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Article

Clinicopathological analysis of the hydroa vacciniforme‑like lymphoproliferative disorder with natural killer cell phenotype compared with cutaneous natural killer T‑cell lymphoma

  • Authors:
    • Guan‑Nan Wang
    • Yong Cui
    • Wu‑Gan Zhao
    • Ling Li
    • Xu‑Dong Zhang
    • Yu Chang
    • Xian‑Zheng Gao
    • Ye Li
    • Ming‑Zhi Zhang
    • Wen‑Cai Li
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, Department of Urology, The First Affiliated Hospital of Henan University of TCM, Zhengzhou, Henan 450052, P.R. China, Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
  • Pages: 4772-4778
    |
    Published online on: September 19, 2018
       https://doi.org/10.3892/etm.2018.6768
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Abstract

Hydroa vacciniforme‑like lymphoproliferative disorder (HVLPD) is defined as a distinctive clinicopathological type of cutaneous lymphoma and a subset of patients with this disease exhibit the natural killer (NK)‑cell phenotype. The HVLPD‑NK cell phenotype may be difficult to distinguish from cutaneous natural killer T‑cell lymphoma (CNKTL), as these two diseases share similar immunophenotypic markers. Therefore, the aim of the present study was to analyze the clinicopathological features of this rare disease and compare these features with those of CNKTL. The clinical, histopathological and molecular features of 5 patients with the HVLPD‑NK cell phenotype and 11 patients with CNKTL were evaluated. As well as certain subtle histopathological differences, there marked differences the age, distribution of lesions and clinical course differed between patients with these two diseases. These results suggest that the HVLPD‑NK cell phenotype should be classified as a separate disorder and treated accordingly.
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Copy and paste a formatted citation
Spandidos Publications style
Wang GN, Cui Y, Zhao WG, Li L, Zhang XD, Chang Y, Gao XZ, Li Y, Zhang MZ, Li WC, Li WC, et al: Clinicopathological analysis of the hydroa vacciniforme‑like lymphoproliferative disorder with natural killer cell phenotype compared with cutaneous natural killer T‑cell lymphoma. Exp Ther Med 16: 4772-4778, 2018.
APA
Wang, G., Cui, Y., Zhao, W., Li, L., Zhang, X., Chang, Y. ... Li, W. (2018). Clinicopathological analysis of the hydroa vacciniforme‑like lymphoproliferative disorder with natural killer cell phenotype compared with cutaneous natural killer T‑cell lymphoma. Experimental and Therapeutic Medicine, 16, 4772-4778. https://doi.org/10.3892/etm.2018.6768
MLA
Wang, G., Cui, Y., Zhao, W., Li, L., Zhang, X., Chang, Y., Gao, X., Li, Y., Zhang, M., Li, W."Clinicopathological analysis of the hydroa vacciniforme‑like lymphoproliferative disorder with natural killer cell phenotype compared with cutaneous natural killer T‑cell lymphoma". Experimental and Therapeutic Medicine 16.6 (2018): 4772-4778.
Chicago
Wang, G., Cui, Y., Zhao, W., Li, L., Zhang, X., Chang, Y., Gao, X., Li, Y., Zhang, M., Li, W."Clinicopathological analysis of the hydroa vacciniforme‑like lymphoproliferative disorder with natural killer cell phenotype compared with cutaneous natural killer T‑cell lymphoma". Experimental and Therapeutic Medicine 16, no. 6 (2018): 4772-4778. https://doi.org/10.3892/etm.2018.6768
Copy and paste a formatted citation
x
Spandidos Publications style
Wang GN, Cui Y, Zhao WG, Li L, Zhang XD, Chang Y, Gao XZ, Li Y, Zhang MZ, Li WC, Li WC, et al: Clinicopathological analysis of the hydroa vacciniforme‑like lymphoproliferative disorder with natural killer cell phenotype compared with cutaneous natural killer T‑cell lymphoma. Exp Ther Med 16: 4772-4778, 2018.
APA
Wang, G., Cui, Y., Zhao, W., Li, L., Zhang, X., Chang, Y. ... Li, W. (2018). Clinicopathological analysis of the hydroa vacciniforme‑like lymphoproliferative disorder with natural killer cell phenotype compared with cutaneous natural killer T‑cell lymphoma. Experimental and Therapeutic Medicine, 16, 4772-4778. https://doi.org/10.3892/etm.2018.6768
MLA
Wang, G., Cui, Y., Zhao, W., Li, L., Zhang, X., Chang, Y., Gao, X., Li, Y., Zhang, M., Li, W."Clinicopathological analysis of the hydroa vacciniforme‑like lymphoproliferative disorder with natural killer cell phenotype compared with cutaneous natural killer T‑cell lymphoma". Experimental and Therapeutic Medicine 16.6 (2018): 4772-4778.
Chicago
Wang, G., Cui, Y., Zhao, W., Li, L., Zhang, X., Chang, Y., Gao, X., Li, Y., Zhang, M., Li, W."Clinicopathological analysis of the hydroa vacciniforme‑like lymphoproliferative disorder with natural killer cell phenotype compared with cutaneous natural killer T‑cell lymphoma". Experimental and Therapeutic Medicine 16, no. 6 (2018): 4772-4778. https://doi.org/10.3892/etm.2018.6768
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