Characterization and evolution of intestine injury at the anhepatic phase in portal hypertensive rats

  • Authors:
    • Guijun Ren
    • Xiaoye Yuan
    • Xin Zhao
    • Qingchun Hao
    • Jinglin Cao
    • Yang Wang
    • Qingjun Gao
    • Jian Dou
    • Qiang Zeng
  • View Affiliations

  • Published online on: September 27, 2018     https://doi.org/10.3892/etm.2018.6800
  • Pages: 4765-4771
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Abstract

The aim of the present study was to investigate the characteristics and progression of intestinal injury at the anhepatic phase in portal hypertensive rats. A total of 120 healthy male Wistar rats were purchased, with 15 rats in the normal control group and 105 rats were assigned to establish a prehepatic portal hypertension model. The 105 model rats were further divided into seven treatment groups following ischemia‑reperfusion. Meanwhile, portal vein pressure, the area of lower esophageal mucosal vein, endotoxin levels in portal vein blood and the level of malondialdehyde (MDA) and superoxide dismutase (SOD) were measured. Morphology changes of the intestine were observed using optical microscopy and transmission electron microscopy. A portal hypertension rat model was successfully established. Furthermore, endotoxin, MDA and SOD level reached a peak at 12‑24 h following reperfusion and then decreased gradually to normal levels at 1 week following reperfusion. However, cytological damage did not recover to preoperative level within 1 week. These findings suggest that intestinal injury was most severe within 12‑24 h following ischemia‑reperfusion and most indicators recovered to almost normal levels. Therefore, further study on the intestinal mucosal damage is required, with the aim to reduce the production of intestinal endotoxin.
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December-2018
Volume 16 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Ren G, Yuan X, Zhao X, Hao Q, Cao J, Wang Y, Gao Q, Dou J and Zeng Q: Characterization and evolution of intestine injury at the anhepatic phase in portal hypertensive rats. Exp Ther Med 16: 4765-4771, 2018
APA
Ren, G., Yuan, X., Zhao, X., Hao, Q., Cao, J., Wang, Y. ... Zeng, Q. (2018). Characterization and evolution of intestine injury at the anhepatic phase in portal hypertensive rats. Experimental and Therapeutic Medicine, 16, 4765-4771. https://doi.org/10.3892/etm.2018.6800
MLA
Ren, G., Yuan, X., Zhao, X., Hao, Q., Cao, J., Wang, Y., Gao, Q., Dou, J., Zeng, Q."Characterization and evolution of intestine injury at the anhepatic phase in portal hypertensive rats". Experimental and Therapeutic Medicine 16.6 (2018): 4765-4771.
Chicago
Ren, G., Yuan, X., Zhao, X., Hao, Q., Cao, J., Wang, Y., Gao, Q., Dou, J., Zeng, Q."Characterization and evolution of intestine injury at the anhepatic phase in portal hypertensive rats". Experimental and Therapeutic Medicine 16, no. 6 (2018): 4765-4771. https://doi.org/10.3892/etm.2018.6800