Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2018 Volume 16 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2018 Volume 16 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Atorvastatin reverses the dysfunction of human umbilical vein endothelial cells induced by angiotensin II

  • Authors:
    • Haiming Dang
    • Bangrong Song
    • Ran Dong
    • Hongjia Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Chaoyang, Beijing 100029, P.R. China
  • Pages: 5286-5297
    |
    Published online on: October 11, 2018
       https://doi.org/10.3892/etm.2018.6846
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Statins exert pleiotropic effects on endothelial cells, in addition to lowering cholesterol. This study evaluated angiotensin II (Ang II)‑induced dysfunction in human umbilical vein endothelial cells (HUVECs), and the effects of atorvastatin (Ator) on induced HUVECs in vitro. The cytotoxicity of Ang II and Ator was determined by the MTT assay. A series of cellular responses were screened, including oxidative stress, cellular apoptosis, inflammatory response, autophagy, expression of endothelial nitric oxide synthase and the angiogenic function of HUVECs. Ator returned these cellular responses to a normal level. The present study also examined cellular organelle dysfunction. In HUVECs, Ang II triggered mitochondrial damage, as demonstrated by a decreased mitochondrial membrane potential, while Ator attenuated this Ang II‑induced damage. The observed cellular dysfunction may cause endothelial senescence due to excessive cell injury. The current study examined several aging markers, which revealed that these disorders of cellular functions triggered endothelial senescence, which was delayed by Ator. Ator also suppressed Ang II‑induced angiogenesis damage. The data presented in this study strongly suggested that Ang II induced a series of processes that lead to cellular dysfunction in HUVECs, including oxidative stress, inflammation, and mitochondrial damage, leading to apoptosis and endothelial senescence. However, Ator significantly reversed these effects and modulated intracellular stability. The present study indicated that Ator serves an antagonistic role against HUVEC dysfunction and may potentially prevent several diseases, including coronary disease and atherosclerosis, by maintaining cellular homeostasis.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

View References

1 

Whaley-Connell A, Johnson MS and Sowers JR: Aldosterone: Role in the cardiometabolic syndrome and resistant hypertension. Prog Cardiovasc Dis. 52:401–409. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Touyz RM: The role of angiotensin II in regulating vascular structural and functional changes in hypertension. Curr Hypertens Rep. 5:155–164. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Olkowicz M, Chlopicki S and Smolenski RT: Perspectives for angiotensin profiling with liquid chromatography/mass spectrometry to evaluate ACE/ACE2 balance in endothelial dysfunction and vascular pathologies. Pharmacol Rep. 67:778–785. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Gallo S, Sala V, Gatti S and Crepaldi T: Cellular and molecular mechanisms of HGF/Met in the cardiovascular system. Clin Sci (Lond). 129:1173–1193. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Kawai T, Forrester SJ, O'Brien S, Baggett A, Rizzo V and Eguchi S: AT1 receptor signaling pathways in the cardiovascular system. Pharmacol Res. 125:4–13. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Lucas AM, Caldas FR, da Silva AP, Ventura MM, Leite IM, Filgueiras AB, Silva CG, Kowaltowski AJ and Facundo HT: Diazoxide prevents reactive oxygen species and mitochondrial damage, leading to anti-hypertrophic effects. Chem Biol Interact. 261:50–55. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Lim W, Yang C, Jeong M, Bazer FW and Song G: Coumestrol induces mitochondrial dysfunction by stimulating ROS production and calcium ion influx into mitochondria in human placental choriocarcinoma cells. Mol Hum Reprod. 23:786–802. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Meng XM, Ren GL, Gao L, Yang Q, Li HD, Wu WF, Huang C, Zhang L, Lv XW and Li J: NADPH oxidase 4 promotes cisplatin-induced acute kidney injury via ROS-mediated programmed cell death and inflammation. Lab Invest. 98:63–78. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Tsai CY, Chen CY, Chiou YH, Shyu HW, Lin KH, Chou MC, Huang MH and Wang YF: Epigallocatechin-3-gallate suppresses human herpesvirus 8 replication and induces ROS leading to apoptosis and autophagy in primary effusion lymphoma cells. Int J Mol Sci. 19(pii): E162017. View Article : Google Scholar : PubMed/NCBI

10 

Tseng CY, Wang JS and Chao MW: Causation by diesel exhaust particles of endothelial dysfunctions in cytotoxicity, pro-inflammation, permeability, and apoptosis induced by ROS generation. Cardiovasc Toxicol. 17:384–392. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Hong S, Kwon J, Kim DW, Lee HJ, Lee D and Mar W: Mulberrofuran G protects ischemic injury-induced cell death via inhibition of NOX4-mediated ROS generation and ER stress. Phytother Res. 31:321–329. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Marchi S, Giorgi C, Suski JM, Agnoletto C, Bononi A, Bonora M, De Marchi E, Missiroli S, Patergnani S, Poletti F, et al: Mitochondria-ros crosstalk in the control of cell death and aging. J Signal Transduct. 2012:3296352012. View Article : Google Scholar : PubMed/NCBI

