1 diabetes mellitus: A systematic review and meta-analysis. Clin Immunol. 170:61–69. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Luan YY, Yin CF, Qin QH, Dong N, Zhu XM, Sheng ZY, Zhang QH and Yao YM: Effect of regulatory T cells on promoting apoptosis of T lymphocyte and its regulatory mechanism in sepsis. J Interferon Cytokine Res. 35:969–980. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Hu J, Kang HJ, Liu C, Hu P, Yang MM and Zhou FH: Response of regulatory T cells to classic heat stroke in mice. Exp Ther Med 16: 4609-4615, 2018.
APA
Hu, J., Kang, H., Liu, C., Hu, P., Yang, M., & Zhou, F. (2018). Response of regulatory T cells to classic heat stroke in mice. Experimental and Therapeutic Medicine, 16, 4609-4615. https://doi.org/10.3892/etm.2018.6766
MLA
Hu, J., Kang, H., Liu, C., Hu, P., Yang, M., Zhou, F."Response of regulatory T cells to classic heat stroke in mice". Experimental and Therapeutic Medicine 16.6 (2018): 4609-4615.
Chicago
Hu, J., Kang, H., Liu, C., Hu, P., Yang, M., Zhou, F."Response of regulatory T cells to classic heat stroke in mice". Experimental and Therapeutic Medicine 16, no. 6 (2018): 4609-4615. https://doi.org/10.3892/etm.2018.6766
Copy and paste a formatted citation
x
Spandidos Publications style
Hu J, Kang HJ, Liu C, Hu P, Yang MM and Zhou FH: Response of regulatory T cells to classic heat stroke in mice. Exp Ther Med 16: 4609-4615, 2018.
APA
Hu, J., Kang, H., Liu, C., Hu, P., Yang, M., & Zhou, F. (2018). Response of regulatory T cells to classic heat stroke in mice. Experimental and Therapeutic Medicine, 16, 4609-4615. https://doi.org/10.3892/etm.2018.6766
MLA
Hu, J., Kang, H., Liu, C., Hu, P., Yang, M., Zhou, F."Response of regulatory T cells to classic heat stroke in mice". Experimental and Therapeutic Medicine 16.6 (2018): 4609-4615.
Chicago
Hu, J., Kang, H., Liu, C., Hu, P., Yang, M., Zhou, F."Response of regulatory T cells to classic heat stroke in mice". Experimental and Therapeutic Medicine 16, no. 6 (2018): 4609-4615. https://doi.org/10.3892/etm.2018.6766
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team