Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2018 Volume 16 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2018 Volume 16 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Dynamic changes and diagnostic and prognostic significance of serum PCT, hs‑CRP and s-100 protein in central nervous system infection

  • Authors:
    • Jiaan Wang
    • Xicai Wu
    • Yufeng Tian
    • Xueyuan Li
    • Xia Zhao
    • Min Zhang
  • View Affiliations / Copyright

    Affiliations: Inspection Department, People's Hospital of Rizhao, Rizhao, Shandong 276800, P.R. China, Rizhao Disease Prevention and Control Center, People's Hospital of Rizhao, Rizhao, Shandong 276800, P.R. China, Nursing Department, People's Hospital of Rizhao, Rizhao, Shandong 276800, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5156-5160
    |
    Published online on: October 16, 2018
       https://doi.org/10.3892/etm.2018.6866
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the study was to analyze the dynamic changes and diagnostic and prognostic significance of serum procalcitonin (PCT), high‑sensitivity C-reactive protein (hs‑CRP) and s-100 protein in central nervous system infection. A total of 110 patients diagnosed with central nervous system infection in Department of Neurology in the People's Hospital of Rizhao from January 2014 to January 2016 were selected and retrospectively analyzed; they were divided into the bacterium (n=70) and virus (n=40) groups. Another 45 normal subjects were selected as the control group. PCT, hs‑CRP and s-100 protein values in serum and cerebrospinal fluid were measured. The serum PCT, hs‑CRP and s-100 protein levels in the bacterium group were significantly higher than those in the virus and control groups (p<0.05). The serum PCT, hs‑CRP and s-100 protein levels in the bacterium and virus groups after treatment were obviously decreased compared with those before treatment (p<0.05). PCT, hs‑CRP and s-100 protein levels in serum and cerebrospinal fluid in the bacterium and virus groups had no statistically significant differences after treatment (p>0.05). PCT, hs‑CRP and s-100 protein levels in deaths in bacterium group were significantly higher than those in survivors (p<0.05). The serum PCT, hs‑CRP and s-100 protein levels, can serve as important indexes for the diagnosis of central nervous system infection and their dynamic changes can be used to monitor the changes in disease condition, severity of bacterial infection and prognosis, providing help for the clinical treatment thereof.
View Figures

Figure 1

Figure 2

View References

1 

Assicot M, Gendrel D, Carsin H, Raymond J, Guilbaud J and Bohuon C: High serum procalcitonin concentrations in patients with sepsis and infection. Lancet. 341:515–518. 1993. View Article : Google Scholar : PubMed/NCBI

2 

Nylen ES, Whang KT, Snider RH Jr, Steinwald PM, White JC and Becker KL: Mortality is increased by procalcitonin and decreased by an antiserum reactive to procalcitonin in experimental sepsis. Crit Care Med. 26:1001–1006. 1998. View Article : Google Scholar : PubMed/NCBI

3 

Whang KT, Vath SD, Becker KL, Snider RH, Nylen ES, Muller B, Li Q, Tamarkin L and White JC: Procalcitqnin and proinflammatory cytokine interaction in sepsis. Shock. 11:73–78. 2000. View Article : Google Scholar

4 

Barati M, Alinejad F, Bahar MA, Tabrisi MS, Shamshiri AR, Bodouhi NO and Karimi H: Comparison of WBC ESR, CRP and PCT serum levels in septic and non-septic burn cases. Burns. 34:770–774. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Alkholi UM, Abd Al-Monem N, Abd El-Azim AA and Sultan MH: Serum procalcitonin in viral and bacterial meningitis. J Glob Infect Dis. 3:14–18. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Viallon A, Guyomarc'h P, Guyomarc'h S, Tardy B, Robert F, Marjollet O, Caricajo A, Lambert C, Zéni F and Bertrand JC: Decrease in serum procalcitonin levels over time during treatment of acute bacterial meningitis. Crit Care. 9:R344–R350. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Jereb M, Muzlovic I, Hojker S and Strle F: Predictive value of serum and cerebrospinal fluid procalcitonin levels for the diagnosis of bacterial meningitis. Infection. 29:209–212. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Lorrot M, Moulin F, Coste J, Ravilly S, Guérin S, Lebon P, Lacombe C, Raymond J, Bohuon C and Gendrel D: Procalcitonin in pediatric emergencies: Comparison with C-reactive protein, interleukin-6 and interferon alpha in the differentiation between bacterial and viral infections. Presse Med. 29:128–134. 2000.(In French). PubMed/NCBI