13 

Zheng J, Li G, Chen S, Bihl J, Buck J, Zhu Y, Xia H, Lazartigues E, Chen Y and Olson JE: Activation of the ACE2/Ang-(1–7)/Mas pathway reduces oxygen-glucose deprivation-induced tissue swelling, ROS production, and cell death in mouse brain with angiotensin II overproduction. Neuroscience. 273:39–51. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Schachter M: Chemical, pharmacokinetic and pharmacodynamic properties of statins: An update. Fundam Clin Pharmacol. 19:117–125. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Yang ZX, Wang YZ, Jia BB, Mao GX, Lv YD, Wang GF and Yu H: Downregulation of miR-146a, cyclooxygenase-2 and advanced glycation end-products in simvastatin-treated older patients with hyperlipidemia. Geriatr Gerontol Int. 16:322–328. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Čarnická S, Adameová A, Nemčeková M, Matejíková J, Pancza D and Ravingerová T: Distinct effects of acute pretreatment with lipophilic and hydrophilic statins on myocardial stunning, arrhythmias and lethal injury in the rat heart subjected to ischemia/reperfusion. Physiol Res. 60:825–830. 2011.PubMed/NCBI

17 

Davignon J: Beneficial cardiovascular pleiotropic effects of statins. Circulation. 109(23): Suppl 1:III39–III43. 2004.PubMed/NCBI

18 

Cui W, Matsuno K, Iwata K, Ibi M, Katsuyama M, Kakehi T, Sasaki M, Ikami K, Zhu K and Yabe-Nishimura C: NADPH oxidase isoforms and anti-hypertensive effects of atorvastatin demonstrated in two animal models. J Pharmacol Sci. 111:260–268. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Ren C, Hu X, Li X and Zhou Q: Ultra-trace graphene oxide in a water environment triggers Parkinson's disease-like symptoms and metabolic disturbance in zebrafish larvae. Biomaterials. 93:83–94. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Assmus B, Urbich C, Aicher A, Hofmann WK, Haendeler J, Rössig L, Spyridopoulos I, Zeiher AM and Dimmeler S: HMG-CoA reductase inhibitors reduce senescence and increase proliferation of endothelial progenitor cells via regulation of cell cycle regulatory genes. Circ Res. 92:1049–1055. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Brand MD and Nicholls DG: Assessing mitochondrial dysfunction in cells. Biochem J. 435:297–312. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Liang X, Zhang J, Guo F, Wei L and Zhou Q: Oxidative stress and inflammatory responses in the liver of swamp eel (Monopterus albus) exposed to carbon tetrachloride. Aquaculture. 496:232–238. 2018. View Article : Google Scholar

23 

Levine B and Klionsky DJ: Development by self-digestion: Molecular mechanisms and biological functions of autophagy. Dev Cell. 6:463–477. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Zhang L, Wang X, Miao Y, Chen Z, Qiang P, Cui L, Jing H and Guo Y: Magnetic ferroferric oxide nanoparticles induce vascular endothelial cell dysfunction and inflammation by disturbing autophagy. J Hazard Mater. 304:186–195. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Zhang Q, Lai S, Hou X, Cao W, Zhang Y and Zhang Z: Protective effects of PI3K/Akt signal pathway induced cell autophagy in rat knee joint cartilage injury. Am J Transl Res. 10:762–770. 2018.PubMed/NCBI

26 

Chatterjee A, Black SM and Catravas JD: Endothelial nitric oxide (NO) and its pathophysiologic regulation. Vascul Pharmacol. 49:134–140. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Chen L, Xia W and Hou M: Mesenchymal stem cells attenuate doxorubicin-induced cellular senescence through the VEGF/Notch/TGF-β signaling pathway in H9c2 cardiomyocytes. Int J Mol Med. 42:674–684. 2018.PubMed/NCBI

28 

Skrzypek K, Nibbelink MG, Karbaat LP, Karperien M, van Apeldoorn A and Stamatialis D: An important step towards a prevascularized islet macroencapsulation device-effect of micropatterned membranes on development of endothelial cell network. J Mater Sci Mater Med. 29:912018. View Article : Google Scholar : PubMed/NCBI

