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Article

Overexpression of epithelial cell adhesion molecule as a predictor of poor outcome in patients with hepatocellular carcinoma

  • Authors:
    • Chih‑Jan Ko
    • Chia‑Jung Li
    • Meng‑Yu Wu
    • Pei‑Yi Chu
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Changhua Christian Hospital, Changhua 500, Taiwan, R.O.C., Research Assistant Center, Show Chwan Memorial Hospital, Changhua 500, Taiwan, R.O.C., Department of Emergency Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei 231, Taiwan, R.O.C., School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei 242, Taiwan, R.O.C.
  • Pages: 4810-4816
    |
    Published online on: September 26, 2018
       https://doi.org/10.3892/etm.2018.6794
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Abstract

Cancer growth, metastasis and development are regulated by a number of genes, whose expression mediates important processes, including cellular plasticity, motility and internal interactions in the tumor microenvironment. The epithelial cell adhesion molecule (EpCAM) serves an important role in cell‑cell migration and tumorigenicity, particularly metastasis. The aim of the present study was to measure EpCAM expression using immunohistochemistry and to investigate the association between clinicopathological features and prognosis in hepatocellular carcinoma (HCC). The results revealed that EpCAM expression may be a biomarker for poor prognosis in patients with HCC and may therefore be used to predict clinical outcome. The present study suggests that EpCAM expression in HCC can be considered as a routine biomarker for unfavorable prognosis and may provide a basis for the future development of anti‑EpCAM‑targeted therapy.
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1 

Chen DS: Hepatocellular carcinoma in taiwan. Hepatol Res. 2 Suppl 37:S101–S105. 2007. View Article : Google Scholar

2 

Hung TH, Liang CM, Hsu CN, Tai WC, Tsai KL, Ku MK, Wang JW, Tseng KL, Yuan LT, Nguang SH, et al: Association between complicated liver cirrhosis and the risk of hepatocellular carcinoma in taiwan. PLoS one. 12:e01818582017. View Article : Google Scholar : PubMed/NCBI

3 

Kim GA, Lee HC, Choe J, Kim MJ, Lee MJ, Chang HS, Bae IY, Kim HK, An J, Shim JH, et al: Association between non-alcoholic fatty liver disease and cancer incidence rate. J Hepatol. 2:32294–32298. 2017.

4 

Huang YT, Yang HI, Liu J, Lee MH, Freeman JR and Chen CJ: Mediation analysis of hepatitis b and c in relation to hepatocellular carcinoma risk. Epidemiology. 27:14–20. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Altekruse SF, McGlynn KA and Reichman ME: Hepatocellular carcinoma incidence, mortality, and survival trends in the united states from 1975 to 2005. J Clin Oncol. 27:1485–1491. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Tazi el M, Essadi I, M'Rabti H, Touyar A and Errihani PH: Systemic treatment and targeted therapy in patients with advanced hepatocellular carcinoma. N Am J Med Sci. 3:167–175. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Yuan S, Wang J, Yang Y, Zhang J, Liu H, Xiao J, Xu Q, Huang X, Xiang B, Zhu S, et al: The prediction of clinical outcome in hepatocellular carcinoma based on a six-gene metastasis signature. Clini Cancer Res. 23:289–297. 2017. View Article : Google Scholar

8 

Yu GP, Xiao QY, Shi ZQ, Tang LS, Ma XP, Zhang LY, Chen HT, Wang WJ, Zhang PY, Ding DL, et al: Genetic polymorphisms in apoptosis-related genes and the prognosis of hepatocellular carcinoma. Am J Cancer Res. 5:3249–3259. 2015.PubMed/NCBI

9 

Cai J, Li B, Zhu Y, Fang X, Zhu M, Wang M, Liu S, Jiang X, Zheng J, Zhang X and Chen P: Prognostic biomarker identification through integrating the gene signatures of hepatocellular carcinoma properties. EbioMedicine. 19:18–30. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Song BN and Chu IS: A gene expression signature of FOXM1 predicts the prognosis of hepatocellular carcinoma. Exp Mol Med. 50:e4182018. View Article : Google Scholar : PubMed/NCBI

11 

Llovet JM and Bruix J: Testing molecular therapies in hepatocellular carcinoma: The need for randomized phase II trials. J Clin Oncol. 27:833–835. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Ringelhan M, Pfister D, O'Connor T, Pikarsky E and Heikenwalder M: The immunology of hepatocellular carcinoma. Nat Immunol. 19:222–232. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Zhou Y, Wang B, Wu J, Zhang C, Zhou Y, Yang X, Zhou J, Guo W and Fan J: Association of preoperative EpCAM circulating tumor cells and peripheral treg cell levels with early recurrence of hepatocellular carcinoma following radical hepatic resection. BMC Cancer. 16:5062016. View Article : Google Scholar : PubMed/NCBI

