Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2018 Volume 16 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2018 Volume 16 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Steroid sulfatase promotes invasion through epithelial‑mesenchymal transition and predicts the progression of bladder cancer

  • Authors:
    • Yasuomi Shimizu
    • Satoshi Tamada
    • Minoru Kato
    • Yuji Takeyama
    • Masaki Fujioka
    • Anna Kakehashi
    • Tatsuya Nakatani
    • Hideki Wanibuchi
    • Min Gi
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Osaka City University Graduate School of Medicine, Osaka 545‑8585, Japan, Department of Pathology, Osaka City University Graduate School of Medicine, Osaka 545‑8585, Japan
    Copyright: © Shimizu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4463-4470
    |
    Published online on: September 21, 2018
       https://doi.org/10.3892/etm.2018.6787
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Androgen signal has been recently suggested to be associated with the progression of bladder cancer. Steroid sulfatase (STS) is a steroid sulfate activation enzyme, considered to be one of the key enzymes in the androgen signaling pathway. However, the role of STS in bladder cancer has not been elucidated. The purpose of the present study was to determine the clinical and functional significance of STS in bladder cancer. Immunohistochemical analysis of surgical specimens obtained by radical cystectomy (n=114) demonstrated that overexpression of STS was associated with the invasion of bladder cancer, as evidenced by the incidence of STS‑positive cancers (11.5 and 37.1% in non‑muscle invasive and muscle invasive bladder cancers, respectively; P=0.003). STS‑positive cancer demonstrated shorter recurrence‑free survival and cancer‑specific survival (P=0.0027 and 0.0030, respectively). Furthermore, knockdown of STS significantly reduced cell migration and invasion capacities of bladder cancer cells (P<0.001 and P=0.005, respectively), accompanied by the upregulation of E‑cadherin and downregulation of vimentin. In summary, the present study demonstrated that STS promotes the invasion capability of bladder cancer via regulation of the epithelial‑mesenchymal transition, and may be a useful marker for predicting the progression of bladder cancers.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Siegel R, Ward E, Brawley O and Jemal A: Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin. 61:212–236. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Hartge P, Harvey EB, Linehan WM, Silverman DT, Sullivan JW, Hoover RN and Fraumeni JF Jr: Unexplained excess risk of bladder cancer in men. J Natl Cancer Inst. 82:1636–1640. 1990. View Article : Google Scholar : PubMed/NCBI

3 

Hemelt M, Yamamoto H, Cheng KK and Zeegers MP: The effect of smoking on the male excess of bladder cancer: A meta-analysis and geographical analyses. Int J Cancer. 124:412–419. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Kato M, Wei M, Yamano S, Kakehashi A, Tamada S, Nakatani T and Wanibuchi H: DDX39 acts as a suppressor of invasion for bladder cancer. Cancer Sci. 103:1363–1369. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Imada S, Akaza H, Ami Y, Koiso K, Ideyama Y and Takenaka T: Promoting effects and mechanisms of action of androgen in bladder carcinogenesis in male rats. Eur Urol. 31:360–364. 1997. View Article : Google Scholar : PubMed/NCBI

6 

Miyamoto H, Yang Z, Chen YT, Ishiguro H, Uemura H, Kubota Y, Nagashima Y, Chang YJ, Hu YC, Tsai MY, et al: Promotion of bladder cancer development and progression by androgen receptor signals. J Natl Cancer Inst. 99:558–568. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Shiota M, Takeuchi A, Yokomizo A, Kashiwagi E, Tatsugami K, Kuroiwa K and Naito S: Androgen receptor signaling regulates cell growth and vulnerability to doxorubicin in bladder cancer. J Urol. 188:276–286. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Mir C, Shariat SF, van der Kwast TH, Ashfaq R, Lotan Y, Evans A, Skeldon S, Hanna S, Vajpeyi R, Kuk C, et al: Loss of androgen receptor expression is not associated with pathological stage, grade, gender or outcome in bladder cancer: A large multi-institutional study. BJU Int. 108:24–30. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Johnson AM, O'Connell MJ, Miyamoto H, Huang J, Yao JL, Messing EM and Reeder JE: Androgenic dependence of exophytic tumor growth in a transgenic mouse model of bladder cancer: A role for thrombospondin-1. BMC Urol. 8:72008. View Article : Google Scholar : PubMed/NCBI

10 

Rainey WE, Carr BR, Sasano H, Suzuki T and Mason JI: Dissecting human adrenal androgen production. Trends Endocrinol Metab. 13:234–239. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Selcer KW, Kabler H, Sarap J, Xiao Z and Li PK: Inhibition of steryl sulfatase activity in LNCaP human prostate cancer cells. Steroids. 67:821–826. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Purohit A and Foster PA: Steroid sulfatase inhibitors for estrogen- and androgen-dependent cancers. J Endocrinol. 212:99–110. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Nakamura Y, Suzuki T, Fukuda T, Ito A, Endo M, Moriya T, Arai Y and Sasano H: Steroid sulfatase and estrogen sulfotransferase in human prostate cancer. Prostate. 66:1005–1012. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Sobin LH and Compton CC: TNM seventh edition: What's new, what's changed: Communication from the International Union Against Cancer and the American Joint Committee on Cancer. Cancer. 116:5336–5339. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Montironi R and Lopez-Beltran A: The 2004 WHO classification of bladder tumors: A summary and commentary. Int J Surg Pathol. 13:143–153. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Tachibana H, Gi M, Kato M, Yamano S, Fujioka M, Kakehashi A, Hirayama Y, Koyama Y, Tamada S, Nakatani T and Wanibuchi H: Carbonic anhydrase 2 is a novel invasion-associated factor in urinary bladder cancers. Cancer Sci. 108:331–337. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Lee WM, Jang KS, Bae J and Koh AR: The role of steroid sulfatase as a prognostic factor in patients with endometrial cancer. Yonsei Med J. 57:754–760. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Gravdal K, Halvorsen OJ, Haukaas SA and Akslen L: A switch from E-cadherin to N-cadherin expression indicates epithelial to mesenchymal transition and is of strong and independent importance for the progress of prostate cancer. Clin Cancer Res. 13:7003–7011. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Zhang Q, Helfand BT, Jang TL, Zhu LJ, Chen L, Yang XJ, Kozlowski J, Smith N, Kundu SD, Yang G, et al: Nuclear factor-kappaB-mediated transforming growth factor-beta-induced expression of vimentin is an independent predictor of biochemical recurrence after radical prostatectomy. Clin Cancer Res. 15:3557–3567. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Mendez MG, Kojima S and Goldman RD: Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition. FASEB J. 24:1838–1851. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Sánchez-Tilló E, Lázaro A, Torrent R, Cuatrecasas M, Vaquero EC, Castells A, Engel P and Postigo A: ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1. Oncogene. 29:3490–3500. 2010. View Article : Google Scholar : PubMed/NCBI