9 

Knudsen TB, Larsen K, Kristiansen TB, Møller HJ, Tvede M, Eugen-Olsen J and Kronborg G: Diagnostic value of soluble CD163 serum levels in patients suspected of meningitis: Comparison with CRP and procalcitonin. Scand J Infect Dis. 39:542–553. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Taskin E, Turgut M, Kilic M, Akbulut H and Aygun AD: Serum procalcitonin and cerebrospinal fluid cytokines level in children with meningitis. Mediators Inflamm. 13:269–273. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Kang YA, Kwon SY, Yoon HI, Lee JH and Lee CT: Role of C-reactive protein and procalcitonin in differentiation of tuberculosis from bacterial community acquired pneumonia. Korean J Intern Med. 24:337–342. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Jiang J, Shi HZ, Liang QL, Qin SM and Qin XJ: Diagnostic value of interferon-gamma in tuberculous pleurisy: A metaanalysis. Chest. 131:1133–1141. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Carrol ED, Newland P, Thomson AP and Hart CA: Prognostic value of procalcitonin in children with meningococcal sepsis. Crit Care Med. 33:224–225. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Stich O, Andres TA, Gross CM, Gerber SI, Rauer S and Langosch JM: An observational study of inflammation in the central nervous system in patients with bipolar disorder. Bipolar Disord. 17:291–302. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Petros S, Leonhardt U and Engelmann L: Serum procalcitonin and proinflammatory cytokines in a patient with acute severe leptospirosis. Scand J Infect Dis. 32:104–105. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Mills GD, Lala HM, Oehley MR, Craig AB, Barratt K, Hood D, Thornley CN, Nesdale A, Manikkam NE and Reeve P: Elevated procalcitonin as a diagnostic marker in meningococcal disease. Eur J Clin Microbiol Infect Dis. 25:501–509. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Christ-Crain M, Jaccard-Stolz D, Bingisser R, Gencay MM, Huber PR, Tamm M and Müller B: Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: Cluster-randomised, single-blinded intervention trial. Lancet. 363:600–607. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Viallon A, Pouze V, Zéni F, Tardy B, Guyomarc'h S, Lambert C, Page Y and Bertrand JC: Rapid diagnosis of the type of meningitis (bacterial or viral) by the assay of serum procalcitionin. Presse Med. 29:584–588. 2000.(In French). PubMed/NCBI

19 

Dubos F, Korczowski B, Aygun DA, Martinot A, Prat C, Galetto-Lacour A, Casado-Flores J, Taskin E, Leclerc F, Rodrigo C, et al: Distinguishing between bacterial and aseptic meningitis in children: European comparison of two clinical decision rules. Arch Dis Child. 95:963–967. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang J, Wu X, Tian Y, Li X, Zhao X and Zhang M: Dynamic changes and diagnostic and prognostic significance of serum PCT, hs‑CRP and s-100 protein in central nervous system infection. Exp Ther Med 16: 5156-5160, 2018.
APA
Wang, J., Wu, X., Tian, Y., Li, X., Zhao, X., & Zhang, M. (2018). Dynamic changes and diagnostic and prognostic significance of serum PCT, hs‑CRP and s-100 protein in central nervous system infection. Experimental and Therapeutic Medicine, 16, 5156-5160. https://doi.org/10.3892/etm.2018.6866
MLA
Wang, J., Wu, X., Tian, Y., Li, X., Zhao, X., Zhang, M."Dynamic changes and diagnostic and prognostic significance of serum PCT, hs‑CRP and s-100 protein in central nervous system infection". Experimental and Therapeutic Medicine 16.6 (2018): 5156-5160.
Chicago
Wang, J., Wu, X., Tian, Y., Li, X., Zhao, X., Zhang, M."Dynamic changes and diagnostic and prognostic significance of serum PCT, hs‑CRP and s-100 protein in central nervous system infection". Experimental and Therapeutic Medicine 16, no. 6 (2018): 5156-5160. https://doi.org/10.3892/etm.2018.6866
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Wu X, Tian Y, Li X, Zhao X and Zhang M: Dynamic changes and diagnostic and prognostic significance of serum PCT, hs‑CRP and s-100 protein in central nervous system infection. Exp Ther Med 16: 5156-5160, 2018.
APA
Wang, J., Wu, X., Tian, Y., Li, X., Zhao, X., & Zhang, M. (2018). Dynamic changes and diagnostic and prognostic significance of serum PCT, hs‑CRP and s-100 protein in central nervous system infection. Experimental and Therapeutic Medicine, 16, 5156-5160. https://doi.org/10.3892/etm.2018.6866
MLA
Wang, J., Wu, X., Tian, Y., Li, X., Zhao, X., Zhang, M."Dynamic changes and diagnostic and prognostic significance of serum PCT, hs‑CRP and s-100 protein in central nervous system infection". Experimental and Therapeutic Medicine 16.6 (2018): 5156-5160.
Chicago
Wang, J., Wu, X., Tian, Y., Li, X., Zhao, X., Zhang, M."Dynamic changes and diagnostic and prognostic significance of serum PCT, hs‑CRP and s-100 protein in central nervous system infection". Experimental and Therapeutic Medicine 16, no. 6 (2018): 5156-5160. https://doi.org/10.3892/etm.2018.6866
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team