14 

Wang MH, Sun R, Zhou XM, Zhang MY, Lu JB, Yang Y, Zeng LS, Yang XZ, Shi L, Xiao RW, et al: Epithelial cell adhesion molecule overexpression regulates epithelial-mesenchymal transition, stemness and metastasis of nasopharyngeal carcinoma cells via the PTEN/AKT/mTOR pathway. Cell Death Dis. 9:22018. View Article : Google Scholar : PubMed/NCBI

15 

Beer TW, Shepherd P and Theaker JM: Ber EP4 and epithelial membrane antigen aid distinction of basal cell, squamous cell and basosquamous carcinomas of the skin. Histopathology. 37:218–223. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Sheibani K, Shin SS, Kezirian J and Weiss LM: Ber-EP4 antibody as a discriminant in the differential diagnosis of malignant mesothelioma versus adenocarcinoma. Am J Surg Pathol. 15:779–784. 1991. View Article : Google Scholar : PubMed/NCBI

17 

Chen YL, Chen PM, Lin PY, Hsiau YT and Chu PY: ABCG2 overexpression confers poor outcomes in hepatocellular carcinoma of elderly patients. Anticancer Res. 36:2983–2988. 2016.PubMed/NCBI

18 

Yu HC, Hung MH, Chen YL, Chu PY, Wang CY, Chao TT, Liu CY, Shiau CW and Chen KF: Erlotinib derivative inhibits hepatocellular carcinoma by targeting CIP2A to reactivate protein phosphatase 2A. Cell Death Dis. 5:e13592014. View Article : Google Scholar : PubMed/NCBI

19 

Maetzel D, Denzel S, Mack B, Canis M, Went P, Benk M, Kieu C, Papior P, Baeuerle PA, Munz M and Gires O: Nuclear signalling by tumour-associated antigen EpCAM. Nat Cell Biol. 11:162–171. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Litvinov SV, van Driel W, van Rhijn CM, Bakker HA, van Krieken H, Fleuren GJ and Warnaar SO: Expression of Ep-CAM in cervical squamous epithelia correlates with an increased proliferation and the disappearance of markers for terminal differentiation. Am J Pathol. 148:865–875. 1996.PubMed/NCBI

21 

Osta WA, Chen Y, Mikhitarian K, Mitas M, Salem M, Hannun YA, Cole DJ and Gillanders WE: EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy. Cancer Res. 64:5818–5824. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Chaves-Perez A, Mack B, Maetzel D, Kremling H, Eggert C, Harréus U and Gires O: EpCAM regulates cell cycle progression via control of cyclin D1 expression. Oncogene. 32:641–650. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Yamashita T, Budhu A, Forgues M and Wang XW: Activation of hepatic stem cell marker EpCAM by Wnt-beta-catenin signaling in hepatocellular carcinoma. Cancer Res. 67:10831–10839. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Spizzo G, Went P, Dirnhofer S, Obrist P, Simon R, Spichtin H, Maurer R, Metzger U, von Castelberg B, Bart R, et al: High Ep-CAM expression is associated with poor prognosis in node-positive breast cancer. Breast cancer Res Treat. 86:207–213. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Spizzo G, Went P, Dirnhofer S, Obrist P, Moch H, Baeuerle PA, Mueller-Holzner E, Marth C, Gastl G and Zeimet AG: Overexpression of epithelial cell adhesion molecule (Ep-CAM) is an independent prognostic marker for reduced survival of patients with epithelial ovarian cancer. Gynecol Oncol. 103:483–488. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Stoecklein NH, Siegmund A, Scheunemann P, Luebke AM, Erbersdobler A, Verde PE, Eisenberger CF, Peiper M, Rehders A, Esch JS, et al: Ep-CAM expression in squamous cell carcinoma of the esophagus: A potential therapeutic target and prognostic marker. BMC Cancer. 6:1652006. View Article : Google Scholar : PubMed/NCBI

27 

Schmelzer E, Wauthier E and Reid LM: The phenotypes of pluripotent human hepatic progenitors. Stem Cells. 24:1852–1858. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Bae JS, Noh SJ, Jang KY, Park HS, Chung MJ, Park CK and Moon WS: Expression and role of epithelial cell adhesion molecule in dysplastic nodule and hepatocellular carcinoma. Int J Oncol. 41:2150–2158. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Yeh CT, Kuo CJ, Lai MW, Chen TC, Lin CY, Yeh TS and Lee WC: CD133-positive hepatocellular carcinoma in an area endemic for hepatitis B virus infection. BMC Cancer. 9:3242009. View Article : Google Scholar : PubMed/NCBI

