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Electroacupuncture stimulates the proliferation and differentiation of endogenous neural stem cells in a rat model of ischemic stroke

  • Authors:
    • Feng Tan
    • Jian Wang
    • Jing Xian Liu
    • Chen Wang
    • Miaodan Li
    • Yong Gu
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Foshan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Foshan, Guangdong 528000, P.R. China, Department of Neurology, Yunnan Provincial Hospital of Traditional Chinese Medical, Kunming, Yunnan 650000, P.R. China, Department of Neurology, Nan Fang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China
    Copyright: © Tan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4943-4950
    |
    Published online on: October 11, 2018
       https://doi.org/10.3892/etm.2018.6848
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Abstract

Electroacupuncture (EA) may stimulate neurogenesis in animal models of ischemic stroke; however, the associated mechanisms are not clear. The present study aimed to evaluate the neurogenesis efficacy of EA on ischemic stroke and the underlying associated mechanisms. A model of middle cerebral artery occlusion (MCAO) was employed as the rat model of brain ischemia and reperfusion. EA treatment at the GV20 (Baihui) and GV14 (Dazhui) acupoints was conducted for 30 min daily following MCAO. Immunofluorescence was performed to measure the number of bromodeoxyuridine (BrdU)/nestin‑ or BrdU/doublecortin (DCX)‑positive cells in the sham, MCAO and MCAO + EA groups. Results indicated that EA stimulation significantly decreased the neurological score and neuronal loss in rats in the MCAO group (both P<0.05). Furthermore, immunostaining assays indicated that BrdU/nestin‑ and BrdU/DCX‑positive cells in EA‑treated rats were significantly increased (P<0.05) when compared with the rats in the MCAO group, indicating EA may induce the proliferation and differentiation of endogenous neural stem cells (eNSCs) during cerebral ischemia‑reperfusion. In addition, EA treatment significantly enhanced the protein expression levels of plasticity‑related gene 5 (PRG5), a critical neurogenesis factor, and significantly decreased the protein expression levels of three neurogenesis inhibiting molecules, NogoA, lysophosphatidic acid and RhoA (all P<0.05). These results suggested that EA promotes the proliferation and differentiation of eNSCs, likely through modulating PRG5/RhoA signaling.
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1 

Kline AE, Leary JB, Radabaugh HL, Cheng JP and Bondi CO: Combinationtherapies for neurobehavioral and cognitive recovery after experimental traumatic brain injury: Is more better? Prog Neurobiol. 142:45–67. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Thored P, Arvidsson A, Cacci E, Ahlenius H, Kallur T, Darsalia V, Ekdahl CT, Kokaia Z and Lindvall O: Persistent production of neurons from adult brain stem cells during recovery after stroke. Stem Cells. 24:739–747. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Gregoire CA, Goldenstein BL, Floriddia EM, Barnabe- Heider F and Fernandes KJ: Endogenous neural stem cell responses to stroke and spinal cord injury. Glia. 63:1469–1482. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Tobin MK, Bonds JA, Minshall RD, Pelligrino DA, Testai FD and Lazarov O: Neurogenesis and inflammation after ischemic stroke: What is known and where we go from here. J Cereb Blood Flow Metab. 34:1573–1584. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Liu D, Wang Z, Zhan J, Zhang Q, Wang J, Zhang Q, Xian X, Luan Q and Hao A: Hydrogen sulfide promotes proliferation and neuronal differentiation of neural stem cells andprotects hypoxia-induced decrease in hippocampal neurogenesis. Pharmacol Biochem Behav. 116:55–63. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Guo F, Song W, Jiang T, Liu L, Wang F, Zhong H, Yin H, Wang Q and Xiong L: Electroacupuncture pretreatment inhibits NADPH oxidase-mediated oxidative stress in diabetic mice with cerebral ischemia. Brain Res. 1573:84–91. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Tao J, Zheng Y, Liu W, Yang S, Huang J, Xue X, Shang G, Wang X, Lin R and Chen L: Electro-acupuncture at LI11 and ST36 acupoints exerts neuroprotective effects via reactive astrocyte proliferation after ischemia and reperfusion injury in rats. Brain Res Bull. 120:14–24. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Lee S, Kim W, Park J, Jang HH, Lee SM, Woo JS, Kim HS, Lee KH, Kwon YJ, Lee U, et al: Effects of electroacupuncture on endothelial function and circulating endothelial progenitor cells in patients with cerebral infarction. Clin Exp Pharmacol Physiol. 42:822–827. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Liu AJ, Li JH, Li HQ, Fu DL, Lu L, Bian ZX and Zheng GQ: Electroacupuncture for acute ischemic stroke: A meta-analysis of randomized controlled trials. Am J Chin Med. 43:1541–1566. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Huang J, Ye X, You Y, Liu W, Gao Y, Yang S, Peng J, Hong Z, Tao J and Chen L: Electroacupuncture promotes neural cell proliferation in vivo through activation of the ERK1/2 signaling pathway. Int J Mol Med. 33:1547–1553. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Shen MH, Zhang CB, Zhang JH and Li PF: Electroacupuncture attenuatescerebral ischemia and reperfusion injury in middle cerebral artery occlusion of rat via modulation of apoptosis, inflammation, oxidative stress, and excitotoxicity. Evid Based Complement Alternat Med. 2016:94386502016. View Article : Google Scholar : PubMed/NCBI

