Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2018 Volume 16 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2018 Volume 16 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Therapy with high‑dose long‑term antioxidant free radicals for severe paraquat poisoning: A pilot study

  • Authors:
    • Shunlin Hu
    • Chuanhu Qiao
    • Zhengli Yuan
    • Min  Li
    • Jiangfeng Ye
    • Huimin Ma
    • Jinghui Wang
    • Siyi Xin
    • Jing Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Xiangyang First People's Hospital, Hubei University of Medicine, Xiangyang, Hubei 441000, P.R. China
    Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5149-5155
    |
    Published online on: October 2, 2018
       https://doi.org/10.3892/etm.2018.6823
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

This study investigated the effects of high‑dose long‑term antioxidant free radicals on the mortality rate, creatinine (Cr) value, partial pressure of oxygen (PaO2), alanine aminotransferase (ALT), as well as the incidence rates of lung fibrosis and dysfunction in the treatment of patients with severe paraquat (PQ) poisoning [toxic dose, 20 ml stock solution (20% w/v)]. A total of 23 cases of severe PQ poisoning treated in Xiangyang First People's Hospital, Hubei University of Medicine were collected (group 1), and they received conventional treatments such as immunosuppressive agents and/or hemoperfusion. Six patients were given high‑dose long‑term antioxidant therapy on the basis of conventional treatments (group 2). After treatment, 6 out of the 23 patients in group 1 survived, and all the 6 patients in group 2 survived, with the survival rate of 26.1 vs. 100% (p<0.01). The lowest PaO2 value in group 1 was lower than that in group 2 (70.26±16.38 vs. 91.17±3.43 mmHg, p<0.01). The highest ALT value in group 1 was higher than that in group 2 (216.74±126.23 vs. 52.50±24.83 U/l, p<0.01). There was no significant difference in the incidence rate of lung fibrosis between the two groups of survived patients, but there were 6 patients that died of severe lung fibrosis in group 1. Besides, the incidence rate of lung dysfunction in patients in group 2 was significantly lower than that in survived patients in group 1 (p<0.01). High‑dose long‑term antioxidants are the most critical treatment option to improve the survival rate of high‑dose PQ poisoning, they increase the patient's PaO2, enhance liver function, reduce lung fibrosis and refine lung dysfunction.
View Figures

Figure 1

Figure 2

View References

1 

Cochemé HM and Murphy MP: Complex I is the major site of mitochondrial superoxide production by paraquat. J Biol Chem. 283:1786–1798. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Castello PR, Drechsel DA and Patel M: Mitochondria are a major source of paraquat-induced reactive oxygen species production in the brain. J Biol Chem. 282:14186–14193. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Dinis-Oliveira RJ, Duarte JA, Sánchez-Navarro A, Remião F, Bastos ML and Carvalho F: Paraquat poisonings: Mechanisms of lung toxicity, clinical features, and treatment. Crit Rev Toxicol. 38:13–71. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Weng CH, Chen HH, Hu CC, Huang WH, Hsu CW, Fu JF, Lin WR, Wang IK and Yen TH: Predictors of acute kidney injury after paraquat intoxication. Oncotarget. 8:51345–51354. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Gil HW, Hong JR, Jang SH and Hong SY: Diagnostic and therapeutic approach for acute paraquat intoxication. J Korean Med Sci. 29:1441–1449. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Gawarammana IB and Buckley NA: Medical management of paraquat ingestion. Br J Clin Pharmacol. 72:745–757. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Hsu CW, Lin JL, Lin-Tan DT, Chen KH, Yen TH, Wu MS and Lin SC: Early hemoperfusion may improve survival of severely paraquat-poisoned patients. PLoS One. 7:e483972012. View Article : Google Scholar : PubMed/NCBI

