Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2018 Volume 16 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2018 Volume 16 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Effects of dexmedetomidine on postoperative cognitive function in patients undergoing coronary artery bypass grafting

  • Authors:
    • Zheng Gong
    • Jun Li
    • Yuling Zhong
    • Xuehai Guan
    • Ailan Huang
    • Li Ma
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi 530021, P.R. China
  • Pages: 4685-4689
    |
    Published online on: September 19, 2018
       https://doi.org/10.3892/etm.2018.6778
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Effects of dexmedetomidine on postoperative cognitive function in patients undergoing coronary artery bypass grafting were investigated. Eighty patients undergoing systemic anesthesia with extracorporeal coronary artery bypass grafting in The People's Hospital of Guangxi Zhuang Autonomous Region from January 2015 to August 2017 were selected and randomly divided into the observation group (n=40) and control group (n=40). The two groups were treated with dexmedetomidine and equal volume of normal saline, respectively. Moreover, safety indexes including EEG bispectral index (BIS) at 30 min before induction of anesthesia (T0), immediately after intubation (T1), when incision was made (T2), when chest was closed (T3), when operation was completed (T4) and at 6 h after operation (T5), intraoperative circulatory system-related complications, cortisol, epinephrine and norepinephrine levels at the end of surgery as well as anesthesia recovery time and postoperative mechanical ventilation time were recorded and compared. All the patients were followed up for 1 week. Mini-mental state examination (MMSE) and Montreal cognitive assessment (MoCA) were administered at 1, 3 and 7 days after operation, and the incidence of intraoperative awareness and postoperative cognitive dysfunction was recorded. BIS value in the observation group was lower than that in the control group (P<0.05) at T1-T4 time points, and the BIS value in the observation group was higher than that in the control group (P<0.05) at T5. Incidence rates of intraoperative arrhythmia, hypertension and hypotension in the observation group was significantly lower than those in the control group (P<0.05). At the end of operation, levels of cortisol, epinephrine and norepinephrine in the observation group were significantly lower than those in the control group (P<0.05). Anesthesia recovery time and postoperative mechanical ventilation time in the observation group was significantly shorter than the time in the control group (P<0.05). MMSE and MoCA scores of the observation group were better than those of the control group (P<0.05). The incidence of cognitive impairment and postoperative cognitive impairment in the observation group was significantly lower than those in the control group (P<0.05). Therefore, it is concluded that dexmedetomidine can effectively reduce the incidence of postoperative cognitive impairment in patients undergoing coronary artery bypass grafting, and it is of high safety for circulatory function.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Jo YY, Kim JY, Lee JY, Choi CH, Chang YJ and Kwak HJ: The effect of intraoperative dexmedetomidine on acute kidney injury after pediatric congenital heart surgery: A prospective randomized trial. Medicine (Baltimore). 96:e74802017. View Article : Google Scholar : PubMed/NCBI

2 

Anton-Martin P, Modem V, Taylor D, Potter D and Darnell-Bowens C: A retrospective study of sedation and analgesic requirements of pediatric patients on extracorporeal membrane oxygenation (ECMO) from a single-center experience. Perfusion. 32:183–191. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Bulow NMH, Colpo E, Pereira RP, Correa EFM, Waczuk EP, Duarte MF and Rocha JBT: Dexmedetomidine decreases the inflammatory response to myocardial surgery under mini-cardiopulmonary bypass. Braz J Med Biol Res. 49:e46462016. View Article : Google Scholar : PubMed/NCBI

4 

Cheng X, Zuo Y, Zhao Q, Gu E and Huang Y: Comparison of the effects of dexmedetomidine and propofol on hemodynamics and oxygen balance in children with complex congenital heart disease undergoing cardiac surgery. Congenit Heart Dis. 10:E123–E130. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Klamt JG, Vicente WV, Garcia LV and Ferreira CA: Hemodynamic effects of the combination of dexmedetomidine-fentanyl versus midazolam-fentanyl in children undergoing cardiac surgery with cardiopulmonary bypass. Rev Bras Anestesiol. 60:350–362. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Tang W, Wang J, Fu GQ and Yuan L: Effect of dexmedetomidine and midazolam on respiration and circulation functions in patients undergoing open heart surgery under acupuncture-assisted general anesthesia. Zhen Ci Yan Jiu. 39:216–221. 2014.(In Chinese). PubMed/NCBI

7 

Ueki M, Kawasaki T, Habe K, Hamada K, Kawasaki C and Sata T: The effects of dexmedetomidine on inflammatory mediators after cardiopulmonary bypass. Anaesthesia. 69:693–700. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Ji F, Li Z, Young JN, Yeranossian A and Liu H: Post-bypass dexmedetomidine use and postoperative acute kidney injury in patients undergoing cardiac surgery with cardiopulmonary bypass. PLoS One. 8:e774462013. View Article : Google Scholar : PubMed/NCBI