12 

Wang Q, Li X, Chen Y, Wang F, Yang Q, Chen S, Min Y, Li X and Xiong L: Activation of epsilon protein kinase C-mediated anti-apoptosis is involved in rapid tolerance induced by electroacupuncturepretreatment through cannabinoid receptor type 1. Stroke. 42:389–396. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Tan F, Chen J, Liang Y, Gu M, Li Y, Wang X and Meng D: Electroacupuncture attenuates cervical spinal cord injury following cerebral ischemia/reperfusion in stroke-prone renovascular hypertensive rats. Exp Ther Med. 7:1529–1534. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Naylor M, Bowen KK, Sailor KA, Dempsey RJ and Vemuganti R: Preconditioning-induced ischemic tolerance stimulates growth factor expression and neurogenesis in adult rat hippocampus. Neurochem Int. 47:565–572. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Yang ZJ, Shen DH, Guo X and Sun FY: Electroacupuncture enhances striatal neurogenesis in adult rat brains after a transient cerebral middle artery occlusion. Acupunct Electrother Res. 30:185–199. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Kim YR, Kim HN, Ahn SM, Choi YH, Shin HK and Choi BT: Electroacupuncture promotes post-stroke functional recovery via enhancing endogenous neurogenesis in mouse focal cerebral ischemia. PLoS One. 9:e900002014. View Article : Google Scholar : PubMed/NCBI

17 

Zhao J, Sui M, Lu X, Jin D, Zhuang Z and Yan T: Electroacupuncture promotes neural stem cell proliferation and neurogenesis in the dentate gyrus of rats following stroke via upregulation of Notch1 expression. Mol Med Rep. 12:6911–6917. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Petrinovic MM, Hourez R, Aloy EM, Dewarrat G, Gall D, Weinmann O, Gaudias J, Bachmann LC, Schiffmann SN, Vogt KE and Schwab ME: Neuronal Nogo-A negatively regulates dendritic morphology and synaptic transmission in the cerebellum. Proc Natl Acad Sci USA. 110:1083–1088. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Wang F, Xing S, He M, Hou Q, Chen S, Zou X, Pei Z and Zeng J: Nogo-A is associated with secondary degeneration of substantia nigra in hypertensive rats with focal cortical infarction. Brain Res. 1469:153–163. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Pernet V and Schwab ME: The role of Nogo-A in axonal plasticity, regrowth and repair. Cell Tissue Res. 349:97–104. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Zhu WW, Ma XL, Guo AL, Zhao HY and Luo HH: Neuroprotective effects of NEP1-40 and fasudil on Nogo-A expression in neonatal rats with hypoxic-ischemic brain damage. Genet Mol Res. 10:2987–2995. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Tsai SY, Papadopoulos CM, Schwab ME and Kartje GL: Delayed anti-nogo-a therapy improves function after chronic stroke in adult rats. Stroke. 42:186–190. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Yung YC, Stoddard NC and Chun J: LPA receptor signaling: Pharmacology, physiology, and pathophysiology. J Lipid Res. 55:1192–1214. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Broggini T, Nitsch R and Savaskan NE: Plasticity-related gene 5 (PRG5) induces filopodia and neurite growth and impedes lysophosphatidic acid- and nogo-A-mediated axonal retraction. Mol Biol Cell. 21:521–537. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Coiro P, Stoenica L, Strauss U and Brauer AU: Plasticity-related gene 5 promotes spine formation in murine hippocampal neurons. J Biol Chem. 289:24956–24970. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Gu Y, Zheng G, Xu M, Li Y, Chen X, Zhu W, Tong Y, Chung SK, Liu KJ and Shen J: Caveolin-1 regulates nitric oxide-mediated matrix metalloproteinases activity and blood-brain barrier permeability in focal cerebral ischemia and reperfusion injury. J Neurochem. 120:147–156. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Attardi LD, de Vries A and Jacks T: Activation of the p53-dependent G1 checkpoint response in mouse embryo fibroblasts depends on the specific DNA damage inducer. Oncogene. 23:973–980. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Feng X, Yang S, Liu J, Huang J, Peng J, Lin J, Tao J and Chen L: Electroacupuncture ameliorates cognitive impairment through inhibition of NF-κB-mediatedneuronal cell apoptosis in cerebral ischemia-reperfusion injured rats. Mol Med Rep. 7:1516–1522. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Wakayama T, Nakata H, Kumchantuek T, Gewaily MS and Iseki S: Identification of 5-bromo-2′-deoxyuridine-labeled cells during mouse spermatogenesis by heat-induced antigen retrieval in lectin staining and immunohistochemistry. J Histochem Cytochem. 63:190–205. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Rueger MA, Muesken S, Walberer M, Jantzen SU, Schnakenburg K, Backes H, Graf R, Neumaier B, Hoehn M, Fink GR and Schroeter M: Effects of minocycline on endogenous neural stem cells after experimental stroke. Neuroscience. 215:174–183. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Batailler M, Droguerre M, Baroncini M, Fontaine C, Prevot V and Migaud M: DCX-expressing cells in the vicinity of the hypothalamic neurogenic niche: A comparative study between mouse, sheep, and human tissues. J Comp Neurol. 522:1966–1985. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Ren L, Zhang WA, Fang NY and Wang JX: The influence of electro-acupuncture on neural plasticity in acute cerebral infarction. Neurol Res. 30:985–989. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Kernie SG and Parent JM: Forebrain neurogenesis after focal Ischemic andtraumatic brain injury. Neurobiol Dis. 37:267–274. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Kempermann G, Song H and Gage FH: Neurogenesis in the adult hippocampus. Cold Spring Harb Perspect Biol. 7:a0188122015. View Article : Google Scholar : PubMed/NCBI