29 

Nashimoto Y, Hayashi T, Kunita I, Nakamasu A, Torisawa Y, Nakayama M, Takigawa-Imamura H, Kotera H, Nishiyama K, Miura T and Yokokawa R: Integrating perfusable vascular networks with a three-dimensional tissue in a microfluidic device. Integr Biol (Camb). 9:506–518. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Kou B, Vatish M and Singer DR: Effects of angiotensin II on human endothelial cells survival signalling pathways and its angiogenic response. Vascul Pharmacol. 47:199–208. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Buharalioglu CK, Song CY, Yaghini FA, Ghafoor HU, Motiwala M, Adris T, Estes AM and Malik KU: Angiotensin II-induced process of angiogenesis is mediated by spleen tyrosine kinase via VEGF receptor-1 phosphorylation. Am J Physiol Heart Circ Physiol. 301:H1043–H1055. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Jagadeeswaran R, Vazquez BA, Thiruppathi M, Ganesh BB, Ibanez V, Cui S, Engel JD, Diamond AM, Molokie RE, DeSimone J, et al: Pharmacological inhibition of LSD1 and mTOR reduces mitochondrial retention and associated ROS levels in the red blood cells of sickle cell disease. Exp Hematol. 50:46–52. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Márquez-Ramírez SG, Delgado-Buenrostro NL, Chirino YI, Iglesias GG and López-Marure R: Titanium dioxide nanoparticles inhibit proliferation and induce morphological changes and apoptosis in glial cells. Toxicology. 302:146–156. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Chen L, Chen DQ, Wang M, Liu D, Chen H, Dou F, Vaziri ND and Zhao YY: Role of RAS/Wnt/β-catenin axis activation in the pathogenesis of podocyte injury and tubulo-interstitial nephropathy. Chem Biol Interact. 273:56–72. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Alvarenga EM, Souza LK, Araújo TS, Nogueira KM, Sousa FB, Araújo AR, Martins CS, Pacífico DM, de C Brito GA, Souza EP, et al: Carvacrol reduces irinotecan-induced intestinal mucositis through inhibition of inflammation and oxidative damage via TRPA1 receptor activation. Chem Biol Interact. 260:129–140. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Levine B and Klionsky DJ: Development by self-digestion: Molecular mechanisms and biological functions of autophagy. Dev Cell. 6:463–477. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Yorimitsu T and Klionsky DJ: Autophagy: Molecular machinery for self-eating. Cell Death Differ. 12 (Suppl 2):S1542–S1552. 2005. View Article : Google Scholar

38 

Li C, Liu H, Sun Y, Wang H, Guo F, Rao S, Deng J, Zhang Y, Miao Y, Guo C, et al: PAMAM nanoparticles promote acute lung injury by inducing autophagic cell death through the Akt-TSC2-mTOR signaling pathway. J Mol Cell Biol. 1:37–45. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Deretic V, Saitoh T and Akira S: Autophagy in infection, inflammation and immunity. Nat Rev Immunol. 13:722–737. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Levine B, Mizushima N and Virgin HW: Autophagy in immunity and inflammation. Nature. 469:323–335. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Saitoh T and Akira S: Regulation of innate immune responses by autophagy-related proteins. J Cell Biol. 189:925–935. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Zhou R, Yazdi AS, Menu P and Tschopp J: A role for mitochondria in NLRP3 inflammasome activation. Nature. 469:221–225. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Vesa J, Su H, Watts GD, Krause S, Walter MC, Martin B, Smith C, Wallace DC and Kimonis VE: Valosin containing protein associated inclusion body myopathy: abnormal vacuolization, autophagy and cell fusion in myoblasts. Neuromuscul Disord. 19:766–772. 2009. View Article : Google Scholar : PubMed/NCBI

44 

Mishra AR, Zheng J, Tang X and Goering PL: Silver nanoparticle-induced autophagic-lysosomal disruption and NLRP3-inflammasome activation in HepG2 cells is size-dependent. Toxicol Sci. 150:473–487. 2016. View Article : Google Scholar : PubMed/NCBI

45 

Yang G, Wang S, Zhong L, Dong X, Zhang W, Jiang L, Geng C, Sun X, Liu X, Chen M and Ma Y: 6-Gingerol induces apoptosis through lysosomal-mitochondrial axis in human hepatoma G2 cells. Phytother Res. 26:1667–1673. 2012. View Article : Google Scholar : PubMed/NCBI

46 

Lane N: Mitochondrial disease: Powerhouse of disease. Nature. 440:600–602. 2006. View Article : Google Scholar : PubMed/NCBI

47 

Bouchier-Hayes L, Lartigue L and Newmeyer DD: Mitochondria: Pharmacological manipulation of cell death. J Clin Invest. 115:2640–2647. 2005. View Article : Google Scholar : PubMed/NCBI

