Open Access

Significance of malondialdehyde, superoxide dismutase and endotoxin levels in Budd‑Chiari syndrome in patients and a rat model

  • Authors:
    • De‑Lei Cheng
    • Nan Zhu
    • Cheng‑Li Li
    • Wei‑Fu Lv
    • Wei‑Wei Fang
    • Ya Liu
    • Chuan‑Ting Li
  • View Affiliations

  • Published online on: October 9, 2018     https://doi.org/10.3892/etm.2018.6835
  • Pages: 5227-5235
  • Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Budd‑Chiari syndrome (BCS) is a rare clinical syndrome caused by the obstruction of hepatic venous outflow. In theory, hepatic congestion and hypoxia induce pathological damage and changes in the liver. However, at present, laboratory evidence supporting this theory is lacking. The aim of the present study was to assess the expression and significance of the hypoxia‑associated indicators malondialdehyde (MDA), superoxide dismutase (SOD) and endotoxin (ET) in the liver and serum of subjects with BCS. An animal model of BCS was established by partial ligation of the inferior vena cava (IVC) in rats. The levels of MDA, SOD and ET in the serum of BCS patients, as well as in the liver and serum of rats with BCS, were detected and analyzed. In human patients with BCS, the serum levels of MDA, ET and SOD were significantly different from those in healthy control subjects. In the animal model, similar trends were observed regarding the MDA, ET and SOD levels in liver homogenate and serum (P<0.05), the degree of which was more pronounced in the liver homogenate than in the serum. At 6 weeks after the surgery, these indicators reached peak/valley levels in the experimental group and were at least partially restored by week 12. A negative correlation between MDA and SOD, a positive correlation between MDA and ET, and a negative correlation between SOD and ET was identified. In conclusion, the levels of hypoxia‑associated indicators significantly changed with BCS progression, suggesting that hypoxia is a major factor in the pathogenesis of BCS.
View Figures
View References

Related Articles

Journal Cover

December-2018
Volume 16 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Cheng DL, Zhu N, Li CL, Lv WF, Fang WW, Liu Y and Li CT: Significance of malondialdehyde, superoxide dismutase and endotoxin levels in Budd‑Chiari syndrome in patients and a rat model. Exp Ther Med 16: 5227-5235, 2018
APA
Cheng, D., Zhu, N., Li, C., Lv, W., Fang, W., Liu, Y., & Li, C. (2018). Significance of malondialdehyde, superoxide dismutase and endotoxin levels in Budd‑Chiari syndrome in patients and a rat model. Experimental and Therapeutic Medicine, 16, 5227-5235. https://doi.org/10.3892/etm.2018.6835
MLA
Cheng, D., Zhu, N., Li, C., Lv, W., Fang, W., Liu, Y., Li, C."Significance of malondialdehyde, superoxide dismutase and endotoxin levels in Budd‑Chiari syndrome in patients and a rat model". Experimental and Therapeutic Medicine 16.6 (2018): 5227-5235.
Chicago
Cheng, D., Zhu, N., Li, C., Lv, W., Fang, W., Liu, Y., Li, C."Significance of malondialdehyde, superoxide dismutase and endotoxin levels in Budd‑Chiari syndrome in patients and a rat model". Experimental and Therapeutic Medicine 16, no. 6 (2018): 5227-5235. https://doi.org/10.3892/etm.2018.6835