35 

Luskin MB and Boone MS: Rate and pattern of migration of lineally-related olfactory bulb interneurons generated postnatally in the subventricular zone of the rat. Chem Senses. 19:695–714. 1994. View Article : Google Scholar : PubMed/NCBI

36 

Villasana LE, Kim KN, Westbrook GL and Schnell E: Functional integration of adult-born hippocampal neurons after traumatic brain injury(1,2,3). eNeuro. 2:ENEURO.0056-0015. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Shimada IS, Peterson BM and Spees JL: Isolation of locally derived stem/progenitor cells from the peri-infarct area that do not migrate from the lateral ventricle after cortical stroke. Stroke. 41:e552–e560. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Vadodaria KC and Jessberger S: Maturation and integration of adult born hippocampal neurons: Signal convergence onto small rho GTPases. Front Synaptic Neurosci. 5:42013. View Article : Google Scholar : PubMed/NCBI

39 

Savaskan NE, Brauer AU and Nitsch R: Molecular cloning and expression regulation of PRG-3, a new member of the plasticity-related gene family. Eur J Neurosci. 19:212–220. 2004. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tan F, Wang J, Liu JX, Wang C, Li M and Gu Y: Electroacupuncture stimulates the proliferation and differentiation of endogenous neural stem cells in a rat model of ischemic stroke. Exp Ther Med 16: 4943-4950, 2018.
APA
Tan, F., Wang, J., Liu, J.X., Wang, C., Li, M., & Gu, Y. (2018). Electroacupuncture stimulates the proliferation and differentiation of endogenous neural stem cells in a rat model of ischemic stroke. Experimental and Therapeutic Medicine, 16, 4943-4950. https://doi.org/10.3892/etm.2018.6848
MLA
Tan, F., Wang, J., Liu, J. X., Wang, C., Li, M., Gu, Y."Electroacupuncture stimulates the proliferation and differentiation of endogenous neural stem cells in a rat model of ischemic stroke". Experimental and Therapeutic Medicine 16.6 (2018): 4943-4950.
Chicago
Tan, F., Wang, J., Liu, J. X., Wang, C., Li, M., Gu, Y."Electroacupuncture stimulates the proliferation and differentiation of endogenous neural stem cells in a rat model of ischemic stroke". Experimental and Therapeutic Medicine 16, no. 6 (2018): 4943-4950. https://doi.org/10.3892/etm.2018.6848
Copy and paste a formatted citation
x
Spandidos Publications style
Tan F, Wang J, Liu JX, Wang C, Li M and Gu Y: Electroacupuncture stimulates the proliferation and differentiation of endogenous neural stem cells in a rat model of ischemic stroke. Exp Ther Med 16: 4943-4950, 2018.
APA
Tan, F., Wang, J., Liu, J.X., Wang, C., Li, M., & Gu, Y. (2018). Electroacupuncture stimulates the proliferation and differentiation of endogenous neural stem cells in a rat model of ischemic stroke. Experimental and Therapeutic Medicine, 16, 4943-4950. https://doi.org/10.3892/etm.2018.6848
MLA
Tan, F., Wang, J., Liu, J. X., Wang, C., Li, M., Gu, Y."Electroacupuncture stimulates the proliferation and differentiation of endogenous neural stem cells in a rat model of ischemic stroke". Experimental and Therapeutic Medicine 16.6 (2018): 4943-4950.
Chicago
Tan, F., Wang, J., Liu, J. X., Wang, C., Li, M., Gu, Y."Electroacupuncture stimulates the proliferation and differentiation of endogenous neural stem cells in a rat model of ischemic stroke". Experimental and Therapeutic Medicine 16, no. 6 (2018): 4943-4950. https://doi.org/10.3892/etm.2018.6848
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