48 

Toporsian M, Gros R, Kabir MG, Vera S, Govindaraju K, Eidelman DH, Husain M and Letarte M: A role for endoglin in coupling eNOS activity and regulating vascular tone revealed in hereditary hemorrhagic telangiectasia. Circ Res. 96:684–692. 2005. View Article : Google Scholar : PubMed/NCBI

49 

Shyu KG, Wang BW, Chen WJ, Kuan P and Hung CR: Mechanism of the inhibitory effect of atorvastatin on endoglin expression induced by transforming growth factor-beta1 in cultured cardiac fibroblasts. Eur J Heart Fail. 12:219–226. 2010. View Article : Google Scholar : PubMed/NCBI

50 

Giordano A, Romano S, Monaco M, Sorrentino A, Corcione N, Di Pace AL, Ferraro P, Nappo G, Polimeno M and Romano MF: Differential effect of atorvastatin and tacrolimus on proliferation of vascular smooth muscle and endothelial cells. Am J Physiol Heart Circ Physiol. 302:H135–H142. 2012. View Article : Google Scholar : PubMed/NCBI

51 

Zemankova L, Varejckova M, Dolezelova E, Fikrova P, Jezkova K, Rathouska J, Cerveny L, Botella LM, Bernabeu C, Nemeckova I and Nachtigal P: Atorvastatin-induced endothelial nitric oxide synthase expression in endothelial cells is mediated by endoglin. J Physiol Pharmacol. 66:403–413. 2015.PubMed/NCBI

52 

von Muhlinen N, Horikawa I, Alam F, Isogaya K, Lissa D, Vojtesek B, Lane DP and Harris CC: p53 isoforms regulate premature aging in human cells. Oncogene. 37:2379–2393. 2018. View Article : Google Scholar : PubMed/NCBI

53 

Isaev NK, Genrikhs EE, Oborina MV and Stelmashook EV: Accelerated aging and aging process in the brain. Rev Neurosci. 29:233–240. 2018. View Article : Google Scholar : PubMed/NCBI

54 

Moruno-Manchon JF, Uzor NE, Kesler SR, Wefel JS, Townley DM, Nagaraja AS, Pradeep S, Mangala LS, Sood AK and Tsvetkov AS: Peroxisomes contribute to oxidative stress in neurons during doxorubicin-based chemotherapy. Mol Cell Neurosci. 86:65–71. 2018. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Dang H, Song B, Dong R and Zhang H: Atorvastatin reverses the dysfunction of human umbilical vein endothelial cells induced by angiotensin II. Exp Ther Med 16: 5286-5297, 2018.
APA
Dang, H., Song, B., Dong, R., & Zhang, H. (2018). Atorvastatin reverses the dysfunction of human umbilical vein endothelial cells induced by angiotensin II. Experimental and Therapeutic Medicine, 16, 5286-5297. https://doi.org/10.3892/etm.2018.6846
MLA
Dang, H., Song, B., Dong, R., Zhang, H."Atorvastatin reverses the dysfunction of human umbilical vein endothelial cells induced by angiotensin II". Experimental and Therapeutic Medicine 16.6 (2018): 5286-5297.
Chicago
Dang, H., Song, B., Dong, R., Zhang, H."Atorvastatin reverses the dysfunction of human umbilical vein endothelial cells induced by angiotensin II". Experimental and Therapeutic Medicine 16, no. 6 (2018): 5286-5297. https://doi.org/10.3892/etm.2018.6846
Copy and paste a formatted citation
x
Spandidos Publications style
Dang H, Song B, Dong R and Zhang H: Atorvastatin reverses the dysfunction of human umbilical vein endothelial cells induced by angiotensin II. Exp Ther Med 16: 5286-5297, 2018.
APA
Dang, H., Song, B., Dong, R., & Zhang, H. (2018). Atorvastatin reverses the dysfunction of human umbilical vein endothelial cells induced by angiotensin II. Experimental and Therapeutic Medicine, 16, 5286-5297. https://doi.org/10.3892/etm.2018.6846
MLA
Dang, H., Song, B., Dong, R., Zhang, H."Atorvastatin reverses the dysfunction of human umbilical vein endothelial cells induced by angiotensin II". Experimental and Therapeutic Medicine 16.6 (2018): 5286-5297.
Chicago
Dang, H., Song, B., Dong, R., Zhang, H."Atorvastatin reverses the dysfunction of human umbilical vein endothelial cells induced by angiotensin II". Experimental and Therapeutic Medicine 16, no. 6 (2018): 5286-5297. https://doi.org/10.3892/etm.2018.6846
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team