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Effects of permanent cardiac pacemaker implantation on vascular endothelial function, blood coagulation and cardiac function in patients with bradycardia

  • Authors:
    • Xinling Zhang
    • Yan Li
    • Nan Wang
    • Chunxiang Zhang
    • Debing Zhang
    • Qiang Li
  • View Affiliations / Copyright

    Affiliations: The Heart Center, Jining First People's Hospital, Jining, Shandong 272011, P.R. China, Department of Stomatology, Affiliated Hospital of Jining Medical University, Jining, Shandong 272011, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4717-4721
    |
    Published online on: September 28, 2018
       https://doi.org/10.3892/etm.2018.6808
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Abstract

Changes in vascular endothelial function, blood coagulation and cardiac function indexes after the implantation of a permanent cardiac pacemaker in patients with bradycardia were investigated. A total of 53 healthy people and 117 patients with bradycardia in Jining First People's Hospital from January 2015 to August 2017 were selected. Factor VIII: coagulation (FVIII:C), von Willebr and factor (vWF), antithrombin activity (AT:A), D-dimmer (D-D), thrombomodulin (TM), tissue factor (TF), left ventricular ejection fraction (LVEF) and left ventricular end-systolic volume (LVESV) in the non-pacemaker group and the pacemaker group were significantly different from those in the control group (P<0.05), in which FVIII:C, vWF, D-D, TM, TF and LVESV were significantly higher than those in the control group, while LVEFs were significantly lower than that in the control group. After the implantation of a pacemaker, the FVIII:C, vWF, fibrinogen (FIB), D-D, TF and LVESV in patients were significantly higher than those before implantation (P<0.05), while the LVEF was significantly lower than that before implantation (P<0.05). In addition, in different pacemaker groups, there were no significant differences in blood coagulation and vascular endothelial indexes, but differences in cardiac function levels were obvious, in which LVEF in dual-chamber (DDD) pacemaker group was significantly higher than that in ventricular inhibited (VVI) pacemaker group, and LVESV in the former was significantly lower than that in the latter (P<0.05). Finally, here was no significant difference in the quality of life of patients implanted with different pacemakers (P>0.05), but the quality of life of patients in the DDD pacemaker group was better than that of patients in the VVI group. Therefore, implanting pacemakers in patients with bradycardia affects vascular endothelial function, blood coagulation, and cardiac function indexes in patients, and complications become less after the implantation of DDD pacemakers.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang X, Li Y, Wang N, Zhang C, Zhang D and Li Q: Effects of permanent cardiac pacemaker implantation on vascular endothelial function, blood coagulation and cardiac function in patients with bradycardia. Exp Ther Med 16: 4717-4721, 2018.
APA
Zhang, X., Li, Y., Wang, N., Zhang, C., Zhang, D., & Li, Q. (2018). Effects of permanent cardiac pacemaker implantation on vascular endothelial function, blood coagulation and cardiac function in patients with bradycardia. Experimental and Therapeutic Medicine, 16, 4717-4721. https://doi.org/10.3892/etm.2018.6808
MLA
Zhang, X., Li, Y., Wang, N., Zhang, C., Zhang, D., Li, Q."Effects of permanent cardiac pacemaker implantation on vascular endothelial function, blood coagulation and cardiac function in patients with bradycardia". Experimental and Therapeutic Medicine 16.6 (2018): 4717-4721.
Chicago
Zhang, X., Li, Y., Wang, N., Zhang, C., Zhang, D., Li, Q."Effects of permanent cardiac pacemaker implantation on vascular endothelial function, blood coagulation and cardiac function in patients with bradycardia". Experimental and Therapeutic Medicine 16, no. 6 (2018): 4717-4721. https://doi.org/10.3892/etm.2018.6808
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang X, Li Y, Wang N, Zhang C, Zhang D and Li Q: Effects of permanent cardiac pacemaker implantation on vascular endothelial function, blood coagulation and cardiac function in patients with bradycardia. Exp Ther Med 16: 4717-4721, 2018.
APA
Zhang, X., Li, Y., Wang, N., Zhang, C., Zhang, D., & Li, Q. (2018). Effects of permanent cardiac pacemaker implantation on vascular endothelial function, blood coagulation and cardiac function in patients with bradycardia. Experimental and Therapeutic Medicine, 16, 4717-4721. https://doi.org/10.3892/etm.2018.6808
MLA
Zhang, X., Li, Y., Wang, N., Zhang, C., Zhang, D., Li, Q."Effects of permanent cardiac pacemaker implantation on vascular endothelial function, blood coagulation and cardiac function in patients with bradycardia". Experimental and Therapeutic Medicine 16.6 (2018): 4717-4721.
Chicago
Zhang, X., Li, Y., Wang, N., Zhang, C., Zhang, D., Li, Q."Effects of permanent cardiac pacemaker implantation on vascular endothelial function, blood coagulation and cardiac function in patients with bradycardia". Experimental and Therapeutic Medicine 16, no. 6 (2018): 4717-4721. https://doi.org/10.3892/etm.2018.6808
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