23 

McConkey DJ, Choi W, Marquis L, Martin F, Williams MB, Shah J, Svatek R, Das A, Adam L, Kamat A, et al: Role of epithelial-to-mesenchymal transition (EMT) in drug sensitivity and metastasis in bladder cancer. Cancer Metastasis Rev. 28:335–344. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Suh BY, Jung JJ, Park N, Seong CH, Im HJ, Kwon Y, Kim D and Chun YJ: Induction of steroid sulfatase expression by tumor necrosis factor-α through phosphatidylinositol 3-kinase/Akt signaling pathway in PC-3 human prostate cancer cells. Exp Mol Med. 43:646–652. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Hughes PJ, Steinmeyer A, Chandraratna RA and Brown G: 1alpha,25-dihydroxyvitamin D3 stimulates steroid sulphatase activity in HL60 and NB4 acute myeloid leukaemia cell lines by different receptor-mediated mechanisms. J Cell Biochem. 94:1175–1189. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Shin S, Im HJ, Kwon YJ, Ye DJ, Baek HS, Kim D, Choi HK and Chun YJ: Human steroid sulfatase induces Wnt/β-catenin signaling and epithelial-mesenchymal transition by upregulating Twist1 and HIF-1α in human prostate and cervical cancer cells. Oncotarget. 8:61604–61617. 2017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Shimizu Y, Tamada S, Kato M, Takeyama Y, Fujioka M, Kakehashi A, Nakatani T, Wanibuchi H and Gi M: Steroid sulfatase promotes invasion through epithelial‑mesenchymal transition and predicts the progression of bladder cancer. Exp Ther Med 16: 4463-4470, 2018.
APA
Shimizu, Y., Tamada, S., Kato, M., Takeyama, Y., Fujioka, M., Kakehashi, A. ... Gi, M. (2018). Steroid sulfatase promotes invasion through epithelial‑mesenchymal transition and predicts the progression of bladder cancer. Experimental and Therapeutic Medicine, 16, 4463-4470. https://doi.org/10.3892/etm.2018.6787
MLA
Shimizu, Y., Tamada, S., Kato, M., Takeyama, Y., Fujioka, M., Kakehashi, A., Nakatani, T., Wanibuchi, H., Gi, M."Steroid sulfatase promotes invasion through epithelial‑mesenchymal transition and predicts the progression of bladder cancer". Experimental and Therapeutic Medicine 16.6 (2018): 4463-4470.
Chicago
Shimizu, Y., Tamada, S., Kato, M., Takeyama, Y., Fujioka, M., Kakehashi, A., Nakatani, T., Wanibuchi, H., Gi, M."Steroid sulfatase promotes invasion through epithelial‑mesenchymal transition and predicts the progression of bladder cancer". Experimental and Therapeutic Medicine 16, no. 6 (2018): 4463-4470. https://doi.org/10.3892/etm.2018.6787
Copy and paste a formatted citation
x
Spandidos Publications style
Shimizu Y, Tamada S, Kato M, Takeyama Y, Fujioka M, Kakehashi A, Nakatani T, Wanibuchi H and Gi M: Steroid sulfatase promotes invasion through epithelial‑mesenchymal transition and predicts the progression of bladder cancer. Exp Ther Med 16: 4463-4470, 2018.
APA
Shimizu, Y., Tamada, S., Kato, M., Takeyama, Y., Fujioka, M., Kakehashi, A. ... Gi, M. (2018). Steroid sulfatase promotes invasion through epithelial‑mesenchymal transition and predicts the progression of bladder cancer. Experimental and Therapeutic Medicine, 16, 4463-4470. https://doi.org/10.3892/etm.2018.6787
MLA
Shimizu, Y., Tamada, S., Kato, M., Takeyama, Y., Fujioka, M., Kakehashi, A., Nakatani, T., Wanibuchi, H., Gi, M."Steroid sulfatase promotes invasion through epithelial‑mesenchymal transition and predicts the progression of bladder cancer". Experimental and Therapeutic Medicine 16.6 (2018): 4463-4470.
Chicago
Shimizu, Y., Tamada, S., Kato, M., Takeyama, Y., Fujioka, M., Kakehashi, A., Nakatani, T., Wanibuchi, H., Gi, M."Steroid sulfatase promotes invasion through epithelial‑mesenchymal transition and predicts the progression of bladder cancer". Experimental and Therapeutic Medicine 16, no. 6 (2018): 4463-4470. https://doi.org/10.3892/etm.2018.6787
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team