8 

Bonilla E, Medina-Leendertz S, Villalobos V, Molero L and Bohórquez A: Paraquat-induced oxidative stress in drosophila melanogaster Effects of melatonin, glutathione, serotonin, minocycline, lipoic acid and ascorbic acid. Neurochem Res. 31:1425–1432. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Cappelletti G, Maggioni MG and Maci R: Apoptosis in human lung epithelial cells: Triggering by paraquat and modulation by antioxidants. Cell Biol Int. 22:671–678. 1998. View Article : Google Scholar : PubMed/NCBI

10 

Moon JM and Chun BJ: The efficacy of high doses of vitamin C in patients with paraquat poisoning. Hum Exp Toxicol. 30:844–850. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Hong SY, Hwang KY, Lee EY, Eun SW, Cho SR, Han CS, Park YH and Chang SK: Effect of vitamin C on plasma total antioxidant status in patients with paraquat intoxication. Toxicol Lett. 126:51–59. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Hong SY, Yang JO, Lee EY and Lee ZW: Effects of N-acetyl-L-cysteine and glutathione on antioxidant status of human serum and 3T3 fibroblasts. J Korean Med Sci. 18:649–654. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Hong SY, Gil HW, Yang JO, Lee EY, Kim HK, Kim SH, Chung YH, Hwang SK and Lee ZW: Pharmacokinetics of glutathione and its metabolites in normal subjects. J Korean Med Sci. 20:721–726. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Jang YJ, Won JH, Back MJ, Fu Z, Jang JM, Ha HC, Hong S, Chang M and Kim DK: Paraquat induces apoptosis through a mitochondria-dependent pathway in RAW264.7 cells. Biomol Ther (Seoul). 23:407–413. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Musatov A and Robinson NC: Susceptibility of mitochondrial electron-transport complexes to oxidative damage. Focus on cytochrome c oxidase. Free Radic Res. 46:1313–1326. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Indo HP, Davidson M, Yen HC, Suenaga S, Tomita K, Nishii T, Higuchi M, Koga Y, Ozawa T and Majima HJ: Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage. Mitochondrion. 7:106–118. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Ortiz MS, Forti KM, Suárez Martinez EB, Muñoz LG, Husain K and Muñiz WH: Effects of antioxidant N-acetylcysteine against paraquat-induced oxidative stress in vital tissues of mice. Int J Sci Basic Appl Res. 26:26–46. 2016.PubMed/NCBI

18 

Płoszaj T, Robaszkiewicz A and Witas H: Oxidative damage of mitochondrial DNA: The result or consequence of enhanced generation of reactive oxygen species. Postepy Biochem. 56:139–146. 2010.(In Polish). PubMed/NCBI

19 

Bacsi A, Chodaczek G, Hazra TK, Konkel D and Boldogh I: Increased ROS generation in subsets of OGG1 knockout fibroblast cells. Mech Ageing Dev. 128:637–649. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Liu RM and Gaston Pravia KA: Oxidative stress and glutathione in TGF-beta-mediated fibrogenesis. Free Radic Biol Med. 48:1–15. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Cheresh P, Kim SJ, Tulasiram S and Kamp DW: Oxidative stress and pulmonary fibrosis. Biochim Biophys Acta. 1832:1028–1040. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Mittal M, Siddiqui MR, Tran K, Reddy SP and Malik AB: Reactive oxygen species in inflammation and tissue injury. Antioxid Redox Signal. 20:1126–1167. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Mariappan N, Elks CM, Fink B and Francis J: TNF-induced mitochondrial damage: A link between mitochondrial complex I activity and left ventricular dysfunction. Free Radic Biol Med. 46:462–470. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Awadalla EA: Efficacy of vitamin C against liver and kidney damage induced by paraquat toxicity. Exp Toxicol Pathol. 64:431–434. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Boer LA, Panatto JP, Fagundes DA, Bassani C, Jeremias IC, Daufenbach JF, Rezin GT, Constantino L, Dal-Pizzol F and Streck EL: Inhibition of mitochondrial respiratory chain in the brain of rats after hepatic failure induced by carbon tetrachloride is reversed by antioxidants. Brain Res Bull. 80:75–78. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Kamata H, Honda S, Maeda S, Chang L, Hirata H and Karin M: Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell. 120:649–661. 2005. View Article : Google Scholar : PubMed/NCBI