30 

Kim H, Choi GH, Na DC, Ahn EY, Kim GI, Lee JE, Cho JY, Yoo JE, Choi JS and Park YN: Human hepatocellular carcinomas with ‘Stemness’-related marker expression: Keratin 19 expression and a poor prognosis. Hepatology. 54:1707–1717. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Yang XR, Xu Y, Yu B, Zhou J, Qiu SJ, Shi GM, Zhang BH, Wu WZ, Shi YH, Wu B, et al: High expression levels of putative hepatic stem/progenitor cell biomarkers related to tumour angiogenesis and poor prognosis of hepatocellular carcinoma. Gut. 59:953–962. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Shan YF, Huang YL, Xie YK, Tan YH, Chen BC, Zhou MT, Shi HQ, Yu ZP, Song QT and Zhang QY: Angiogenesis and clinicopathologic characteristics in different hepatocellular carcinoma subtypes defined by EpCAM and α-fetoprotein expression status. Med Oncol. 28:1012–1016. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Yamashita T, Forgues M, Wang W, Kim JW, Ye Q, Jia H, Budhu A, Zanetti KA, Chen Y, Qin LX, et al: EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma. Cancer Res. 68:1451–1461. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Sung JJ, Noh SJ, Bae JS, Park HS, Jang KY, Chung MJ and Moon WS: Immunohistochemical expression and clinical significance of suggested stem cell markers in hepatocellular carcinoma. J Pathol Transl Med. 50:52–57. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Fong D, Seeber A, Terracciano L, Kasal A, Mazzoleni G, Lehne F, Gastl G and Spizzo G: Expression of EpCAM(MF) and EpCAM(MT) variants in human carcinomas. J Clin Pathol. 67:408–414. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Liu CJ, Chen PJ, Chen DS, Tseng TC and Kao JH: Perspectives on dual hepatitis B and C infection in taiwan. J Formos Med Assoc. 115:298–305. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Hussain SP, Schwank J, Staib F, Wang XW and Harris CC: TP53 mutations and hepatocellular carcinoma: Insights into the etiology and pathogenesis of liver cancer. Oncogene. 26:2166–2176. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Vilchez V, Turcios L, Marti F and Gedaly R: Targeting Wnt/β-catenin pathway in hepatocellular carcinoma treatment. World J Gastroenterol. 22:823–832. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Shi F, Lian S, Wu P and Shen L: Transarterial chemoembolization with or without microwave ablation in the treatment of intermediate (BCLC B) hepatocellular carcinoma. J Clin Oncol. 35:e156352017. View Article : Google Scholar

40 

Kimura O, Kondo Y, Kogure T, Kakazu E, Ninomiya M, Iwata T, Morosawa T and Shimosegawa T: Expression of EpCAM increases in the Hepatitis B related and the treatment-resistant hepatocellular carcinoma. BioMed Res Int. 2014:1729132014. View Article : Google Scholar : PubMed/NCBI

41 

Seino S, Tsuchiya A, Watanabe Y, Kawata Y, Kojima Y, Ikarashi S, Yanai H, Nakamura K, Kumaki D, Hirano M, et al: Clinical outcome of hepatocellular carcinoma can be predicted by the expression of hepatic progenitor cell markers and serum tumour markers. Oncotarget. 9:21844–21860. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ko CJ, Li CJ, Wu MY and Chu PY: Overexpression of epithelial cell adhesion molecule as a predictor of poor outcome in patients with hepatocellular carcinoma. Exp Ther Med 16: 4810-4816, 2018.
APA
Ko, C., Li, C., Wu, M., & Chu, P. (2018). Overexpression of epithelial cell adhesion molecule as a predictor of poor outcome in patients with hepatocellular carcinoma. Experimental and Therapeutic Medicine, 16, 4810-4816. https://doi.org/10.3892/etm.2018.6794
MLA
Ko, C., Li, C., Wu, M., Chu, P."Overexpression of epithelial cell adhesion molecule as a predictor of poor outcome in patients with hepatocellular carcinoma". Experimental and Therapeutic Medicine 16.6 (2018): 4810-4816.
Chicago
Ko, C., Li, C., Wu, M., Chu, P."Overexpression of epithelial cell adhesion molecule as a predictor of poor outcome in patients with hepatocellular carcinoma". Experimental and Therapeutic Medicine 16, no. 6 (2018): 4810-4816. https://doi.org/10.3892/etm.2018.6794
Copy and paste a formatted citation
x
Spandidos Publications style
Ko CJ, Li CJ, Wu MY and Chu PY: Overexpression of epithelial cell adhesion molecule as a predictor of poor outcome in patients with hepatocellular carcinoma. Exp Ther Med 16: 4810-4816, 2018.
APA
Ko, C., Li, C., Wu, M., & Chu, P. (2018). Overexpression of epithelial cell adhesion molecule as a predictor of poor outcome in patients with hepatocellular carcinoma. Experimental and Therapeutic Medicine, 16, 4810-4816. https://doi.org/10.3892/etm.2018.6794
MLA
Ko, C., Li, C., Wu, M., Chu, P."Overexpression of epithelial cell adhesion molecule as a predictor of poor outcome in patients with hepatocellular carcinoma". Experimental and Therapeutic Medicine 16.6 (2018): 4810-4816.
Chicago
Ko, C., Li, C., Wu, M., Chu, P."Overexpression of epithelial cell adhesion molecule as a predictor of poor outcome in patients with hepatocellular carcinoma". Experimental and Therapeutic Medicine 16, no. 6 (2018): 4810-4816. https://doi.org/10.3892/etm.2018.6794
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