9 

Lu JG, Pensiero A, Aponte-Patel L, de Villa Velez B, Rusanov A, Cheng B, Cabreriza SE and Spotnitz HM: Short-term reduction in intrinsic heart rate during biventricular pacing after cardiac surgery: A substudy of a randomized clinical trial. J Thorac Cardiovasc Surg. 146:1494–1500. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Curtis JA, Hollinger MK and Jain HB: Propofol-based versus dexmedetomidine-based sedation in cardiac surgery patients. J Cardiothorac Vasc Anesth. 27:1289–1294. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Bhaskar P, John J, Sivamurthy SK, Lone RA, Tysarowski PA, Riyas MK, Syed SA, Bhat AN and Sallehuddin A: Anesthetic management of an infant with Joubert syndrome for cardiac surgery. J Clin Anesth. 25:488–490. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Naguib AN, Tobias JD, Hall MW, Cismowski MJ, Miao Y, Barry N, Preston T, Galantowicz M and Hoffman TM: The role of different anesthetic techniques in altering the stress response during cardiac surgery in children: A prospective, double-blinded, and randomized study. Pediatr Crit Care Med. 14:481–490. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Wagner D, Pasko D, Phillips K, Waldvogel J and Annich G: In vitro clearance of dexmedetomidine in extracorporeal membrane oxygenation. Perfusion. 28:40–46. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Neema PK: Dexmedetomidine in pediatric cardiac anesthesia. Ann Card Anaesth. 15:177–179. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Yoshitomi O, Cho S, Hara T, Shibata I, Maekawa T, Ureshino H and Sumikawa K: Direct protective effects of dexmedetomidine against myocardial ischemia-reperfusion injury in anesthetized pigs. Shock. 38:92–97. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Kunisawa T, Ueno M, Kurosawa A, Nagashima M, Hayashi D, Sasakawa T, Suzuki A, Takahata O and Iwasaki H: Dexmedeto-midine can stabilize hemodynamics and spare anesthetics before cardiopulmonary bypass. J Anesth. 25:818–822. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Huang J, Dinh M, Kuchle N and Zhou J: Anesthetic management for combined mitral valve replacement and aortic valve repair in a patient with osteogenesis imperfecta. Ann Card Anaesth. 14:115–118. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Leino K, Hynynen M, Jalonen J, Salmenperä M, Scheinin H and Aantaa R; Dexmedetomidine in Cardiac Surgery Study Group, : Renal effects of dexmedetomidine during coronary artery bypass surgery: A randomized placebo-controlled study. BMC Anesthesiol. 11:92011. View Article : Google Scholar : PubMed/NCBI

19 

Butt WW: Minimize stress and maximize clinical outcome! Pediatr Crit Care Med. 14:1–548. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Maldonado JR, Wysong A, van der Starre PJ, Block T, Miller C and Reitz BA: Dexmedetomidine and the reduction of postoperative delirium after cardiac surgery. Psychosomatics. 50:206–217. 2009. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Gong Z, Li J, Zhong Y, Guan X, Huang A and Ma L: Effects of dexmedetomidine on postoperative cognitive function in patients undergoing coronary artery bypass grafting. Exp Ther Med 16: 4685-4689, 2018.
APA
Gong, Z., Li, J., Zhong, Y., Guan, X., Huang, A., & Ma, L. (2018). Effects of dexmedetomidine on postoperative cognitive function in patients undergoing coronary artery bypass grafting. Experimental and Therapeutic Medicine, 16, 4685-4689. https://doi.org/10.3892/etm.2018.6778
MLA
Gong, Z., Li, J., Zhong, Y., Guan, X., Huang, A., Ma, L."Effects of dexmedetomidine on postoperative cognitive function in patients undergoing coronary artery bypass grafting". Experimental and Therapeutic Medicine 16.6 (2018): 4685-4689.
Chicago
Gong, Z., Li, J., Zhong, Y., Guan, X., Huang, A., Ma, L."Effects of dexmedetomidine on postoperative cognitive function in patients undergoing coronary artery bypass grafting". Experimental and Therapeutic Medicine 16, no. 6 (2018): 4685-4689. https://doi.org/10.3892/etm.2018.6778
Copy and paste a formatted citation
x
Spandidos Publications style
Gong Z, Li J, Zhong Y, Guan X, Huang A and Ma L: Effects of dexmedetomidine on postoperative cognitive function in patients undergoing coronary artery bypass grafting. Exp Ther Med 16: 4685-4689, 2018.
APA
Gong, Z., Li, J., Zhong, Y., Guan, X., Huang, A., & Ma, L. (2018). Effects of dexmedetomidine on postoperative cognitive function in patients undergoing coronary artery bypass grafting. Experimental and Therapeutic Medicine, 16, 4685-4689. https://doi.org/10.3892/etm.2018.6778
MLA
Gong, Z., Li, J., Zhong, Y., Guan, X., Huang, A., Ma, L."Effects of dexmedetomidine on postoperative cognitive function in patients undergoing coronary artery bypass grafting". Experimental and Therapeutic Medicine 16.6 (2018): 4685-4689.
Chicago
Gong, Z., Li, J., Zhong, Y., Guan, X., Huang, A., Ma, L."Effects of dexmedetomidine on postoperative cognitive function in patients undergoing coronary artery bypass grafting". Experimental and Therapeutic Medicine 16, no. 6 (2018): 4685-4689. https://doi.org/10.3892/etm.2018.6778
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team