27 

He F, Xu P, Zhang J, Zhang Q, Gu S, Liu Y and Wang J: Efficacy and safety of pulse immunosuppressive therapy with glucocorticoid and cyclophosphamide in patients with paraquat poisoning: A meta-analysis. Int Immunopharmacol. 27:1–7. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Kim JH, Gil HW, Yang JO, Lee EY and Hong SY: Effect of glutathione administration on serum levels of reactive oxygen metabolites in patients with paraquat intoxication: A pilot study. Korean J Intern Med (Korean Assoc Intern Med). 25:282–287. 2010.

29 

Kim SJ, Cheresh P, Jablonski RP, Williams DB and Kamp DW: The role of mitochondrial DNA in mediating alveolar epithelial cell apoptosis and pulmonary fibrosis. Int J Mol Sci. 16:21486–21519. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Yu WC, Tian LY and Cheng W: Efficacy study of edaravone and acetylcysteine towards bleomycin-induced rat pulmonary fibrosis. Int J Clin Exp Med. 8:8730–8739. 2015.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Hu S, Qiao C, Yuan Z, Li M, Ye J, Ma H, Wang J, Xin S and Zhang J: Therapy with high‑dose long‑term antioxidant free radicals for severe paraquat poisoning: A pilot study. Exp Ther Med 16: 5149-5155, 2018.
APA
Hu, S., Qiao, C., Yuan, Z., Li, M., Ye, J., Ma, H. ... Zhang, J. (2018). Therapy with high‑dose long‑term antioxidant free radicals for severe paraquat poisoning: A pilot study. Experimental and Therapeutic Medicine, 16, 5149-5155. https://doi.org/10.3892/etm.2018.6823
MLA
Hu, S., Qiao, C., Yuan, Z., Li, M., Ye, J., Ma, H., Wang, J., Xin, S., Zhang, J."Therapy with high‑dose long‑term antioxidant free radicals for severe paraquat poisoning: A pilot study". Experimental and Therapeutic Medicine 16.6 (2018): 5149-5155.
Chicago
Hu, S., Qiao, C., Yuan, Z., Li, M., Ye, J., Ma, H., Wang, J., Xin, S., Zhang, J."Therapy with high‑dose long‑term antioxidant free radicals for severe paraquat poisoning: A pilot study". Experimental and Therapeutic Medicine 16, no. 6 (2018): 5149-5155. https://doi.org/10.3892/etm.2018.6823
Copy and paste a formatted citation
x
Spandidos Publications style
Hu S, Qiao C, Yuan Z, Li M, Ye J, Ma H, Wang J, Xin S and Zhang J: Therapy with high‑dose long‑term antioxidant free radicals for severe paraquat poisoning: A pilot study. Exp Ther Med 16: 5149-5155, 2018.
APA
Hu, S., Qiao, C., Yuan, Z., Li, M., Ye, J., Ma, H. ... Zhang, J. (2018). Therapy with high‑dose long‑term antioxidant free radicals for severe paraquat poisoning: A pilot study. Experimental and Therapeutic Medicine, 16, 5149-5155. https://doi.org/10.3892/etm.2018.6823
MLA
Hu, S., Qiao, C., Yuan, Z., Li, M., Ye, J., Ma, H., Wang, J., Xin, S., Zhang, J."Therapy with high‑dose long‑term antioxidant free radicals for severe paraquat poisoning: A pilot study". Experimental and Therapeutic Medicine 16.6 (2018): 5149-5155.
Chicago
Hu, S., Qiao, C., Yuan, Z., Li, M., Ye, J., Ma, H., Wang, J., Xin, S., Zhang, J."Therapy with high‑dose long‑term antioxidant free radicals for severe paraquat poisoning: A pilot study". Experimental and Therapeutic Medicine 16, no. 6 (2018): 5149-5155. https://doi.org/10.3892/etm.2018.6823
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team